| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia V Busi. Lipid metabolism dysregulation in diabetic retinopathy. Journal of lipid research. vol 62. 2021-10-13. PMID:33581416. |
although several clinical trials demonstrated that treatment with fibrates leads to improvement of dr, there is a dissociation between the protective effects of fibrates in the retina, and the intended blood lipid classes, including plasma triglycerides, total cholesterol, or hdl:ldl cholesterol ratio. |
2021-10-13 |
2023-08-13 |
Not clear |
| Dadi A Srinivasarao, S Sreenivasa Reddy, G Bhanuprakash Reddy, Dhirendra S Katt. Simultaneous amelioration of diabetic ocular complications in lens and retinal tissues using a non-invasive drug delivery system. International journal of pharmaceutics. vol 608. 2021-10-12. PMID:34481006. |
the results demonstrated that administration of pdtc nps + ta nps minimized oxidative stress in lens as evidenced by reduced levels of protein carbonyls and malondialdehyde, and, ameliorated dr complications in retina as evidenced by reduced expression of hypoxia inducible factor-1α along with a reduction in number of neovascular tufts and acellular capillaries. |
2021-10-12 |
2023-08-13 |
rat |
| Nirojini Sivachandran, Afreen Ahmad, Jenn Qian, Prima Moinul, Joshua Barbosa, Forough Farrokhyar, Varun Chaudhar. Baseline Diabetes Knowledge Assessment Amongst Adults With Type 1 and Type 2 Diabetes Receiving Eye Care at a Tertiary Ophthalmic Centre in Canada. Canadian journal of diabetes. vol 45. issue 1. 2021-10-11. PMID:32800763. |
the aim of this work was to assess the current state of baseline knowledge of diabetes and diabetic retinopathy (dr) in new patients referred to a tertiary retina service from their primary eye care provider. |
2021-10-11 |
2023-08-13 |
Not clear |
| Yang Guo, Xiaomin Cang, Linling Zhu, Manhui Zhu, Aihong Li, Zhenzhen Wang, Yuting Zhang, Xueqin Wang, E Son. PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy. Experimental eye research. vol 210. 2021-10-08. PMID:34280391. |
during dr, the retinal microvascular injury and neurodegeneration derived from chronic hyperglycemia have attracted global attention to retinal müller cells (rmcs), the major macroglia in the retina contributes to neuroprotection. |
2021-10-08 |
2023-08-13 |
mouse |
| Licheng Sun, Ruonan Wang, Guangyi Hu, Huazhen Liu, Kangjia Lv, Yi Duan, Ning Shen, Jiali Wu, Jing Hu, Yujuan Liu, Qihuang Jin, Fang Zhang, Xun X. Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas. Experimental eye research. vol 210. 2021-10-08. PMID:34364890. |
due to the delicate and complicated structure of the retina, the pathology of dr has not been completely elucidated yet. |
2021-10-08 |
2023-08-13 |
Not clear |
| Deoye Tonade, Timothy S Ker. Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Progress in retinal and eye research. vol 83. 2021-10-07. PMID:33188897. |
recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (rpe) play an important role in the development of vascular lesions characteristic of dr. |
2021-10-07 |
2023-08-13 |
Not clear |
| Deoye Tonade, Timothy S Ker. Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Progress in retinal and eye research. vol 83. 2021-10-07. PMID:33188897. |
diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit dr. |
2021-10-07 |
2023-08-13 |
Not clear |
| Honglian Wu, Mengqi Wang, Xiaorong Li, Yan Sha. The Metaflammatory and Immunometabolic Role of Macrophages and Microglia in Diabetic Retinopathy. Human cell. vol 34. issue 6. 2021-10-05. PMID:34324139. |
through the pathogenesis of dr, macrophages or microglia play a critical role in the inflammation, neovascularization, and neurodegeneration of the retina. |
2021-10-05 |
2023-08-13 |
Not clear |
| Yee H Wong, Shen H Wong, Xiao T Wong, Qiao Yi Yap, Khar Y Yip, Liang Z Wong, Dinesh K Chellappan, Subrat K Bhattamisra, Mayuren Candasam. Genetic associated complications of type 2 Diabetes Mellitus: a review. Panminerva medica. 2021-10-05. PMID:34609116. |
over-expression of gene enpp1, il-6 pro-inflammatory cytokine, arhgap22's protein rs3844492 polymorphism and tlr4 heterozygous genotype are contributing to significant pathophysiological process causing dr, while research found increases level of ucp1 gene protects retina cells from oxidative stress. |
2021-10-05 |
2023-08-13 |
Not clear |
| Ahmed Dellaa, Sihem Mbarek, Rim Kahloun, Mohamed Dogui, Moncef Khairallah, Imane Hammoum, Narjess Ben Rayana-Chekir, Ridha Charfeddine, Pierre Lachapelle, Rafika Ben Chaouacha-Cheki. Functional alterations of retinal neurons and vascular involvement progress simultaneously in the Psammomys obesus model of diabetic retinopathy. The Journal of comparative neurology. vol 529. issue 10. 2021-09-30. PMID:33474721. |
