| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Bernardini, F Bianchi, M Lupetti, A Dolf. Immunohistochemical localization of the epidermal growth factor, transforming growth factor alpha, and their receptor in the human mesonephros and metanephros. Developmental dynamics : an official publication of the American Association of Anatomists. vol 206. issue 3. 1997-02-19. PMID:8896979. |
the distribution of tgf alpha reactivity in the mesonephros was similar to that observed for egf but with a lower intensity. |
1997-02-19 |
2023-08-12 |
human |
| J E Nutt, J Lune. Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells. European journal of cancer (Oxford, England : 1990). vol 32A. issue 12. 1997-02-18. PMID:9014756. |
the levels of the matrix metalloproteinase mmp1 mrna in three breast tumour cell lines with varying numbers of epidermal growth factor (egf) receptors, mda-mb-231, t47d and mcf7, were investigated following treatment with egf or tgf alpha in serum-free medium for up to 24 h. a higher level of mmp1 mrna was found in both control and treated mda-mb-231 cells compared with the other two cell lines. |
1997-02-18 |
2023-08-12 |
human |
| J E Nutt, J Lune. Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells. European journal of cancer (Oxford, England : 1990). vol 32A. issue 12. 1997-02-18. PMID:9014756. |
a 2-fold increase in mmp1 transcripts was observed in mda-mb-231 cells following a 30 min treatment with egf and 2 h with tgf alpha. |
1997-02-18 |
2023-08-12 |
human |
| E van der Zee, V Everts, W Beertse. Cytokine-induced endogenous procollagenase stored in the extracellular matrix of soft connective tissue results in a burst of collagen breakdown following its activation. Journal of periodontal research. vol 31. issue 7. 1997-02-13. PMID:8915951. |
recently, we have demonstrated that, upon culturing under the influence of il-1 alpha + egf, a large amount of inactive procollagenase (mmp-1) is stored in the extracellular matrix of periosteal tissue. |
1997-02-13 |
2023-08-12 |
Not clear |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) bind to a common receptor and are both present in the normal gastrointestinal tract. |
1997-02-12 |
2023-08-12 |
rat |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
we examined the relative potency of tgf alpha and egf in stimulating 3h-thymidine uptake into primary rat hepatocytes at various doses in vitro and on the crypt cell production rate (ccpr) within the gastrointestinal tract when infused intravenously at 49 nmol/kg/day into rats receiving total parenteral nutrition. |
1997-02-12 |
2023-08-12 |
rat |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
in vitro, maximal stimulatory activity was similar in egf- and tgf alpha-treated cells, however, the dose of egf required to stimulate 3h-thymidine uptake to 50% of maximal levels was only one third of that required using tgf alpha. |
1997-02-12 |
2023-08-12 |
rat |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
in vivo, egf and tgf alpha significantly increased the weight and proliferative indices throughout the gastrointestinal tract. |
1997-02-12 |
2023-08-12 |
rat |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
the response (as determined by ccpr) was about 80% higher in animals which had received egf when compared to animals receiving tgf alpha. |
1997-02-12 |
2023-08-12 |
rat |
| R J Playford, R Boulton, M A Ghatei, S R Bloom, N A Wright, R A Goodla. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. vol 57. issue 5. 1997-02-12. PMID:8886581. |
treatment with egf also caused significant rises in plasma pyy, enteroglucagon and gastrin levels, whereas the equivalent dose of tgf alpha only caused a significant rise in plasma gastrin levels. |
1997-02-12 |
2023-08-12 |
rat |
| E J van Zoelen, A E Lenferink, R H Kramer, M L van de Pol. Rational design for the development of epidermal growth factor receptor antagonists. Pathology, research and practice. vol 192. issue 7. 1997-02-04. PMID:8880877. |
epidermal growth factor (egf) and transforming growth factor-alpha (tgf alpha) bind with similar high affinity to the human egf receptor. |
1997-02-04 |
2023-08-12 |
human |
