| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrique Blázquez Fernánde. [Contribution of metabolic sensors on feeding behaviour and the control of body weight]. Anales de la Real Academia Nacional de Medicina. vol 129. issue 2. 2014-01-09. PMID:24298863. |
thus, glp-1 reduced significantly the glucose metabolism in areas of the hypothalamus and brainstem related with food intake, which open new ways to the study of pathophysiologicals aspects of feeding behaviour. |
2014-01-09 |
2023-08-12 |
Not clear |
| Rozita Shirazi, Vilborg Palsdottir, Jim Collander, Fredrik Anesten, Heike Vogel, Fanny Langlet, Alexander Jaschke, Annette Schürmann, Vincent Prévot, Ruijin Shao, John-Olov Jansson, Karolina Patrycja Skibick. Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24048027. |
here we found that central injection of a clinically used glp-1 receptor agonist, exendin-4, potently increased the expression of il-6 in the hypothalamus (11-fold) and the hindbrain (4-fold) and of il-1β in the hypothalamus, without changing the expression of other inflammation-associated genes. |
2013-12-03 |
2023-08-12 |
mouse |
| Sze Wa Chan, Ge Lin, David Tai Wai Yew, Chi Kong Yeung, John A Rud. Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew). Neuropharmacology. vol 70. 2013-11-26. PMID:23357334. |
these data suggest that exendin-4 exerts its emetic effects in the brainstem and/or hypothalamus via glp-1 receptors. |
2013-11-26 |
2023-08-12 |
Not clear |
| K Gotoh, T Masaki, S Chiba, H Ando, K Fujiwara, T Shimasaki, K Mitsutomi, I Katsuragi, T Kakuma, T Sakata, H Yoshimats. Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves. Journal of neuroendocrinology. vol 25. issue 3. 2013-08-12. PMID:23157205. |
we investigate whether: (i) the central infusion of bdnf stimulates glucagon and/or insulin secretion via the pancreatic efferent nerve from the hypothalamus; (ii) the intraportal infusion of glp-1 regulates glucose metabolism via the central and peripheral nervous system; and (iii) bdnf receptor and/or bdnf-positive fibres are localised near α cells of islets. |
2013-08-12 |
2023-08-12 |
human |
| R John Rodgers, Matthias H Tschöp, John P H Wildin. Anti-obesity drugs: past, present and future. Disease models & mechanisms. vol 5. issue 5. 2013-01-07. PMID:22915024. |
recent improvements in the understanding of peptidergic signalling of hunger and satiety from the gastrointestinal tract mediated by ghrelin, cholecystokinin (cck), peptide yy (pyy) and glucagon-like peptide-1 (glp-1), and of homeostatic mechanisms related to leptin and its upstream pathways in the hypothalamus, have opened up new possibilities. |
2013-01-07 |
2023-08-12 |
Not clear |
| Kazunori Kageyama, Satoshi Yamagata, Kanako Akimoto, Aya Sugiyama, Shingo Murasawa, Toshihiro Sud. Action of glucagon-like peptide 1 and glucose levels on corticotropin-releasing factor and vasopressin gene expression in rat hypothalamic 4B cells. Molecular and cellular endocrinology. vol 362. issue 1-2. 2013-01-04. PMID:22801106. |
to elucidate the direct regulation of crf and avp genes by glp-1 in the hypothalamus, we examined the effect of glp-1 in hypothalamic 4b cells, which show the characteristics of hypothalamic paraventricular nucleus neurons. |
2013-01-04 |
2023-08-12 |
rat |
| Verónica Hurtado-Carneiro, Carmen Sanz, Isabel Roncero, Patricia Vazquez, Enrique Blazquez, Elvira Alvare. Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour. Molecular neurobiology. vol 45. issue 2. 2012-12-04. PMID:22311299. |
the anorexigenic peptide, glucagon-like peptide-1 (glp-1), reduces glucose metabolism in the human hypothalamus and brain stem. |
2012-12-04 |
2023-08-12 |
human |
| Vishal Gupt. Pleiotropic effects of incretins. Indian journal of endocrinology and metabolism. vol 16 Suppl 1. 2012-10-02. PMID:22701844. |
glp-1 mediates its effects via the glp-1 receptor, which has a wide tissue distribution [pancreas, lung, heart, vascular smooth muscle cells, endothelial cells, macrophages and monocytes, kidney, gastrointestinal tract (stomach and intestine), central nervous system (neoortex, cerebellum, hypothalamus, hippocampus, brainstem nucleus tractus solitarius) and peripheral nervous system]. |
2012-10-02 |
2023-08-12 |
Not clear |
| Cendrine Cabou, Rémy Burceli. GLP-1, the gut-brain, and brain-periphery axes. The review of diabetic studies : RDS. vol 8. issue 3. 2012-06-28. PMID:22262078. |
glp-1 can also be considered as a neuropeptide synthesized by neuronal cells in the brain stem that release the peptide directly into the hypothalamus. |
2012-06-28 |
2023-08-12 |
Not clear |
| Paul-Emile Poleni, Sayaka Akieda-Asai, Shuichi Koda, Maya Sakurai, Cho-Rong Bae, Kazuyo Senba, Youn-Soo Cha, Mayumi Furuya, Yukari Dat. Possible involvement of melanocortin-4-receptor and AMP-activated protein kinase in the interaction of glucagon-like peptide-1 and leptin on feeding in rats. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22390932. |
