| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y J Ma, K Berg-von der Emde, F Rage, W C Wetsel, S R Ojed. Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977380. |
in vitro exposure of purified hypothalamic astrocytes to tgf alpha or egf in a defined medium led to activation of the cyclooxygenase-mediated pathway of arachidonic acid metabolism, as indicated by an increase in pge2 release, but failed to affect lipooxygenase-mediated metabolism, as assessed by the lack of increase in leukotriene c4 production; addition of tgf alpha- (t-cm) or egf-conditioned medium to cultures of lhrh-producing gt1-1 cells stimulated lhrh release. |
1997-01-23 |
2023-08-12 |
Not clear |
| A De Bellis, P Ghiandi, A Comerci, G Fiorelli, C Grappone, S Milani, R Salerno, F Marra, M Seri. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-alpha in human hyperplastic prostate tissue: expression and cellular localization. The Journal of clinical endocrinology and metabolism. vol 81. issue 11. 1997-01-17. PMID:8923874. |
to add information on the mechanism of action of egf and transforming growth factor-alpha (tgf alpha), a peptide correlated to egf, and the egf receptor (egf-r) in the human prostate, we studied the expression and cellular localization of messenger ribonucleic acid (rna) encoding egf, egf-r, and tgf alpha in bph tissue. |
1997-01-17 |
2023-08-12 |
human |
| A De Bellis, P Ghiandi, A Comerci, G Fiorelli, C Grappone, S Milani, R Salerno, F Marra, M Seri. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-alpha in human hyperplastic prostate tissue: expression and cellular localization. The Journal of clinical endocrinology and metabolism. vol 81. issue 11. 1997-01-17. PMID:8923874. |
reverse transcriptase-pcr of total rna extracted from bph tissues documented the presence of specific transcripts for egf, egf-r, and tgf alpha. |
1997-01-17 |
2023-08-12 |
human |
| A De Bellis, P Ghiandi, A Comerci, G Fiorelli, C Grappone, S Milani, R Salerno, F Marra, M Seri. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-alpha in human hyperplastic prostate tissue: expression and cellular localization. The Journal of clinical endocrinology and metabolism. vol 81. issue 11. 1997-01-17. PMID:8923874. |
in situ hybridization with specific rna probes synthesized from the respective complementary dna demonstrated that egf, egf-r, and tgf alpha messenger rnas were mainly localized in the epithelial cells. |
1997-01-17 |
2023-08-12 |
human |
| A De Bellis, P Ghiandi, A Comerci, G Fiorelli, C Grappone, S Milani, R Salerno, F Marra, M Seri. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-alpha in human hyperplastic prostate tissue: expression and cellular localization. The Journal of clinical endocrinology and metabolism. vol 81. issue 11. 1997-01-17. PMID:8923874. |
immunprecipitation and western blot analysis showed that bph tissue contained the corresponding proteins, egf and tgf alpha. |
1997-01-17 |
2023-08-12 |
human |
| A De Bellis, P Ghiandi, A Comerci, G Fiorelli, C Grappone, S Milani, R Salerno, F Marra, M Seri. Epidermal growth factor, epidermal growth factor receptor, and transforming growth factor-alpha in human hyperplastic prostate tissue: expression and cellular localization. The Journal of clinical endocrinology and metabolism. vol 81. issue 11. 1997-01-17. PMID:8923874. |
our findings provide additional support for the idea that egf and tgf alpha may be considered specialized symbols in the language of cell-cell interactions and for the hypothesis that in the human prostate they seem to act in an autocrine fashion. |
1997-01-17 |
2023-08-12 |
human |
| S M Puddicombe, L Wood, S G Chamberlin, D E Davie. The interaction of an epidermal growth factor/transforming growth factor alpha tail chimera with the human epidermal growth factor receptor reveals unexpected complexities. The Journal of biological chemistry. vol 271. issue 48. 1997-01-07. PMID:8940002. |
it has been assumed that substitution of homologous regions of transforming growth factor alpha (tgf-alpha) into epidermal growth factor (egf) can be used to probe ligand-receptor recognition without detrimental effects on ligand characteristics for the human egf receptor (egfr). |
1997-01-07 |
2023-08-12 |
human |
| C Schmitz-Peiffer, C L Browne, T J Bide. Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle. The Biochemical journal. vol 320 ( Pt 1). 1997-01-06. PMID:8947489. |
