| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fredrik Anesten, Devesh Mishra, Adrià Dalmau Gasull, Linda Engström-Ruud, Jakob Bellman, Vilborg Palsdottir, Fuping Zhang, Stefan Trapp, Karolina P Skibicka, Matti Poutanen, John-Olov Jansso. Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus. Neuroendocrinology. vol 109. issue 4. 2020-05-29. PMID:30889580. |
interleukin (il)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (glp-1) receptor stimulation. |
2020-05-29 |
2023-08-13 |
mouse |
| Tadashi Okada, Yuichiro Mita, Hideyuki Sakoda, Masamitsu Nakazat. Impaired adaptation of energy intake induces severe obesity in aged mice on a high-fat diet. Physiological reports. vol 7. issue 3. 2020-04-20. PMID:30706678. |
intraperitoneal administration of glp-1 did not induce expression of genes that regulate feeding in the hypothalamus of aged mice. |
2020-04-20 |
2023-08-13 |
mouse |
| O V Kornyushin, A A Bakhtyukov, I I Zorina, Y G Toropova, K V Derkach, O M Berko, M N Todosenko, L S Litvinova, A O Shpakov, M M Galagudz. [The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.] Advances in gerontology = Uspekhi gerontologii. vol 32. issue 1-2. 2019-08-28. PMID:31228372. |
in the hypothalamus, the expression of the genes encoding glp-1 receptor, orexigenic agouti-related peptide (agrp), as well as phosphotyrosine phosphatase 1b and socs3, the negative regulators of the leptin and insulin pathways was increased. |
2019-08-28 |
2023-08-13 |
rat |
| Se Hwan Park, Jin Hwan Yoon, Dae Yun Seo, Tae Nyun Kim, Jeong Rim Ko, Jin Ha. Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats. International journal of environmental research and public health. vol 16. issue 5. 2019-07-08. PMID:30866463. |
resistance exercise training attenuates the loss of endogenous glp-1 receptor in the hypothalamus of type 2 diabetic rats. |
2019-07-08 |
2023-08-13 |
rat |
| Jan Detka, Joanna Ślusarczyk, Anna Kurek, Mateusz Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta-Kaim, Władysław Lasoń, Bogusława Budziszewsk. Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line. Pharmacological reports : PR. vol 71. issue 2. 2019-06-17. PMID:30831439. |
current study was aimed at investigating the influence of prenatal stress (ps) on insulin, glp-1 and their receptor (ir and glp-1r) levels in the hypothalamus. |
2019-06-17 |
2023-08-13 |
Not clear |
| Chao Chen, Hong-Cai Wang, Xu Zhai, Feng Huang, Dong Wu, Pei-Jing Ron. [Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 9. 2019-04-08. PMID:30232872. |
results showed that acupuncture intervention can relieve dm by 1) reducing body weight through up-regulating leptin level, suppressing insulin resistance and appetite to reduce food intake possibly by way of down-regulating expression of neuropeptide y in the hypothalamus, retarding gastric emptying velocity, increasing small intestinal peristalsis, raising plasma levels of glucagon-like peptide-1 (glp-1) and peptide yy, etc. |
2019-04-08 |
2023-08-13 |
Not clear |
| Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibat. Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Scientific reports. vol 7. issue 1. 2019-02-20. PMID:28717164. |
the effects of chronic administration of glp-1 (7-36) and liraglutide, a glp-1 receptor agonist, on pancreatic morphological alterations, c-fos expression and brain-derived neurotrophic factor (bdnf) content in the hypothalamus, and glucose metabolism were investigated in hfd-induced obese rats that underwent hepatic afferent vagotomy (vgx) and/or pancreatic efferent sympathectomy (spx). |
2019-02-20 |
2023-08-13 |
rat |
| Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibat. Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Scientific reports. vol 7. issue 1. 2019-02-20. PMID:28717164. |
chronic glp-1 (7-36) administration to hfd-induced obese rats elevated c-fos expression and bdnf content in the hypothalamus, followed by a reduction in pancreatic β-cell hyperplasia and insulin content, thus resulting in improved glucose tolerance. |
2019-02-20 |
2023-08-13 |
rat |
| Hisae Ando, Koro Gotoh, Kansuke Fujiwara, Manabu Anai, Seiichi Chiba, Takayuki Masaki, Tetsuya Kakuma, Hirotaka Shibat. Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats. Scientific reports. vol 7. issue 1. 2019-02-20. PMID:28717164. |
these data suggest that glp-1 normalizes the obesity-induced compensatory increase in β-cell mass and glucose intolerance through a neuronal relay system consisting of hepatic afferent nerves, the hypothalamus, and pancreatic efferent nerves. |
2019-02-20 |
2023-08-13 |
rat |
| Yan Yang, Pique P Choi, Wanli W Smith, Weijie Xu, Delin Ma, Zachary A Cordner, Nu-Chu Liang, Timothy H Mora. Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761132. |
exendin-4 (ex-4), a glucagon-like peptide-1 (glp-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (pomc) gene expression in the hypothalamus. |
2019-02-19 |
2023-08-13 |
rat |
| Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkal. Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease. Diabetes & metabolic syndrome. vol 12. issue 3. 2018-09-26. PMID:29598932. |
neuronal cells in nucleus tractus solitarius (nts) can synthesize glp-1 and extends to hypothalamus, some thalamic and cortical areas. |
2018-09-26 |
2023-08-13 |
