| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Huang, Yunyi Lan, Liyue Qin, Huaihuai Dong, Hailian Shi, Hui Wu, Qinrui Zou, Zhibi Hu, Xiaojun W. Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse through CXCL1/CXCR2 Signaling. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-11-12. PMID:30158469. |
correspondingly, asi increased the protein expression of hippocampal dcx, gfap and neun. |
2018-11-12 |
2023-08-13 |
mouse |
| Lisa Rancan, Sergio D Paredes, Cruz García, Pablo González, Cruz Rodríguez-Bobada, Mario Calvo-Soto, Bryan Hyacinthe, Elena Vara, Jesús A F Tresguerre. Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029514. |
in general, animals treated with melatonin from 24 h prior to surgery until 7 days after the surgical procedure (prevt) experienced a significant decrease in the levels of tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), glial fibrillary acidic protein (gfap), bcl-2-associated death promoter (bad), and bcl-2-associated x protein (bax) in both cortex and hippocampus, while hippocampal levels of sirtuin 1 (sirt1) and b-cell lymphoma 2 (bcl-2) increased. |
2018-10-29 |
2023-08-13 |
rat |
| Ismini E Papageorgiou, Nektarios A Valous, Bernd Lahrmann, Hana Janova, Zin-Juan Klaft, Arend Koch, Ulf C Schneider, Peter Vajkoczy, Frank L Heppner, Niels Grabe, Niels Halama, Uwe Heinemann, Oliver Kan. Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. vol 66. issue 5. 2018-10-25. PMID:29350438. |
human mesial temporal lobe epilepsy (mtle) features subregion-specific hippocampal neurodegeneration and reactive astrogliosis, including up-regulation of the glial fibrillary acidic protein (gfap) and down-regulation of glutamine synthetase (gs). |
2018-10-25 |
2023-08-13 |
human |
| Ismini E Papageorgiou, Nektarios A Valous, Bernd Lahrmann, Hana Janova, Zin-Juan Klaft, Arend Koch, Ulf C Schneider, Peter Vajkoczy, Frank L Heppner, Niels Grabe, Niels Halama, Uwe Heinemann, Oliver Kan. Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus. Glia. vol 66. issue 5. 2018-10-25. PMID:29350438. |
we assessed gfap and gs expression in strict correlation with the local neuronal number in cortical and hippocampal surgical specimens from 16 mtle patients using immunohistochemistry, stereology and high-resolution image analysis for digital pathology and whole-slide imaging. |
2018-10-25 |
2023-08-13 |
human |
| Rui Yang, Wei Chen, Ye Lu, Yingke Li, Hongli Du, Songyan Gao, Xin Dong, Hongbin Yua. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Scientific reports. vol 7. 2018-10-15. PMID:28059131. |
moreover, neuro-inflammation and neurogenesis within hippocampus were indexed using quantitative immunofluorescence analysis of gfap dcx and ki67, as well as real-time rt-pcr analysis of some gene expression levels in hippocampus. |
2018-10-15 |
2023-08-13 |
Not clear |
| Yu-On Jeong, Soo Jung Shin, Jun Yong Park, Bo Kyeong Ku, Ji Soo Song, Jwa-Jin Kim, Seong Gak Jeon, Sang Min Lee, Minho Moo. MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease. International journal of molecular sciences. vol 19. issue 6. 2018-10-10. PMID:29912176. |
to visualize aβ accumulation, neuroinflammation, and neurodegeneration, thioflavin-s staining and immunostaining with antibodies against aβ (4g8), ionized calcium-binding adaptor molecule 1 (iba-1), glial fibrillary acidic protein (gfap), neuronal nuclear antigen (neun), and synaptophysin were conducted in the neocortex of 5xfad and wild-type mice, and to evaluate changes of phosphorylated cyclic adenosine monophosphate (camp) response element binding protein (pcreb) levels, immunostaining with antibody against pcreb was performed in dentate gyrus of the hippocampus of 5xfad and wild-type mice. |
2018-10-10 |
2023-08-13 |
mouse |
| Ze-Qun Li, Zhi-Yuan Yan, Fu-Jun Lan, Yi-Qun Dong, Ye Xion. Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice. Biochemical and biophysical research communications. vol 501. issue 4. 2018-10-09. PMID:29775613. |
