| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanam Zeib Khan, Nida Ajmal, Rozeena Shaik. Diabetic Retinopathy and Vascular Endothelial Growth Factor Gene Insertion/Deletion Polymorphism. Canadian journal of diabetes. vol 44. issue 3. 2021-01-08. PMID:31859041. |
diabetic retinopathy (dr) is a microvascular complication of the retina of the eye and represents a major cause of blindness worldwide. |
2021-01-08 |
2023-08-13 |
Not clear |
| Vienna Mazzoli, Lexy H Zhong, Vi T Dang, Yuanyuan Shi, Geoff H Werstuc. Characterization of Retinal Microvascular Complications and the Effects of Endoplasmic Reticulum Stress in Mouse Models of Diabetic Atherosclerosis. Investigative ophthalmology & visual science. vol 61. issue 10. 2021-01-06. PMID:32852545. |
the aim of this study is to investigate the molecular mechanisms by which diabetes promotes the development of microvascular disease (diabetic retinopathy [dr]) through characterization of the effects of hyperglycemia in the retina of mouse models of diabetic atherosclerosis. |
2021-01-06 |
2023-08-13 |
mouse |
| Ali Mohammad Tohari, Mohammad Almarhoun, Reem Hasaballah Alhasani, Lincoln Biswas, Xinzhi Zhou, James Reilly, Zhihong Zeng, Xinhua Sh. Protection by vitamin D against high-glucose-induced damage in retinal pigment epithelial cells. Experimental cell research. vol 392. issue 1. 2020-12-30. PMID:32325079. |
diabetic retinopathy (dr) is a diabetes-associated complication characterized by irreversible deterioration of the microvessels within the retina, leading subsequently to severe retinal damage and vision loss. |
2020-12-30 |
2023-08-13 |
mouse |
| Sampathkumar Rangasamy, Finny Monickaraj, Christophe Legendre, Andrea P Cabrera, Lorida Llaci, Cherae Bilagody, Paul McGuire, Arup Da. Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy. Experimental eye research. vol 195. 2020-12-22. PMID:32376470. |
further validation of other degs to identify cell specific molecular change through whole transcriptomic approach in diabetic retina will provide novel insight into the pathogenesis of dr and novel therapeutic targets. |
2020-12-22 |
2023-08-13 |
mouse |
| Bruce A Berkowit. Preventing diabetic retinopathy by mitigating subretinal space oxidative stress Visual neuroscience. vol 37. 2020-12-21. PMID:32536351. |
yet newer data surprisingly finds that the avascular outer retina is the primary site of oxidative stress before microvascular histopathology in experimental dr. |
2020-12-21 |
2023-08-13 |
Not clear |
| Cyril G Eleftheriou, Elena Ivanova, Botir T Sagdullae. Of neurons and pericytes: The neuro-vascular approach to diabetic retinopathy. Visual neuroscience. vol 37. 2020-12-21. PMID:32778188. |
indeed, it has been increasingly realized that dr is in fact a disease of the retina's neurovascular unit (nvu), the multi-cellular framework underlying functional hyperemia, coupling neuronal computations to blood flow. |
2020-12-21 |
2023-08-13 |
Not clear |
| Cyril G Eleftheriou, Elena Ivanova, Botir T Sagdullae. Of neurons and pericytes: The neuro-vascular approach to diabetic retinopathy. Visual neuroscience. vol 37. 2020-12-21. PMID:32778188. |
this is further supported by the recent data showing down-regulation of connexin 43 gap junctions along the vascular relay from capillary to feeding arteriole as one of the earliest indicators of experimental dr, with rippling consequences to the anatomical and physiological integrity of the retina. |
2020-12-21 |
2023-08-13 |
Not clear |
| Yunlong He, Wanzhen Jiao, Yunfeng Shi, Jian Lian, Bojun Zhao, Wei Zou, Yuemin Zhu, Yuanjie Zhen. Segmenting Diabetic Retinopathy Lesions in Multispectral Images Using Low-Dimensional Spatial-Spectral Matrix Representation. IEEE journal of biomedical and health informatics. vol 24. issue 2. 2020-12-11. PMID:31021778. |
multispectral imaging (msi) provides a sequence of en-face fundus spectral slices and allows for the examination of structures and signatures throughout the thickness of retina to characterize diabetic retinopathy (dr) lesions comprehensively. |
2020-12-11 |
2023-08-13 |
Not clear |
| Z Schreiberová, O Chrapek, J Šimičá. OCULAR COMPLICATIONS OF DIABETES MELLITUS IN PREGNANCY - CASE REPORT. Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti. vol 76. issue 4. 2020-12-11. PMID:33297701. |
the diagnosis of advanced proliferative dr and advanced dme in both eyes was made so we performed panretinal laser photocoagulation of the retina of both eyes. |
2020-12-11 |
2023-08-13 |
Not clear |
| Farhad Ghaseminejad, Lew Kaplan, Anna M Pfaller, Stefanie M Hauck, Antje Grosch. The role of Müller cell glucocorticoid signaling in diabetic retinopathy. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 258. issue 2. 2020-12-01. PMID:31734719. |
although these approaches have been moderately efficacious in treating or de-escalating dr pathomechanisms, there are various side effects and gaps of knowledge with regard to introducing exogenous glucocorticoids to the diseased retina. |
2020-12-01 |
2023-08-13 |
Not clear |
