| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuya Tachibana, Keiko Hirofuji, Mako Matsumoto, Mitsuhiro Furuse, Shin Hasegawa, Fumiaki Yoshizawa, Kunio Sugahar. The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 137. issue 1. 2004-10-21. PMID:14720603. |
the present study was carried out to investigate whether the hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 (glp-1) in chicks. |
2004-10-21 |
2023-08-12 |
chicken |
| Tetsuya Tachibana, Keiko Hirofuji, Mako Matsumoto, Mitsuhiro Furuse, Shin Hasegawa, Fumiaki Yoshizawa, Kunio Sugahar. The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 137. issue 1. 2004-10-21. PMID:14720603. |
to examine this, fos expression in the chick hypothalamus were immunohistochemically detected after intracerebroventricular (icv) injection of 30-pmol glp-1. |
2004-10-21 |
2023-08-12 |
chicken |
| Sumit Sarkar, Csaba Fekete, Gábor Légrádi, Ronald M Lecha. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain research. vol 985. issue 2. 2003-11-10. PMID:12967720. |
glp-1 immunoreactive (ir) fibers and terminals are widely distributed in the septum, hypothalamus, thalamus and brainstem, likely originating from glp-1-ir neuronal cell bodies from the nucleus of the solitary tract of the medulla oblongata. |
2003-11-10 |
2023-08-12 |
rat |
| Kimberly P Kinzig, David A D'Alessio, James P Herman, Randall R Sakai, Torsten P Vahl, Helmer F Figueiredo, Erin K Murphy, Randy J Seeley, Helmer F Figuered. CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867498. |
the endocrine response is preferentially activated by glp-1 administration in the paraventricular nucleus of the hypothalamus, whereas the anxiety response is preferentially activated by administration in the central nucleus of the amygdala. |
2003-08-13 |
2023-08-12 |
rat |
| Rafael R Schick, Jens P Zimmermann, Thomas vorm Walde, Volker Schusdziarr. Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 284. issue 6. 2003-06-17. PMID:12776726. |
these data strongly support and extend the concept of glp-1 as a physiological regulator of food intake in the hypothalamus. |
2003-06-17 |
2023-08-12 |
rat |
| T Tachibana, S Tanaka, M Furuse, S Hasegawa, H Kato, K Sugahar. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks. British poultry science. vol 43. issue 1. 2002-10-22. PMID:12003328. |
we measured the concentrations of dopamine (da), norepinephrine (ne), epinephrine (e) and 5-hydroxytryptamine (5-ht) in the hypothalamus of 21-d-old male brown-egg layer-type chicks after intracerebroventricular injection of glucagon-like peptide-1 (glp-1). |
2002-10-22 |
2023-08-12 |
chicken |
| T Tachibana, S Tanaka, M Furuse, S Hasegawa, H Kato, K Sugahar. Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks. British poultry science. vol 43. issue 1. 2002-10-22. PMID:12003328. |
the monoamine concentrations of the whole hypothalamus, paraventricular nucleus and lateral hypothalamic area were not significantly affected by glp-1. |
2002-10-22 |
2023-08-12 |
chicken |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
high concentrations of glucagon-like peptide-1 (7-36) amide (glp-1) and its specific receptor (glp-1r) have been found in the rat hypothalamus. |
2002-06-12 |
2023-08-12 |
rat |
| A A Owji, Z Khoshdel, F Sanea, M R Panjehshahin, M Shojaee Fard, D M Smith, H A Coppock, M A Ghatei, S R Bloo. Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Brain research. vol 929. issue 1. 2002-06-12. PMID:11852032. |
in this study the actions of glp-1 and its related peptides, exendin-4 (glp-1r agonist), exendin (9-39) (glp-1r antagonist) and glp-1 (9-36) amide (the major glp-1 metabolite) on levels of serotonin (5-ht), 5-hydroxyindolacetic acid (5-hiaa) and amino acids (glu, asp, gln, gly, tyr, trp, gaba) in the hypothalamus were investigated. |
2002-06-12 |
2023-08-12 |
rat |
| M Tang-Christensen, N Vrang, P J Larse. Glucagon-like peptide containing pathways in the regulation of feeding behaviour. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. vol 25 Suppl 5. 2002-04-05. PMID:11840214. |
glp-1 given centrally to naive rats results in a marked induction of c-fos protein in the supraoptic nucleus, paraventricular nucleus of the hypothalamus (pvn) and central nucleus of the amygdala, but only a moderate increase in the arcuate nucleus. |
