| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C C Tseng, X Y Zhan. Role of regulator of G protein signaling in desensitization of the glucose-dependent insulinotropic peptide receptor. Endocrinology. vol 139. issue 11. 1998-11-06. PMID:9794454. |
recent studies have indicated that elevated serum gip concentrations in type ii diabetic patients might induce desensitization of the gip-r, and this mechanism could contribute to impaired insulin secretion. |
1998-11-06 |
2023-08-12 |
human |
| C C Tseng, X Y Zhan. Role of regulator of G protein signaling in desensitization of the glucose-dependent insulinotropic peptide receptor. Endocrinology. vol 139. issue 11. 1998-11-06. PMID:9794454. |
in betatc3 cells, preincubation of gip attenuated gip-induced insulin release by 45% at 15 min and by 55% at 30 min. |
1998-11-06 |
2023-08-12 |
human |
| E Ferrannin. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocrine reviews. vol 19. issue 4. 1998-10-29. PMID:9715376. |
incidentally, any defect in insulin secretion, whether in normoglycemic or hyperglycemic persons, could be due to other factors than primary beta-cell dysfunction: amyloid deposits in the pancreas (126), changes in insulin secretagogues (amylin, glp-1, gip, galanin) (127-130), early intrauterine malnutrition (131). |
1998-10-29 |
2023-08-12 |
human |
| C C Tseng, X Y Zhan. The cysteine of the cytoplasmic tail of glucose-dependent insulinotropic peptide receptor mediates its chronic desensitization and down-regulation. Molecular and cellular endocrinology. vol 139. issue 1-2. 1998-10-15. PMID:9705086. |
recent studies have shown that elevated serum gip level in diabetic patients may induce chronic desensitization of the gip-r, and that this mechanism could contribute to impaired insulin secretion. |
1998-10-15 |
2023-08-12 |
Not clear |
| J H Lavin, G A Wittert, J Andrews, B Yeap, J M Wishart, H A Morris, J E Morley, M Horowitz, N W Rea. Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate. The American journal of clinical nutrition. vol 68. issue 3. 1998-09-29. PMID:9734735. |
insulin, gastric inhibitory polypeptide (gip), glucagon-like peptide 1 (glp-1), and appetite ratings were measured during, and food intake was measured after, intraduodenal infusions of glucose or saline. |
1998-09-29 |
2023-08-12 |
human |
| J H Lavin, G A Wittert, J Andrews, B Yeap, J M Wishart, H A Morris, J E Morley, M Horowitz, N W Rea. Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate. The American journal of clinical nutrition. vol 68. issue 3. 1998-09-29. PMID:9734735. |
raising plasma insulin with intravenous insulin infusion to concentrations slightly above usual postprandial concentrations (356.4 +/- 4.8 pmol/l) had no effect on gip, glp-1, or appetite ratings before the intraduodenal infusions began. |
1998-09-29 |
2023-08-12 |
human |
| J H Lavin, G A Wittert, J Andrews, B Yeap, J M Wishart, H A Morris, J E Morley, M Horowitz, N W Rea. Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate. The American journal of clinical nutrition. vol 68. issue 3. 1998-09-29. PMID:9734735. |
intraduodenal glucose infusion resulted in a further increase in plasma insulin to a peak of 779.4 +/- 114.0 pmol/l, caused an early increase in plasma gip and a later increase in glp-1 concentrations (p < 0.01), suppressed appetite (p < 0.05), and reduced energy intake (p < 0.01) compared with intraduodenal infusion of saline. |
1998-09-29 |
2023-08-12 |
human |
| J H Lavin, G A Wittert, J Andrews, B Yeap, J M Wishart, H A Morris, J E Morley, M Horowitz, N W Rea. Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate. The American journal of clinical nutrition. vol 68. issue 3. 1998-09-29. PMID:9734735. |
infusion of octreotide to suppress the release of gastrointestinal hormones prevented the rise in insulin, gip, and glp-1 induced by intraduodenal glucose infusion and reversed the suppression of appetite and reduction in energy intake. |
1998-09-29 |
2023-08-12 |
human |
| A Faulkner, P A Marti. Changes in the concentrations of glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide during the lactation cycle in goats. The Journal of dairy research. vol 65. issue 3. 1998-09-10. PMID:9718496. |
serum insulin concentrations correlated positively with plasma glucose concentrations but not with either gip or glp concentrations. |
1998-09-10 |
2023-08-12 |
Not clear |
| R A Pederson, H A White, D Schlenzig, R P Pauly, C H McIntosh, H U Demut. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes. vol 47. issue 8. 1998-09-09. PMID:9703325. |
the hormones glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide (glp)-1 act on the pancreas to potentiate glucose-induced insulin secretion (enteroinsular axis). |
1998-09-09 |
2023-08-12 |
rat |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
these studies were conducted to determine whether the age-related impairment in insulin release was caused by a decreased beta-cell sensitivity to glucose-dependent insulinotropic polypeptide (gip). |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
basal plasma insulin and gip levels were similar in the young (41 +/- 6 and 51 +/- 6 pmol/l) and the old subjects (42 +/- 6 and 66 +/- 12 pmol/l) in all studies. |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
first- and second-phase insulin responses were similar during the control study and during the first 60 min of each gip infusion study in both groups. |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
in response to the gip infusions, significant increases in insulin occurred in young and old at both glucose levels (p < 0.01). |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
the potentiation of the insulin response caused by gip was greater in the young subjects than in the old, in the g + 5.4 mmol/l studies (p < 0.05). |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
however, the insulin response to gip was similar in both young and old during the g + 12.8 mmol/l clamps. |
1998-09-02 |
2023-08-12 |
human |
| G S Meneilly, A S Ryan, K L Minaker, D Elah. The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. The Journal of clinical endocrinology and metabolism. vol 83. issue 8. 1998-09-02. PMID:9709971. |
we conclude that normal aging is characterized by a decreased beta-cell sensitivity to gip during modest hyperglycemia, which may explain, in part, the age-related impairment in glucose-induced insulin release. |
1998-09-02 |
2023-08-12 |
human |
| C Seifarth, J Bergmann, J J Holst, R Ritzel, W Schmiegel, M A Nauc. Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in Type 2 diabetic patients. Diabetic medicine : a journal of the British Diabetic Association. vol 15. issue 6. 1998-08-27. PMID:9632123. |
plasma levels of glp-1, insulin, c-peptide, glugacon, gip, glucose and h2-exhalation were measured over 6 h. differences in the integrated responses over the observation period were evaluated by repeated measurement analysis of variance with fasting values used as covariates. |
1998-08-27 |
2023-08-12 |
human |
| C Seifarth, J Bergmann, J J Holst, R Ritzel, W Schmiegel, M A Nauc. Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in Type 2 diabetic patients. Diabetic medicine : a journal of the British Diabetic Association. vol 15. issue 6. 1998-08-27. PMID:9632123. |
initially (0-150 min), glucose (p = 0.001), insulin (p = 0.001), and gip (p < 0.001) were suppressed by acarbose, whereas later there were no significant differences. |
1998-08-27 |
2023-08-12 |
human |
| L Morgan, J Arendt, D Owens, S Folkard, S Hampton, S Deacon, J English, D Ribeiro, K Taylo. Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism. The Journal of endocrinology. vol 157. issue 3. 1998-08-10. PMID:9691977. |
during each cr salivary melatonin and plasma glucose, triacylglycerol (tag), non-essential fatty acids (nefa), insulin, gastric inhibitory peptide (gip) and glucagon-like peptide-1 (glp-1) were measured hourly. |
1998-08-10 |
2023-08-12 |
human |