| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Yasuda, Y Sein. [Gastric inhibitory polypeptide (GIP) and GIP receptor (GIPR)]. Nihon rinsho. Japanese journal of clinical medicine. vol 54. issue 4. 1996-12-31. PMID:8920677. |
in vivo and in vitro experiments have indicated that gip auguments glucose-stimulated insulin secretion, suggesting that gip plays an important role in the regulation of insulin secretion as an incretin. |
1996-12-31 |
2023-08-12 |
rat |
| A A Vaag, J J Holst, A Vølund, H B Beck-Nielse. Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)--evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins. European journal of endocrinology. vol 135. issue 4. 1996-12-30. PMID:8921824. |
gender was identified as the major independent covariate for incremental glucose, insulin, gip and glp-1 responses, with higher values of all parameters in females. |
1996-12-30 |
2023-08-12 |
Not clear |
| A A Vaag, J J Holst, A Vølund, H B Beck-Nielse. Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)--evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins. European journal of endocrinology. vol 135. issue 4. 1996-12-30. PMID:8921824. |
however, decreased secretion of gut incretin hormones (glp-1 or gip) does not explain all of the defects of pancreatic insulin secretion in niddm patients/twins or in non-diabetic individuals (identical twins) with a genetic predisposition to niddm. |
1996-12-30 |
2023-08-12 |
Not clear |
| A Kubota, Y Yamada, T Hayami, K Yasuda, Y Someya, Y Ihara, S Kagimoto, R Watanabe, T Taminato, K Tsuda, Y Sein. Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes. vol 45. issue 12. 1996-12-30. PMID:8922354. |
gastric inhibitory polypeptide (gip) potently stimulates insulin secretion from pancreatic islets in the presence of glucose as an incretin. |
1996-12-30 |
2023-08-12 |
human |
| A Kubota, Y Yamada, T Hayami, K Yasuda, Y Someya, Y Ihara, S Kagimoto, R Watanabe, T Taminato, K Tsuda, Y Sein. Identification of two missense mutations in the GIP receptor gene: a functional study and association analysis with NIDDM: no evidence of association with Japanese NIDDM subjects. Diabetes. vol 45. issue 12. 1996-12-30. PMID:8922354. |
because the insulinotropic effect of gip is reduced in niddm, it should be clarified whether defects in the gip receptor gene contribute to the impaired insulin secretion in niddm. |
1996-12-30 |
2023-08-12 |
human |
| R A Pederson, T J Kieffer, R Pauly, H Kofod, J Kwong, C H McIntos. The enteroinsular axis in dipeptidyl peptidase IV-negative rats. Metabolism: clinical and experimental. vol 45. issue 11. 1996-12-19. PMID:8931636. |
a decrease of 30% in the sensitivity of the perfused pancreas of dpiv-negative rats to gip was observed, whereas the insulin response to glp(7-36) was identical in both groups. |
1996-12-19 |
2023-08-12 |
rat |
| R A Pederson, T J Kieffer, R Pauly, H Kofod, J Kwong, C H McIntos. The enteroinsular axis in dipeptidyl peptidase IV-negative rats. Metabolism: clinical and experimental. vol 45. issue 11. 1996-12-19. PMID:8931636. |
it was hypothesized that the reduced gip response and decreased sensitivity of the pancreas to gip are compensatory mechanisms that maintain insulin and glucose levels within a normal range despite abnormal degradation of gip. |
1996-12-19 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, M H Giroix, M N Gangnerau, B Porth. Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP. The American journal of physiology. vol 271. issue 4 Pt 1. 1996-12-16. PMID:8897861. |
decreased glucose-induced camp and insulin release in islets of diabetic rats: reversal by ibmx, glucagon, gip. |
1996-12-16 |
2023-08-12 |
rat |
| N Dachicourt, P Serradas, M H Giroix, M N Gangnerau, B Porth. Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP. The American journal of physiology. vol 271. issue 4 Pt 1. 1996-12-16. PMID:8897861. |
the addition of ibmx, glucagon, or gastric inhibitory polypeptide (gip) to perifused islets of diabetic rats amplified their insulin response to glucose, and a clear biphasic pattern of the release was regained. |
1996-12-16 |
2023-08-12 |
rat |
| Y Wang, C Montrose-Rafizadeh, L Adams, M Raygada, O Nadiv, J M Ega. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Molecular and cellular endocrinology. vol 116. issue 1. 1996-12-10. PMID:8822268. |
gip regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in rin 1046-38 cells. |
1996-12-10 |
2023-08-12 |
