| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Jie, Yang Xuefeng, Yang Mengxue, Yang Xuesong, Yang Jing, Tang Yin, Xu Ji. Mechanism of nonylphenol-induced neurotoxicity in F1 rats during sexual maturity. Wiener klinische Wochenschrift. vol 128. issue 11-12. 2017-05-05. PMID:26905877. |
the purpose of this study was to examine whether gestational and lactational exposure to environmental endocrine disrupting chemical, nonylphenol (np), in pregnant dams would lead to the alterations in hormone levels in the body, apoptosis and glial fibrillary acidic protein (gfap) in hippocampus during weaning and sexual maturity periods in pups of rats. |
2017-05-05 |
2023-08-13 |
rat |
| Jacqueline A Hubbard, Jenny I Szu, Jennifer M Yonan, Devin K Binde. Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27155358. |
we used real-time polymerase chain reaction (rt-pcr), western blot, and immunohistochemical analysis at 1, 4, 7, and 30days after kainic acid-induced status epilepticus (se) to determine hippocampal glial fibrillary acidic protein (gfap, a marker for reactive astrocytes), glt1, and aqp4 expression changes during the development of epilepsy (epileptogenesis). |
2017-05-05 |
2023-08-13 |
mouse |
| Angela L Cumberland, Hannah K Palliser, Gabrielle K Crombie, David W Walker, Jonathan J Hirs. Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 58. 2017-03-29. PMID:28192175. |
there were no differences in the neurodevelopmental markers assessed; map2, neun, mbp, gfap or gad67 between intrauterine finasteride or vehicle exposure, in either the hippocampus or amygdala whereas gat1 staining was decreased. |
2017-03-29 |
2023-08-13 |
Not clear |
| Ramiro Diaz, Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Sílvia Barbosa, Monique Culturato Padilha Mendonça, Maria Alice da Cruz-Höfling, Lenir Orlandi Pereir. Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 53. 2017-03-27. PMID:27326908. |
the bbb permeability and integrity was assessed by evans blue staining and the immunohistochemistry for gfap in the ca1 region of the hippocampus were also performed. |
2017-03-27 |
2023-08-13 |
rat |
| Ramiro Diaz, Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Sílvia Barbosa, Monique Culturato Padilha Mendonça, Maria Alice da Cruz-Höfling, Lenir Orlandi Pereir. Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 53. 2017-03-27. PMID:27326908. |
the results showed an hi-induced decreased occludin expression at pnd 22 and low levels of occludin, β-catenin and gfap at pnd 60 in the hippocampus of the hypoxic-ischemic rats. |
2017-03-27 |
2023-08-13 |
rat |
| Amélie Barthélémy, Amandine Mouchard, Marc Bouji, Kelly Blazy, Renaud Puigsegur, Anne-Sophie Villégie. Glial markers and emotional memory in rats following acute cerebral radiofrequency exposures. Environmental science and pollution research international. vol 23. issue 24. 2017-03-17. PMID:27696165. |
long-term memory was reduced, and cytosolic gfap was increased in the hippocampus (+119 %) and in the olfactory bulb (+46 %) at 6 w/kg (15 min). |
2017-03-17 |
2023-08-13 |
rat |
| Ying-Ying Chen, Li Zhang, Dong-Ling Shi, Xing-Hui Song, Yue-Liang Shen, Ming-Zhi Zheng, Lin-Lin Wan. Resveratrol Attenuates Subacute Systemic Inflammation-Induced Spatial Memory Impairment via Inhibition of Astrocyte Activation and Enhancement of Synaptophysin Expression in the Hippocampus. Annals of clinical and laboratory science. vol 47. issue 1. 2017-03-13. PMID:28249911. |
immunohistochemistry and western blot analysis revealed that lps increased hippocampal gfap expression and inhibited synaptophysin expression, which were prevented by resveratrol treatment. |
2017-03-13 |
2023-08-13 |
mouse |
| Patrícia Nardin, Caroline Zanotto, Fernanda Hansen, Cristiane Batassini, Manuela Sangalli Gasparin, Patrícia Sesterheim, Carlos-Alberto Gonçalve. Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27084774. |
herein, we investigate specific astrocyte changes in the rat hippocampus in a model of dm induced by stz, particularly looking at glial fibrillary acidic protein (gfap), s100b protein and glutamate uptake, as well as the content of advanced glycated end products (ages) in serum and cerebrospinal fluid (csf), as a consequence of elevated hyperglycemia and the content of receptor for ages in the hippocampus. |
2017-03-03 |
2023-08-13 |
rat |
| Takeshi Tanaka, Hajime Abe, Masayuki Kimura, Nobuhiko Onda, Sayaka Mizukami, Toshinori Yoshida, Makoto Shibutan. Developmental exposure to T-2 toxin reversibly affects postnatal hippocampal neurogenesis and reduces neural stem cells and progenitor cells in mice. Archives of toxicology. vol 90. issue 8. 2017-03-02. PMID:26314264. |
in the hippocampal dentate gyrus of male pnd 21 offspring, gfap(+) and blbp(+) type-1 stem cells and pax6(+) and tbr2(+) type-2 progenitor cells decreased in the subgranular zone (sgz) at 9 and ≥3 ppm, respectively, in parallel with increased apoptosis at ≥3 ppm. |
2017-03-02 |
2023-08-13 |
mouse |
| Reza Sedaghat, Yosra Taab, Zahra Kiasalari, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 87. 2017-02-21. PMID:28061403. |
it also significantly restored hippocampal level of reactive oxygen species (ros), glutathione (gsh), nuclear factor (erythroid-derived 2)-like 2 (nrf2), activity of catalase and caspase 3, nuclear factor-b (nf-κb), toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), interleukin-1β (il-1β), neural cell adhesion molecule (ncam), glial fibrillary acidic protein (gfap), cathepsin d, and heme oxygenase 1 (ho-1). |
