All Relations between glp-1 and hypothalamus

Publication Sentence Publish Date Extraction Date Species
James R C Parkinson, Owais B Chaudhri, Yu-Ting Kuo, Benjamin C T Field, Amy H Herlihy, Waljit S Dhillo, Mohammad A Ghatei, Stephen R Bloom, Jimmy D Bel. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage. vol 44. issue 3. 2009-02-19. PMID:18983926. in the hypothalamus, glp-1 administration induced a significant reduction in si in the paraventricular nucleus and an increase in the ventromedial hypothalamic nucleus whereas oxm reduced si in the arcuate and supraoptic nuclei of the hypothalamus. 2009-02-19 2023-08-12 mouse
Sanghee Seo, Sunghee Ju, Hyunju Chung, Dahm Lee, Seungjoon Par. Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats. Endocrine journal. vol 55. issue 5. 2009-01-21. PMID:18506089. intracerebroventricular (icv) administration of glucagon-like peptide-1 (glp-1) inhibits food intake and induces c-fos expression in the hypothalamus. 2009-01-21 2023-08-12 rat
Sanghee Seo, Sunghee Ju, Hyunju Chung, Dahm Lee, Seungjoon Par. Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats. Endocrine journal. vol 55. issue 5. 2009-01-21. PMID:18506089. therefore we conclude that the anorectic effect of glp-1 seems to be mediated by, at least in part, by the hypothalamus. 2009-01-21 2023-08-12 rat
Luigi Brunetti, Giustino Orlando, Lucia Recinella, Sheila Leone, Claudio Ferrante, Annalisa Chiavaroli, Francesco Lazzarin, Michele Vacc. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides. vol 29. issue 8. 2008-12-01. PMID:18502539. glucagon-like peptide 1 (7-36) amide (glp-1) and exendin-4 stimulate serotonin release in rat hypothalamus. 2008-12-01 2023-08-12 rat
Luigi Brunetti, Giustino Orlando, Lucia Recinella, Sheila Leone, Claudio Ferrante, Annalisa Chiavaroli, Francesco Lazzarin, Michele Vacc. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Peptides. vol 29. issue 8. 2008-12-01. PMID:18502539. we can conclude that the central anorectic effects of glp-1 agonists could be partially mediated by increased serotonin release in the hypothalamus, leaving the catecholamine release unaffected. 2008-12-01 2023-08-12 rat
Golnaz Madadi, Prasad S Dalvi, Denise D Belsha. Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18809381. the insulin cis-regulatory regions differ between the pancreas and the hypothalamus, and glucose and glp-1 regulate the expression of hypothalamic insulin. 2008-11-13 2023-08-12 mouse
Carmen Sanz, Patricia Vázquez, M Angeles Navas, Elvira Alvarez, Enrique Blázque. Leptin but not neuropeptide Y up-regulated glucagon-like peptide 1 receptor expression in GT1-7 cells and rat hypothalamic slices. Metabolism: clinical and experimental. vol 57. issue 1. 2008-03-10. PMID:18078857. in an attempt to gain better insight into the central effects of glucagon-like peptide (glp-1), we studied the action of glucose and of regulatory peptides on the expression of its receptor (glp-1r) in hypothalamic gt1-7 cells and in ventromedial (vmh) and lateral (lh) rat hypothalamus slices. 2008-03-10 2023-08-12 rat
Attila Juhász, Evelin Katona, Eva Csongrádi, György Parag. [The regulation of body mass and its relation to the development of obesity]. Orvosi hetilap. vol 148. issue 39. 2007-12-21. PMID:17890170. body mass--strictly speaking: the adipose tissue mass--is regulated in a feed-back system by the hypothalamus and brainstem, where adiposity signals (leptin, insulin, amylin) and intestinal peptides (ghrelin, pyy, pp, glp-1, oxm, cck) and the vagal nerve provide afferent information to the central controller on the size of white adipose tissue and the actual nutritional state, respectively. 2007-12-21 2023-08-12 Not clear
Nicola Pannacciulli, Duc Son N T Le, Arline D Salbe, Kewei Chen, Eric M Reiman, Pietro A Tataranni, Jonathan Krakof. Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans. NeuroImage. vol 35. issue 2. 2007-06-04. PMID:17317222. the peak postprandial increases in plasma glp-1 concentrations were correlated with increases in rcbf in the left dorsolateral prefrontal cortex (including the left middle and inferior frontal gyri), previously implicated in pet studies of human satiation, and the hypothalamus, previously implicated in the regulation of food intake in animal and human studies, both before and after adjustment for sex, age, body fat, and changes in plasma glucose, insulin, and serum ffa concentrations. 2007-06-04 2023-08-12 human
Owais B Chaudhri, James R C Parkinson, Yu-Ting Kuo, Maralyn R Druce, Amy H Herlihy, Jimmy D Bell, Waljit S Dhillo, Sarah A Stanley, Mohammad A Ghatei, Stephen R Bloo. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17007819. using manganese-enhanced magnetic resonance imaging, we have shown distinct patterns of neuronal activation in the hypothalamus in response to intraperitoneal injections into fasted mice of 900 and 5400 nmol/kg oxm or 900 nmol/kg glp-1. 2006-12-04 2023-08-12 mouse
