| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A R Dunn, G B Mann, K J Fowler, D Grail, M L Hibbs, W S Alexander, F Walker, A W Burges. Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature. Princess Takamatsu symposia. vol 24. 1997-05-29. PMID:8983082. |
rather than add to their number, this review focuses on new insights into the importance of tgf alpha and signaling through the egf receptor considered in the context of the laboratory mouse. |
1997-05-29 |
2023-08-12 |
mouse |
| S Mesiano, R B Jaff. Role of growth factors in the developmental regulation of the human fetal adrenal cortex. Steroids. vol 62. issue 1. 1997-05-29. PMID:9029717. |
the roles of several growth factors, including the insulin like growth factors i and ii (igf-i and igf-ii), epidermal growth factor (egf), basic fibroblast growth factor (bfgf), activin, inhibin, and the transforming growth factors alpha and beta (tgf-alpha and tgf-beta) have been examined. |
1997-05-29 |
2023-08-12 |
human |
| A Geier, R Hemi, M Haimsohn, R Beery, A Karasi. Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells. In vitro cellular & developmental biology. Animal. vol 33. issue 2. 1997-05-29. PMID:9081220. |
the inactive phorbol ester alpha tpa, epidermal growth factor (egf), and 8-bromoadenosine 3'5'-cyclic monophosphate (br-camp) did not increase phosphorylation of the 27-kda protein. |
1997-05-29 |
2023-08-12 |
rabbit |
| B T Edmonds, J Wyckoff, Y G Yeung, Y Wang, E R Stanley, J Jones, J Segall, J Condeeli. Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. Journal of cell science. vol 109 ( Pt 11). 1997-05-23. PMID:8937988. |
following stimulation with egf, there is a parallel increase in the amount of f-actin and ef1 alpha associated with the cytoskeleton. |
1997-05-23 |
2023-08-12 |
rat |
| B T Edmonds, J Wyckoff, Y G Yeung, Y Wang, E R Stanley, J Jones, J Segall, J Condeeli. Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. Journal of cell science. vol 109 ( Pt 11). 1997-05-23. PMID:8937988. |
the response to egf can be blocked with cytochalasin d indicating that the binding of ef1 alpha to the cytoskeleton is mediated by f-actin. |
1997-05-23 |
2023-08-12 |
rat |
| S Koyama, K Ikeda, M Sato, K Shibahara, K Yuhara, H Fukutomi, K Fukunaga, N Kanazawa, K Yuzawa, K Fukao, T Iijima, M Kikuchi, T Tomiya, K Fujiwar. Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. Journal of gastroenterology. vol 32. issue 1. 1997-05-23. PMID:9058298. |
immunohistological analysis showed coexpression of transforming growth factor alpha (tgf-alpha) and epidermal growth factor (egf) receptors in the tumor from the stomach. |
1997-05-23 |
2023-08-12 |
Not clear |
| S Koyama, K Ikeda, M Sato, K Shibahara, K Yuhara, H Fukutomi, K Fukunaga, N Kanazawa, K Yuzawa, K Fukao, T Iijima, M Kikuchi, T Tomiya, K Fujiwar. Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. Journal of gastroenterology. vol 32. issue 1. 1997-05-23. PMID:9058298. |
this suggests that the tgf alpha stimulates the proliferation of keratinocytes involved with egf receptor. |
1997-05-23 |
2023-08-12 |
Not clear |
| W I De Boer, A B Houtsmuller, V Izadifar, B Muscatelli-Groux, T H Van der Kwast, D K Chopi. Expression and functions of EGF, FGF and TGFbeta-growth-factor family members and their receptors in invasive human transitional-cell-carcinoma cells. International journal of cancer. vol 71. issue 2. 1997-05-23. PMID:9139855. |
in human transitional-cell carcinomas (tcc), enhanced expression of tgf alpha and egf receptors correlated with an aggressive phenotype. |
1997-05-23 |
2023-08-12 |
human |
| D A Cross, P W Watt, M Shaw, J van der Kaay, C P Downes, J C Holder, P Cohe. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS letters. vol 406. issue 1-2. 1997-05-15. PMID:9109420. |
the small and very transient effects of egf on phosphatidylinositol (3,4,5)p3 pkb alpha and gsk3 in adipocytes, compared to the strong and sustained effects of insulin, explains why egf does not stimulate glucose uptake or glycogen synthesis in adipocytes. |
1997-05-15 |
2023-08-12 |
Not clear |
| Y Nasuhara, M Munakata, A Sato, M Amishima, Y Homma, Y Kawakam. Mechanisms of epidermal growth factor-induced contraction of guinea pig airways. European journal of pharmacology. vol 296. issue 2. 1997-05-01. PMID:8838452. |
measurement of prostanoids showed that egf (300 ng/ml) did not increase the prostaglandin f2 alpha level in either epithelium-intact or epithelium-denuded strips. |
