| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elias Kovoor, Sunil K Chauhan, Amir Hajrasoulih. Role of inflammatory cells in pathophysiology and management of diabetic retinopathy. Survey of ophthalmology. 2022-08-01. PMID:35914582. |
inflammatory cells play a significant role in the earliest changes seen in dr including the breakdown of the blood retinal barrier leading to leakage of blood into the retina. |
2022-08-01 |
2023-08-14 |
Not clear |
| Sanil Joseph, Renu P Rajan, Balagiri Sundar, Soundarya Venkatachalam, John H Kempen, Ramasamy Ki. Validation of diagnostic accuracy of retinal image grading by trained non-ophthalmologist grader for detecting diabetic retinopathy and diabetic macular edema. Eye (London, England). 2022-07-29. PMID:35906419. |
to validate the fundus image grading results by a trained grader (non-ophthalmologist) and an ophthalmologist grader for detecting diabetic retinopathy (dr) and diabetic macular oedema (dmo) against fundus examination by a retina specialist (gold standard). |
2022-07-29 |
2023-08-14 |
Not clear |
| Maria Consiglia Trotta, Francesco Petrillo, Carlo Gesualdo, Settimio Rossi, Alberto Della Corte, Judit Váradi, Ferenc Fenyvesi, Michele D'Amico, Anca Hermenea. Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway. Molecules (Basel, Switzerland). vol 27. issue 15. 2022-07-28. PMID:35897964. |
diabetic retinopathy (dr) is a neurovascular disease characterized by the reduction of retina integrity and functionality, as a consequence of retinal pigment epithelial cell fibrosis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Muhammad Mohsin Butt, D N F Awang Iskandar, Sherif E Abdelhamid, Ghazanfar Latif, Runna Alghaz. Diabetic Retinopathy Detection from Fundus Images of the Eye Using Hybrid Deep Learning Features. Diagnostics (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35885512. |
manual detection of dr is a difficult task since it can affect the retina, causing structural changes such as microaneurysms (mas), exudates (exs), hemorrhages (hms), and extra blood vessel growth. |
2022-07-27 |
2023-08-14 |
Not clear |
| Shintaro Horie, Kyoko Ohno-Matsu. Progress of Imaging in Diabetic Retinopathy-From the Past to the Present. Diagnostics (Basel, Switzerland). vol 12. issue 7. 2022-07-27. PMID:35885588. |
since retinal vascular changes of dr are found in the whole retina up to periphery, it would be one of the best targets in uwf imaging. |
2022-07-27 |
2023-08-14 |
Not clear |
| Diego Sbardella, Grazia Raffaella Tundo, Alice Mecchia, Camilla Palumbo, Maria Grazia Atzori, Lauretta Levati, Alessandra Boccaccini, Anna Maria Caccuri, Paolo Cascio, Pedro Miguel Lacal, Grazia Graziani, Monica Varano, Massimiliano Coletta, Mariacristina Parravan. A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose. Cell & bioscience. vol 12. issue 1. 2022-07-16. PMID:35842713. |
although the pathogenesis of dr is largely unknown, several preclinical data have pointed out to a main role of muller glia (mg), a cell type which spans across the retina layers providing nourishment and support for retina ganglion cells (rgcs), in sensing hyper-glycemia and in acquiring a pro-inflammatory polarization in response to this insult. |
2022-07-16 |
2023-08-14 |
human |
| Araya Umetsu, Masato Furuhashi, Megumi Watanabe, Ei Ohkawa, Yuri Tsugeno, Soma Suzuki, Kaku Itoh, Yosuke Ida, Fumihito Hikage, Hiroshi Ohgur. Fatty acid metabolism is involved in both retinal physiology and the pathology of retinal vascular diseases. Prostaglandins, leukotrienes, and essential fatty acids. vol 183. 2022-07-12. PMID:35820353. |
