| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrian Schmalen, Lea Lorenz, Antje Grosche, Diana Pauly, Cornelia A Deeg, Stefanie M Hauc. Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity. Frontiers in pharmacology. vol 12. 2021-11-17. PMID:34776983. |
while microglial cells, the resident immune cells of the retina are considered as main players in inflammatory processes associated with dr, the implication of activated müller cells in chronic retinal inflammation remains to be elucidated. |
2021-11-17 |
2023-08-13 |
human |
| Lihui Sun, Xuezheng Liu, Zhongfu Zu. Regulatory role of miRNA-23a in diabetic retinopathy. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-13. PMID:34765018. |
mirna-23a may regulate microvascular growth at the retina via vegf and contribute to dr progression. |
2021-11-13 |
2023-08-13 |
human |
| Shuai Wang, Shanshan Du, Yong Lv, Wenzhan Wang, Fengyan Zhan. Elevated microRNA-20b-3p and reduced thioredoxin-interacting protein ameliorate diabetic retinopathy progression by suppressing the NLRP3 inflammasomes. IUBMB life. vol 72. issue 7. 2021-11-12. PMID:32150340. |
we have found in this study that elevated mir-20b-3p could repress the levels of inflammatory factors by inhibiting txnip, thus attenuating the pathology of retina in dr rats, which provided new candidates for dr treatment. |
2021-11-12 |
2023-08-13 |
human |
| Jianan Li, Ruotian Xie, Feng Jiang, Yiming Li, Yanfang Zhu, Zhiheng Liu, Mengyu Liao, Yuanyuan Liu, Xiangda Meng, Song Chen, Jinguo Yu, Mei Du, Xiaohong Wang, Yupeng Chen, Hua Ya. Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 11. 2021-11-12. PMID:34679191. |
collectively, our findings reveal that loss of tl1a in the retina leads to increased vascular permeability in dr, and that tl1a treatment is of potential therapeutic interest for the treatment of dme. |
2021-11-12 |
2023-08-13 |
mouse |
| Rahmeh Othman, Gael Cagnone, Jean-Sébastien Joyal, Elvire Vaucher, Réjean Coutur. Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies. Cells. vol 10. issue 8. 2021-11-11. PMID:34440682. |
in this review, we provide an overview of the kks with emphasis on kinin receptors in the healthy retina and their detrimental roles in dr and amd. |
2021-11-11 |
2023-08-13 |
human |
| Jie Min, Tianshu Zeng, Margaretha Roux, David Lazar, Lulu Chen, Slavica Tudzarov. The Role of HIF1α-PFKFB3 Pathway in Diabetic Retinopathy. The Journal of clinical endocrinology and metabolism. vol 106. issue 9. 2021-11-10. PMID:34019671. |
therefore, the hif1α-pfkfb3 signaling pathway is unique as being a pervasive pathological component across multiple cell types in the retina in the early as well as late stages of dr. a metabolic point-of-intervention based on hif1α-pfkfb3 targeting thus deserves further consideration in dr. |
2021-11-10 |
2023-08-13 |
Not clear |
| Maria Stella Valle, Cristina Russo, Lucia Malaguarner. Protective role of vitamin D against oxidative stress in diabetic retinopathy. Diabetes/metabolism research and reviews. vol 37. issue 8. 2021-11-09. PMID:33760363. |
there is much evidence showing that a high level of mitochondrial overproduction of reactive oxygen species in the diabetic retina contributes in modifying cellular signalling and leads to retinal cell damage and finally to the development of dr pathogenesis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jee Taek Kim, Eun Jung Par. Correlation of Photoreceptor Integrity with Retinal Vessel Density and Choriocapillaris in Eyes with Diabetic Retinopathy. Retina (Philadelphia, Pa.). 2021-11-07. PMID:34743130. |
to investigate the correlation of foveal photoreceptor integrity with the vessel density (vd) of the retina and choriocapillaris using swept-source optical coherence tomography (oct) angiography (octa) in eyes with diabetic retinopathy (dr). |
2021-11-07 |
2023-08-13 |
Not clear |
| Dhananjay Shukla, Anuradha Dhawan, Jay Kalliat. Featureless retina in diabetic retinopathy: Clinical and fluorescein angiographic profile. Indian journal of ophthalmology. vol 69. issue 11. 2021-11-04. PMID:34708771. |
"featureless retina" (flr) has been only briefly mentioned in textbooks; this deceptively benign appearance of diabetic retinopathy (dr) merits a detailed description. |
2021-11-04 |
2023-08-13 |
Not clear |
| Silke Becker, Lara S Carroll, Frans Vinber. Diabetic photoreceptors: Mechanisms underlying changes in structure and function. Visual neuroscience. vol 37. 2021-10-28. PMID:33019947. |
retinal neuronal dysfunction is now recognized as an early event in the diabetic retina before development of overt dr. |
2021-10-28 |
2023-08-13 |
Not clear |
| Silke Becker, Lara S Carroll, Frans Vinber. Diabetic photoreceptors: Mechanisms underlying changes in structure and function. Visual neuroscience. vol 37. 2021-10-28. PMID:33019947. |
finally, we consider the possibility that early photoreceptor pathology contributes to the progression of dr, and discuss possible mechanisms of photoreceptor damage in the diabetic retina, such as enhanced production of reactive oxygen species and other inflammatory factors whose detrimental effects may be augmented by phototransduction. |