the results further demonstrated that nlgn3-knockout improved the degenerative neurons in cortex and hippocampus of cums-treated mice, accompanied with a significant decrease of ionized calciumbinding adapter molecule 1 (iba-1) and glial fibrillary acidic protein (gfap) expressions. |
2018-10-09 |
2023-08-13 |
mouse |
| Bingyou Yang, Bo Liu, Yan Liu, Hua Han, Haixue Kuan. Cognitive enhancement of volatile oil from the stems of Schisandra chinensis Baill. in Alzheimer's disease rats. Canadian journal of physiology and pharmacology. vol 96. issue 6. 2018-10-03. PMID:29714500. |
alzheimer's disease (ad) models were established by injecting aβ(1-42) into the rat hippocampus and the effects of learning and memory were observed by a morris water maze test, immunohistological alterations, and correlative indicators covering nerve growth (brain-derived neurotrophic factor, glial-cell-derived trophic factor, and nerve growth factor), interleukin 1β, tumor necrosis factor, superoxide dismutase (sod), glutathione peroxidase (gsh-px), malondialdehyde (mda), glial fibrillary acidic protein (gfap), and microglial cd11b in ad rats. |
2018-10-03 |
2023-08-13 |
rat |
| Kartik T Nakhate, Ashish P Bharne, Vinay Sagar Verma, Deepali N Aru, Dadasaheb M Kokar. Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer's disease via activation of Nrf2/ARE pathway and inhibition of β-secretase. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-12. PMID:29501041. |
while the loss of learning and memory performance was evident in the mice subjected to morris water maze (mwm), there was a striking increase in the population of astrocytes labelled with glial fibrillary acidic protein (gfap) in the hippocampus. |
2018-09-12 |
2023-08-13 |
mouse |
| Mohammad-Reza Khajevand-Khazaei, Pouria Ziaee, Seyyed-Alireza Motevalizadeh, Mahdi Rohani, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat. European journal of pharmacology. vol 826. 2018-09-10. PMID:29518393. |
additionally, naringenin was able to lower hippocampal nuclear factor-kappab (nf-κb), toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), cyclooxygenase-2 (cox2), inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) level and its immunoreactivity, and to elevate nuclear factor (erythroid-derived 2)-like 2 (nrf2). |
2018-09-10 |
2023-08-13 |
rat |
| Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskira. Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study. Journal of biochemical and molecular toxicology. vol 32. issue 6. 2018-08-15. PMID:29660801. |
hippocampal ca1-ca3 areas revealed significantly lower neuronal count in aspartame and increased gfap expression in all groups. |
2018-08-15 |
2023-08-13 |
rat |
| Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısma. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical cellular pathology (Amsterdam). vol 2017. 2018-08-10. PMID:28458992. |
levels of dopamine, secreted from the substantia nigra, nerve growth factor (ngf) developed from the hippocampal neurons, and gfap, secreted from astrocyte cells, were detected to be significantly lower in the toluene-administration group than in the control group ( |
2018-08-10 |
2023-08-13 |
rabbit |
| Hailin Qin, Jie Qin, Junmin Hu, He Huang, Lianting M. Malva Sylvestris Attenuates Cognitive Deficits in a Repetitive Mild Traumatic Brain Injury Rat Model by Reducing Neuronal Degeneration and Astrocytosis in the Hippocampus. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-09. PMID:29276216. |
histopathology studies were performed on the hippocampal region by nissl staining and anti gfap staining. |
2018-08-09 |
2023-08-13 |
rat |
| Adriana Fernanda K Vizuete, Matheus Mittmann Hennemann, Carlos Alberto Gonçalves, Diogo Losch de Oliveir. Phase-Dependent Astroglial Alterations in Li-Pilocarpine-Induced Status Epilepticus in Young Rats. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28444637. |
phase-dependent signs of hippocampal astrogliosis were observed, as demonstrated by increments in gfap, s100b and gs. |
