| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting M. Malva Sylvestris Attenuates Cognitive Deficits in a Repetitive Mild Traumatic Brain Injury Rat Model by Reducing Neuronal Degeneration and Astrocytosis in the Hippocampus. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-09. PMID:29276216. |
histopathology studies were performed on the hippocampal region by nissl staining and anti gfap staining. |
2018-08-09 |
2023-08-13 |
rat |
| Adriana Fernanda K Vizuete, Matheus Mittmann Hennemann, Carlos Alberto Gonçalves, Diogo Losch de Oliveir. Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28444637. |
phase-dependent signs of hippocampal astrogliosis were observed, as demonstrated by increments in gfap, s100b and gs. |
2018-08-07 |
2023-08-13 |
rat |
| Cassiana Siebert, Paula Pierozan, Janaina Kolling, Tiago Marcon Dos Santos, Matheus Coimbra Sebotaio, Eduardo Peil Marques, Helena Biasibetti, Aline Longoni, Fernanda Ferreira, Regina Pessoa-Pureur, Carlos Alexandre Netto, Angela T S Wys. Vitamin D Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28689355. |
ovx altered hippocampal cytoskeleton phosphorylating system, evidenced by the hyperphosphorylation of glial fibrillary acidic protein (gfap), low molecular weight neurofilament subunit (nfl), medium molecular weight neurofilament subunit (nfm) and high molecular weight neurofilament subunit (nfh), and increased the immunocontent of c-jun n-terminal protein kinases (jnk), ca |
2018-08-06 |
2023-08-13 |
rat |
| Monika Kapoor, Neha Sharma, Rajat Sandhir, Bimla Nehr. Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29091896. |
enhanced glial activation was observed and an upregulated expression of gfap and iba-1 in hippocampus along with that of the transcription factor nfκb and inflammatory markers inos, il-1α, il-1β and tnf-α.the activity of mitochondrial electron transport chain (etc) complexes i, ii, iv and v were significantly decreased following ischemia. |
2018-08-03 |
2023-08-13 |
rat |
| Vladimirs Pilipenko, Karina Narbute, Ulrika Beitnere, Juris Rumaks, Jolanta Pupure, Baiba Jansone, Vija Klus. Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease. European journal of pharmacology. vol 818. 2018-07-27. PMID:29133125. |
in the present study, we used a non-transgenic rat model of ad obtained by intracerebroventricular streptozocin (stz) injection and assessed the effects of muscimol and baclofen at very low doses (0.01-0.05mg/kg) on spatial memory and the expression of cortical and hippocampal proteins related to neuroinflammation, namely proteins involved in astroglial functions (glial fibrillary acidic protein, gfap), gaba synthesis (gaba synthesizing enzyme, glutamic acid decarboxylase 67, gad67) and acetylcholine degradation (acetylcholine esterase). |
2018-07-27 |
2023-08-13 |
rat |
| Chia-Mei Chou, Yueh-Lun Lee, Chien-Wei Liao, Ying-Chieh Huang, Chia-Kwung Fa. Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess Aβ accumulation in the hippocampus of mice with persistent cerebral toxocariasis. Parasites & vectors. vol 10. issue 1. 2018-07-20. PMID:29273062. |
the present study intended to assess pathological changes, expressions of neurodegeneration-associated factors (ndafs), including transforming growth factor (tgf)-β1, s100b, glial fibrillary acidic protein (gfap), transglutaminase type 2 (tg2), claudin-5, substance p (sp) and interleukin (il)-1β, and the ubiquitin-proteasome system (ups) function in the hippocampus and associated cognitive behavior in icr mice orally inoculated with a high, medium or low-dose of t. canis embryonated ova during a 20-week investigation. |
2018-07-20 |
2023-08-13 |
mouse |
| Meghan E Jones, Christina L Lebonville, Jacqueline E Paniccia, Megan E Balentine, Kathryn J Reissner, Donald T Lysl. Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28963000. |
