| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Dimitri, Christian L Rot. Treatment of Hypothalamic Obesity With GLP-1 Analogs. Journal of the Endocrine Society. vol 9. issue 1. 2024-12-20. PMID:39703362. |
glucagon-like peptide-1 (glp-1) acts via central pathways that are independent from the hypothalamus to induce satiety. |
2024-12-20 |
2024-12-22 |
Not clear |
| Thatiany S Marinho, Matheus M Fabiano, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Principal components analysis on genes related to inflammasome complex and microglial activation in the hypothalamus of obese mice treated with semaglutide (GLP-1 analog). Brain research. 2024-09-07. PMID:39243951. |
principal components analysis on genes related to inflammasome complex and microglial activation in the hypothalamus of obese mice treated with semaglutide (glp-1 analog). |
2024-09-07 |
2024-09-10 |
mouse |
| Zijun Chen, Xiaofei Deng, Cuijie Shi, Haiyang Jing, Yu Tian, Jiafeng Zhong, Gaowei Chen, Yunlong Xu, Yixiao Luo, Yingjie Zh. GLP-1R-positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice. The Journal of clinical investigation. vol 134. issue 17. 2024-09-03. PMID:39225090. |
targeted knockdown of glp-1 receptors within the ls, but not in the hypothalamus, substantially attenuated liraglutide's ability to inhibit feeding and lower body weight. |
2024-09-03 |
2024-09-05 |
mouse |
| Yan Wang, Shuai Ma, Mindie Zhao, Lei Wu, Ruqian Zha. Antibiotic-Induced Gut Microbial Dysbiosis Reduces the Growth of Weaning Rats via FXR-Mediated Hepatic IGF-2 Inhibition. Nutrients. vol 16. issue 11. 2024-06-19. PMID:38892577. |
furthermore, decreased appetite may be attributed to elevated levels of glucagon-like peptide-1 (glp-1) in the serum, along with reduced neuropeptide y (npy) and increased cocaine and amphetamine-regulated transcript (cart) in the hypothalamus at the mrna level. |
2024-06-19 |
2024-06-21 |
rat |
| Tong Bu, Ziyan Sun, Yi Pan, Xia Deng, Guoyue Yua. Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism. Diabetes & metabolism journal. 2024-04-23. PMID:38650100. |
glucagon-like peptide-1 (glp-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. |
2024-04-23 |
2024-04-26 |
Not clear |
| Olivier Lavoie, Audrey Turmel, Paige Mattoon, William James Desrosiers, Julie Plamondon, Natalie Jane Michael, Alexandre Caro. Hypothalamic GABAergic neurons expressing Cellular Retinoic Acid Binding Protein 1 (CRABP1) are sensitive to metabolic status and liraglutide in male mice. Neuroendocrinology. 2024-04-17. PMID:38631315. |
owing to their privileged anatomical location, neurons of the arcuate nucleus of the hypothalamus (arc) play critical roles in sensing and responding to metabolic signals such as leptin and glucagon-like peptide 1 (glp-1). |
2024-04-17 |
2024-04-20 |
mouse |
| Victoria Wen Wei Ng, Gheslynn Gerard, Jonathan Jin Kai Koh, Kah Yin Loke, Yung Seng Lee, Nicholas Beng Hui N. The role of glucagon-like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity-A systematic review. Clinical obesity. 2024-01-25. PMID:38273176. |
glp-1 receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. |
2024-01-25 |
2024-01-28 |
Not clear |
| Antonella M D'Ascanio, Jamie A Mullally, William H Frishma. Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity. Cardiology in review. 2023-03-08. PMID:36883831. |
semaglutide, a glp-1 receptor agonist, reduces appetite via glp-1 receptors in the hypothalamus and increases the production of insulin, and reduces glucagon secretion, delaying gastric emptying. |
2023-03-08 |
2023-08-14 |
Not clear |
| Joao Carlos Ribeiro-Silva, Caio A M Tavares, Adriana C C Girard. The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: A mini-review of the potential mechanisms. Current opinion in pharmacology. vol 69. 2023-03-01. PMID:36857807. |
glp-1 receptors are present in the hypothalamus and brainstem, the carotid body, the vasculature, and the kidneys. |
2023-03-01 |
2023-08-14 |
Not clear |
| Pilar Vigil, Jaime Meléndez, Grace Petkovic, Juan Pablo Del Rí. The importance of estradiol for body weight regulation in women. Frontiers in endocrinology. vol 13. 2022-11-24. PMID:36419765. |
like estradiol, glp-1 acts on receptors at the hypothalamus. |
2022-11-24 |
2023-08-14 |
Not clear |
| Yanan Zhang, Xuan Li, Guowen Huang, Haifeng Wang, Huizi Chen, Yong Su, Kaifan Yu, Weiyun Zh. Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model. Animal nutrition (Zhongguo xu mu shou yi xue hui). vol 10. 2022-08-11. PMID:35949198. |
we characterized the effects of propionate administration on peptide yy (pyy) and glucagon-like peptide 1 (glp-1) secretion from colonic tissue, and investigated the role of propionate infusion on the expression of appetite-related genes in the colon and hypothalamus. |