2021-10-28 |
2023-08-13 |
Not clear |
| Patrice E Fort, Thekkelnaycke M Rajendiran, Tanu Soni, Jaeman Byun, Yang Shan, Helen C Looker, Robert G Nelson, Matthias Kretzler, George Michailidis, Jerome E Roger, Thomas W Gardner, Steven F Abcouwer, Subramaniam Pennathur, Farsad Afshinni. Diminished retinal complex lipid synthesis and impaired fatty acid β-oxidation associated with human diabetic retinopathy. JCI insight. vol 6. issue 19. 2021-10-28. PMID:34437304. |
a mass-spectrometry-based lipidomic platform was used to measure serum and tissue lipids.resultsin the postmortem retinas, we found a graded decrease of long-chain acylcarnitines and longer-chain fatty acid ester of hydroxyl fatty acids, diacylglycerols, triacylglycerols, phosphatidylcholines, and ceramide(ns) in central retina from individuals with no diabetes to those with diabetes with dr. |
2021-10-28 |
2023-08-13 |
human |
| Beau J Fenner, Raymond L M Wong, Wai-Ching Lam, Gavin S W Tan, Gemmy C M Cheun. Advances in Retinal Imaging and Applications in Diabetic Retinopathy Screening: A Review. Ophthalmology and therapy. vol 7. issue 2. 2021-10-27. PMID:30415454. |
rising prevalence of diabetes worldwide has necessitated the implementation of population-based diabetic retinopathy (dr) screening programs that can perform retinal imaging and interpretation for extremely large patient cohorts in a rapid and sensitive manner while minimizing inappropriate referrals to retina specialists. |
2021-10-27 |
2023-08-13 |
Not clear |
| Viviane Aline Oliveira Silva, Nayara Delgado André, Thaís Amaral E Sousa, Vâni Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucc. Nuclear PKR in retinal neurons in the early stage of diabetic retinopathy in streptozotocin‑induced diabetic rats. Molecular medicine reports. vol 24. issue 2. 2021-10-27. PMID:34184090. |
in order to assess the role of pkr in dr prior to apoptosis of retinal neurons, immunofluorescence and western blotting were performed to investigate the cellular localization and expression of pkr in the retina in the early stage of stz‑induced diabetes in rats. |
2021-10-27 |
2023-08-13 |
rat |
| Viviane Aline Oliveira Silva, Nayara Delgado André, Thaís Amaral E Sousa, Vâni Maria Alves, Isis Do Carmo Kettelhut, Fernando Luiz De Lucc. Nuclear PKR in retinal neurons in the early stage of diabetic retinopathy in streptozotocin‑induced diabetic rats. Molecular medicine reports. vol 24. issue 2. 2021-10-27. PMID:34184090. |
apoptotic cells were not detected in the retina in the early stage of dr. a model was proposed to explain the mechanism by which apoptosis of retinal neurons by pkr is suppressed in the early stage of dr. |
2021-10-27 |
2023-08-13 |
rat |
| Sehrish Qummar, Fiaz Gul Khan, Sajid Shah, Ahmad Khan, Ahmad Din, Jinfeng Ga. Deep Learning Techniques for Diabetic Retinopathy Detection. Current medical imaging. vol 16. issue 10. 2021-10-26. PMID:32107999. |
dr occurs due to the mutilation of the blood vessels in the retina. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sehrish Qummar, Fiaz Gul Khan, Sajid Shah, Ahmad Khan, Ahmad Din, Jinfeng Ga. Deep Learning Techniques for Diabetic Retinopathy Detection. Current medical imaging. vol 16. issue 10. 2021-10-26. PMID:32107999. |
moreover, we also discussed the different steps of detection, that are: segmentation of blood vessels in a retina, detection of lesions, and other abnormalities of dr. |
2021-10-26 |
2023-08-13 |
Not clear |
| Steven F Abcouwe. Angiogenic Factors and Cytokines in Diabetic Retinopathy. Journal of clinical & cellular immunology. vol Suppl 1. issue 11. 2021-10-21. PMID:24319628. |
although severe dr can be treated as a vascular disease, abundant data suggests that inflammation is also occurring in the diabetic retina.thus, anti-inflammatory therapies may also be useful for treatment and prevention of dr. herein, the evidence for altered expression of angiogenic factors and cytokines in dr is reviewed and possible mechanisms by which the expression of vegf and cytokines may be increased in the diabetic retina are examined. |
2021-10-21 |
2023-08-12 |
Not clear |
| Ryan J Fante, Thomas W Gardner, Jeffrey M Sundstro. Current and future management of diabetic retinopathy: a personalized evidence-based approach. Diabetes management (London, England). vol 3. issue 6. 2021-10-21. PMID:24932222. |
in addition, early studies of vitreous fluid in patients with dr have resulted in a new paradigm: diabetes causes inflammation in the retina, which is mediated by multiple small signaling molecules that induce angiogenesis and vascular permeability. |
2021-10-21 |
2023-08-13 |
Not clear |
| Rong Luo, Lan Li, Yu-Xiang Hu, Fan Xia. LncRNA H19 inhibits high glucose-induced inflammatory responses of human retinal epithelial cells by targeting miR-19b to increase SIRT1 expression. The Kaohsiung journal of medical sciences. vol 37. issue 2. 2021-10-15. PMID:33022863. |
inflammatory responses play crucial roles in the progress of dr. long noncoding rna (lncrnas) and micrornas (mirnas) are key signal transduction molecules in retina, and tightly connected with dr occurrence and development. |
2021-10-15 |
2023-08-13 |
human |