| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeffrey H Meye. Neuroprogression and Immune Activation in Major Depressive Disorder. Modern trends in pharmacopsychiatry. vol 31. 2019-05-06. PMID:28738332. |
in postmortem studies, gfap reductions in the orbitofrontal cortex, anterior cingulate cortex, and hippocampus indicate a deficit in reactive astroglia. |
2019-05-06 |
2023-08-13 |
Not clear |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
hippocampal modifications were studied through cellular survival by brdu in the dentate gyrus, expression of apoptosis-regulatory proteins (procaspase 3, caspase 3, and bcl-2), bdnf, and neuroinflammatory modulation by interleukins, mhc-i, mhc-ii, iba-1, and gfap proteins. |
2019-05-06 |
2023-08-13 |
rat |
| Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Ali-Mohammad Rousta, Mohammad-Reza Azadi, Javad Fahanik-Babaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghan. Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects. Cytokine. vol 104. 2019-04-29. PMID:29102164. |
furthermore, genistein administration to lps-injected group lowered hippocampal level of interleukin 6 (il-6), nuclear factor-kappab (nf-κb) p65, toll-like receptor 4 (tlr4), tumor necrosis factor α (tnfα), cyclooxygenase-2 (cox2), inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap), and increased hippocampal level of antioxidant element nuclear factor (erythroid-derived 2)-like 2 (nrf2). |
2019-04-29 |
2023-08-13 |
rat |
| Elizabeth Monserrat Hernández-Hernández, Karen Caporal Hernandez, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Fidel de la Cruz, Benjamin Florán, Gonzalo Flore. The neuropeptide-12 improves recognition memory and neuronal plasticity of the limbic system in old rats. Synapse (New York, N.Y.). vol 72. issue 8. 2019-04-22. PMID:29740871. |
in the present work, we evaluated the effect of n-pep-12 on motor activity and recognition memory, as well as its effects on dendritic morphology and the immunoreactivity of gfap, synaptophysin (syp), and bdnf in neurons of the prefrontal cortex (pfc), dorsal hippocampus (dh) and nucleus accumbens (nacc) of aged rats. |
2019-04-22 |
2023-08-13 |
rat |
| Shuai Lian, Bin Xu, Di Wang, Lipeng Wang, Wenjie Li, Ruizhi Yao, Hong Ji, Jianfa Wang, Jingru Guo, Shize Li, Huanmin Yan. Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats. Behavioural brain research. vol 359. 2019-04-19. PMID:30423388. |
to further understand the effects of prenatal cold stress on offspring, we investigated the behavior change; the expression of glucocorticoid receptor (gr), mineralocorticoid receptor (mr), brain-derived neurotrophic factor (bdnf), insulin-like growth factor 1 receptor (igf1r), neuronal nuclei (neun), glial fibrillary acidic protein (gfap), corticotropin-releasing hormone receptor 1 (crhr1), gamma-aminobutyric acid b receptor, 2 (gabab2) proteins in hippocampus; the ratio of cd4/cd8 lymphocyte subsets and the level of norepinephrine (ne), dopamine (da) in the peripheral blood of weaned offspring rats using behavioral tests and biology analysis methods. |
2019-04-19 |
2023-08-13 |
rat |
| Shuai Lian, Bin Xu, Di Wang, Lipeng Wang, Wenjie Li, Ruizhi Yao, Hong Ji, Jianfa Wang, Jingru Guo, Shize Li, Huanmin Yan. Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats. Behavioural brain research. vol 359. 2019-04-19. PMID:30423388. |
the expression levels of neun and gfap in the hippocampus of male and female offspring were also reduced, which may have affected the growth and development of neurons. |
2019-04-19 |
2023-08-13 |
rat |
| Zhong-Ren Sun, Xiao-Lin Lü, Hong-Na Yin, Ji-Shun Hao, Xiang-Xin Zeng, Zhu-Xin L. [Progress of Researches on Mechanisms of Acupuncture Therapy in Regulating Brain Plasticity]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 10. 2019-04-08. PMID:30365266. |