although coadministration of glp-1 with leptin did not enhance leptin signal transduction in the hypothalamus, it significantly decreased phosphorylation of amp-activated protein kinase (ampk). |
2012-05-16 |
2023-08-12 |
rat |
| Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma, Hironobu Yoshimats. Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22035323. |
this study aimed to determine whether dpp-iv inhibitor-induced elevation of portal glp-1 levels affect insulin secretion and feeding behavior via the vagal afferent nerve and hypothalamus. |
2012-05-03 |
2023-08-12 |
rat |
| S Polakof, J M Míguez, J L Soenga. Evidence for a gut-brain axis used by glucagon-like peptide-1 to elicit hyperglycaemia in fish. Journal of neuroendocrinology. vol 23. issue 6. 2011-09-12. PMID:21564347. |
we have assessed the effects of glp-1 on glucose metabolism in the liver as well as the glucose-sensing potential in the hypothalamus and hindbrain. |
2011-09-12 |
2023-08-12 |
Not clear |
| S Polakof, J M Míguez, J L Soenga. Evidence for a gut-brain axis used by glucagon-like peptide-1 to elicit hyperglycaemia in fish. Journal of neuroendocrinology. vol 23. issue 6. 2011-09-12. PMID:21564347. |
glp-1 has a direct effect in parameters involved in glucose sensing in the hindbrain, whereas, in the hypothalamus, changes occurred indirectly through hyperglycaemia. |
2011-09-12 |
2023-08-12 |
Not clear |
| Atsushi Nakagawa, Makoto Nishizawa, Daisuke Koy. [Food intake-suppressing action of incretin and anti-obesity therapy]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 5. 2011-07-08. PMID:21595266. |
neurons expressing preproglucagon (ppg) in the nucleus tractus solitarius (nts) are the only source of "central" glp-1, and they project to the hypothalamus. |
2011-07-08 |
2023-08-12 |
mouse |
| Taiki Takahash. Toward molecular neuroeconomics of obesity. Medical hypotheses. vol 75. issue 4. 2010-12-22. PMID:20462703. |
it is suggested that neurobiological substrates such as adiponectin, dopamine (d2 receptors), endocannabinoids, ghrelin, leptin, nesfatin-1, norepinephrine, orexin, oxytocin, serotonin, vasopressin, cck, glp-1, mch, pyy, and stress hormones (e.g., crf) in the brain (e.g., ofc, vta, nacc, and the hypothalamus) may determine parameters in the economic theory of obesity. |
2010-12-22 |
2023-08-12 |
Not clear |
| Rong Zhang, Ryan Jankord, Jonathan N Flak, Matia B Solomon, David A D'Alessio, James P Herma. Role of glucocorticoids in tuning hindbrain stress integration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048149. |
our data indicate that chronic variable stress (cvs) causes downregulation of preproglucagon (glp-1 precursor) mrna in the nts and reduction of glp-1 innervation to the paraventricular nucleus of the hypothalamus. |
2010-12-08 |
2023-08-12 |
Not clear |
| Michael Patterson, Kevin G Murphy, Sejal R Patel, Neekhil A Patel, Hannah C Greenwood, Jenny H Cooke, Daniel Campbell, Gavin A Bewick, Mohammad A Ghatei, Stephen R Bloo. Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity. Endocrinology. vol 150. issue 8. 2009-08-05. PMID:19359390. |
administration of 1 nmol oxyntomodulin directly into the arcuate nucleus of the hypothalamus significantly reduced total and acylated ghrelin levels, and administration of 3 nmol oxyntomodulin into the lateral ventricle induced c-fos mrna expression in arcuate nucleus neurons expressing the glucagon-like peptide-1 (glp-1) receptor. |
2009-08-05 |
2023-08-12 |
Not clear |
| J Girar. The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions. Diabetes & metabolism. vol 34. issue 6 Pt 1. 2009-02-26. PMID:19036624. |
glp-1 has specific effects on pancreatic alpha cells, the hypothalamus, and gastrointestinal and cardiovascular systems. |
2009-02-26 |
2023-08-12 |
Not clear |
| James R C Parkinson, Owais B Chaudhri, Yu-Ting Kuo, Benjamin C T Field, Amy H Herlihy, Waljit S Dhillo, Mohammad A Ghatei, Stephen R Bloom, Jimmy D Bel. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage. vol 44. issue 3. 2009-02-19. PMID:18983926. |
differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of glp-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (memri). |
2009-02-19 |
2023-08-12 |
mouse |
| James R C Parkinson, Owais B Chaudhri, Yu-Ting Kuo, Benjamin C T Field, Amy H Herlihy, Waljit S Dhillo, Mohammad A Ghatei, Stephen R Bloom, Jimmy D Bel. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage. vol 44. issue 3. 2009-02-19. PMID:18983926. |
we have used manganese-enhanced magnetic resonance imaging (memri) to show distinct patterns of neuronal activation within the hypothalamus and brainstem of fasted mice in response to peripheral injection of the anorexigenic agents glucagon-like peptide-1 (glp-1), oxyntomodulin (oxm) and lithium chloride. |
2009-02-19 |
2023-08-12 |
mouse |