| Yi Stephanie Zhang, Ilda Mucollari, Changyow C Kwan, Gianna Dingillo, Jaspreet Amar, Gregory W Schwartz, Amani A Fawz. Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy. Journal of clinical medicine. vol 9. issue 11. 2020-11-28. PMID:33142724. |
diabetic retinopathy (dr) has traditionally been viewed as either a microvasculopathy or a neuropathy, though neurovascular coupling deficits have also been reported and could potentially be the earliest derangement in dr. to better understand neurovascular coupling in the diabetic retina, we investigated retinal hemodynamics by optical coherence tomography angiography (octa) in individuals with diabetes mellitus (dm) but without dr (dm no dr) and mild non-proliferative dr (mild npdr) compared to healthy eyes. |
2020-11-28 |
2023-08-13 |
human |
| Gemma Aragonès, Sheldon Rowan, Sarah G Francisco, Wenxin Yang, Jasper Weinberg, Allen Taylor, Eloy Bejaran. Glyoxalase System as a Therapeutic Target against Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 9. issue 11. 2020-11-28. PMID:33143048. |
we specifically feature the potential of the glyoxalase system in the retina in the prevention of ages-associated damage linked to dr. we provide a comparative analysis of glyoxalase activity in different tissues from wild-type mice, supporting a major role for the glyoxalase system in the detoxification of ages in the retina, and present the manipulation of this system as a therapeutic strategy to prevent the onset of dr. |
2020-11-28 |
2023-08-13 |
mouse |
| Chao Huang, Kiera P Fisher, Sandra S Hammer, Julia V Busi. Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition. International journal of molecular sciences. vol 21. issue 5. 2020-11-24. PMID:32121610. |
several studies have suggested that there is a link between membrane attack complex (mac) deposition in the retina and the progression of diabetic retinopathy (dr). |
2020-11-24 |
2023-08-13 |
human |
| Yuqi Liu, Juan Li, Jinfang Ma, Nanwei Ton. The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials. Journal of diabetes research. vol 2020. 2020-11-20. PMID:32016124. |
intensive glucose therapy can protect the retina of individuals with diabetes, but it is unknown if it provides the same protection to patients with different severity of diabetic retinopathy (dr). |
2020-11-20 |
2023-08-13 |
Not clear |
| Yuqi Liu, Juan Li, Jinfang Ma, Nanwei Ton. The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials. Journal of diabetes research. vol 2020. 2020-11-20. PMID:32016124. |
we found that individuals who have dr lesions that are equivalent to or less severe than moderate npdr achieve benefits for the retina by intensive glycemic control. |
2020-11-20 |
2023-08-13 |
Not clear |
| Ioannis N Mammas, Demetrios A Spandido. Retinopathy of prematurity and neonatal gut microbiome: An interview with Professor Dimitra Skondra, Associate Professor of Ophthalmology and Vitreoretinal Surgeon at The University of Chicago (USA). Experimental and therapeutic medicine. vol 20. issue 6. 2020-11-20. PMID:33209138. |
according to dr dimitra skondra, associate professor of ophthalmology and vitreoretinal surgeon at the university of chicago school of medicine in chicago, usa, the neonatal gut microbiome may be implicated in the neoangiogenesis process in the neonatal retina and this role may be one of the missing links in the pathogenesis of rop. |
2020-11-20 |
2023-08-13 |
human |
| Mong-Heng Wang, George Hsiao, Mohamed Al-Shabrawe. Eicosanoids and Oxidative Stress in Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 9. issue 6. 2020-11-09. PMID:32545552. |
oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (dr) because the retina has high vascularization and long-time light exposition. |
2020-11-09 |
2023-08-13 |
Not clear |
| Mong-Heng Wang, George Hsiao, Mohamed Al-Shabrawe. Eicosanoids and Oxidative Stress in Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 9. issue 6. 2020-11-09. PMID:32545552. |
this review will focus on the critical information related the function of these eicosanoids in the retina, the interaction between eicosanoids and reactive oxygen species (ros), and the involvement of eicosanoids in dr. we also identify potential targets for the treatment of dr. |
2020-11-09 |
2023-08-13 |
Not clear |
| Jiang-Hui Wang, Georgina Eloise Roberts, Guei-Sheung Li. Updates on Gene Therapy for Diabetic Retinopathy. Current diabetes reports. vol 20. issue 7. 2020-11-02. PMID:32415508. |
diabetic retinopathy (dr), a leading cause of visual impairment in the developed country, is characterized by vascular lesions and neuronal damage of the retina. |
2020-11-02 |
2023-08-13 |
Not clear |
| Mohamed Chetoui, Moulay A Akhlouf. Explainable Diabetic Retinopathy using EfficientNET Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2020. 2020-10-23. PMID:33018388. |
explainable diabetic retinopathy using efficientnet diabetic retinopathy (dr) is a medical condition due to diabetes mellitus that can damage the patient retina and cause blood leaks. |
2020-10-23 |
2023-08-13 |
Not clear |