Not clear |
| Y Wang, C Montrose-Rafizadeh, L Adams, M Raygada, O Nadiv, J M Ega. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Molecular and cellular endocrinology. vol 116. issue 1. 1996-12-10. PMID:8822268. |
acute studies of glucose-dependent insulinotropic peptide (gip) have shown that gip can synergize with glucose in stimulating insulin secretion both in vivo and in vitro. |
1996-12-10 |
2023-08-12 |
Not clear |
| Y Wang, C Montrose-Rafizadeh, L Adams, M Raygada, O Nadiv, J M Ega. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Molecular and cellular endocrinology. vol 116. issue 1. 1996-12-10. PMID:8822268. |
here we studied the effects of extended exposure of rin 1046-38 cells, an insulin-secreting cell line, to gip and the mechanisms by which gip synergizes with glucose in stimulating insulin secretion. |
1996-12-10 |
2023-08-12 |
Not clear |
| Y Wang, C Montrose-Rafizadeh, L Adams, M Raygada, O Nadiv, J M Ega. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Molecular and cellular endocrinology. vol 116. issue 1. 1996-12-10. PMID:8822268. |
incubation of the cells with 100 nm gip in the presence of glucose for 12 h significantly increased insulin release (287 +/- 31.7 vs. 102 +/- 9.7 ng/mg protein; n = 3), intracellular insulin content (12.8 +/- 0.83 vs. 8.2 +/- 0.52 ng/mg protein; n = 3), and insulin mrna (approximately 2.7-fold; 24 h incubation) when compared to cells cultured with glucose alone. |
1996-12-10 |
2023-08-12 |
Not clear |
| Y Wang, C Montrose-Rafizadeh, L Adams, M Raygada, O Nadiv, J M Ega. GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Molecular and cellular endocrinology. vol 116. issue 1. 1996-12-10. PMID:8822268. |
our study suggests that the mechanism by which extended exposure of rin 1046-38 cells to gip increases glucose-stimulated insulin secretion includes up-regulation of glucose sensing elements. |
1996-12-10 |
2023-08-12 |
Not clear |
| C Orskov, A Wettergren, J J Hols. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scandinavian journal of gastroenterology. vol 31. issue 7. 1996-12-06. PMID:8819215. |
the insulinotropic hormones gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (glp-1), secreted from the k-cells of the upper small intestine and from the l-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. |
1996-12-06 |
2023-08-12 |
Not clear |
| C C Tseng, M O Boylan, L A Jarboe, T B Usdin, M M Wolf. Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats. The American journal of physiology. vol 270. issue 4 Pt 1. 1996-11-20. PMID:8928774. |
in response to gip infusion, the serum insulin concentration increased at 30 min, followed by a gradual decrease, and at 4 h, no increase in insulin levels was detected despite a sustained elevated serum gip level. |
1996-11-20 |
2023-08-12 |
rat |
| M P van der Burg, O R Guicherit, M Frölich, H G Goosze. Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets. Regulatory peptides. vol 60. issue 1. 1996-10-08. PMID:8747785. |
gip enhanced insulin release 1.1- and 1.2-fold, at the 7.5 and 10 mm glucose level, respectively. |
1996-10-08 |
2023-08-12 |
Not clear |
| S G Straub, G W Shar. Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway. Biochemical and biophysical research communications. vol 224. issue 2. 1996-08-30. PMID:8702397. |
the effect of wortmannin, a fungal metabolite which is known to inhibit phosphatidylinositol 3-kinase (pi3-kinase) at low concentrations, has been examined for its effect on insulin secretion stimulated by glucose-dependent insulinotropic polypeptide (gip). |
1996-08-30 |
2023-08-12 |
Not clear |
| S G Straub, G W Shar. Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway. Biochemical and biophysical research communications. vol 224. issue 2. 1996-08-30. PMID:8702397. |
thus gip, like vasoactive intestinal polypeptide (vip) and pituitary adenylyl cyclase activating polypeptide (pacap), exerts some of its stimulatory effect on insulin release via a wortmannin-sensitive signal transduction pathway. |
1996-08-30 |
2023-08-12 |
Not clear |
| M A Nauck, J Siemsglüss, C Orskov, J J Hols. Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections. Zeitschrift fur Gastroenterologie. vol 34. issue 3. 1996-07-19. PMID:8650968. |
release of glucagon-like peptide 1 (glp-1 [7-36 amide]), gastric inhibitory polypeptide (gip) and insulin in response to oral glucose after upper and lower intestinal resections. |
1996-07-19 |
2023-08-12 |
Not clear |