| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V A Gault, J C Parker, P Harriott, P R Flatt, F P M O'Hart. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. The Journal of endocrinology. vol 175. issue 2. 2003-01-06. PMID:12429050. |
in brin-bd11 cells, gip(3-42) was significantly less potent at stimulating insulin secretion (1.9- to 3.2-fold; p<0.001), compared with native gip and significantly inhibited gip-stimulated (10(-7) m) insulin secretion with maximal inhibition (48.8+/-6.2%; p<0.001) observed at 10(-7) m. in (ob/ob) mice, administration of gip(3-42) significantly inhibited gip-stimulated insulin release (2.1-fold decrease; p<0.001) and exaggerated the glycaemic excursion (1.4-fold; p<0.001) induced by a conjoint glucose load. |
2003-01-06 |
2023-08-12 |
mouse |
| V A Gault, J C Parker, P Harriott, P R Flatt, F P M O'Hart. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. The Journal of endocrinology. vol 175. issue 2. 2003-01-06. PMID:12429050. |
these data indicate that the n-terminally truncated gip(3-42) fragment acts as a gip receptor antagonist, moderating the insulin secreting and metabolic actions of gip in vivo. |
2003-01-06 |
2023-08-12 |
mouse |
| Mitsuhiro Nakazaki, Ana Crane, Min Hu, Victor Seghers, Susanne Ullrich, Lydia Aguilar-Bryan, Joseph Brya. cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets. Diabetes. vol 51. issue 12. 2002-12-20. PMID:12453898. |
while investigating potential compensatory mechanisms, we found that incretins, specifically glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), can increase the camp content of sur1ko islets but do not potentiate glucose-stimulated insulin release. |
2002-12-20 |
2023-08-12 |
mouse |
| Victor A Gault, Peter R Flatt, Clifford J Bailey, Patrick Harriott, Brett Greer, Mark H Mooney, Finbarr P M O'hart. Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. The Biochemical journal. vol 367. issue Pt 3. 2002-12-04. PMID:12150711. |
glucose-dependent insulinotropic polypeptide (gip) is an important incretin hormone, which potentiates glucose-induced insulin secretion. |
2002-12-04 |
2023-08-12 |
mouse |
| Victor A Gault, Peter R Flatt, Clifford J Bailey, Patrick Harriott, Brett Greer, Mark H Mooney, Finbarr P M O'hart. Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. The Biochemical journal. vol 367. issue Pt 3. 2002-12-04. PMID:12150711. |
this was associated with a significantly greater auc for insulin (2.1-fold; p <0.001) for both analogues compared with native gip. |
2002-12-04 |
2023-08-12 |
mouse |
| Jan A Ehses, Steven L Pelech, Raymond A Pederson, Christopher H S McIntos. Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. The Journal of biological chemistry. vol 277. issue 40. 2002-11-20. PMID:12138104. |
the gastrointestinal hormone, glucose-dependent insulinotropic polypeptide (gip), is one of the most important regulators of insulin secretion following ingestion of a meal. |
2002-11-20 |
2023-08-12 |
Not clear |
| Jan A Ehses, Steven L Pelech, Raymond A Pederson, Christopher H S McIntos. Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. The Journal of biological chemistry. vol 277. issue 40. 2002-11-20. PMID:12138104. |
gip stimulates insulin secretion from the pancreatic beta-cell via its g protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways, but there is little known regarding subsequent protein kinase pathways that are activated. |
2002-11-20 |
2023-08-12 |
Not clear |
| D Böcker, E J Verspoh. Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. International journal of experimental diabetes research. vol 2. issue 3. 2002-10-30. PMID:12369712. |
the interplay of protein kinase c (pkc), pi3-kinase and cellular tyrosine kinase with map kinase activity using inhibitors and compounds such as glucose, phorbol 12-myristate 13-acetate (pma) and agonists of g-protein coupled receptors like gastrin releasing peptide (grp), oxytocin (ot) and glucose-dependent insulinotropic peptide (gip) was investigated in ins-1 cells, an insulin secreting cell line. |
2002-10-30 |
2023-08-12 |
Not clear |
| D Böcker, E J Verspoh. Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. International journal of experimental diabetes research. vol 2. issue 3. 2002-10-30. PMID:12369712. |
inhibition of map kinase by 20 microm pd 098059 did not influence insulin secretion modulated by either compound (glucose, grp, ot or gip). |
2002-10-30 |
2023-08-12 |
Not clear |
| José Pierluissi, Raiza de Pierluissi, Angela de Martíne. Enhancement of insulin secretory response to glucose-dependent insulinotropic polypeptide (GIP) by growth hormone in dogs. Acta cientifica venezolana. vol 53. issue 1. 2002-10-21. PMID:12216497. |
enhancement of insulin secretory response to glucose-dependent insulinotropic polypeptide (gip) by growth hormone in dogs. |