Not clear |
| K Kaineder, T Birngruber, G Rauter, B Obermüller, J Eichler, J Münzker, W Al-Zoughbi, S I Mautner, S S Torekov, B Hartmann, P Kotzbeck, T R Piebe. Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system. International journal of obesity (2005). vol 41. issue 8. 2018-04-30. PMID:28507313. |
the glp-1 receptor agonist liraglutide is marketed for obesity treatment where it induces body weight reduction possibly via the hypothalamus, which regulates energy homeostasis. |
2018-04-30 |
2023-08-13 |
Not clear |
| Calyn B Maske, Christine M Jackson, Sarah J Terrill, Lisa A Eckel, Diana L William. Estradiol modulates the anorexic response to central glucagon-like peptide 1. Hormones and behavior. vol 93. 2018-01-30. PMID:28558993. |
glp-1 significantly increased c-fos expression in the area postrema (ap) and nucleus of the solitary tract (nts), and the presence of estrogens may be required for this effect in the paraventricular nucleus of the hypothalamus (pvn). |
2018-01-30 |
2023-08-13 |
rat |
| R Saito, M So, Y Motojima, T Matsuura, M Yoshimura, H Hashimoto, Y Yamamoto, K Kusuhara, Y Uet. Activation of Nesfatin-1-Containing Neurones in the Hypothalamus and Brainstem by Peripheral Administration of Anorectic Hormones and Suppression of Feeding via Central Nesfatin-1 in Rats. Journal of neuroendocrinology. vol 28. issue 9. 2018-01-16. PMID:27203571. |
administration of glp-1 and cck-8 and co-administrations of glp-1 and leptin at subthreshold doses as confirmed by measurement of food intake, on nesfatin-1-immunoreactive (-ir) neurones in the hypothalamus and brainstem of rats by fos immunohistochemistry. |
2018-01-16 |
2023-08-13 |
rat |
| R Saito, M So, Y Motojima, T Matsuura, M Yoshimura, H Hashimoto, Y Yamamoto, K Kusuhara, Y Uet. Activation of Nesfatin-1-Containing Neurones in the Hypothalamus and Brainstem by Peripheral Administration of Anorectic Hormones and Suppression of Feeding via Central Nesfatin-1 in Rats. Journal of neuroendocrinology. vol 28. issue 9. 2018-01-16. PMID:27203571. |
no differences in the percentage of nesfatin-1-ir neurones expressing fos-immunoreactivity in the nuclei of the hypothalamus and brainstem were observed between rats treated with saline, glp-1 (33 μg/kg) or leptin. |
2018-01-16 |
2023-08-13 |
rat |
| Ji Liu, Kristie Conde, Peng Zhang, Varoth Lilascharoen, Zihui Xu, Byung Kook Lim, Randy J Seeley, J Julius Zhu, Michael M Scott, Zhiping P Pan. Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus. Neuron. vol 96. issue 4. 2017-12-22. PMID:29056294. |
glucagon-like peptide 1 (glp-1)-expressing neurons in the hindbrain send robust projections to the paraventricular nucleus of the hypothalamus (pvn), which is involved in the regulation of food intake. |
2017-12-22 |
2023-08-13 |
Not clear |
| Fredrik Anesten, Marie K Holt, Erik Schéle, Vilborg Pálsdóttir, Frank Reimann, Fiona M Gribble, Cecilia Safari, Karolina P Skibicka, Stefan Trapp, John-Olov Jansso. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. American journal of physiology. Regulatory, integrative and comparative physiology. vol 311. issue 1. 2017-07-24. PMID:27097661. |
we have recently shown that treatment with exendin-4 (ex-4), an analog of the proglucagon-derived molecule glucagon-like peptide 1 (glp-1), markedly increases mrna expression of the cytokine interleukin-6 (il-6) in the hypothalamus and hindbrain and that this increase partly mediates the suppression of food intake and body weight by ex-4. |
2017-07-24 |
2023-08-13 |
mouse |
| Sriparna Ghosal, Amy E B Packard, Parinaz Mahbod, Jessica M McKlveen, Randy J Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P Smith, David A D'Alessio, James P Herma. Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053040. |
the glp-1 receptor (glp1r) in mice was knocked down in neurons expressing single-minded 1, a transcription factor abundantly expressed in the paraventricular nucleus (pvn) of the hypothalamus. |
2017-07-24 |
2023-08-13 |
mouse |
| Scott E Kanoski, Matthew R Hayes, Karolina P Skibick. GLP-1 and weight loss: unraveling the diverse neural circuitry. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 10. 2017-06-27. PMID:27030669. |
particular attention is devoted to discussion regarding the numerous neural substrates through which glp-1 and glp-1 analogs act to reduce food intake and body weight, including various hypothalamic nuclei (arcuate nucleus of the hypothalamus, periventricular hypothalamus, lateral hypothalamic area), hindbrain nuclei (parabrachial nucleus, medial nucleus tractus solitarius), hippocampus (ventral subregion; vhp), and nuclei embedded within the mesolimbic reward circuitry [ventral tegmental area (vta) and nucleus accumbens (nac)]. |
2017-06-27 |
2023-08-13 |
Not clear |
| Olivia M Farr, Michail Sofopoulos, Michael A Tsoukas, Fadime Dincer, Bindiya Thakkar, Ayse Sahin-Efe, Andreas Filippaios, Jennifer Bowers, Alexandra Srnka, Anna Gavrieli, Byung-Joon Ko, Chrysoula Liakou, Nickole Kanyuch, Sofia Tseleni-Balafouta, Christos S Mantzoro. GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. Diabetologia. vol 59. issue 5. 2017-01-23. PMID:26831302. |
glp-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the glp-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. |
2017-01-23 |
2023-08-13 |
human |