| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye-Hwang Cheong, Mi-Kyung Kim, Moon-Ho Son, Bong-Kiun Kaan. Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells. Biochemical and biophysical research communications. vol 414. issue 1. 2011-12-12. PMID:21945929. |
in type 2 diabetes, stimulation of insulin secretion by glucagon-like peptide-1 (glp-1) has been found to be reduced, and the results of recent studies have shown that the expression of the glp-1 receptor (glp-1r) is reduced by chronic hyperglycemia. |
2011-12-12 |
2023-08-12 |
rat |
| Ye-Hwang Cheong, Mi-Kyung Kim, Moon-Ho Son, Bong-Kiun Kaan. Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells. Biochemical and biophysical research communications. vol 414. issue 1. 2011-12-12. PMID:21945929. |
in comparison to both the shg and control groups, ihg conditions induced a more significant impairment of insulin release and calcium influx in response to 1nm glp-1 treatment. |
2011-12-12 |
2023-08-12 |
rat |
| John W Apolzan, Heather J Leidy, Richard D Mattes, Wayne W Campbel. Effects of food form on food intake and postprandial appetite sensations, glucose and endocrine responses, and energy expenditure in resistance trained v. sedentary older adults. The British journal of nutrition. vol 106. issue 7. 2011-12-09. PMID:21492495. |
the present study assessed the effects of the ffns and rt on postprandial appetite sensations (hunger and fullness), endocrine responses (plasma insulin, cholecystokinin, ghrelin and glucagon-like peptide-1 (glp-1)), metabolism (glucose, energy expenditure and rer) and food intake (satiation) in older adults. |
2011-12-09 |
2023-08-12 |
Not clear |
| Joan Vendrell, Rajaa El Bekay, Belén Peral, Eduardo García-Fuentes, Anna Megia, Manuel Macias-Gonzalez, José Fernández Real, Yolanda Jimenez-Gomez, Xavier Escoté, Gisela Pachón, Rafael Simó, David M Selva, María M Malagón, Francisco J Tinahone. Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology. vol 152. issue 11. 2011-12-08. PMID:21862620. |
study of the potential association of adipose tissue glp-1 receptor with obesity and insulin resistance. |
2011-12-08 |
2023-08-12 |
human |
| Joan Vendrell, Rajaa El Bekay, Belén Peral, Eduardo García-Fuentes, Anna Megia, Manuel Macias-Gonzalez, José Fernández Real, Yolanda Jimenez-Gomez, Xavier Escoté, Gisela Pachón, Rafael Simó, David M Selva, María M Malagón, Francisco J Tinahone. Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology. vol 152. issue 11. 2011-12-08. PMID:21862620. |
furthermore, no relationship has been established between glp-1 receptor (glp-1r) in at and obesity and insulin resistance (ir). |
2011-12-08 |
2023-08-12 |
human |
| Joan Vendrell, Rajaa El Bekay, Belén Peral, Eduardo García-Fuentes, Anna Megia, Manuel Macias-Gonzalez, José Fernández Real, Yolanda Jimenez-Gomez, Xavier Escoté, Gisela Pachón, Rafael Simó, David M Selva, María M Malagón, Francisco J Tinahone. Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance. Endocrinology. vol 152. issue 11. 2011-12-08. PMID:21862620. |
furthermore, prospective studies carried out with patients that underwent biliopancreatic diversion surgery showed that subjects with high levels of glp-1r expression in at, which indicates a deficit of glp-1 in this tissue, were those whose insulin sensitivity improved after surgery, suggesting the potential relationship between at glp-1r and insulin sensitivity amelioration in obese subjects. |
2011-12-08 |
2023-08-12 |
human |
| L B Katz, J J Gambale, P L Rothenberg, S R Vanapalli, N Vaccaro, L Xi, D C Polidori, E Vets, T C Sarich, P P Stei. Pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-38431055, a novel GPR119 receptor agonist and potential antidiabetes agent, in healthy male subjects. Clinical pharmacology and therapeutics. vol 90. issue 5. 2011-12-07. PMID:21975348. |
as compared with placebo, single-dose oral jnj-38431055 increased postmeal plasma glucagon-like peptide 1 (glp-1), glucose-dependent insulinotropic peptide (gip), and peptide yy (pyy) concentrations but did not significantly decrease glucose excursion or increase insulin secretion. |
2011-12-07 |
2023-08-12 |
human |
| Nadja Herbach, Martina Bergmayr, Burkhard Göke, Eckhard Wolf, Ruediger Wank. Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice. PloS one. vol 6. issue 7. 2011-12-06. PMID:21818396. |
insulin secretion in response to pharmacological doses of gip was preserved in gipr(dn) transgenic mice, and serum insulin to pancreatic insulin content in response to glp-1 and arginine was significantly higher in gipr(dn) transgenic mice vs. controls. |
2011-12-06 |
2023-08-12 |
mouse |
| Enrico Mossello, Elena Ballini, Marta Boncinelli, Matteo Monami, Giuseppe Lonetto, Anna Maria Mello, Francesca Tarantini, Samuele Baldasseroni, Edoardo Mannucci, Niccolò Marchionn. Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities. Experimental diabetes research. vol 2011. 2011-12-02. PMID:21747826. |
glucagon-like peptide 1 (glp-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. |
2011-12-02 |