| E J van Zoelen, A E Lenferink, R H Kramer, M L van de Pol. Rational design for the development of epidermal growth factor receptor antagonists. Pathology, research and practice. vol 192. issue 7. 1997-02-04. PMID:8880877. |
this identification of a receptor binding domain in egf/tgf alpha provides an important initial step in the development of egf receptor antagonists with significant clinical potential. |
1997-02-04 |
2023-08-12 |
human |
| Y Yokoyama, Y Takahashi, M Hashimoto, S Morishita, T Tamay. Immunohistochemical study of estradiol, epidermal growth factor, transforming growth factor alpha and epidermal growth factor receptor in endometrial neoplasia. Japanese journal of clinical oncology. vol 26. issue 6. 1997-02-04. PMID:9001345. |
in a total of 113 cases of endometrial neoplasm, we studied the immunohistochemical expression of estradiol (e2), epidermal growth factor (egf), transforming growth factor alpha (tgfalpha), and epidermal growth factor receptor (egfr). |
1997-02-04 |
2023-08-12 |
Not clear |
| L E Lipeski, J M Boylan, P A Gruppus. A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes. Biochemistry and molecular biology international. vol 39. issue 5. 1997-01-27. PMID:8866014. |
we compared the ability of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) to transduce a mitogenic signal via their common receptor, the egf receptor, in primary cultures of fetal rat hepatocytes. |
1997-01-27 |
2023-08-12 |
rat |
| L E Lipeski, J M Boylan, P A Gruppus. A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes. Biochemistry and molecular biology international. vol 39. issue 5. 1997-01-27. PMID:8866014. |
mitogenic potency, measured as dna synthesis, was similar in response to egf and tgf alpha although signal initiation, measured as egf receptor tyrosine phosphorylation, was more than 3-fold higher in response to egf compared to tgf alpha. |
1997-01-27 |
2023-08-12 |
rat |
| L E Lipeski, J M Boylan, P A Gruppus. A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes. Biochemistry and molecular biology international. vol 39. issue 5. 1997-01-27. PMID:8866014. |
these data suggest that tgf alpha may preferentially activate an egf receptor population linked to the ras/map kinase pathway. |
1997-01-27 |
2023-08-12 |
rat |
| L Goya, P T Feng, S Aliabadi, P S Timira. Effect of growth factors on the in vitro growth and differentiation of early and late passage C6 glioma cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 14. issue 4. 1997-01-24. PMID:8884374. |
young cultures (passage 26), mainly oligodendrocytic, and older cultures (passage 134), predominantly astrocytic, were treated with 10 microm dexamethasone, 20 ng/ml transforming growth factor alpha (tgf alpha), 10 ng/ml insulin, 20 ng/ml platelet-derived growth factor (pdgf), and 20 ng/ml, epidermal growth factor (egf) in serum-free chemically defined media. |
1997-01-24 |
2023-08-12 |
rat |
| L Goya, P T Feng, S Aliabadi, P S Timira. Effect of growth factors on the in vitro growth and differentiation of early and late passage C6 glioma cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 14. issue 4. 1997-01-24. PMID:8884374. |
pdgf and insulin promoted in vitro growth only in late passage but not in early passage cells, whereas egf and tgf alpha did not significantly affect growth. |
1997-01-24 |
2023-08-12 |
rat |
| Y J Ma, K Berg-von der Emde, F Rage, W C Wetsel, S R Ojed. Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977380. |
previous studies demonstrated the involvement of transforming growth factor-alpha (tgf alpha), a member of the epidermal growth factor (egf) family, in the developmental regulation of hypothalamic lhrh release. |
1997-01-23 |
2023-08-12 |
Not clear |
| Y J Ma, K Berg-von der Emde, F Rage, W C Wetsel, S R Ojed. Hypothalamic astrocytes respond to transforming growth factor-alpha with the secretion of neuroactive substances that stimulate the release of luteinizing hormone-releasing hormone. Endocrinology. vol 138. issue 1. 1997-01-23. PMID:8977380. |
although both tgf alpha and egf stimulate lhrh release, they do not appear to act directly on lhrh neurons, as no egf/tgf alpha receptors are detected on these cells in vivo. |
1997-01-23 |
2023-08-12 |
Not clear |