2002-10-21 |
2023-08-12 |
cattle |
| José Pierluissi, Raiza de Pierluissi, Angela de Martíne. Enhancement of insulin secretory response to glucose-dependent insulinotropic polypeptide (GIP) by growth hormone in dogs. Acta cientifica venezolana. vol 53. issue 1. 2002-10-21. PMID:12216497. |
in the present work we examined the incretin role of gut glucose-dependent insulinotropic polypeptide (gip) in the insulin over-response to meal ingestion found in states of hypersomatotrophism. |
2002-10-21 |
2023-08-12 |
cattle |
| José Pierluissi, Raiza de Pierluissi, Angela de Martíne. Enhancement of insulin secretory response to glucose-dependent insulinotropic polypeptide (GIP) by growth hormone in dogs. Acta cientifica venezolana. vol 53. issue 1. 2002-10-21. PMID:12216497. |
the data suggest that in this state of high circulating levels of growth hormone of short duration, the secretion of insulin in response to the stimulus of glucose alone and also combined with gip is clearly enhanced. |
2002-10-21 |
2023-08-12 |
cattle |
| Gunnar Gregersen, J J Holst, A Trankjaer, F Stadil, Anne M Mogense. Case report: somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma. Metabolism: clinical and experimental. vol 51. issue 9. 2002-09-26. PMID:12200764. |
very high levels of somatostatin and low levels of insulin, c-peptide, gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) in peripheral blood were constantly present. |
2002-09-26 |
2023-08-12 |
Not clear |
| John A Pospisilik, Sara G Stafford, Hans-Ulrich Demuth, Christopher H S McIntosh, Raymond A Pederso. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Diabetes. vol 51. issue 9. 2002-09-18. PMID:12196458. |
upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) are rapidly cleaved and inactivated by the enzyme dipeptidyl peptidase iv (dp iv). |
2002-09-18 |
2023-08-12 |
rat |
| Erin B Ramshur, Teena R Rull, Burton M Wic. Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. Journal of cellular physiology. vol 192. issue 3. 2002-08-23. PMID:12124779. |
bioactive insulin was stored and then released following stimulation with arginine, peptones, and bombesin-physiological gip secretagogues. |
2002-08-23 |
2023-08-12 |
Not clear |
| Erin B Ramshur, Teena R Rull, Burton M Wic. Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. Journal of cellular physiology. vol 192. issue 3. 2002-08-23. PMID:12124779. |
however, glucose did not regulate insulin or gip secretion or mrna levels. |
2002-08-23 |
2023-08-12 |
Not clear |
| Rosalie Vozzo, Ben Baker, Gary A Wittert, Judith M Wishart, Howard Morris, Michael Horowitz, Ian Chapma. Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes. Metabolism: clinical and experimental. vol 51. issue 8. 2002-08-15. PMID:12145765. |
to investigate the relative effects of fructose and glucose on blood glucose, plasma insulin and incretin (glucagon-like peptide-1 [glp-1] and gastric inhibitory peptide [gip]) concentrations, and acute food intake, 10 (6 men, 4 women) patients with diet-controlled type 2 diabetes (diabetic) (44 to 71 years) and 10 age and body mass index (bmi)-matched (6 men, 4 women) nondiabetic, control subjects with varying degrees of glucose tolerance (nondiabetic), were studied on 3 days. |
2002-08-15 |
2023-08-12 |
human |
| Kazumasa Miyawaki, Yuichiro Yamada, Nobuhiro Ban, Yu Ihara, Katsushi Tsukiyama, Heying Zhou, Shimpei Fujimoto, Akira Oku, Kinsuke Tsuda, Shinya Toyokuni, Hiroshi Hiai, Wataru Mizunoya, Tohru Fushiki, Jens Juul Holst, Mitsuhiro Makino, Akira Tashita, Yukari Kobara, Yoshiharu Tsubamoto, Takayoshi Jinnouchi, Takahito Jomori, Yutaka Sein. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12068290. |
wild-type mice fed a high-fat diet exhibited both hypersecretion of gip and extreme visceral and subcutaneous fat deposition with insulin resistance. |
2002-08-05 |
2023-08-12 |
mouse |
| Kazumasa Miyawaki, Yuichiro Yamada, Nobuhiro Ban, Yu Ihara, Katsushi Tsukiyama, Heying Zhou, Shimpei Fujimoto, Akira Oku, Kinsuke Tsuda, Shinya Toyokuni, Hiroshi Hiai, Wataru Mizunoya, Tohru Fushiki, Jens Juul Holst, Mitsuhiro Makino, Akira Tashita, Yukari Kobara, Yoshiharu Tsubamoto, Takayoshi Jinnouchi, Takahito Jomori, Yutaka Sein. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12068290. |
in contrast, mice lacking the gip receptor (gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance. |
2002-08-05 |
2023-08-12 |
mouse |
| J A Pospisilik, S G Stafford, H-U Demuth, R Brownsey, W Parkhouse, D T Finegood, C H S McIntosh, R A Pederso. Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats. Diabetes. vol 51. issue 4. 2002-05-10. PMID:11916911. |
the incretins, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide 1 (glp-1) are responsible for >50% of nutrient-stimulated insulin secretion. |
2002-05-10 |
2023-08-12 |
rat |