| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daisy Mohanasundaram, Chris Drogemuller, John Brealey, Claire F Jessup, Clyde Milner, Chiara Murgia, Carol J Lang, Austin Milton, Peter D Zalewski, Graeme R Russ, Patrick T Coate. Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in New world primate (Callithrix jacchus) and human pancreatic islets. General and comparative endocrinology. vol 174. issue 2. 2012-05-15. PMID:21821034. |
antibody staining for insulin, glucagon, somatostatin and glucagon-like peptide-1 (glp-1) showed that the distribution pattern of the different cell types within islets was comparable to pig and human islets. |
2012-05-15 |
2023-08-12 |
human |
| Joanna Hlebowicz, Sandra Lindstedt, Ola Björgell, Magnus Dencke. The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure. Cardiovascular ultrasound. vol 9. 2012-05-15. PMID:22206473. |
the aim of this study was to evaluate the effect of endogenously released glucose, insulin, glucagon-like peptide 1 (glp-1), ghrelin on co, hr, stroke volume (sv), and blood pressure. |
2012-05-15 |
2023-08-12 |
Not clear |
| Özlem Erdogdu, Linnéa Eriksson, Thomas Nyström, Åke Sjöholm, Qimin Zhan. Exendin-4 restores glucolipotoxicity-induced gene expression in human coronary artery endothelial cells. Biochemical and biophysical research communications. vol 419. issue 4. 2012-05-11. PMID:22390929. |
exendin-4, a stable glp-1 receptor agonist, has been shown to stimulate insulin secretion. |
2012-05-11 |
2023-08-12 |
human |
| T Vilsbøll, A J Garbe. Non-glycaemic effects mediated via GLP-1 receptor agonists and the potential for exploiting these for therapeutic benefit: focus on liraglutide. Diabetes, obesity & metabolism. vol 14 Suppl 2. 2012-05-09. PMID:22405268. |
the glucagon-like peptide-1 receptor agonists (glp-1 ras) liraglutide and exenatide can improve glycaemic control by stimulating insulin release through pancreatic β-cells in a glucose-dependent manner. |
2012-05-09 |
2023-08-12 |
Not clear |
| Lakshminarayanan Varadhan, Tracy Humphreys, Christian Hariman, Adrian B Walker, George I Varughes. GLP-1 agonist treatment: implications for diabetic retinopathy screening. Diabetes research and clinical practice. vol 94. issue 3. 2012-05-08. PMID:21906831. |
rapid improvement in glycaemic control induced by glp-1 agonist therapy could be yet another illustration of transient or permanent progression of diabetic retinopathy, similar to documented examples such as pregnancy and continuous subcutaneous insulin infusion. |
2012-05-08 |
2023-08-12 |
Not clear |
| Tae-Il Kim, Minhyung Lee, Sung Wan Ki. Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer. Journal of controlled release : official journal of the Controlled Release Society. vol 157. issue 2. 2012-05-08. PMID:21945681. |
when transfection medium containing secreted glp-1 was transferred to nit-1 insulinoma cells, the highest secretion level of insulin was induced in abp/tsta (sp-glp-1) polyplex medium-treated cells. |
2012-05-08 |
2023-08-12 |
Not clear |
| A-H Wei, W-J Wang, X-P Mu, H-M Li, W-Q Ya. Enhanced differentiation of human adipose tissue-derived stromal cells into insulin-producing cells with glucagon-like peptide-1. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 120. issue 1. 2012-05-07. PMID:21915820. |
in addition, flow cytometry analysis and elisa showed that, in the presence of glp-1, the percentage of insulin-producing cells was increased from 5.9% to 28.0% and the release of insulin increased from 9.53±0.7 pmol/106 cells to 15.86±1.3 pmol/106 cells. |
2012-05-07 |
2023-08-12 |
human |
| K Esposito, P Chiodini, G Bellastella, M I Maiorino, D Giuglian. Proportion of patients at HbA1c target <7% with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78 945 patients. Diabetes, obesity & metabolism. vol 14. issue 3. 2012-05-04. PMID:21958121. |
we assessed the efficacy of eight classes of diabetes medications used in current clinical practice [metformin, sulphonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 (glp-1) analogues and insulin analogues] to reach the hba1c target <7% in type 2 diabetes. |
2012-05-04 |
2023-08-12 |
Not clear |
