| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin J Lamont, Yazhou Li, Edwin Kwan, Theodore J Brown, Herbert Gaisano, Daniel J Drucke. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. The Journal of clinical investigation. vol 122. issue 1. 2012-03-06. PMID:22182839. |
glucagon-like peptide-1 (glp-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet β cells. |
2012-03-06 |
2023-08-12 |
mouse |
| Megan J Dailey, Katherine C Stingl, Timothy H Mora. Disassociation between preprandial gut peptide release and food-anticipatory activity. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128024. |
mealtime feeding not only induces an increase in activity but also appears to entrain the secretion of various peptides prior to a meal including insulin, ghrelin, and glucagon-like peptide-1 (glp-1). |
2012-03-05 |
2023-08-12 |
rat |
| Megan J Dailey, Katherine C Stingl, Timothy H Mora. Disassociation between preprandial gut peptide release and food-anticipatory activity. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128024. |
these data suggest that separate mechanisms may underlie the preprandial increases in ghrelin and glp-1 and changes in faa, insulin, and glucose. |
2012-03-05 |
2023-08-12 |
rat |
| Brittany M Vester Boler, Trevor A Faber, Laura L Bauer, Kelly S Swanson, Scott Smiley, Peter J Bechtel, George C Fahe. Acute satiety response of mammalian, avian and fish proteins in dogs. The British journal of nutrition. vol 107. issue 1. 2012-02-23. PMID:21733332. |
blood was collected at 0, 5, 15, 30, 60, 90 and 120 min postprandially and analysed for glucose, insulin, total ghrelin, active glucagon-like peptide-1 (glp-1) and plasma amino acids (aa). |
2012-02-23 |
2023-08-12 |
chicken |
| Kyuzi Kamoi, You Shinozaki, Kazuo Furukawa, Hideo Sasak. Decreased active GLP-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues. Endocrine journal. vol 58. issue 10. 2012-02-23. PMID:21878743. |
decreased active glp-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues. |
2012-02-23 |
2023-08-12 |
human |
| Kyuzi Kamoi, You Shinozaki, Kazuo Furukawa, Hideo Sasak. Decreased active GLP-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues. Endocrine journal. vol 58. issue 10. 2012-02-23. PMID:21878743. |
postprandial plasma immunoreactive active glucagon-like peptide-1 (p-active glp-1) levels in type 1 diabetic patients who did not use bolus insulin responded normally following ingestion of test meal, while a small response of p-active glp-1 levels was seen in type 2 diabetic patients. |
2012-02-23 |
2023-08-12 |
human |
| Kyuzi Kamoi, You Shinozaki, Kazuo Furukawa, Hideo Sasak. Decreased active GLP-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues. Endocrine journal. vol 58. issue 10. 2012-02-23. PMID:21878743. |
to determine whether p-active glp-1 levels are affected by ingestion of test meal in type 1 diabetic japanese patients who used bolus rapid-acting insulin analogues, plasma glucose (pg), serum immunoreactive insulin (s-iri), serum immunoreactive c-peptide (s-cpr), and p-active glp-1 levels were measured 0, 30, and 60 min after ingestion of test meal in japanese patients without diabetic complications (n=10, group 1) and control subjects with normal glucose tolerance (n=15, group 2). |
2012-02-23 |
2023-08-12 |
human |
| Kyuzi Kamoi, You Shinozaki, Kazuo Furukawa, Hideo Sasak. Decreased active GLP-1 response following large test meal in patients with type 1 diabetes using bolus insulin analogues. Endocrine journal. vol 58. issue 10. 2012-02-23. PMID:21878743. |
these results indicated that postprandial p-active glp-1 levels following ingestion of test meal in type 1 diabetic japanese patients using bolus rapid-acting insulin analogues were decreased relative to those in controls. |
2012-02-23 |
2023-08-12 |
human |
| María L Villanueva-Peñacarrillo, Antonio Martín-Duce, Irene Ramos-Álvarez, Irene Gutiérrez-Rojas, Paola Moreno, Bernardo Nuche-Berenguer, Alicia Acitores, Verónica Sancho, Isabel Valverde, Nieves Gonzále. Characteristic of GLP-1 effects on glucose metabolism in human skeletal muscle from obese patients. Regulatory peptides. vol 168. issue 1-3. 2012-02-16. PMID:21419173. |
in ob, the control value of all kinases analyzed - pi3k, pkb, mapks, and p70s6k - although lower than that in normal or t2d subjects, the cells maintained their response capability to glp-1, ex-4, ex-9 and insulin, with some exceptions. |
2012-02-16 |
2023-08-12 |
human |
| Andrew J Mulherin, Amy H Oh, Helena Kim, Anthony Grieco, Lina M Lauffer, Patricia L Brubake. Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell. Endocrinology. vol 152. issue 12. 2012-02-16. PMID:21971158. |
glucagon-like peptide-1(7-36nh2) (glp-1) is secreted by the intestinal l cell in response to both nutrient and neural stimulation, resulting in enhanced glucose-dependent insulin secretion. |
2012-02-16 |
2023-08-12 |
human |
