| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L R Ranganath, J M Beety, L M Morga. Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 4. 1999-07-01. PMID:10333081. |
insulin, gip and glp-1 secretion post-carbohydrate was markedly reduced by octreotide in lean and obese subjects. |
1999-07-01 |
2023-08-12 |
human |
| L R Ranganath, J M Beety, L M Morga. Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 4. 1999-07-01. PMID:10333081. |
inhibition of postprandial insulin, gip and glp-1 secretion acutely did not reduce post-heparin lpl activity either in lean or obese subjects. |
1999-07-01 |
2023-08-12 |
human |
| E Svanberg, C Ohlsson, A Hyltander, K G Lundhol. The role of diet components, gastrointestinal factors, and muscle innervation on activation of protein synthesis in skeletal muscles following oral refeeding. Nutrition (Burbank, Los Angeles County, Calif.). vol 15. issue 4. 1999-06-25. PMID:10319356. |
the aim of this study was to quantify the effect of oral refeeding on the synthesis of soluble and contractile proteins in skeletal muscles, and to evaluate to what extent diet components (carbohydrate, fat, amino acids), hormones (insulin, igf-i, gip), ca2+ flux, polyamine synthesis, cyclooxygenase activity, and muscle innervation are related to activation of protein synthesis at the translational level following oral refeeding. |
1999-06-25 |
2023-08-12 |
mouse |
| H J Kissler, H Gepp, A Schmiedl, P O Schwill. Preservation of the incretin effect after orthotopic pancreas transplantation in inbred rats. Metabolism: clinical and experimental. vol 48. issue 5. 1999-06-03. PMID:10337868. |
to establish whether the incretin effect is under neural control, insulin, c-peptide, and glucose-dependent insulinotropic peptide (gip) responses and hepatic insulin clearance were investigated after oral and "isoglycemic" intravenous glucose in 12 inbred rats after denervation of the pancreas by orthotopic transplantation with portal venous drainage (tx group) and in 12 laparotomized controls (sham group). |
1999-06-03 |
2023-08-12 |
rat |
| H J Kissler, H Gepp, A Schmiedl, P O Schwill. Preservation of the incretin effect after orthotopic pancreas transplantation in inbred rats. Metabolism: clinical and experimental. vol 48. issue 5. 1999-06-03. PMID:10337868. |
the incretin effects for insulin (tx group, 5.6 +/- 2.7; sham group, 3.0 +/- 0.8) and c-peptide (tx group, 1.4 +/- 0.2; sham group, 1.1 +/- 0.2), calculated as the ratio of the integrated oral response and integrated intravenous response, and gip responses to oral and intravenous glucose were not significantly different between the two groups. |
1999-06-03 |
2023-08-12 |
rat |
| H J Kissler, H Gepp, A Schmiedl, P O Schwill. Preservation of the incretin effect after orthotopic pancreas transplantation in inbred rats. Metabolism: clinical and experimental. vol 48. issue 5. 1999-06-03. PMID:10337868. |
hepatic insulin clearance and insulinotropic hormones such as gip appear to be more important. |
1999-06-03 |
2023-08-12 |
rat |
| F P O'Harte, M H Mooney, P R Flat. NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity. Diabetes. vol 48. issue 4. 1999-04-15. PMID:10102692. |
this was associated with a significantly greater and more protracted insulin response after tyr1-glucitol gip than gip (auc 773 +/- 41 vs. 639 +/- 39 ng x ml(-1) x min(-1); p < 0.05). |
1999-04-15 |
2023-08-12 |
human |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
reduced insulin secretion has been described as part of normal ageing although there is no information on age-related changes in the secretion of the major insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide (7-36 amide) (glp-1). |
1999-02-11 |
2023-08-12 |
human |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
we hypothesise that an age-related impairment of insulin secretion to insulinotropic hormones, gip and glp-1, contributes to a reduction in glucose tolerance in this age group. |
1999-02-11 |
2023-08-12 |
human |
| L Ranganath, I Sedgwick, L Morgan, J Wright, V Mark. The ageing entero-insular axis. Diabetologia. vol 41. issue 11. 1999-02-11. PMID:9833938. |
the pronounced compensatory increase in postprandial secretion of gip and glp-1 provides further evidence not only for the negative feedback relation between incretin and insulin secretion but also for the importance of the entero-insular axis in the regulation of insulin secretion. |
1999-02-11 |
2023-08-12 |
human |