Owais B Chaudhri, James R C Parkinson, Yu-Ting Kuo, Maralyn R Druce, Amy H Herlihy, Jimmy D Bell, Waljit S Dhillo, Sarah A Stanley, Mohammad A Ghatei, Stephen R Bloo. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochemical and biophysical research communications. vol 350. issue 2. 2006-12-04. PMID:17007819. our data show that these two apparently similar peptides generate distinct patterns of activation within the hypothalamus, suggesting that glp-1 and oxm may act via different hypothalamic pathways. 2006-12-04 2023-08-12 mouse
Diva D De León, Michael F Crutchlow, Jee-Young Nina Ham, Doris A Stoffer. Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. The international journal of biochemistry & cell biology. vol 38. issue 5-6. 2006-05-08. PMID:16202636. the glp-1 receptor is expressed in a variety of other tissues important for carbohydrate metabolism, including pancreatic alpha-cells, hypothalamus and brainstem, and proximal intestinal tract. 2006-05-08 2023-08-12 Not clear
Koro Gotoh, Koji Fukagawa, Tomiyo Fukagawa, Hitoshi Noguchi, Tetsuya Kakuma, Toshiie Sakata, Hironobu Yoshimats. Glucagon-like peptide-1, corticotropin-releasing hormone, and hypothalamic neuronal histamine interact in the leptin-signaling pathway to regulate feeding behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 9. 2006-02-23. PMID:15894564. i3vt infusion of glp-1 increased the crh content and histamine turnover assessed using the pargyline-induced accumulation of tele-methyl histamine (t-mh), a major metabolite of neuronal histamine, in the hypothalamus. 2006-02-23 2023-08-12 rat
Koro Gotoh, Koji Fukagawa, Tomiyo Fukagawa, Hitoshi Noguchi, Tetsuya Kakuma, Toshiie Sakata, Hironobu Yoshimats. Glucagon-like peptide-1, corticotropin-releasing hormone, and hypothalamic neuronal histamine interact in the leptin-signaling pathway to regulate feeding behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 9. 2006-02-23. PMID:15894564. pretreatment with exendin(9-39), a glp-1 receptor antagonist, attenuated the leptin-induced increase in crh content of the hypothalamus. 2006-02-23 2023-08-12 rat
J J Hols. On the physiology of GIP and GLP-1. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655703. apparently, before it is degraded, glp-1 activates sensory afferents in the gastrointestinal mucosa with cell bodies in the nodose ganglion, signaling onwards to the brain stem and the hypothalamus. 2005-05-12 2023-08-12 Not clear
B Thoren. Physiology of GLP-1--lessons from glucoincretin receptor knockout mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 11-12. 2005-05-12. PMID:15655706. glp-1 has both peripheral and central actions, as this hormone is secreted by gut endocrine cells and brainstem neurons projecting into the hypothalamus and other brain regions. 2005-05-12 2023-08-12 mouse
Peter J Kin. The hypothalamus and obesity. Current drug targets. vol 6. issue 2. 2005-04-29. PMID:15777192. short-term signal hormones including cholecystokinin (cck), ghrelin, peptide yy (pyy(3-36)) and glucagon-like peptide 1 (glp-1) control meal size via pathways converging on the hypothalamus. 2005-04-29 2023-08-12 Not clear
Elvira Alvarez, M Dolores Martínez, Isabel Roncero, Julie A Chowen, Beatriz García-Cuartero, Juan D Gispert, Carmen Sanz, Patricia Vázquez, Antonio Maldonado, Javier de Cáceres, Manuel Desco, Miguel Angel Pozo, Enrique Blázque. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686481. the expression of glp-1 receptor mrna and protein allows the effect of glp-1 on glucose metabolism in the human hypothalamus and brainstem. 2005-03-21 2023-08-12 human
Elvira Alvarez, M Dolores Martínez, Isabel Roncero, Julie A Chowen, Beatriz García-Cuartero, Juan D Gispert, Carmen Sanz, Patricia Vázquez, Antonio Maldonado, Javier de Cáceres, Manuel Desco, Miguel Angel Pozo, Enrique Blázque. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686481. statistical analysis of the pet studies revealed that the administration of glp-1(7-36) amide significantly reduced (p < 0.001) cerebral glucose metabolism in hypothalamus and brainstem. 2005-03-21 2023-08-12 human
Jennifer L Lachey, David A D'Alessio, Linda Rinaman, Joel K Elmquist, Daniel J Drucker, Randy J Seele. The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology. vol 146. issue 1. 2005-01-18. PMID:15459118. in rats, central administration of glucagon-like peptide-1 (glp-1) elicits symptoms of visceral illness like those caused by the toxin lithium chloride (licl), including anorexia, conditioned taste aversion (cta) formation, and neural activation in the hypothalamus and hindbrain including activation of brainstem preproglucagon cells. 2005-01-18 2023-08-12 mouse