| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J T Lewis, B Dayanandan, J F Habener, T J Kieffe. Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology. vol 141. issue 10. 2000-10-31. PMID:11014226. |
a novel gip receptor antagonist was developed to evaluate the acute role of glucose-dependent insulinotropic polypeptide (gip) in the insulin response to oral glucose in rats. |
2000-10-31 |
2023-08-12 |
rat |
| J T Lewis, B Dayanandan, J F Habener, T J Kieffe. Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology. vol 141. issue 10. 2000-10-31. PMID:11014226. |
treatment with gipr ab (1 microg/g bw) blocked the potentiation of glucose-stimulated insulin secretion by gip (60 pmol) but not glucagon-like peptide-1 (glp-1, 60 pmol) in anesthetized rats. |
2000-10-31 |
2023-08-12 |
rat |
| J T Lewis, B Dayanandan, J F Habener, T J Kieffe. Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology. vol 141. issue 10. 2000-10-31. PMID:11014226. |
we conclude that release of gip following oral glucose may act as an anticipatory signal to pancreatic beta-cells to promote rapid release of insulin for glucose disposal. |
2000-10-31 |
2023-08-12 |
rat |
| G S Meneilly, H U Demuth, C H McIntosh, R A Pederso. Effect of ageing and diabetes on glucose-dependent insulinotropic polypeptide and dipeptidyl peptidase IV responses to oral glucose. Diabetic medicine : a journal of the British Diabetic Association. vol 17. issue 5. 2000-10-03. PMID:10872532. |
glucose-dependent insulinotropic polypeptide (gip) acts on the pancreas to potentiate glucose-induced insulin secretion (enteroinsular axis). |
2000-10-03 |
2023-08-12 |
Not clear |
| F P O'Harte, M H Mooney, C M Kelly, P R Flat. Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. The Journal of endocrinology. vol 165. issue 3. 2000-08-29. PMID:10828847. |
this was associated with a significantly greater and more protracted insulin response following tyr(1)-glucitol gip than gip (auc, 491+/-118 vs 180+/-33 ng/ml.min; p<0.05). |
2000-08-29 |
2023-08-12 |
mouse |
| F P O'Harte, M H Mooney, C M Kelly, P R Flat. Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. The Journal of endocrinology. vol 165. issue 3. 2000-08-29. PMID:10828847. |
administration of tyr(1)-glucitol gip also enhanced the glucose-lowering ability of 50 units/kg insulin (218.4+/-30.2 vs insulin alone 133.9+/-16.2 mmol/l.min; p<0.05). |
2000-08-29 |
2023-08-12 |
mouse |
| M Ebinger, D R Jehle, R D Fussgaenger, H C Fehmann, P M Jehl. Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes. American journal of physiology. Endocrinology and metabolism. vol 279. issue 1. 2000-08-08. PMID:10893327. |
glucagon, gastric inhibitory peptide (gip), and gip-(1---30) did not affect insulin binding. |
2000-08-08 |
2023-08-12 |
human |
| M Peracchi, A Santangelo, D Conte, M Fraquelli, R Tagliabue, C Gebbia, M Porrin. The physical state of a meal affects hormone release and postprandial thermogenesis. The British journal of nutrition. vol 83. issue 6. 2000-07-31. PMID:10911770. |
variables assayed were plasma glucose, insulin and glucose-dependent insulinotropic peptide (gip) levels for 2 h and diet-induced thermogenesis (dit) for 5 h. plasma glucose pattern was similar after both meals. |
2000-07-31 |
2023-08-12 |
Not clear |
| M Peracchi, A Santangelo, D Conte, M Fraquelli, R Tagliabue, C Gebbia, M Porrin. The physical state of a meal affects hormone release and postprandial thermogenesis. The British journal of nutrition. vol 83. issue 6. 2000-07-31. PMID:10911770. |
however, hm induced significantly greater insulin, gip and dit responses than sm. |
2000-07-31 |
2023-08-12 |
Not clear |
| M Peracchi, A Santangelo, D Conte, M Fraquelli, R Tagliabue, C Gebbia, M Porrin. The physical state of a meal affects hormone release and postprandial thermogenesis. The British journal of nutrition. vol 83. issue 6. 2000-07-31. PMID:10911770. |
mean integrated areas under the curves (auc) were 1.7 (sem 0.38) v. 1.2 (sem 0.33) u/l per 120 min (p = 0.005) for insulin, 19.9 (sem 2.44) v. 16 (sem 1.92) nmol/l per 120 min (p = 0.042) for gip, and 237.7 (sem 16.32) v. 126.4 (sem 23.48) kj/300 min (p = 0.0029) for dit respectively. |