to study the pathophysiological roles of the fatty acid-binding proteins (fabps) within the retina, we performed; (1) immunolabeling of human retinas, wild type (wt) rat and mouse retinas, rat models for diabetic retinopathy (dr) and retinitis pigmentosa (rp) with anti-fabp3, fabp4, fabp5, fabp7, fabp8 and fabp12, (2) electroretinogram (erg) measurements of wt and fabp4-deficient (fabp4 |
2022-07-12 |
2023-08-14 |
mouse |
| Dragana Avramovic, Sébastien A Archaimbault, Alicia M Kemble, Sabine Gruener, Mirjana Lazendic, Peter D Westensko. TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740425. |
diabetic retinopathy (dr) is a microvascular disease of the retina and a serious complication of type i and type ii diabetes mellitus. |
2022-06-24 |
2023-08-14 |
Not clear |
| Xiaoling Xu, Xinmei Lan, Shuhua Fu, Qian Zhang, Fu Gui, Qifang Jin, Lin Xie, Yu Xion. Dickkopf-1 exerts protective effects by inhibiting PANoptosis and retinal neovascularization in diabetic retinopathy. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-12. PMID:35691117. |
additionally, wnt signaling including the expression of wnt, β-catenin and ldl receptor-related protein 5/6 (lrp5/6) was also highly prohibited in retina of dkk1-injected rats with dr. |
2022-06-12 |
2023-08-14 |
rat |
| Andrzej Grzybowski, Piotr Brona, Tomasz Krzywicki, Magdalena Gaca-Wysocka, Arleta Berlińska, Anna Święc. Variability of Grading DR Screening Images among Non-Trained Retina Specialists. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683522. |
variability of grading dr screening images among non-trained retina specialists. |
2022-06-10 |
2023-08-14 |
human |
| Andrzej Grzybowski, Piotr Brona, Tomasz Krzywicki, Magdalena Gaca-Wysocka, Arleta Berlińska, Anna Święc. Variability of Grading DR Screening Images among Non-Trained Retina Specialists. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683522. |
four patients had discordant grades ranging from no dr to severe dr between the human graders and idx-dr. retina specialists achieved kappa scores of 0.52, 0.78, and 0.61. |
2022-06-10 |
2023-08-14 |
human |
| Minal Hardas, Sumit Mathur, Anand Bhaskar, Mukesh Kall. Retinal fundus image classification for diabetic retinopathy using SVM predictions. Physical and engineering sciences in medicine. 2022-06-09. PMID:35678993. |
inadequate blood supply to the retina, retinal vascular exudation, and intraocular hemorrhage cause dr. |
2022-06-09 |
2023-08-14 |
Not clear |
| Diego Aquino-Brítez, Jordan Ayala Gómez, José Luis Vázquez Noguera, Miguel García-Torres, Julio César Mello Román, Pedro E Gardel-Sotomayor, Veronica Elisa Castillo Benitez, Ingrid Castro Matto, Diego P Pinto-Roa, Jaques Facon, Sebastian Alberto Grill. Automatic Diagnosis of Diabetic Retinopathy from Fundus Images Using Neuro-Evolutionary Algorithms. Studies in health technology and informatics. vol 290. 2022-06-08. PMID:35673105. |
to combat this disease, called diabetic retinopathy (dr), retinography, using images of the fundus of the retina, is the most used method for the diagnosis of diabetic retinopathy. |
2022-06-08 |
2023-08-14 |
human |
| Malita A Jones, Ravirajsinh N Jadeja, Orneika Flandrin, Ammar A Abdelrahman, Menaka C Thounojam, Shakera Thomas, Caihong Dai, Haiyan Xiao, Jian-Kang Chen, Sylvia B Smith, Manuela Bartoli, Pamela M Martin, Folami L Powel. Autonomous regulation of retinal insulin biosynthesis in diabetes. Neuropeptides. vol 94. 2022-06-06. PMID:35660758. |
the expression of insulin in the retina was altered with the progression of diabetes in stz mice and donors with dr. |