importantly, however, the activities differed in that pkc alpha 1 phosphorylated histone iiis, and also peptides derived from the egf receptor and glycogen synthase, to a much greater extent than did pkc alpha 2. |
1997-01-06 |
2023-08-12 |
Not clear |
| K Y Ilio, J A Sensibar, C Le. Effect of TGF-beta 1, TGF-alpha, and EGF on cell proliferation and cell death in rat ventral prostatic epithelial cells in culture. Journal of andrology. vol 16. issue 6. 1997-01-03. PMID:8867596. |
a tissue culture system for rat prostatic epithelial cells was developed, and the effect of epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), and transforming growth factor beta 1 (tgf-beta 1) on these cells was evaluated. |
1997-01-03 |
2023-08-12 |
rat |
| T Senoo, K Takahashi, K Chiba, K Hasegawa, S Yamaok. [Stimulation of corneal endothelial cell proliferation by interleukins, complete mitogens and corneal parenchymal cell-derived factors]. Nippon Ganka Gakkai zasshi. vol 100. issue 11. 1996-12-31. PMID:8953886. |
complete mitogens such as epidermal growth factor (egf), transforming growth factor alpha (tgf-alpha), and hepatocyte growth factor (hgf) stimulated proliferation of corneal endothelial cells 1.5 to 2 times the control. |
1996-12-31 |
2023-08-12 |
rabbit |
| K Gray, B Bullock, R Dickson, K Raszmann, D Walmer, J McLachlan, G Merlin. Potentiation of diethylstilbestrol-induced alterations in the female mouse reproductive tract by transforming growth factor-alpha transgene expression. Molecular carcinogenesis. vol 17. issue 3. 1996-12-27. PMID:8944077. |
because of the evidence that there is an integral relationship between the egf family, estrogen action, and the regulation of the growth and differentiation of the reproductive tract, we used transforming growth factor-alpha (tgf alpha) transgenic mice to investigate the interaction of constitutive tgf alpha expression with the potent estrogen diethylstilbestrol (des) in the induction of reproductive-tract alterations. |
1996-12-27 |
2023-08-12 |
mouse |
| R A Bennett, R Osathanondh, J Ye. Immunohistochemical localization of transforming growth factor-alpha, epidermal growth factor (EGF), and EGF receptor in the human fetal ovary. The Journal of clinical endocrinology and metabolism. vol 81. issue 8. 1996-12-23. PMID:8768877. |
this study is an attempt to identify and localize transforming growth factor-alpha (tgf alpha), epidermal growth factor (egf), and egf receptor (egf-r) in human fetal ovaries. |
1996-12-23 |
2023-08-12 |
human |
| V Caussanel, E Tabone, C Mauduit, F Dacheux, M Benahme. Cellular distribution of EGF, TGFalpha and their receptor during postnatal development and spermatogenesis of the boar testis. Molecular and cellular endocrinology. vol 123. issue 1. 1996-12-20. PMID:8912812. |
the epidermal growth factor (egf), the transforming growth factor alpha (tgfalpha) and the epidermal growth factor receptor (egfr) have been immunolocalized, (i) during the testicular postnatal development (i.e. |
1996-12-20 |
2023-08-12 |
Not clear |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
however, the existence of cross interaction between tnf alpha and egf receptor has been proposed. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
in this study, we investigated the modulatory effect of tnf alpha on egf receptor of a human hepatocellular carcinoma cell line-hepg2. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
the results suggested that tnf alpha was able to modulate the egf receptor of hepg2 cells. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
the modulatory effect of tnf alpha on the egf receptor of hepg2 cells exhibited its unique characteristics in comparison with the previous reports on other tumor cells. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
tnf alpha could also enhance the tyrosine phosphorylation of the egf receptor of hepg2 cells. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
however, the effect appeared only if egf was present, and was not mediated by tnf alpha alone. |
1996-12-18 |
2023-08-12 |
human |
| D Wang, E B Yang, L Y Chen. Modulation of EGF receptor by tumor necrosis factor-alpha in human hepatocellular carcinoma HepG2 cells. Anticancer research. vol 16. issue 5A. 1996-12-18. PMID:8917420. |
therefore, the effect of tnf alpha on egf receptor tyrosine phosphorylation in hepg2 cells was due to enhancing the receptor's response to egf. |
1996-12-18 |
2023-08-12 |
human |