2002-04-05 |
2023-08-12 |
rat |
| J I Oka, N Goto, T Kameyam. Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus. Neuroreport. vol 10. issue 8. 1999-11-15. PMID:10501550. |
in order to assess effects of glucagon-like peptide-1 (glp-1) in the brain excluding the hypothalamus, the effects of glp-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male wistar rats were examined. |
1999-11-15 |
2023-08-12 |
rat |
| L Rinama. Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus. The American journal of physiology. vol 277. issue 2. 1999-09-23. PMID:10444567. |
this study tested the hypothesis that systemic stressors in rats activate glucagon-like peptide-1 (glp-1)-immunoreactive neurons in the caudal brain stem, including those that project to the paraventricular nucleus of the hypothalamus (pvn). |
1999-09-23 |
2023-08-12 |
rat |
| S P Kalra, M G Dube, S Pu, B Xu, T L Horvath, P S Kalr. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine reviews. vol 20. issue 1. 1999-04-22. PMID:10047974. |
2) similarly, anorexigenic signal-producing pathways (e.g., crh, glp-1, alpha msh, and cart) orchestrate neural events for dissipation of appetite and to terminate feeding, possibly by interrupting npy efflux and action at a postsynaptic level within the hypothalamus. |
1999-04-22 |
2023-08-12 |
rat |
| B Ahré. Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 20. issue 8. 1998-11-17. PMID:9780839. |
finally, glp-1 is also expressed in neurons in the hypothalamus, and may be involved in the regulation of feeding behaviour, since it inhibits food intake. |
1998-11-17 |
2023-08-12 |
Not clear |
| J L Dunphy, R G Taylor, P J Fulle. Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Molecular and cellular endocrinology. vol 141. issue 1-2. 1998-11-12. PMID:9723898. |
by southern blot analysis of rt-pcr products, glp-1 receptor mrna was detected in lung, hypothalamus, hippocampus, cerebral cortex, kidney, pancreas, and throughout the gastrointestinal tract. |
1998-11-12 |
2023-08-12 |
rat |
| P J Larsen, M Tang-Christensen, D S Jesso. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology. vol 138. issue 10. 1997-10-23. PMID:9322962. |
hypothalamic neuroendocrine neurons are centrally involved in the regulatory mechanisms controlling these behaviors, and high densities of glp-1 binding sites are present in the rat hypothalamus. |
1997-10-23 |
2023-08-12 |
rat |
| J van Delft, L O Uttenthal, O G Hermida, T Fontela, M Ghiglion. Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay. Regulatory peptides. vol 70. issue 2-3. 1997-10-02. PMID:9272633. |
total concentrations of amidated glp-1 immunoreactivity in extracts of rat hypothalamus, pancreas and intestine were determined by ria, and resolved into glp-1(7-36)amide, glp-1(1-36)amide and unidentified cross-reacting substances by hplc. |
1997-10-02 |
2023-08-12 |
rat |
| J van Delft, L O Uttenthal, O G Hermida, T Fontela, M Ghiglion. Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay. Regulatory peptides. vol 70. issue 2-3. 1997-10-02. PMID:9272633. |
whereas only glp-1(7-36)amide could be identified in the hypothalamus, in amounts that represented 55-94% of total glucagon-like immunoreactivity (gli), the pancreas produced chiefly glp-1(1-36)amide, representing 0.8-3.4% of total gli, and only trace or undetectable amounts of glp-1(7-36)amide (0-0.36% of total gli). |
1997-10-02 |
2023-08-12 |
rat |
| P J Shughrue, M V Lane, I Merchenthale. Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus. Endocrinology. vol 137. issue 11. 1996-12-17. PMID:8895391. |
glp-1 has been shown to dramatically reduce food intake in fasted rats and is thought to exert its effects by modulating neuronal function in the hypothalamus. |
1996-12-17 |
2023-08-12 |
rat |
| M Tang-Christensen, P J Larsen, R Göke, A Fink-Jensen, D S Jessop, M Møller, S P Sheik. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. The American journal of physiology. vol 271. issue 4 Pt 2. 1996-12-16. PMID:8897973. |
however, rat glp-1 receptors are also localized in the brain, in hypothalamus, and in areas without a blood-brain barrier. |
1996-12-16 |
2023-08-12 |
rat |