the depressed of ergs, disruption of retinal architecture, and the appearance of exudates may reflect vascular and neuronal damage throughout the retina as are seen in the advanced stages of human dr. |
2021-09-30 |
2023-08-13 |
human |
| Jennifer M Enright, Sheng Zhang, Christina Thebeau, Emily Siebert, Alexander Jin, Veda Gadiraju, Xiaodong Zhang, Shiming Chen, Clay F Semenkovich, Rithwick Rajagopa. Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression. Journal of clinical medicine. vol 10. issue 1. 2021-09-17. PMID:33396512. |
fenofibrate slows the progression of clinical diabetic retinopathy (dr), but its mechanism of action in the retina remains unclear. |
2021-09-17 |
2023-08-13 |
mouse |
| Mohamed Yacin Sikkanda. Automatic Detection of Genetics and Genomics of Eye Disease Using Deep Assimilation Learning Algorithm. Interdisciplinary sciences, computational life sciences. vol 13. issue 2. 2021-09-07. PMID:33398790. |
diabetic retinopathy (dr) is one of the most prevalent genetic diseases in human and it is caused by damage to the blood vessels in the eye retina. |
2021-09-07 |
2023-08-13 |
human |
| Mohamed Yacin Sikkanda. Automatic Detection of Genetics and Genomics of Eye Disease Using Deep Assimilation Learning Algorithm. Interdisciplinary sciences, computational life sciences. vol 13. issue 2. 2021-09-07. PMID:33398790. |
the cotton wool spot (cws), hard exudates (he) contains a common manifestation of many diseases in retina including dr and acquired immunodeficiency syndrome. |
2021-09-07 |
2023-08-13 |
human |
| Mengyang Yan, Haochen Wang, Yu Gu, Xin Li, Luyang Tao, Peirong L. Melatonin exerts protective effects on diabetic retinopathy via inhibition of Wnt/β-catenin pathway as revealed by quantitative proteomics. Experimental eye research. vol 205. 2021-09-03. PMID:33636209. |
diabetic retinopathy (dr), the most common ocular complication resulting from diabetes in working-age adults, causes vision impairment and even blindness because of microvascular damage to the retina. |
2021-09-03 |
2023-08-13 |
human |
| Madhuri Rudraraju, S Priya Narayanan, Payaningal R Somanat. Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy. Pharmacological research. vol 161. 2021-09-01. PMID:32750417. |
loss of the blood-retinal barrier (brb) integrity and subsequent damage to the neurovascular unit in the retina are the underlying reasons for diabetic retinopathy (dr). |
2021-09-01 |
2023-08-13 |
Not clear |
| Madhuri Rudraraju, S Priya Narayanan, Payaningal R Somanat. Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy. Pharmacological research. vol 161. 2021-09-01. PMID:32750417. |
in this review article, we present our current understanding of the molecular composition of brb, the changes in the brb junctional protein turnover in dr, and how brb functional modulation affects vascular permeability and macular edema in the diabetic retina. |
2021-09-01 |
2023-08-13 |
Not clear |
| Ravirajsinh N Jadeja, Pamela M Marti. Oxidative Stress and Inflammation in Retinal Degeneration. Antioxidants (Basel, Switzerland). vol 10. issue 5. 2021-09-01. PMID:34067655. |
inflammation and oxidative stress play prominent roles in the pathogenesis of many degenerative diseases of the retina, such as age-related macular degeneration (amd), diabetic retinopathy (dr), retinal vein occlusion, and retinitis pigmentosa [...]. |
2021-09-01 |
2023-08-13 |
Not clear |
| Faria Jafarzadeh, Amin Javanbakht, Niloofar Bakhtar, Alaleh Dalvand, Mahya Shabani, Mohammad-Mehdi Mehrabineja. Association between diabetic retinopathy and polymorphisms of cytokine genes: a systematic review and meta-analysis. International ophthalmology. 2021-08-25. PMID:34432176. |
diabetic retinopathy (dr) is a medical condition caused by damage to the blood vessels of retina tissue due to diabetes mellitus. |
2021-08-25 |
2023-08-13 |
Not clear |
| Tian Niu, Junwei Fang, Xin Shi, Mengya Zhao, Xindan Xing, Yihan Wang, Shaopin Zhu, Kun Li. Pathogenesis Study Based on High-Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice. Diabetes. vol 70. issue 5. 2021-08-24. PMID:33674409. |
the complex pathology of dr is difficult to dissect, given the convoluted cytoarchitecture of the retina. |
2021-08-24 |
2023-08-13 |
mouse |
| E S Chekhonin, R R Fayzrakhmanov, A V Sukhanova, E D Boso. [Anti-VEGF therapy for diabetic retinopathy]. Vestnik oftalmologii. vol 137. issue 4. 2021-08-23. PMID:34410069. |
treatment methods used in dr can be divided into three main groups: laser coagulation of the retina, intravitreal injection of medications - inhibitors of the vascular endothelial growth factor (vegf) and glucocorticoids, as well as surgical treatment. |
2021-08-23 |
2023-08-13 |
Not clear |