1997-05-01 |
2023-08-12 |
Not clear |
| M Ogihar. Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. Biological & pharmaceutical bulletin. vol 19. issue 4. 1997-04-30. PMID:8860950. |
cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (egf) in primary cultures of adult rat hepatocytes. |
1997-04-30 |
2023-08-12 |
rat |
| M Ogihar. Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. Biological & pharmaceutical bulletin. vol 19. issue 4. 1997-04-30. PMID:8860950. |
effects of epidermal growth factor (egf) on the expression of alpha(2)-adrenergic responses were examined in primary cultures of adult rat hepatocytes. |
1997-04-30 |
2023-08-12 |
rat |
| M Ogihar. Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. Biological & pharmaceutical bulletin. vol 19. issue 4. 1997-04-30. PMID:8860950. |
hepatocytes cultured with egf (20 ng/ml) at a high cell density (1.0 x 10(5)/cm2) showed almost no response to the alpha(2)-adrenergic agonists, oxymetazoline and uk-14304 (1-100 mu m). |
1997-04-30 |
2023-08-12 |
rat |
| M Ogihar. Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. Biological & pharmaceutical bulletin. vol 19. issue 4. 1997-04-30. PMID:8860950. |
in addition, the effects of egf on the appearance of alpha(2)-responses were almost completely inhibited by treatment of the hepatocytes with genistein (10 mu m) or cytochalasin b (10 mu m). |
1997-04-30 |
2023-08-12 |
rat |
| M Ogihar. Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes. Biological & pharmaceutical bulletin. vol 19. issue 4. 1997-04-30. PMID:8860950. |
these results demonstrate that when cultured at a low cell density with egf, adult rat hepatocytes acquire a significant alpha(2)-adrenergic response. |
1997-04-30 |
2023-08-12 |
rat |
| M Lohmeyer, P M Harrison, S Kannan, M DeSantis, N J O'Reilly, M J Sternberg, D S Salomon, W J Gullic. Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto. Biochemistry. vol 36. issue 13. 1997-04-29. PMID:9092813. |
a comparative structural model of the growth factor cripto was constructed on the basis of its similarity to egf, transforming growth factor alpha (tgf-alpha), and the egf-like domain of human clotting factor ix. |
1997-04-29 |
2023-08-12 |
mouse |
| S B Kondapaka, R Fridman, K B Redd. Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells. International journal of cancer. vol 70. issue 6. 1997-04-25. PMID:9096655. |
the egf family of proteins encompasses several polypeptides such as epidermal growth factor (egf), transforming growth factor alpha (tgf alpha), amphiregulin (ar) and heregulin (hrg-beta 1). |
1997-04-25 |
2023-08-12 |
human |
| C C Leslie, K McCormick-Shannon, J M Shannon, B Garrick, D Damm, J A Abraham, R J Maso. Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells. American journal of respiratory cell and molecular biology. vol 16. issue 4. 1997-04-23. PMID:9115748. |
since mitogens that bind the epidermal growth factor (egf), egf, receptor and transforming growth factor alpha (tgf alpha) have been shown to stimulate type ii cell proliferation, studies were undertaken to determine whether the recently described protein, heparin-binding egf-like growth factor (hb-egf), was a mitogen for rat alveolar type ii cells in primary culture. |
1997-04-23 |
2023-08-12 |
human |
| G B van Setten, P Fagerholm, B Philipson, G Schult. Growth factors and their receptors in the anterior chamber. Absence of epidermal growth factor and transforming growth factor alpha in human aqueous humor. Ophthalmic research. vol 28. issue 6. 1997-04-16. PMID:9032795. |
although we have previously shown that egf is undetectable in the acf of normal eyes undergoing cataract surgery even by the use of high-sensitivity assays, this does not exclude the possible presence of other, egf-like proteins in acf such as transforming growth factor alpha (tgf-alpha). |
1997-04-16 |
2023-08-12 |
human |
| P C Konturek, T Brzozowski, S J Konturek, H Ernst, D Drozdowicz, R Pajdo, E G Hah. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scandinavian journal of gastroenterology. vol 32. issue 1. 1997-04-15. PMID:9018760. |
growth factors such as epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) have been shown to share common receptor (egfr) and to accelerate ulcer healing due to stimulation of cell proliferation, but the time sequence of expression of egf and tgf alpha during ulcer healing has not been investigated. |
1997-04-15 |
2023-08-12 |
Not clear |