| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Kindmark, J Pigon, S Efendi. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. The Journal of clinical endocrinology and metabolism. vol 86. issue 5. 2001-05-31. PMID:11344200. |
stimulation of beta-cell secretion of insulin by gip is seen both in vitro and in vivo at permissive extracellular glucose concentrations (> 6 mmol/l). |
2001-05-31 |
2023-08-12 |
human |
| H Kindmark, J Pigon, S Efendi. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. The Journal of clinical endocrinology and metabolism. vol 86. issue 5. 2001-05-31. PMID:11344200. |
we now show that an infusion of gip in healthy volunteers in whom blood glucose levels were maintained at 5 mmol/l, increased glibenclamide-stimulated levels of plasma insulin without significantly changing the c peptide profile. |
2001-05-31 |
2023-08-12 |
human |
| H Kindmark, J Pigon, S Efendi. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. The Journal of clinical endocrinology and metabolism. vol 86. issue 5. 2001-05-31. PMID:11344200. |
infusion of gip alone caused neither glucose changes nor elevation of c peptide or insulin levels. |
2001-05-31 |
2023-08-12 |
human |
| H Kindmark, J Pigon, S Efendi. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. The Journal of clinical endocrinology and metabolism. vol 86. issue 5. 2001-05-31. PMID:11344200. |
hence, our results show that at a blood glucose concentration of 5 mmol/l, gip augments the increase in plasma insulin levels stimulated by glibenclamide, possibly acting through a mechanism involving decreased insulin extraction in the liver or peripheral tissues, thus increasing insulin availability. |
2001-05-31 |
2023-08-12 |
human |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
glucose-dependent insulinotropic polypeptide (gip) is a peptide hormone that is released postprandially from the small intestine and acts in concert with glucagon-like peptide (glp)-1 to potentiate glucose-induced insulin secretion from the pancreatic beta-cell. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
in type 2 diabetes, there is a decreased responsiveness of the pancreas to gip; however, the insulin response to glp-1 remains intact. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
kg(-1)), whereas the lean animals displayed a significant reduction in blood glucose (gip levels, 50% control after 60 min, p < 0.05) as well as a significant increase in circulating insulin. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
gip also potently stimulated first-phase insulin secretion from isolated perifused islets (10.3 +/- 3.0 x basal), and gip and glp-1 potentiated insulin secretion from the perfused pancreas (6 x control area under the curve [auc]) from lean animals. |
2001-05-21 |
2023-08-12 |
rat |
| F C Lynn, N Pamir, E H Ng, C H McIntosh, T J Kieffer, R A Pederso. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334402. |
gip yielded no significant effect in the vancouver diabetic fatty zucker (vdf) rat pancreases, whereas glp-1 elicited an eightfold increase of insulin secretion from the perfused vdf pancreas. |
2001-05-21 |
2023-08-12 |
rat |
| B Ahrén, J J Hols. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334405. |
the preabsorptive insulin response was not accompanied by any increase in circulating levels of gastric inhibitory polypeptide (gip) or glucagon-like peptide 1 (glp-1). |
2001-05-21 |
2023-08-12 |
Not clear |
| B Ahrén, J J Hols. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes. vol 50. issue 5. 2001-05-21. PMID:11334405. |
in conclusion, 1) the early preabsorptive insulin response to meal ingestion in humans can be largely attributed to autonomic activation mediated by noncholinergic and cholinergic mechanisms, 2) this cephalic insulin response is required for a normal postprandial glucose tolerance, and 3) gip and glp-1 do not contribute to the preabsorptive cephalic phase insulin response to meal ingestion. |
2001-05-21 |
2023-08-12 |
Not clear |
| K Beckoff, C G MacIntosh, I M Chapman, J M Wishart, H A Morris, M Horowitz, K L Jone. Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly. American journal of physiology. Regulatory, integrative and comparative physiology. vol 280. issue 2. 2001-04-12. PMID:11208589. |