2017-02-21 |
2023-08-13 |
rat |
| Hamid Sohanaki, Tourandokht Baluchnejadmojarad, Farnaz Nikbakht, Mehrdad Roghan. Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-01-30. PMID:27470554. |
animals underwent morris water maze (mwm) test in addition to measurement of hippocampal oxidative stress, acetylcholinesterase (ache) activity, glial fibrillary acidic protein (gfap) and inducible nitric oxide synthase (inos). |
2017-01-30 |
2023-08-13 |
rat |
| Hamid Sohanaki, Tourandokht Baluchnejadmojarad, Farnaz Nikbakht, Mehrdad Roghan. Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-01-30. PMID:27470554. |
meanwhile, pel improved hippocampal ache activity and lowered gfap level with no significant change of inos. |
2017-01-30 |
2023-08-13 |
rat |
| Omar El Hiba, Abdeljalil Elgot, Samir Ahboucha, Halima Gamran. Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat. Acta histochemica. vol 118. issue 4. 2017-01-19. PMID:26995310. |
here, we have investigated in an animal model of mild he: the bile duct ligated rat (bdl) at the cirrhotic stage (4 weeks after surgery), the expression of the key marker of mature astrocytes; the glial fibrillary acidic protein (gfap) in different brain areas such as: substantia nigra pars compacta (snc), ventral tegmental area (vta), hippocampus, dorsal striatum and brain cortex by means of immunohistochemistry. |
2017-01-19 |
2023-08-13 |
rat |
| Omar El Hiba, Abdeljalil Elgot, Samir Ahboucha, Halima Gamran. Differential regional responsiveness of astroglia in mild hepatic encephalopathy: An Immunohistochemical approach in bile duct ligated rat. Acta histochemica. vol 118. issue 4. 2017-01-19. PMID:26995310. |
the immunohistochemical study showed, in bdl compared to the operated controls (shams), a diminished astrocyte reactivity corresponding to a loss of gfap expression within snc, vta, hippocampus and dorsal striatum (p<0.05),whereas in the brain cortex astrocytes appeared strongly immunoreactive with increased gfap expression (p<0.05) as compared to shams. |
2017-01-19 |
2023-08-13 |
rat |
| Xue-Yan Li, Fang Wang, Gui-Hai Chen, Xue-Wei Li, Qi-Gang Yang, Lei Cao, Wen-Wen Ya. Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice. Age (Dordrecht, Netherlands). vol 38. issue 3. 2017-01-12. PMID:27194408. |
the neurobiochemical results indicated that gestational lps exposure also intensified age-related hippocampal changes, including increased amyloid-β42, phosphorylated tau, synaptotagmin-1 and gfap, and decreased syntaxin-1 and h4k8ac. |
2017-01-12 |
2023-08-13 |
mouse |
| Veysel Haktan Ozacmak, Hale Sayan-Ozacmak, Figen Baru. Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion. Nutritional neuroscience. vol 19. issue 4. 2017-01-10. PMID:26005194. |
assessment of the potential was based on the determination of brain oxidative status, caspase-3 level, glial fibrillary acidic protein (gfap), and neuronal damage on hippocampus and cerebral cortex. |
2017-01-10 |
2023-08-13 |
rat |
| Rufi Tambe, Pankaj Jain, Sachin Patil, Priya Ghumatkar, Sadhana Sathay. Antiepileptogenic effects of borneol in pentylenetetrazole-induced kindling in mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 5. 2017-01-09. PMID:26887325. |
gfap was also evaluated in the hippocampus region of the brain by using immunohistochemistry. |
2017-01-09 |
2023-08-13 |
mouse |
| Christian Griñan-Ferré, David Pérez-Cáceres, Sofía Martínez Gutiérrez-Zetina, Antoni Camins, Verónica Palomera-Avalos, Daniel Ortuño-Sahagún, M Teresa Rodrigo, M Pallà. Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8). Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26014386. |
in addition, we demonstrated broad molecular correlation in the hippocampus by an increase in neun and ki67 expression, as well as an increase in the expression of neurotrophic factors, such as pleiotrophin (ptn) and brain-derived neurotrophic factor (bdnf), with a parallel decrease in neurodegenerative markers such as gsk3, amyloid-beta precursor protein, and phosphorylated beta-catenin, and a reduction of sbdp120, bax, gfap, and interleukin-6 (il-6), resulting in a neuroprotective panorama. |
2016-12-26 |
2023-08-13 |
mouse |
| Fatma M Ghoneim, Hanaa A Khalaf, Ayman Z Elsamanoudy, Salwa M Abo El-Khair, Ahmed M N Helaly, El-Hassanin M Mahmoud, Saad H Elshafe. Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339337. |
hippocampal tissue bdnf and its receptor (trkb) gene expression by real time rt-pcr in addition to immunohistochemical study of gfap and ki67 immunoreactivity were performed for all rats in the study. |
2016-12-14 |
2023-08-13 |
rat |
| Leonardo Ortiz-López, Carlos Pérez-Beltran, Gerardo Ramírez-Rodrígue. Chronic administration of a melatonin membrane receptor antagonist, luzindole, affects hippocampal neurogenesis without changes in hopelessness-like behavior in adult mice. Neuropharmacology. vol 103. 2016-12-13. PMID:26686389. |
however, after the chronic administration of luzindole, cell proliferation (ki67) significantly decreased (36%) with increasing (>100%) number of neural stem cells (nscs; gfap(+)/sox2(+)) in the subgranular zone of the dentate gyrus of the hippocampus. |
2016-12-13 |
2023-08-13 |
mouse |