| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
epidermal growth factor and transforming growth factor alpha mrna expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and egf receptor content. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
among the peptide growth factors active in breast glandular cell proliferation epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) are thought to play a major role in tumour development. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
therefore, we investigated the expression of egf and tgf alpha mrna in 146 breast cancer biopsies by slot blot analysis using specific 32p-labelled probes. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
our results showed that egf and tgf alpha coexisted in all tumour samples, and that their level of mrna expression was similar in half of the tumours. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
tgf alpha and egf mrna levels were significantly higher in er+ (p = 0.0015 and p = 0.0001, respectively) and in pgr+ tumours (p < 0.005 and p = 0.0001) than in their negative counterparts. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
in conclusion, it was shown that tgf alpha and egf mrna were coexpressed in all the tumour biopsies tested and that their level was higher in the hormone receptor positive than in negative samples. |
1997-07-10 |
2023-08-12 |
human |
| N Artagaveytia, S Le Penven, N Falette, R Lucero, E G Garófalo, S Sae. Epidermal growth factor and transforming growth factor alpha mRNA expression in human breast cancer biopsies; analysis in relation to estradiol, progesterone and EGF receptor content. The Journal of steroid biochemistry and molecular biology. vol 60. issue 3-4. 1997-07-10. PMID:9191980. |
the correlation between the presence of er/pgr sites, high level of tgf alpha/egf mrna and egf-r occupancy by endogenous ligand is in favour of er mediated control of tgf alpha and egf production. |
1997-07-10 |
2023-08-12 |
human |
| P P Jokhi, A King, Y W Lok. Cytokine production and cytokine receptor expression by cells of the human first trimester placental-uterine interface. Cytokine. vol 9. issue 2. 1997-06-26. PMID:9071564. |
the cytokines assayed were egf, interleukin 1 beta (il-1 beta), il-2, il-3, interferon alpha (ifn-alpha), ifn-gamma, tumour necrosis factor alpha (tnf-alpha) and transforming growth factor beta 1 (tgf-beta 1). |
1997-06-26 |
2023-08-12 |
human |
| E J Kelly, S J Newell, K G Brownlee, S M Farmery, C Cullinane, W A Reid, P Jackson, S F Gray, J N Primrose, M Lagopoulo. Role of epidermal growth factor and transforming growth factor alpha in the developing stomach. Archives of disease in childhood. Fetal and neonatal edition. vol 76. issue 3. 1997-06-26. PMID:9175944. |
to determine whether epidermal growth factor (egf) or the related transforming growth factor alpha (tgf alpha) may have a role in the developing human stomach; to substantiate the presence of egf in human liquor in the non-stressed infant and whether egf in amniotic fluid is maternally or fetally derived. |
1997-06-26 |
2023-08-12 |
human |
| M Schmidt, E Vakalopoulou, D W Schneider, W Wel. Construction and functional characterization of scFv(14E1)-ETA - a novel, highly potent antibody-toxin specific for the EGF receptor. British journal of cancer. vol 75. issue 11. 1997-06-26. PMID:9184171. |
we have previously characterized a recombinant antibody - pseudomonas exotoxin a fusion protein, scfv(225)-eta, which displayes antitumoral activity towards egf receptor-overexpressing tumour cells but is less potent in tumour cell killing than tgf-alpha-eta, a recombinant toxin using the natural egf receptor ligand transforming growth factor alpha (tgf-alpha) as a targeting domain. |
1997-06-26 |
2023-08-12 |
human |
| P C Konturek, H Ernst, S J Konturek, A J Bobrzyński, G Faller, C Klingler, E G Hah. Mucosal expression and luminal release of epidermal and transforming growth factors in patients with duodenal ulcer before and after eradication of Helicobacter pylori. Gut. vol 40. issue 4. 1997-06-24. PMID:9176072. |
epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) are potent gastric acid inhibitors and stimuli of mucosal growth and protection but their involvement in helicobacter pylori associated duodenal ulcer has been little examined. |
1997-06-24 |
2023-08-12 |
Not clear |
| N F Liu, Q L H. The regulatory effects of cytokines on lymphatic angiogenesis. Lymphology. vol 30. issue 1. 1997-06-23. PMID:9106134. |
the effects of fibroblast growth factor basic (bfgf), transforming growth factor alpha (tgf alpha), recombinant human epidermal growth factor (egf), recombinant human tumor necrosis factor alpha (tnf alpha), and recombinant interleukin 1 alpha (il-1 alpha) on lymphatic angiogenesis were assessed in cultured newborn bovine lymphatic endothelial cells (nblec). |
1997-06-23 |
2023-08-12 |
human |
| H Chang, D J Riese, W Gilbert, D F Stern, U J McMaha. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature. vol 387. issue 6632. 1997-06-19. PMID:9168114. |
the encoded product of the neuregulin-2 gene has a motif structure similar to that of neuregulins and an alternative splicing site in the epidermal growth factor(egf)-like domain gives rise to two isoforms (alpha and beta). |
1997-06-19 |
2023-08-12 |
rat |
| P C Konture. Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 48. issue 1. 1997-06-17. PMID:9098824. |
this adaptation may be of short term (adaptive cytoprotection) and follows the exposure to "mild" irritants that activate local mucosal biosynthesis of protective prostaglandins (pg) and nitric oxide (no) and stimulate sensory nerves and mucosal cell migration and proliferation through enhanced expression of growth factors such as egf, tgf alpha and trefoil peptides. |
1997-06-17 |
2023-08-12 |
Not clear |
| P C Konture. Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 48. issue 1. 1997-06-17. PMID:9098824. |
with repeated insults of ulcerogens such as stress aspirin, hp-derived gastrotoxins, especially ammonia, a long-term adaptation develops which is mediated mainly by overexpression of egf and tgf alpha and their common receptor (egfr) with subsequent increase of mucosal cell proliferation and enhanced healing of mucosal lesions. |
1997-06-17 |
2023-08-12 |
Not clear |
| W L Wang, W Porter, R Burghardt, S H Saf. Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis. vol 18. issue 5. 1997-06-12. PMID:9163677. |
in contrast, tcdd caused a rapid and sustained induction of transforming growth factor alpha (tgf alpha) gene expression and secreted protein (nearly 2-fold); moreover, the growth-inhibitory effects of tcdd could be blocked by antibodies to the egf receptor. |
1997-06-12 |
2023-08-12 |
human |
| F G Hamel, G L Siford, J Jones, W C Duckwort. Intraendosomal degradation of transforming growth factor alpha. Molecular and cellular endocrinology. vol 126. issue 2. 1997-06-03. PMID:9089656. |
transforming growth factor alpha (tgf alpha) and epidermal growth factor (egf) bind to the same receptor, but have different potencies and actions. |
1997-06-03 |
2023-08-12 |
rat |
| F G Hamel, G L Siford, J Jones, W C Duckwort. Intraendosomal degradation of transforming growth factor alpha. Molecular and cellular endocrinology. vol 126. issue 2. 1997-06-03. PMID:9089656. |
we have examined tgf alpha and egf processing in isolated rat hepatocytes with and without various protease inhibitors and inhibitors of endosomal processing. |
1997-06-03 |
2023-08-12 |
rat |
| F G Hamel, G L Siford, J Jones, W C Duckwort. Intraendosomal degradation of transforming growth factor alpha. Molecular and cellular endocrinology. vol 126. issue 2. 1997-06-03. PMID:9089656. |
we conclude that tgf alpha is degraded immediately after internalization, at least partly before acidification has occurred, while egf requires prolonged intracellular residence and lysosomal degradation. |
1997-06-03 |
2023-08-12 |
rat |
| A R Dunn, G B Mann, K J Fowler, D Grail, M L Hibbs, W S Alexander, F Walker, A W Burges. Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature. Princess Takamatsu symposia. vol 24. 1997-05-29. PMID:8983082. |
insights into the physiology of tgf alpha and signaling through the egf receptor revealed by gene targeting and acts of nature. |
1997-05-29 |
2023-08-12 |
mouse |