ge of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (glp-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the ge study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). |
2001-04-12 |
2023-08-12 |
human |
| K Beckoff, C G MacIntosh, I M Chapman, J M Wishart, H A Morris, M Horowitz, K L Jone. Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly. American journal of physiology. Regulatory, integrative and comparative physiology. vol 280. issue 2. 2001-04-12. PMID:11208589. |
glucose supplementation accelerated ge of glucose (p < 0.05), but not oil; there was a trend for an increase in gip (at 15 min, p = 0.06), no change in glp-1, an earlier insulin peak (p < 0.01), and a subsequent reduction in blood glucose (at 75 min, p < 0.01). |
2001-04-12 |
2023-08-12 |
human |
| T Vilsbøll, T Krarup, C F Deacon, S Madsbad, J J Hols. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes. vol 50. issue 3. 2001-04-05. PMID:11246881. |
the measurement of intact incretin hormones revealed that total as well as intact gip responses were minimally decreased in patients with type 2 diabetes, whereas the late intact glp-1 response was strongly reduced, supporting the hypothesis that an impaired function of glp-1 as a transmitter in the enteroinsular axis contributes to the inappropriate insulin secretion in type 2 diabetes. |
2001-04-05 |
2023-08-12 |
human |
| A S Baba, J M Harper, P J Butter. Effects of gastric inhibitory polypeptide, somatostatin and epidermal growth factor on lipogenesis in ovine adipose explants. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 127. issue 2. 2001-03-01. PMID:11079371. |
in contrast, in the presence of insulin (0.1 nm), a dose-dependent decrease in lipogenesis was seen with increasing gip concentration (p < 0.001 for the insulin x gip interaction). |
2001-03-01 |
2023-08-12 |
Not clear |
| T Niwa, Y Nimura, I Nik. Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats. American journal of physiology. Endocrinology and metabolism. vol 280. issue 1. 2001-01-25. PMID:11120659. |
loss of potentiation of insulin release was also observed in glucagon and glucose-dependent insulinotropic peptide (gip), whereas modulation of the release by forskolin, dibutyryl camp, or epinephrine remained unaffected. |
2001-01-25 |
2023-08-12 |
rat |
| P Huypens, Z Ling, D Pipeleers, F Schui. Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia. vol 43. issue 8. 2001-01-05. PMID:10990079. |
this study assessed the importance of an interaction between glucose and camp in the stimulation of insulin secretion from human islet cells by investigating expression and functional activity of receptors recognising glucagon, glucagon-like peptide-1 (7-36)amide (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2001-01-05 |
2023-08-12 |
human |
| Q Zhong, R J Bollag, D T Dransfield, J Gasalla-Herraiz, K H Ding, L Min, C M Isale. Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells. Peptides. vol 21. issue 9. 2001-01-04. PMID:11072131. |
glucose-dependent insulinotropic peptide (gip) potentiates glucose-induced insulin secretion. |
2001-01-04 |
2023-08-12 |
Not clear |
| A T Cheung, B Dayanandan, J T Lewis, G S Korbutt, R V Rajotte, M Bryer-Ash, M O Boylan, M M Wolfe, T J Kieffe. Glucose-dependent insulin release from genetically engineered K cells. Science (New York, N.Y.). vol 290. issue 5498. 2000-12-22. PMID:11110661. |
a tumor-derived k-cell line was induced to produce human insulin by providing the cells with the human insulin gene linked to the 5'-regulatory region of the gene encoding glucose-dependent insulinotropic polypeptide (gip). |
2000-12-22 |
2023-08-12 |
mouse |
| H Gin, V Rigallea. Post-prandial hyperglycemia. post-prandial hyperglycemia and diabetes. Diabetes & metabolism. vol 26. issue 4. 2000-11-07. PMID:11011218. |
gastric emptying is influenced by various factors including gut hormones such as gip and glp1, which potentiate insulin secretion, especially in its acute first phase, now referred to as an incretin effect. |
2000-11-07 |
2023-08-12 |
human |