2018-08-07 |
2023-08-13 |
rat |
| Cassiana Siebert, Paula Pierozan, Janaina Kolling, Tiago Marcon Dos Santos, Matheus Coimbra Sebotaio, Eduardo Peil Marques, Helena Biasibetti, Aline Longoni, Fernanda Ferreira, Regina Pessoa-Pureur, Carlos Alexandre Netto, Angela T S Wys. Vitamin D Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28689355. |
ovx altered hippocampal cytoskeleton phosphorylating system, evidenced by the hyperphosphorylation of glial fibrillary acidic protein (gfap), low molecular weight neurofilament subunit (nfl), medium molecular weight neurofilament subunit (nfm) and high molecular weight neurofilament subunit (nfh), and increased the immunocontent of c-jun n-terminal protein kinases (jnk), ca |
2018-08-06 |
2023-08-13 |
rat |
| Monika Kapoor, Neha Sharma, Rajat Sandhir, Bimla Nehr. Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion hippocampus injury in rat brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29091896. |
enhanced glial activation was observed and an upregulated expression of gfap and iba-1 in hippocampus along with that of the transcription factor nfκb and inflammatory markers inos, il-1α, il-1β and tnf-α.the activity of mitochondrial electron transport chain (etc) complexes i, ii, iv and v were significantly decreased following ischemia. |
2018-08-03 |
2023-08-13 |
rat |
| Vladimirs Pilipenko, Karina Narbute, Ulrika Beitnere, Juris Rumaks, Jolanta Pupure, Baiba Jansone, Vija Klus. Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease. European journal of pharmacology. vol 818. 2018-07-27. PMID:29133125. |
in the present study, we used a non-transgenic rat model of ad obtained by intracerebroventricular streptozocin (stz) injection and assessed the effects of muscimol and baclofen at very low doses (0.01-0.05mg/kg) on spatial memory and the expression of cortical and hippocampal proteins related to neuroinflammation, namely proteins involved in astroglial functions (glial fibrillary acidic protein, gfap), gaba synthesis (gaba synthesizing enzyme, glutamic acid decarboxylase 67, gad67) and acetylcholine degradation (acetylcholine esterase). |
2018-07-27 |
2023-08-13 |
rat |
| Chia-Mei Chou, Yueh-Lun Lee, Chien-Wei Liao, Ying-Chieh Huang, Chia-Kwung Fa. Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess Aβ accumulation in the hippocampus of mice with persistent cerebral toxocariasis. Parasites & vectors. vol 10. issue 1. 2018-07-20. PMID:29273062. |
the present study intended to assess pathological changes, expressions of neurodegeneration-associated factors (ndafs), including transforming growth factor (tgf)-β1, s100b, glial fibrillary acidic protein (gfap), transglutaminase type 2 (tg2), claudin-5, substance p (sp) and interleukin (il)-1β, and the ubiquitin-proteasome system (ups) function in the hippocampus and associated cognitive behavior in icr mice orally inoculated with a high, medium or low-dose of t. canis embryonated ova during a 20-week investigation. |
2018-07-20 |
2023-08-13 |
mouse |
| Meghan E Jones, Christina L Lebonville, Jacqueline E Paniccia, Megan E Balentine, Kathryn J Reissner, Donald T Lysl. Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28963000. |
experiment 2 used triple fluorescence immunohistochemistry to examine hippocampal alterations in il-1β, glial fibrillary acidic protein (gfap), an astrocyte-specific marker, and ionized calcium binding adaptor molecule -1 (iba-1), a microglial-specific marker, 48h after exposure to the severe stressor of the sefl paradigm. |
2018-07-11 |
2023-08-13 |
Not clear |
| Meghan E Jones, Christina L Lebonville, Jacqueline E Paniccia, Megan E Balentine, Kathryn J Reissner, Donald T Lysl. Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28963000. |
further, hippocampal gfap immunoreactivity was not altered, whereas hippocampal iba-1 immunoreactivity was significantly attenuated following severe stress. |
2018-07-11 |
2023-08-13 |
Not clear |