2022-08-11 |
2023-08-14 |
Not clear |
| Zhaohuan Huang, Ling Liu, Jian Zhang, Kristie Conde, Jay Phansalkar, Zhongzhong Li, Lei Yao, Zihui Xu, Wei Wang, Jiangning Zhou, Guoqiang Bi, Feng Wu, Randy J Seeley, Michael M Scott, Cheng Zhan, Zhiping P Pang, Ji Li. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Science advances. vol 8. issue 23. 2022-06-08. PMID:35675406. |
here, we defined a population of glucose-sensing glp-1r neurons in the dorsomedial hypothalamic nucleus (dmh), by which endogenous glp-1 decreases glucose levels via the cross-talk between the hypothalamus and pancreas. |
2022-06-08 |
2023-08-14 |
Not clear |
| Vanessa S T Rodrigues, Egberto G Moura, Thamara C Peixoto, Patricia N Soares, Bruna P Lopes, Iala M Bertasso, Beatriz S Silva, S S Cabral, G E G Kluck, G C Atella, P L Trindade, J B Daleprane, Elaine Oliveira, Patricia Cristina Lisbo. The model of litter size reduction induces long-term disruption of the gut-brain axis: An explanation for the hyperphagia of Wistar rats of both sexes. Physiological reports. vol 10. issue 3. 2022-02-11. PMID:35146951. |
only the sl males had decreased hypothalamic glp-1 receptor expression, while only the sl females had lower acetate and propionate in the feces and higher cck receptor expression in the hypothalamus. |
2022-02-11 |
2023-08-13 |
rat |
| Zengbing Lu, Sze Wa Chan, Longlong Tu, Man Piu Ngan, John A Rud. GLP-1 receptors are involved in the GLP-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). European journal of pharmacology. vol 888. 2021-05-17. PMID:32871177. |
exendin (9-39) antagonised the inhibition of food and water intake and emesis induced by glp-1 (7-36) amide and the effects on c-fos expression in the hypothalamus and brainstem, excepting for the bed nucleus of the stria terminalis. |
2021-05-17 |
2023-08-13 |
Not clear |
| Zengbing Lu, Sze Wa Chan, Longlong Tu, Man Piu Ngan, John A Rud. GLP-1 receptors are involved in the GLP-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew). European journal of pharmacology. vol 888. 2021-05-17. PMID:32871177. |
these data suggest that the action of glp-1 (7-36) amide to modulate blood glucose, suppress food and water intake and induce emesis involve glp-1 receptors in the hypothalamus and brainstem. |
2021-05-17 |
2023-08-13 |
Not clear |
| Jessica E Biddinger, Roman M Lazarenko, Michael M Scott, Richard Simerl. Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus. eLife. vol 9. 2021-03-30. PMID:33206596. |
leptin suppresses development of glp-1 inputs to the paraventricular nucleus of the hypothalamus. |
2021-03-30 |
2023-08-13 |
mouse |
| Sodai Kubota, Yanyan Liu, Katsumi Iizuka, Hitoshi Kuwata, Yutaka Seino, Daisuke Yab. A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes. Nutrients. vol 12. issue 9. 2021-03-29. PMID:32825124. |
glp-1 is known to suppress appetite by acting on the hypothalamus via the afferent vagus nerve. |
2021-03-29 |
2023-08-13 |
Not clear |
| Heshma Alruwaili, Babak Dehestani, Carel W le Rou. Clinical Impact of Liraglutide as a Treatment of Obesity. Clinical pharmacology : advances and applications. vol 13. 2021-03-20. PMID:33732030. |
the primary mechanism of glp-1 effect on food intake, metabolism, and weight reduction is mainly due to its actions on peripheral (vagal) and central pathways and activation of hindbrain and hypothalamus. |
2021-03-20 |
2023-08-13 |
Not clear |
| Juan Salazar, Mervin Chávez-Castillo, Joselyn Rojas, Angel Ortega, Manuel Nava, José Pérez, Milagros Rojas, Cristobal Espinoza, Maricarmen Chacin, Yaneth Herazo, Lissé Angarita, Diana Marcela Rojas, Luis D'Marco, Valmore Bermude. Is "Leptin Resistance" Another Key Resistance to Manage Type 2 Diabetes? Current diabetes reviews. vol 16. issue 7. 2020-09-11. PMID:31886750. |
modulators of insulin sensitivity have been tested in animal models and small clinical trials with promising results, especially in combination with agents such as amylin and glp-1 analogs, in particular, due to their central activity in the hypothalamus. |
2020-09-11 |
2023-08-13 |
Not clear |
| Cristina Velasco, Sara Comesaña, Marta Conde-Sieira, Jesús M Míguez, José L Soenga. Effects of CCK-8 and GLP-1 on fatty acid sensing and food intake regulation in trout. Journal of molecular endocrinology. vol 62. issue 3. 2020-07-24. PMID:30608904. |
therefore, we assessed in rainbow trout (oncorhynchus mykiss) the effects of intracerebroventricular treatment with 1 ng/g of cck-8 and with 2 ng/g of glp-1 on food intake, expression of neuropeptides involved in food intake control and the activity of fatty acid-sensing systems in hypothalamus and hindbrain. |
2020-07-24 |
2023-08-13 |
Not clear |