| M T Rose, F Itoh, Y Takahash. Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep. Experimental physiology. vol 83. issue 6. 1999-01-29. PMID:9782188. |
part 2 of the experiment was the same as for part 1 except that insulin was infused between 3 h and 7 h and gip was infused between 5 and 7 h. coincident with the insulin infusion, normal glucose was also infused at a variable rate in order to keep the plasma glucose at basal levels. |
1999-01-29 |
2023-08-12 |
Not clear |
| M T Rose, F Itoh, Y Takahash. Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep. Experimental physiology. vol 83. issue 6. 1999-01-29. PMID:9782188. |
in part 3 of the experiment [6,6-2h2]glucose was infused for 5 h and somatostatin was infused between 3 and 5 h. measurements of glucose turnover were made in the last 40 min of the control, gip only, insulin only, somatostatin only, gip plus somatostatin and gip plus insulin infusion periods. |
1999-01-29 |
2023-08-12 |
Not clear |
| M T Rose, F Itoh, Y Takahash. Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep. Experimental physiology. vol 83. issue 6. 1999-01-29. PMID:9782188. |
expressing glucose disposal as glucose metabolic clearance rate demonstrated that elevated, but still physiological gip levels had no effect on nimgu but significantly increased insulin-mediated glucose uptake when plasma insulin levels were similar to levels typically observed after a meal. |
1999-01-29 |
2023-08-12 |
Not clear |
| M T Rose, F Itoh, Y Takahash. Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep. Experimental physiology. vol 83. issue 6. 1999-01-29. PMID:9782188. |
these results indicate that in sheep, gip may enhance insulin action with respect to glucose disposal following a meal, but has no effect on glucose disposal pathways not responsive to insulin. |
1999-01-29 |
2023-08-12 |
Not clear |
| C H McIntosh, I Bremsak, F C Lynn, R Gill, S A Hinke, R Gelling, C Nian, G McKnight, S Jaspers, R A Pederso. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology. vol 140. issue 1. 1999-01-28. PMID:9886851. |
preincubation of 3t3-l1 cells with insulin inhibited glycerol responses to gip, and the inhibitory effect of insulin was blocked by the phosphatidylinositol 3'-kinase inhibitor, wortmannin. |
1999-01-28 |
2023-08-12 |
Not clear |
| C H McIntosh, I Bremsak, F C Lynn, R Gill, S A Hinke, R Gelling, C Nian, G McKnight, S Jaspers, R A Pederso. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology. vol 140. issue 1. 1999-01-28. PMID:9886851. |
it is concluded that gip stimulates glycerol release in 3t3-l1 cells primarily via stimulation of camp production, and that insulin antagonizes gip-induced lipolysis in a wortmannin-sensitive fashion. |
1999-01-28 |
2023-08-12 |
Not clear |
| C H McIntosh, I Bremsak, F C Lynn, R Gill, S A Hinke, R Gelling, C Nian, G McKnight, S Jaspers, R A Pederso. Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin. Endocrinology. vol 140. issue 1. 1999-01-28. PMID:9886851. |
it is suggested that effects of gip on fat metabolism in vivo may depend upon the circulating insulin level, and that meal-released gip may elevate circulating fatty acids, thus optimizing pancreatic beta-cell responsiveness to stimulation by glucose and gip. |
1999-01-28 |
2023-08-12 |
Not clear |
| M Toft-Nielsen, S Madsbad, J J Hols. Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia. Diabetologia. vol 41. issue 10. 1999-01-14. PMID:9794105. |
with glp-1, infusion of a total of 33.4 +/- 1.3 g glucose was required to obtain plasma glucose concentrations similar to those obtained by glucose infusion alone; with low gip, 28.0 +/- 1.2 g and with high gip 38.4 +/- 3.5 g. insulin concentrations increased 10-fold with glp-1 compared with i.v. |
1999-01-14 |
2023-08-12 |
human |
| V Barto. [Clinical significance of glucose-dependent insulinotropic polypeptide (GIP)]. Vnitrni lekarstvi. vol 44. issue 4. 1998-12-14. PMID:9820111. |
findings on the effects of gip indicate that its incretory effect on stimulation of insulin secretion under conditions of hyperglycaemia is more important than the formerly known effect of enterogastrone. |
1998-12-14 |
2023-08-12 |
Not clear |
| F P O'Harte, Y H Abdel-Wahab, J M Conlon, P R Flat. Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells. Biochimica et biophysica acta. vol 1425. issue 2. 1998-12-02. PMID:9795247. |
this study has examined glycation of gip and effects of such structural modification on insulin secretion from a glucose-responsive clonal pancreatic b-cell line (brin-bd11). |
1998-12-02 |
2023-08-12 |
Not clear |