experiment 2 used triple fluorescence immunohistochemistry to examine hippocampal alterations in il-1β, glial fibrillary acidic protein (gfap), an astrocyte-specific marker, and ionized calcium binding adaptor molecule -1 (iba-1), a microglial-specific marker, 48h after exposure to the severe stressor of the sefl paradigm. |
2018-07-11 |
2023-08-13 |
Not clear |
| Meghan E Jones, Christina L Lebonville, Jacqueline E Paniccia, Megan E Balentine, Kathryn J Reissner, Donald T Lysl. Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28963000. |
further, hippocampal gfap immunoreactivity was not altered, whereas hippocampal iba-1 immunoreactivity was significantly attenuated following severe stress. |
2018-07-11 |
2023-08-13 |
Not clear |
| Francis L Pazini, Mauricio P Cunha, Dayane Azevedo, Julia M Rosa, André Colla, Jade de Oliveira, Ana B Ramos-Hryb, Patricia S Brocardo, Joana Gil-Mohapel, Ana Lúcia S Rodrigue. Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27714631. |
these behavioral effects were associated with decreased hippocampal cell proliferation and neuronal differentiation and increased glial fibrillary acid protein (gfap) immunostaining (suggestive of astrogliosis) in dentate gyrus (dg) of the hippocampus. |
2018-07-09 |
2023-08-13 |
mouse |
| Aline Marcelino de Andrade, Marilda da Cruz Fernandes, Luciano Stürmer de Fraga, Marilene Porawski, Márcia Giovenardi, Renata Padilha Guede. Omega-3 fatty acids revert high-fat diet-induced neuroinflammation but not recognition memory impairment in rats. Metabolic brain disease. vol 32. issue 6. 2018-07-03. PMID:28756577. |
however, no differences in gfap number of cells were found in the hippocampus. |
2018-07-03 |
2023-08-13 |
rat |
| Cássia Sallaberry, Ana Paula Ardais, Andréia Rocha, Maurício Felisberto Borges, Gabriela T Fioreze, Sabrina Mioranzza, Fernanda Nunes, Natália Pagnussat, Paulo Henrique S Botton, Lisiane O Porciúncul. Sex differences in the effects of pre- and postnatal caffeine exposure on behavior and synaptic proteins in pubescent rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 81. 2018-07-03. PMID:28826637. |
behavioral tasks were performed to evaluate locomotor activity (open field task), anxious-like behavior (elevated plus maze task) and recognition memory (object recognition task) and synaptic proteins levels (probdnf, bdnf, gfap and snap-25) were verified in the hippocampus and cerebral cortex. |
2018-07-03 |
2023-08-13 |
rat |
| Joan Liu, Cheryl Reeves, Thomas Jacques, Andrew McEvoy, Anna Miserocchi, Pamela Thompson, Sanjay Sisodiya, Maria Tho. Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity. Glia. vol 66. issue 1. 2018-07-02. PMID:28925561. |
nestin cells represented 29% of the hippocampal proliferative fraction in epilepsy cases; 20% co-expressed βiii tubulin in culture compared with 28% with gfap. |
2018-07-02 |
2023-08-13 |
Not clear |
| Fengguo Liu, Jingjing Wu, Yu Gong, Peng Wang, Lei Zhu, Lijuan Tong, Xiangfan Chen, Yong Ling, Chao Huan. Harmine produces antidepressant-like effects via restoration of astrocytic functions. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28625859. |
in addition, harmine treatment (20mg/kg) increased the protein expression levels of glutamate transporter 1 (glt-1) and prevented the cus-induced decreases in glial fibrillary acidic protein (gfap) protein expressions in the prefrontal cortex and hippocampus, suggesting that restoration of astrocytic functions may be a potential mechanism underlying the antidepressant-like effects of harmine. |
2018-06-12 |
2023-08-13 |
mouse |
| Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondo. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28647536. |