from 1) regulating synaptic plasticity (up-regulating the proportion of hippocampal synapses, increasing synaptic curvature, post-synaptic density, and numerical density, areal density, and lowering synaptic cleft); 2) increasing hippocampal post-synaptic potential slop, peak and peak area of population spikes to evoke long-term potentiation (ltp) by regulating the expression of glutamate n-methyl-d-aspartate (nmda) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (ampa) receptors, and growth associated protein (gap-43); 3) down-regulating the expression of glial fibrillary acidic protein (gfap) to suppress the activity of astrocytes in the ischemic cerebral area and hippocampus in cerebral ischemia rats, and in the spinal cord dorsal horns of bone cancer rats, etc. |
2019-04-08 |
2023-08-13 |
rat |
| Sha Dong, Hui-Li Jiang, Yu Wang, Jun Lu, Lei Chang, Peng Zhang, Sui-Cheng Xin, Ya T. [Effect of Acupuncture on Expression of Glial Fibrillary Acidic Protein in Hippocampus and Prefrontal Cortex and Serum Interleukin-10 in Chronic Restraint Stress Depression Rats]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 4. 2019-04-03. PMID:29888572. |
to observe the effect of acupuncture on the expression of glial fibrillary acidic protein (gfap) in hippocampus and prefrontal cortex and the level of serum interleukin 10 (il-10) in rats with depression, so as to explore its mechanism underlying improvement of depression. |
2019-04-03 |
2023-08-13 |
rat |
| Yun Wang, Liming Xie, Ce Gao, Lingyan Zhai, Ning Zhang, Lin Gu. Astrocytes activation contributes to the antidepressant-like effect of ketamine but not scopolamine. Pharmacology, biochemistry, and behavior. vol 170. 2019-03-22. PMID:29729289. |
the results demonstrated that ketamine, but not scopolamine, could increase significantly the expression of gfap in hippocampus. |
2019-03-22 |
2023-08-13 |
Not clear |
| Yu-Lin Ma, Ji-Lin Xia, Xi Ga. Suppressing Irf2bp2 expressions accelerates metabolic syndrome-associated brain injury and hepatic dyslipidemia. Biochemical and biophysical research communications. vol 503. issue 3. 2019-03-12. PMID:30131248. |
further, irf2bp2-deficiency accelerated the activation of astrocytes and microglia cells, as evidenced by the promoted expressions of glial fibrillary acidic protein (gfap) and iba-1 in hippocampus and hypothalamus of hfd-fed mice. |
2019-03-12 |
2023-08-13 |
mouse |
| Kenta Matsue, Shiori Minakawa, Taichi Kashiwagi, Keiko Toda, Toru Sato, Seiji Shioda, Tatsunori Sek. Dentate granule progenitor cell properties are rapidly altered soon after birth. Brain structure & function. vol 223. issue 1. 2019-02-22. PMID:28836044. |
the embryonic neocortex has radial glia or progenitor cells expressing brain lipid-binding protein (blbp), whereas the adult hippocampus has radial granule progenitor cells expressing blbp and glial fibrillary acidic protein (gfap) in the subgranular zone. |
2019-02-22 |
2023-08-13 |
mouse |
| Kenta Matsue, Shiori Minakawa, Taichi Kashiwagi, Keiko Toda, Toru Sato, Seiji Shioda, Tatsunori Sek. Dentate granule progenitor cell properties are rapidly altered soon after birth. Brain structure & function. vol 223. issue 1. 2019-02-22. PMID:28836044. |
we previously found that embryonic hippocampal granule progenitor cells express gfap, but not blbp, indicating that these cells are different from both embryonic neocortical and adult granule progenitor cells. |
2019-02-22 |
2023-08-13 |
mouse |
| Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Shogo Kadota, Jinichi Isono, Takayo Odaira, Wakana Sakuma, Yuichiro Arai, Takeshi Tadano, Koichi Tan-N. Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice. Neuropharmacology. vol 137. 2019-02-20. PMID:29729893. |
in contrast, the number of activated microglia and astrocytes and the levels of iba1, gfap, p-iκb-α, p-nf-κb p65, tnf-α, il-6, bax, and cleaved caspase-3 were increased in the hippocampus. |
2019-02-20 |
2023-08-13 |
mouse |
| Kristen R Montgomery, A S C Louis Sam Titus, Lulu Wang, Santosh R D'Mell. Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29637441. |