2023-08-12 |
Not clear |
| D Russell-Jone. The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes. International journal of clinical practice. vol 64. issue 10. 2011-11-23. PMID:20716148. |
glp-1 receptor agonists stimulate insulin release only in the presence of elevated blood glucose and are therefore associated with a fairly low risk of hypoglycaemia. |
2011-11-23 |
2023-08-12 |
human |
| Paul Grant, David Lipscomb, John Qui. Psychological and quality of life changes in patients using GLP-1 analogues. Journal of diabetes and its complications. vol 25. issue 4. 2011-11-18. PMID:21601480. |
using psychological and quality of life assessment tools, we prospectively studied changes in health-related quality of life and emotional well-being in patients who had commenced glp-1 analogue therapy (exenatide) and compared them with new insulin starters. |
2011-11-18 |
2023-08-12 |
Not clear |
| C Gilor, T K Graves, S Gilor, T K Ridge, M Ric. The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats. Domestic animal endocrinology. vol 41. issue 1. 2011-11-15. PMID:21645806. |
the glp-1 mimetic exenatide potentiates insulin secretion in healthy cats. |
2011-11-15 |
2023-08-12 |
cat |
| Yukari Takeda, Akira Amano, Akinori Noma, Yasuhiko Nakamura, Shimpei Fujimoto, Nobuya Inagak. Systems analysis of GLP-1 receptor signaling in pancreatic β-cells. American journal of physiology. Cell physiology. vol 301. issue 4. 2011-11-15. PMID:21734192. |
glucagon-like peptide-1 (glp-1) elevates intracellular concentration of camp ([camp]) and facilitates glucose-dependent insulin secretion in pancreatic β-cells. |
2011-11-15 |
2023-08-12 |
Not clear |
| Christian Hölsche. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochemical Society transactions. vol 39. issue 4. 2011-11-15. PMID:21787319. |
in particular, the incretins glp-1 (glucagon-like peptide-1) and gip (glucose-dependent insolinotropic polypeptide) are hormones that re-sensitize insulin signalling. |
2011-11-15 |
2023-08-12 |
mouse |
| Neil A Schwarz, B Rhett Rigby, Paul La Bounty, Brian Shelmadine, Rodney G Bowde. A review of weight control strategies and their effects on the regulation of hormonal balance. Journal of nutrition and metabolism. vol 2011. 2011-11-10. PMID:21822485. |
the purpose of this paper is to provide a synopsis of how exercise, sleep, psychological stress, and meal frequency and composition affect levels of ghrelin, cortisol, insulin glp-1, and leptin and weight control. |
2011-11-10 |
2023-08-12 |
Not clear |
| Anthony H Barnet. Lixisenatide: evidence for its potential use in the treatment of type 2 diabetes. Core evidence. vol 6. 2011-11-10. PMID:22022289. |
both glp-1 receptor agonists and long-acting insulin analogs have demonstrated protective effects on beta cells in preclinical studies. |
2011-11-10 |
2023-08-12 |
Not clear |
| Victor A Gault, Barry D Kerr, Patrick Harriott, Peter R Flat. Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. Clinical science (London, England : 1979). vol 121. issue 3. 2011-11-08. PMID:21332446. |
glp-1, gip, liraglutide, n-acgip(lys(37)myr) (n-acetylgip with myristic acid conjugated at lys(37)), a simple combination of both peptides and a lira-acgip preparation [overnight preparation of liraglutide and n-acgip(lys(37)myr)] were incubated with dpp-iv (dipeptidyl peptidase-iv) to assess peptide stability, and brin-bd11 cells were used to evaluate camp production and insulin secretion. |
2011-11-08 |
2023-08-12 |
mouse |
| Miriam Promintzer-Schifferl, Gerhard Prager, Christian Anderwald, Martina Mandl, Harald Esterbauer, Soheila Shakeri-Leidenmühler, Giovanni Pacini, Marietta Stadler, Martin G Bischof, Bernhard Ludvik, Aanton Luger, Michael Kreb. Effects of gastric bypass surgery on insulin resistance and insulin secretion in nondiabetic obese patients. Obesity (Silver Spring, Md.). vol 19. issue 7. 2011-11-08. PMID:21494227. |
we evaluated time-courses of glucose, insulin, c-peptide, and the incretin glucagon like peptide-1 (glp-1) following an oral glucose load. |
2011-11-08 |
2023-08-12 |
Not clear |
| N M Whalley, L E Pritchard, D M Smith, A Whit. Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells? The Journal of endocrinology. vol 211. issue 1. 2011-11-08. PMID:21795304. |
the aim of this study was to identify mechanisms which switch processing of proglucagon to generate glp-1 in the pancreas, given that glp-1 can increase insulin secretion and β-cell mass. |
2011-11-08 |
2023-08-12 |
human |
| Ying Li, Weiren Xu, Lida Tang, Min Gong, Jianning Zhan. A novel GLP-1 analog exhibits potent utility in the treatment of type 2 diabetes with an extended half-life and efficient glucose clearance in vivo. Peptides. vol 32. issue 7. 2011-11-07. PMID:21664938. |
the long-acting anti-diabetic property of glp715a was revealed by its increased glucose tolerance, higher hba(1c) reduction, more efficient glucose clearance and quicker insulin stimulation upon glucose administration compared to the wild-type glp-1 in rodents. |
2011-11-07 |
2023-08-12 |
Not clear |