| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
intraduodenal glucose increased blood glucose (p < 0.0005), as well as plasma insulin (p < 0.0005) and gip (p < 0.005) more than intraduodenal fructose, whereas there was no difference in the glp-1 response. |
2000-04-07 |
2023-08-12 |
human |
| C K Rayner, H S Park, J M Wishart, M Kong, S M Doran, M Horowit. Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 2. 2000-04-07. PMID:10666136. |
we conclude that, when infused intraduodenally at 2 kcal/min for 90 min 1) fructose and glucose have comparable effects on antropyloric pressures, 2) fructose tends to suppress food intake more than glucose, despite similar glp-1 and less gip release, and 3) gip, rather than glp-1, probably accounts for the greater insulin response to glucose than fructose. |
2000-04-07 |
2023-08-12 |
human |
| R J Bollag, Q Zhong, P Phillips, L Min, L Zhong, R Cameron, A L Mulloy, H Rasmussen, F Qin, K H Ding, C M Isale. Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698200. |
the role of gip in coupling nutrient intake and insulin secretion, the incretin effect, is well known. |
2000-03-16 |
2023-08-12 |
Not clear |
| L Ranganath, F Schaper, R Gama, L Morgan, J Wright, D Teale, V Mark. Effect of glucagon on carbohydrate-mediated secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-36 amide) (GLP-1). Diabetes/metabolism research and reviews. vol 15. issue 6. 2000-02-24. PMID:10634963. |
the insulinotropic hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (7-36 amide) (glp-1), regulate insulin secretion to nutrient intake and constitute the endocrine arm of the entero-insular axis. |
2000-02-24 |
2023-08-12 |
Not clear |
| L Ranganath, F Schaper, R Gama, L Morgan, J Wright, D Teale, V Mark. Effect of glucagon on carbohydrate-mediated secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-36 amide) (GLP-1). Diabetes/metabolism research and reviews. vol 15. issue 6. 2000-02-24. PMID:10634963. |
plasma glucose, gip, glp-1, insulin and paracetamol concentrations were measured before and after a 100 g oral carhohydrate load containing 1.5 g of paracetamol for 6 h during intravenous infusion of either glucagon or saline. |
2000-02-24 |
2023-08-12 |
Not clear |
| R G Yip, M M Wolf. GIP biology and fat metabolism. Life sciences. vol 66. issue 2. 2000-02-22. PMID:10666005. |
in addition to stimulating insulin release, gip has been shown to amplify the effect of insulin on target tissues. |
2000-02-22 |
2023-08-12 |
Not clear |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
the insulin inhibitory neuropeptide galanin (50 nm) caused a decrease of alpha(s)- and alpha(i2)-mrna levels, whereas insulinotropic compounds (incretin hormones) such as gip or glp-1 (both 10 nm) led to an increase of alpha(s)- and alpha(i2)-mrna levels. |
2000-01-31 |
2023-08-12 |
Not clear |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
the changes in alpha(i2)-mrna levels by either compound were paralleled by inverse changes in insulin secretion: preincubation with uk 14,304 for 8 h led to an increased insulin secretion when challenged by either glp-1, gip or glucose (8.3 mm). |
2000-01-31 |
2023-08-12 |
Not clear |
| S Kesper, J Rucha, H Neye, C Mazenot, E J Verspoh. Galpha(i2)-mRNA and -protein regulation as a mechanism for heterologous sensitization and desensitization of insulin secretion. Cellular signalling. vol 11. issue 10. 2000-01-31. PMID:10574331. |
on the other hand, exposure to the incretins gip or glp-1 for 8 h induced a smaller insulin release when challenged afterwards by either uk 14,304, galanin, gip, glp-1, or glucose. |
2000-01-31 |
2023-08-12 |
Not clear |
| K Miyawaki, Y Yamada, H Yano, H Niwa, N Ban, Y Ihara, A Kubota, S Fujimoto, M Kajikawa, A Kuroe, K Tsuda, H Hashimoto, T Yamashita, T Jomori, F Tashiro, J Miyazaki, Y Sein. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611300. |
accordingly, early insulin secretion mediated by gip determines glucose tolerance after oral glucose load in vivo, and because gip plays an important role in the compensatory enhancement of insulin secretion produced by a high insulin demand, a defect in this entero-insular axis may contribute to the pathogenesis of diabetes. |
