| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victor A Gault, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820780. |
in the clonal pancreatic beta cell line brin-bd11, (pro(3))gip over the concentration range 10(-13) to 10(-8) m dose dependently inhibited gip-stimulated (10(-7) m) insulin release (1.2- to 1.7-fold; p < 0.05 to p < 0.001). |
2002-03-15 |
2023-08-12 |
mouse |
| Victor A Gault, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820780. |
in obese diabetic (ob/ob) mice, intraperitoneal administration of (pro(3))gip (25 nmol/kg body wt) countered the ability of native gip to stimulate plasma insulin (2.4-fold decrease; p < 0.001) and lower the glycemic excursion (1.5-fold decrease; p < 0.001) induced by a glucose load (18 mmol/kg body wt). |
2002-03-15 |
2023-08-12 |
mouse |
| Victor A Gault, Finbarr P M O'Harte, Patrick Harriott, Peter R Flat. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochemical and biophysical research communications. vol 290. issue 5. 2002-03-15. PMID:11820780. |
collectively these data demonstrate that (pro(3))gip is a novel and potent enzyme-resistant gip receptor antagonist capable of blocking the ability of native gip to increase camp, stimulate insulin secretion, and improve glucose homeostasis in a commonly employed animal model of type 2 diabetes. |
2002-03-15 |
2023-08-12 |
mouse |
| Simon A Hinke, Richard W Gelling, Raymond A Pederson, Susanne Manhart, Cuilan Nian, Hans-Ulrich Demuth, Christopher H S McIntos. Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes. vol 51. issue 3. 2002-03-15. PMID:11872663. |
when injected subcutaneously in normal wistar, fa/?, or fa/fa vancouver diabetic fatty (vdf) zucker rats, both gip and [d-ala(2)]gip significantly reduced glycemic excursions during a concurrent oral glucose tolerance test via stimulation of insulin release. |
2002-03-15 |
2023-08-12 |
rat |
| Audrey E Brynes, C Mark Edwards, Mohammed A Ghatei, Stephen R Bloom, Gary S Fros. Men at increased risk of coronary heart disease are not different from age- and weight-matched healthy controls in their postprandial triglyceride, nonesterified fatty acid, or incretin responses to sucrose. Metabolism: clinical and experimental. vol 51. issue 2. 2002-03-07. PMID:11833048. |
we measured postprandial tg, nonesterified fatty acids (nefa), insulin, glucose, glucagon-like peptide-1 (glp-1), and gastric inhibitory polypeptide (gip) concentrations in response to a meal containing 75 g glucose or 75 g sucrose with a moderate fat load. |
2002-03-07 |
2023-08-12 |
Not clear |
| R J Bollag, Q Zhong, K H Ding, P Phillips, L Zhong, F Qin, J Cranford, A L Mulloy, R Cameron, C M Isale. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Molecular and cellular endocrinology. vol 177. issue 1-2. 2001-12-28. PMID:11377818. |
glucose-dependent insulinotropic peptide (gip) is a gut-derived hormone known to be important in modulating glucose-induced insulin secretion. |
2001-12-28 |
2023-08-12 |
Not clear |
| J J Meier, K Hücking, J J Holst, C F Deacon, W H Schmiegel, M A Nauc. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes. vol 50. issue 11. 2001-12-07. PMID:11679427. |
with exogenous gip, patients with type 2 diabetes responded with a lower increment (delta) in insulin (p = 0.0003) and c-peptide concentrations (p < 0.0001) than control subjects. |
2001-12-07 |
2023-08-12 |
human |
| J J Meier, K Hücking, J J Holst, C F Deacon, W H Schmiegel, M A Nauc. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes. vol 50. issue 11. 2001-12-07. PMID:11679427. |
the gip effects in first-degree relatives were diminished compared with control subjects (delta insulin: p = 0.04; delta c-peptide: p = 0.016) but significantly higher than in patients with type 2 diabetes (p < or = 0.05). |
2001-12-07 |
2023-08-12 |
human |
| W Creutzfeld. The entero-insular axis in type 2 diabetes--incretins as therapeutic agents. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 109 Suppl 2. 2001-12-05. PMID:11460578. |
the ratio between the integrated insulin response to an oral glucose load and an isoglycaemic intravenous glucose infusion) is markedly diminished in patients with type 2 diabetes mellitus, while the plasma levels of gip and glp-1 and their responses to nutrients are in the normal range. |
2001-12-05 |
2023-08-12 |