| T Narita, H Yokoyama, R Yamashita, T Sato, M Hosoba, T Morii, H Fujita, K Tsukiyama, Y Yamad. Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients. Diabetes, obesity & metabolism. vol 14. issue 3. 2012-05-04. PMID:22051162. |
after 12-week administration of both drugs, during 2-h meal tolerance test, plasma glucose, serum insulin and total gip were significantly decreased and active glp-1 was significantly increased. |
2012-05-04 |
2023-08-12 |
human |
| T Narita, H Yokoyama, R Yamashita, T Sato, M Hosoba, T Morii, H Fujita, K Tsukiyama, Y Yamad. Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients. Diabetes, obesity & metabolism. vol 14. issue 3. 2012-05-04. PMID:22051162. |
in all participants, the relative change in bw was positively correlated with that of insulin significantly and of gip with a weak tendency, but not of glp-1. |
2012-05-04 |
2023-08-12 |
human |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion and suppresses food intake. |
2012-05-03 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
this study aimed to determine whether dpp-iv inhibitor-induced elevation of portal glp-1 levels affect insulin secretion and feeding behavior via the vagal afferent nerve and hypothalamus. |
2012-05-03 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
the effect of dpp-iv inhibitor infusion into the portal vein or peritoneum on portal and peripheral glp-1 levels, food intake, and plasma insulin and glucose was examined in sham-operated and vagotomized male sprague-dawley rats. |
2012-05-03 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
intraportal administration of the dpp-iv inhibitor significantly increased portal (but not peripheral) glp-1 levels, increased insulin levels, and decreased glucose levels. |
2012-05-03 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
our results indicate that dpp-iv inhibitor-induced changes in portal but not systemic glp-1 levels affect insulin secretion and food intake. |
2012-05-03 |
2023-08-12 |
rat |
| Masayuki Miyazaki, Masaki Kato, Kosuke Tanaka, Masatake Tanaka, Motoyuki Kohjima, Kazuhiko Nakamura, Munechika Enjoji, Makoto Nakamuta, Kazuhiro Kotoh, Ryoichi Takayanag. Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Molecular medicine reports. vol 5. issue 3. 2012-05-03. PMID:22179204. |
dipeptidyl peptidase-4 (dpp4) is a serine protease that degrades glucagon-like peptide-1 (glp-1), an incretin hormone that stimulates insulin secretion from pancreatic β-cells. |
2012-05-03 |
2023-08-12 |
human |
| Tenagne Delessa Challa, Nigel Beaton, Myrtha Arnold, Gottfried Rudofsky, Wolfgang Langhans, Christian Wolfru. Regulation of adipocyte formation by GLP-1/GLP-1R signaling. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22207759. |
because glp-1 and liraglutide are used for the treatment of type 2 diabetes, these findings implicate glp-1 as a regulator of adipogenesis, which could be an alternate pathway leading to improved lipid homeostasis and controlled downstream insulin signaling. |
2012-04-25 |
2023-08-12 |
Not clear |
| Michel Marre, Alfred Penforni. GLP-1 receptor agonists today. Diabetes research and clinical practice. vol 93. issue 3. 2012-04-24. PMID:21767888. |
it also concentrates on the physiological basis for early use of glp-1 receptor agonists, their use as an alternative to insulin therapy, the rationale for combining them with insulin and their cost-effectiveness. |
2012-04-24 |
2023-08-12 |
Not clear |
| Sara Baldassano, Guo-Du Wang, Flavia Mulè, Jackie D Woo. Glucagon-like peptide-1 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 3. 2012-04-23. PMID:22075777. |
glucagon-like peptide-1 (glp-1) acts at the g protein-coupled receptor, glp-1r, to stimulate secretion of insulin and to inhibit secretion of glucagon and gastric acid. |
2012-04-23 |
2023-08-12 |
Not clear |
| Roberta Barone Lumaga, Danilo Azzali, Vincenzo Fogliano, Luca Scalfi, Paola Vitaglion. Sugar and dietary fibre composition influence, by different hormonal response, the satiating capacity of a fruit-based and a β-glucan-enriched beverage. Food & function. vol 3. issue 1. 2012-04-16. PMID:22057424. |
appetite ratings over 3 h post-breakfast and energy intakes at ad libitum lunch, blood glucose, insulin, ghrelin, pyy, glp-1, gip, and pp concentrations, and 24 h food intake, were assessed. |
2012-04-16 |
2023-08-12 |
human |