| Laura Mendieta, Teresa Tarrago, Ernest Giral. Recent patents of dipeptidyl peptidase IV inhibitors. Expert opinion on therapeutic patents. vol 21. issue 11. 2012-02-15. PMID:22017411. |
the incretin molecules glucagon-like peptide 1 (glp-1) and glucose-dependent insulinotropic peptide (gip) are hydrolyzed by dpp iv into inactive forms, which are unable to promote insulin secretion. |
2012-02-15 |
2023-08-12 |
Not clear |
| Lihong Chen, Xiaozhou Yao, Andrew Young, Judi McNulty, Don Anderson, Yaping Liu, Christopher Nystrom, Dallas Croom, Sean Ross, Jon Collins, Deepak Rajpal, Kimberly Hamlet, Chari Smith, Bronislava Geduli. Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. American journal of physiology. Endocrinology and metabolism. vol 302. issue 1. 2012-02-14. PMID:21934041. |
an oral glucose tolerance test revealed up to two-fold increase in plasma total glp-1 and three-fold increase in insulin in 264w94 treated zdf rats at doses sufficient to achieve glycemic control. |
2012-02-14 |
2023-08-12 |
rat |
| Naomi J McKay, Scott E Kanoski, Matthew R Hayes, Derek Daniel. Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 6. 2012-02-14. PMID:21975647. |
glp-1 receptor (glp-1r) agonists applied peripherally or centrally decrease food intake and increase glucose-stimulated insulin secretion. |
2012-02-14 |
2023-08-12 |
Not clear |
| N Basso, D Capoccia, M Rizzello, F Abbatini, P Mariani, C Maglio, F Coccia, G Borgonuovo, M L De Luca, R Asprino, G Alessandri, G Casella, F Leonett. First-phase insulin secretion, insulin sensitivity, ghrelin, GLP-1, and PYY changes 72 h after sleeve gastrectomy in obese diabetic patients: the gastric hypothesis. Surgical endoscopy. vol 25. issue 11. 2012-02-13. PMID:21638183. |
first-phase insulin secretion, insulin sensitivity, ghrelin, glp-1, and pyy changes 72 h after sleeve gastrectomy in obese diabetic patients: the gastric hypothesis. |
2012-02-13 |
2023-08-12 |
Not clear |
| Lin Wu, Anna Olverling, Zhen Huang, Leif Jansson, Hongfen Chao, Xin Gao, Åke Sjöhol. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats. Clinical science (London, England : 1979). vol 122. issue 8. 2012-02-13. PMID:22054347. |
glp-1, exendin-4 and c-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats. |
2012-02-13 |
2023-08-12 |
rat |
| Lin Wu, Anna Olverling, Zhen Huang, Leif Jansson, Hongfen Chao, Xin Gao, Åke Sjöhol. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats. Clinical science (London, England : 1979). vol 122. issue 8. 2012-02-13. PMID:22054347. |
since insulin secretion in vivo can be rapidly tuned by changes in islet microcirculation, we evaluated the influence of glp-1, exendin-4 and c-peptide on pancreatic ibf (islet blood flow), and dynamic changes in insulin secretion and glycaemia in the rat. |
2012-02-13 |
2023-08-12 |
rat |
| Lin Wu, Anna Olverling, Zhen Huang, Leif Jansson, Hongfen Chao, Xin Gao, Åke Sjöhol. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats. Clinical science (London, England : 1979). vol 122. issue 8. 2012-02-13. PMID:22054347. |
glp-1, exendin-4 and c-peptide stimulated insulin secretion and significantly decreased glycaemia. |
2012-02-13 |
2023-08-12 |
rat |
| Lin Wu, Anna Olverling, Zhen Huang, Leif Jansson, Hongfen Chao, Xin Gao, Åke Sjöhol. GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats. Clinical science (London, England : 1979). vol 122. issue 8. 2012-02-13. PMID:22054347. |
the vascular modulatory effect on pancreatic islet microcirculation described herein, with subsequent effects on in vivo insulin secretion and glycaemia, might be one of the mechanisms underlying the anti-diabetic actions of glp-1 and its long acting mimetic exendin-4, as well as that of c-peptide. |
2012-02-13 |
2023-08-12 |
rat |
| Atul Sureshrao Akarte, B P Srinivasan, Sonia Gandh. A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats. Biochemical pharmacology. vol 83. issue 2. 2012-02-07. PMID:22015634. |
this study examined chronic (once-a-day dosing for 8 weeks) effects of the dpp-4 inhibitor pkf-275-055 (1, 3, and 10mg/kg) on β-cell regeneration and plasma dpp-iv activity, intact glp-1, glucose, and insulin after an oral glucose load in neonatal wistar rats injected with streptozotocin (stz) (n2-stz model), a recognized model of type 2 diabetes. |
2012-02-07 |
2023-08-12 |
rat |
| Atul Sureshrao Akarte, B P Srinivasan, Sonia Gandh. A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats. Biochemical pharmacology. vol 83. issue 2. 2012-02-07. PMID:22015634. |
in streptozotocin induced diabetic rats, pkf-275-055 (3, and 10mg/kg) significantly reduced glucose excursion during the oral glucose tolerance test conducted 2h and 10h after administration, with increases in plasma insulin and active glucagon-like peptide-1 (glp-1) levels and significantly inhibited (> 50% inhibition) plasma dpp-iv activity during both the 1st and 2nd ogtt in diabetic rats. |
2012-02-07 |
2023-08-12 |
rat |