Not clear |
| R Dühlmeier, E Deegen, H Fuhrmann, A Widdel, H P Sallman. Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 129. issue 2-3. 2001-10-18. PMID:11423326. |
plasma was analysed for concentrations of glucose, glucose-dependent insulinotropic polypeptide (gip) and insulin. |
2001-10-18 |
2023-08-12 |
Not clear |
| R Dühlmeier, E Deegen, H Fuhrmann, A Widdel, H P Sallman. Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 129. issue 2-3. 2001-10-18. PMID:11423326. |
one clinically inconspicuous pony showed hyperinsulinaemia and, in case of the ogtt, insulin resistance, glucose intolerance, and gip hypersecretion. |
2001-10-18 |
2023-08-12 |
Not clear |
| R Dühlmeier, E Deegen, H Fuhrmann, A Widdel, H P Sallman. Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 129. issue 2-3. 2001-10-18. PMID:11423326. |
regarding the elevated plasma gip concentrations of the insulin resistant pony the eia appears to participate in equine hyperinsulinaemia. |
2001-10-18 |
2023-08-12 |
Not clear |
| B Gebhard, J J Holst, C Biegelmayer, J Miholi. Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. Digestive diseases and sciences. vol 46. issue 9. 2001-10-18. PMID:11575444. |
the plasma concentrations of norepinephrine, glp-1, gip, glucagon, insulin, and glucose were measured following a 1.5 g/kg lean body mass glucose meal. |
2001-10-18 |
2023-08-12 |
Not clear |
| F Y Enç, N Imeryüz, L Akin, T Turoğlu, F Dede, G Haklar, N Tekeşin, N Bekiroğlu, B C Yeğen, J F Rehfeld, J J Holst, N B Uluso. Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 3. 2001-09-20. PMID:11518688. |
in meal groups with carbohydrates, acarbose attenuated responses of plasma insulin and glucose-dependent insulinotropic polypeptide (gip) while augmenting responses of cck, glucagon-like peptide-1 (glp-1), and peptide yy (pyy). |
2001-09-20 |
2023-08-12 |
human |
| J A Ehses, S S Lee, R A Pederson, C H McIntos. A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11323439. |
a new pathway for glucose-dependent insulinotropic polypeptide (gip) receptor signaling: evidence for the involvement of phospholipase a2 in gip-stimulated insulin secretion. |
2001-08-16 |
2023-08-12 |
Not clear |
| J A Ehses, S S Lee, R A Pederson, C H McIntos. A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11323439. |
the hormone glucose-dependent insulinotropic polypeptide (gip) is an important regulator of insulin secretion. |
2001-08-16 |
2023-08-12 |
Not clear |
| J A Ehses, S S Lee, R A Pederson, C H McIntos. A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signaling: evidence for the involvement of phospholipase A2 in GIP-stimulated insulin secretion. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11323439. |
although gip did not potentiate insulin release under extracellular ca(2+)-free conditions, it was still capable of elevating intracellular camp and stimulating [(3)h]aa release. |
2001-08-16 |
2023-08-12 |
Not clear |
| M Peracchi, S Porretti, C Gebbia, C Pagliari, P Bucciarelli, P Epaminonda, S Manenti, M Arosi. Increased glucose-dependent insulinotropic polypeptide (GIP) secretion in acromegaly. European journal of endocrinology. vol 145. issue 1. 2001-08-16. PMID:11415859. |
the aim of this study was to characterize the fasting and postprandial pattern of plasma gip and insulin in a group of acromegalic patients. |
2001-08-16 |
2023-08-12 |
Not clear |
| S A Hinke, S Manhart, N Pamir, H Demuth, R W Gelling, R A Pederson, C H McIntos. Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP). Biochimica et biophysica acta. vol 1547. issue 1. 2001-06-21. PMID:11343800. |
intravenous infusion of gip(1-42) (1 pmol/min/100 g) with a concurrent intraperitoneal glucose load (1 g/kg) significantly reduced circulating blood glucose excursions through stimulation of insulin release. |
2001-06-21 |
2023-08-12 |
rat |
| H Kindmark, J Pigon, S Efendi. Glucose-dependent insulinotropic hormone potentiates the hypoglycemic effect of glibenclamide in healthy volunteers: evidence for an effect on insulin extraction. The Journal of clinical endocrinology and metabolism. vol 86. issue 5. 2001-05-31. PMID:11344200. |
stimulation of beta-cell secretion of insulin by gip is seen both in vitro and in vivo at permissive extracellular glucose concentrations (> 6 mmol/l). |
2001-05-31 |
2023-08-12 |
human |