2022-06-06 |
2023-08-14 |
mouse |
| Jing Huang, Qiong Zho. Gene Biomarkers Related to Th17 Cells in Macular Edema of Diabetic Retinopathy: Cutting-Edge Comprehensive Bioinformatics Analysis and Frontiers in immunology. vol 13. 2022-06-02. PMID:35651615. |
gene biomarkers related to th17 cells in macular edema of diabetic retinopathy: cutting-edge comprehensive bioinformatics analysis and previous studies have shown that t-helper 17 (th17) cell-related cytokines are significantly increased in the vitreous of proliferative diabetic retinopathy (pdr), suggesting that th17 cells play an important role in the inflammatory response of diabetic retinopathy (dr), but its cell infiltration and gene correlation in the retina of dr, especially in diabetic macular edema (dme), have not been studied. |
2022-06-02 |
2023-08-13 |
Not clear |
| Sangeetha Srinivasan, Shruthi Suresh, Charanya Chendilnathan, Jaya Prakash V, Sobha Sivaprasad, Ramachandran Rajalakshmi, Ranjit Mohan Anjana, Rayaz A Malik, Vaitheeswaran Kulothungan, Rajiv Raman, Muna Bhend. Inter-observer agreement in grading severity of diabetic retinopathy in wide-field fundus photographs. Eye (London, England). 2022-05-20. PMID:35595962. |
to examine the inter-observer agreement between two retina specialists in grading diabetic retinopathy (dr) severity in ultra-wide-field fundus photographs. |
2022-05-20 |
2023-08-13 |
Not clear |
| Qianyi Luo, Sameer P Leley, Erika Bello, Hurshdeep Dhami, Deepa Mathew, Ashay Dilip Bhatwadeka. Dapagliflozin protects neural and vascular dysfunction of the retina in diabetes. BMJ open diabetes research & care. vol 10. issue 3. 2022-05-16. PMID:35577387. |
in this study, we further expand the therapeutic benefit of dapagliflozin in the neural and vascular retina, with the potential to effectively manage diabetic retinopathy (dr), the most common complication of diabetes. |
2022-05-16 |
2023-08-13 |
Not clear |
| Minqi Zhu, Na Li, Yanuo Wang, Shuang Gao, Jing Wang, Xi She. Regulation of inflammation by VEGF/BDNF signaling in mouse retinal Müller glial cells exposed to high glucose. Cell and tissue research. 2022-04-08. PMID:35394215. |
müller glial cells (mgcs) in the mammalian retina are deeply involved in dr, while the bdnf overexpression reduces inflammation in diabetic mice. |
2022-04-08 |
2023-08-13 |
mouse |
| Yun Luo, Kairui Zhao, Zhaocheng Li, Yanping Gao, Minling Lin, Yadi Li, Shumei Wang, Yi Liu, Lei Che. Effect of the ethyl acetate extract of Sophora flavescens Aiton on diabetic retinopathy based on untargeted retinal metabolomics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1198. 2022-04-08. PMID:35395445. |
results from the pharmacodynamic studies showed that sfe could reduce blood glucose levels in rats, regulate serum lipopolysaccharide, tauroursodeoxycholic acid, and trimethylamine oxide levels, and significantly improve the structure of retina in rats with dr. |
2022-04-08 |
2023-08-13 |
rat |
| Ana Maria Dascalu, Anca Anghelache, Daniela Stana, Andreea Cristina Costea, Vanessa Andrada Nicolae, Denisa Tanasescu, Daniel Ovidiu Costea, Laura Carina Tribus, Anca Zgura, Dragos Serban, Lucian Duta, Miruna Tudosie, Simona Andrea Balasescu, Ciprian Tanasescu, Mihail Silviu Tudosi. Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review). Experimental and therapeutic medicine. vol 23. issue 5. 2022-04-07. PMID:35386624. |
diabetic retinopathy (dr) is a microvascular disorder occurring due to the long-term effects of diabetes, leading to vision-threatening damage to the retina. |
2022-04-07 |
2023-08-13 |
human |