thirty days post ischemia, brain derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) receptor expression, hippocampal neuronal death and inflammation were determined by analyzing immunoreactivity (ir) of neuron-specific nuclear protein (neun), microglia (iba1, ionized calcium binding adaptor molecule 1), astrocytes (gfap, glial fibrillary acidic protein) and tnfα (tumor necrosis factor alpha) a pro-inflammatory cytokine. |
2018-06-12 |
2023-08-13 |
rat |
| Elmira Beirami, Shahrbanoo Oryan, Seyedeh Masoumeh Seyedhosseini Tamijani, Abolhassan Ahmadiani, Leila Dargah. Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation. Neuroscience letters. vol 660. 2018-06-11. PMID:28917981. |
in insulin treatment (0.5iu/day, for 7days after ma discontinuation) attenuated ma-induced anxiety-like behavior in the elevated plus maze task, and significantly decreased the levels of glial cell markers (gfap and iba1), pro-inflammatory cytokines (tnf-α and il-6) as well as cox2 and nf-κb players of neuroinflammation, in the hippocampus of ma-treated animals. |
2018-06-11 |
2023-08-13 |
rat |
| Huimei Hao, Shanshan Wan. Hypothermia induced by anesthesia regulates various signals expressions in the hippocampus of animals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-11. PMID:28938523. |
importantly, isoflurane and propofol anesthesia reduced fibroblast growth factor (fgf2) and activity-regulated cytoskeleton-associated protein (arc) expressions, enhanced glial fibrillary acidic protein (gfap), iba1 and phosphorylated-eukaryotic elongation factor 2 (eef2) levels as well as down-regulated mitogen-activated protein kinases (mapks) family members, including p38, erk1/2 and jnk, in the hippocampus of animals. |
2018-06-11 |
2023-08-13 |
Not clear |
| Taysa B Bassani, Joelle M Turnes, Eric L R Moura, Jéssica M Bonato, Valentín Cóppola-Segovia, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vita. Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer's type. Behavioural brain research. vol 335. 2018-05-22. PMID:28801114. |
four weeks after surgery, stz-lesioned animals exhibited impairments in short-term spatial memory (object location test (olt) and y maze) and short-term recognition memory (object recognition test - ort), decreased cell proliferation and immature neurons (ki-67- and doublecortin-positive cells, respectively) in the subventricular zone (svz) and dentate gyrus (dg) of hippocampus, and increased immunoreactivity for the glial markers gfap and iba-1 (neuroinflammation). |
2018-05-22 |
2023-08-13 |
rat |
| Panos Theofilas, Christian Steinhäuser, Martin Theis, Amin Derouich. Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells. Journal of neuroscience research. vol 95. issue 11. 2018-05-18. PMID:28370142. |
in double staining with cell type-specific markers (gfap, s100ß, glutamine synthetase), cx43 reporter expression in the hippocampus and cortex was restricted to gfap |
2018-05-18 |
2023-08-13 |
mouse |
| Elliot Koo, R Ann Sheldon, Byong Sop Lee, Zinaida S Vexler, Donna M Ferrier. Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. Pediatric research. vol 82. issue 3. 2018-05-16. PMID:28561815. |
analysis revealed decreased gfap and iba1 staining in hippocampal regions, mostly ca2/ca3. |
2018-05-16 |
2023-08-13 |
mouse |
| Elliot Koo, R Ann Sheldon, Byong Sop Lee, Zinaida S Vexler, Donna M Ferrier. Effects of therapeutic hypothermia on white matter injury from murine neonatal hypoxia-ischemia. Pediatric research. vol 82. issue 3. 2018-05-16. PMID:28561815. |
gfap and iba1 directly correlated with injury scores of normothermic brains.conclusionth reduced injury, and qualitative data suggest that hippocampus and lateral caudate are protected from hi. |
2018-05-16 |
2023-08-13 |
mouse |