2000-07-31 |
2023-08-12 |
Not clear |
| R A Heptulla, W V Tamborlane, M Cavaghan, M Bronson, C Limb, Y Z Ma, R S Sherwin, S Capri. Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (GIP) responses in juvenile obesity. Pediatric research. vol 47. issue 5. 2000-07-07. PMID:10813588. |
augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (gip) responses in juvenile obesity. |
2000-07-07 |
2023-08-12 |
human |
| R A Heptulla, W V Tamborlane, M Cavaghan, M Bronson, C Limb, Y Z Ma, R S Sherwin, S Capri. Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (GIP) responses in juvenile obesity. Pediatric research. vol 47. issue 5. 2000-07-07. PMID:10813588. |
this augmented beta-cell secretory response to an oral glucose load results from the release of mainly two gut hormones: gastric inhibitory polypeptide (gip) and glucagon-like peptide-1, which potentiate glucose-induced insulin secretion. |
2000-07-07 |
2023-08-12 |
human |
| R A Heptulla, W V Tamborlane, M Cavaghan, M Bronson, C Limb, Y Z Ma, R S Sherwin, S Capri. Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (GIP) responses in juvenile obesity. Pediatric research. vol 47. issue 5. 2000-07-07. PMID:10813588. |
however, despite similar gip responses, insulin secretion was markedly augmented in obese adolescents. |
2000-07-07 |
2023-08-12 |
human |
| S A Hinke, R P Pauly, J Ehses, P Kerridge, H U Demuth, C H McIntosh, R A Pederso. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide. The Journal of endocrinology. vol 165. issue 2. 2000-06-21. PMID:10810292. |
in the current study we have shown that potentiation of insulin release by the intestinal hormone glucose-dependent insulinotropic polypeptide (gip) is also attenuated after its continuous application. |
2000-06-21 |
2023-08-12 |
mouse |
| S A Hinke, R P Pauly, J Ehses, P Kerridge, H U Demuth, C H McIntosh, R A Pederso. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide. The Journal of endocrinology. vol 165. issue 2. 2000-06-21. PMID:10810292. |
in less than 20 h of maintained stimulus with either hyperglycaemia (11.0 mm glucose) or gip (10 nm) under hyperglycaemic conditions, insulin release returned to basal values. |
2000-06-21 |
2023-08-12 |
mouse |
| S A Hinke, R P Pauly, J Ehses, P Kerridge, H U Demuth, C H McIntosh, R A Pederso. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (betaTC-3) cells to glucose-dependent insulinotropic polypeptide. The Journal of endocrinology. vol 165. issue 2. 2000-06-21. PMID:10810292. |
homologous desensitization of the insulin-potentiating activity of gip was found to affect both gip-stimulated and forskolin-stimulated insulin release, indicating desensitization of distal steps in the stimulus-exocytosis cascade. |
2000-06-21 |
2023-08-12 |
mouse |
| b' A Sj\\xc3\\xb6holm, E Sandberg, C G Ostenson, S Efendi\\xc4\\x8. Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells. Pancreas. vol 20. issue 3. 2000-05-31. PMID:10766455.' |
culture with gastric inhibitory peptide (gip) or glucagon-like peptide i (glp-1), two proposed incretins, did not affect short-term insulin secretion in response to 3.3 or 16.7 mm glucose irrespective of the ambient glucose concentration during culture. |
2000-05-31 |
2023-08-12 |
human |
| b' A Sj\\xc3\\xb6holm, E Sandberg, C G Ostenson, S Efendi\\xc4\\x8. Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells. Pancreas. vol 20. issue 3. 2000-05-31. PMID:10766455.' |
to the contrary, glp-1, but not gip, increased the content of insulin in islets cultured in low glucose. |
2000-05-31 |
2023-08-12 |
human |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
antropyloric pressures, blood glucose, and plasma insulin, gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) were measured concurrently; a buffet meal was offered at the end of the infusion. |
2000-04-07 |
2023-08-12 |
human |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
intraduodenal glucose increased blood glucose (p < 0.0005), as well as plasma insulin (p < 0.0005) and gip (p < 0.005) more than intraduodenal fructose, whereas there was no difference in the glp-1 response. |
2000-04-07 |
2023-08-12 |
human |