mecp2-tg mice display elevated gfap and tau expression within the hippocampus and cortex followed by neuronal loss in these brain regions. |
2019-01-18 |
2023-08-13 |
mouse |
| Yunan Zhao, Zixuan Lin, Lin Chen, Liufeng Ouyang, Ling Gu, Feiyan Chen, Qiang Zhan. Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam. Progress in neuro-psychopharmacology & biological psychiatry. vol 83. 2019-01-03. PMID:29369777. |
in this study, we utilized a repeated corticosterone (cort) injection paradigm to develop a mouse depression model wherein we examined the occurrence of alterations in hippocampal astrocyte population by using two astrocytic markers, namely, glial fibrillary acidic protein (gfap) and s100β. |
2019-01-03 |
2023-08-13 |
mouse |
| Patrizia Ambrogini, Maria Cristina Albertini, Michele Betti, Claudia Galati, Davide Lattanzi, David Savelli, Michael Di Palma, Stefania Saccomanno, Desirée Bartolini, Pierangelo Torquato, Gabriele Ruffolo, Fabiola Olivieri, Francesco Galli, Eleonora Palma, Andrea Minelli, Riccardo Cuppin. Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29468563. |
results show that in α-t-treated epileptic rats, (1) the number of population spikes elicited by pyramidal neurons, as well as the latency to the onset of epileptiform-like network activity recover to control levels; (2) neuronal death is almost prevented; (3) down-regulation of claudin, a blood-brain barrier protein, is fully reversed; (4) neuroinflammation processes are quenched (as indicated by the decrease of tnf-α, il-1β, gfap, iba-1, and increase of il-6); (5) mir-146a, mir-124, and mir-126 expression is coherently modulated in hippocampus and serum by α-t. |
2018-12-18 |
2023-08-13 |
rat |
| RamaRao Golime, Meehir Palit, J Acharya, D K Dube. Neuroprotective Effects of Galantamine on Nerve Agent-Induced Neuroglial and Biochemical Changes. Neurotoxicity research. vol 33. issue 4. 2018-12-11. PMID:28929435. |
mrna expression studies using quantitative real-time pcr revealed significant changes in s-100β, gfap, c-fos, and bdnf in the hippocampus and piriform cortex after soman (90 μg/kg, s.c) exposure. |
2018-12-11 |
2023-08-13 |
rat |
| Yirong Xu, Huifang Zhang, Baolong Pan, Shuhui Zhang, Shan Wang, Qiao Ni. Transcriptome-Wide Identification of Differentially Expressed Genes and Long Non-coding RNAs in Aluminum-Treated Rat Hippocampus. Neurotoxicity research. vol 34. issue 2. 2018-12-11. PMID:29460113. |
additionally, al induced changes to the number and morphology of glial cells in the hippocampus of rats, as shown by glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) immunochemistry. |
2018-12-11 |
2023-08-13 |
rat |
| Hua-Jing Zhang, Ya-Nan Liu, Ping Xian, Jing Ma, Ya-Wen Sun, Jing-Shan Chen, Xi Chen, Nai-Jun Tan. Maternal exposure to TCDD during gestation advanced sensory-motor development, but induced impairments of spatial learning and memory in adult male rat offspring. Chemosphere. vol 212. 2018-12-11. PMID:30176550. |
hippocampus nissl's staining and astrocyte gfap immunohistochemistry were used to evaluate the activity of astrocytes. |
2018-12-11 |
2023-08-13 |
rat |
| Luanna M P Fernandes, Sabrina C Cartágenes, Mayara A Barros, Taiana C V S Carvalheiro, Nair C F Castro, Marissa G Schamne, Rafael R Lima, Rui D Prediger, Marta C Monteiro, Enéas A Fontes-Júnior, Rodrigo A Cunha, Cristiane S F Mai. Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats. Behavioural brain research. vol 350. 2018-11-26. PMID:29752970. |
to investigate the short-term effects of bei during adolescence, rats underwent 1 or 4 cycles of bei, being evaluated at pnd37 and pnd58, respectively: both groups displayed anxiety-like behavior in the open field and elevated plus-maze tests, as well as short-term memory deficits in the object recognition task; this was associated with transient decreases of bdnf levels and increases of gfap levels in the hippocampus. |
2018-11-26 |
2023-08-13 |
rat |