2000-01-27 |
2023-08-12 |
mouse |
| C M Yeung, C K Wong, S K Chung, S S Chung, B K Cho. Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining. Molecular and cellular endocrinology. vol 154. issue 1-2. 1999-11-19. PMID:10509810. |
glucose-dependent insulinotropic polypeptide (gip) plays an important role in stimulating insulin release in the pancreas as well as inhibiting gastric acid secretion in the stomach. |
1999-11-19 |
2023-08-12 |
mouse |
| M B Wheeler, R W Gelling, S A Hinke, B Tu, R A Pederson, F Lynn, J Ehses, C H McIntos. Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization. The Journal of biological chemistry. vol 274. issue 35. 1999-09-30. PMID:10455124. |
glucose-dependent insulinotropic polypeptide (gip) is a gastrointestinal hormone involved in the regulation of insulin secretion. |
1999-09-30 |
2023-08-12 |
rat |
| M B Wheeler, R W Gelling, S A Hinke, B Tu, R A Pederson, F Lynn, J Ehses, C H McIntos. Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor. A role for serines 426 and 427 in regulating the rate of internalization. The Journal of biological chemistry. vol 274. issue 35. 1999-09-30. PMID:10455124. |
in non-insulin-dependent diabetes mellitus insulin responses to gip are blunted, possibly due to altered signal transduction or reduced receptor number. |
1999-09-30 |
2023-08-12 |
rat |
| M D Robertson, G Livesey, L M Morgan, S M Hampton, J C Mather. The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man. The Journal of endocrinology. vol 161. issue 1. 1999-09-01. PMID:10194525. |
circulating levels of glucose, insulin, glucagon, glucose insulinotrophic peptide (gip) and glp-1 were measured over a 9-h postprandial period. |
1999-09-01 |
2023-08-12 |
human |
| N N'Diaye, P Hamet, J Tremblay, J M Boutin, L Gaboury, A Lacroi. Asynchronous development of bilateral nodular adrenal hyperplasia in gastric inhibitory polypeptide-dependent cushing's syndrome. The Journal of clinical endocrinology and metabolism. vol 84. issue 8. 1999-08-19. PMID:10443649. |
plasma cortisol and gip levels were positively correlated (r = 0.95; p = 0.0001); cortisol was stimulated by the administration of human gip iv (225%), but not by glp-1, insulin, trh, gnrh, glucagon, arginine vasopressin, upright posture, or cisapride orally. |
1999-08-19 |
2023-08-12 |
human |
| C C Tseng, X Y Zhang, M M Wolf. Effect of GIP and GLP-1 antagonists on insulin release in the rat. The American journal of physiology. vol 276. issue 6. 1999-07-29. PMID:10362617. |
effect of gip and glp-1 antagonists on insulin release in the rat. |
1999-07-29 |
2023-08-12 |
rat |
| C C Tseng, X Y Zhang, M M Wolf. Effect of GIP and GLP-1 antagonists on insulin release in the rat. The American journal of physiology. vol 276. issue 6. 1999-07-29. PMID:10362617. |
to examine their relative contribution to postprandial insulin release, a specific gip antagonist (antgip) and a glp-1 antagonist, exendin-(9-39)-nh2, were infused into rats after an intragastric glucose meal. |
1999-07-29 |
2023-08-12 |
rat |
| C C Tseng, X Y Zhang, M M Wolf. Effect of GIP and GLP-1 antagonists on insulin release in the rat. The American journal of physiology. vol 276. issue 6. 1999-07-29. PMID:10362617. |
the results of these studies suggest that gip and glp-1 may share a common mechanism in stimulating pancreatic insulin release. |
1999-07-29 |
2023-08-12 |
rat |
| L R Ranganath, J M Beety, L M Morga. Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 4. 1999-07-01. PMID:10333081. |
inhibition of insulin, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity. |
1999-07-01 |
2023-08-12 |
human |
| L R Ranganath, J M Beety, L M Morga. Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 4. 1999-07-01. PMID:10333081. |
this study examines the immediate effect of modulating postprandial insulin and insulinotropic hormone (glucose-dependent insulinotropic polypeptide, gip; glucagon-like peptide-1, glp-1) secretion on the activation of lipoprotein lipase (lpl) in six lean and six obese age-matched women. |
1999-07-01 |
2023-08-12 |
human |