| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacob K Sterling, Amrita Rajesh, Steven Droho, Joyce Gong, Andrew L Wang, Andrew P Voigt, C Elysse Brookins, Jeremy A Lavin. Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease. The Journal of clinical investigation. 2024-08-29. PMID:39207852. |
the blood-retina barrier (brb), which is disrupted in diabetic retinopathy (dr) and uveitis, is an important anatomical characteristic of the retina, regulating nutrient, waste, water, protein, and immune cell flux. |
2024-08-29 |
2024-09-04 |
mouse |
| Francisco Martín-Loro, Fátima Cano-Cano, María J Ortega, Belén Cuevas, Laura Gómez-Jaramillo, María Del Carmen González-Montelongo, Jan Cedric Freisenhausen, Almudena Lara-Barea, Antonio Campos-Caro, Eva Zubía, Manuel Aguilar-Diosdado, Ana I Arrob. Arylphthalide Delays Diabetic Retinopathy via Immunomodulating the Early Inflammatory Response in an Animal Model of Type 1 Diabetes Mellitus. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39126007. |
specifically, type 1 diabetes mellitus (t1d) has an immune component that may determine the evolution of dr by compromising the immune response of the retina, which is mediated by microglia. |
2024-08-10 |
2024-08-13 |
rat |
| Agata Grazia D'Amico, Grazia Maugeri, Benedetta Magrì, Claudio Bucolo, Velia D'Agat. Targeting the PINK1/Parkin Pathway: a new perspective in the prevention and therapy of diabetic retinopathy. Experimental eye research. 2024-08-08. PMID:39117133. |
diabetic retinopathy (dr) is a microvascular complication of diabetes characterized by neurovascular impairment of the retina. |
2024-08-08 |
2024-08-12 |
Not clear |
| Shimei Chen, Dandan Sun, Shuchang Zhang, Li Xu, Ning Wang, Huiming Li, Xun Xu, Fang We. TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia. Cell death and differentiation. 2024-07-30. PMID:39080375. |
progressive dysfunction of the retinal pigment epithelium (rpe) and the adjacent photoreceptor cells in the outer retina plays a pivotal role in the pathogenesis of diabetic retinopathy (dr). |
2024-07-30 |
2024-08-02 |
mouse |
| Manroop Singh Buttar, Kamlesh Guleria, Swarkar Sharma, Ajs Bhanwer, Vasudha Sambya. Association of Vascular Endothelial Growth Factor (VEGF) and Mouse Model Minute 2 (MDM2) Polymorphisms With Diabetic Retinopathy in a Northwest Indian Population: A Case-Control Study. Cureus. vol 16. issue 6. 2024-07-26. PMID:39050338. |
vascular endothelial growth factor (vegf) and mouse model minute 2 (mdm2)are upregulated in the retina due to diabetes, which increases the risk of dr. vegfa and mdm2 genetic variations can influence dr risk. |
2024-07-26 |
2024-07-28 |
mouse |
| Tzu-Yi Lin, Eugene Yu-Chuan Kang, Nan-Kai Wang, Je-Ho Kang, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwan. Association Between Pentoxifylline Use and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Multi-Institutional Cohort Study. Biomedical journal. 2024-07-21. PMID:39033962. |
despite the improvement of capillary blood flow velocity in retina after pentoxifylline use, no evidence has been provided to prove the protective effect for diabetic retinopathy (dr). |
2024-07-21 |
2024-07-24 |
Not clear |
| Lifang Bai, Ying Wan. Mesenchymal stem cells-derived exosomes alleviate senescence of retinal pigment epithelial cells by activating PI3K/AKT-Nrf2 signaling pathway in early diabetic retinopathy. Experimental cell research. 2024-07-17. PMID:39019426. |
additionally, mscs-exos improved the functional and structural integrity of the retina in dr mice. |
2024-07-17 |
2024-07-20 |
mouse |
| Jinyan Zhang, Qianqian Huo, Deyu Xia, Mingfang Wang, Xiuyun L. Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy. Frontiers in ophthalmology. vol 3. 2024-07-10. PMID:38983076. |
it can accurately present the various levels of the retina, choriocapillaris, macula, and the optic papillary microcirculation, which is new to the diagnosis and prognosis of dr. |
2024-07-10 |
2024-07-12 |
Not clear |
| Lu Ye, Yixiu Chen, Wendong Gu, Jun Shao, Yu Xi. Hsa_circ_0004776 regulates the retina neovascularization in progression of diabetic retinopathy Archives of physiology and biochemistry. 2024-07-08. PMID:38975651. |
hsa_circ_0004776 regulates the retina neovascularization in progression of diabetic retinopathy the aim of this work was to identify the regulatory function of hsa_circ_0004776 in the progression of diabetic retinopathy (dr). |
2024-07-08 |
2024-07-11 |
Not clear |
| Qian Yang, Marina Yasvoina, Abraham Olvera-Barrios, Joel Mendes, Meidong Zhu, Cathy Egan, Adnan Tufail, Marcus Fruttige. Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy. Diabetes. 2024-07-05. PMID:38968415. |
diabetic retinopathy (dr), a common diabetes complication leading to vision loss, presents early clinical signs linked to retinal vasculature damage, affecting the neural retina at advanced stages. |
2024-07-05 |
2024-07-08 |
human |
| Qian Yang, Marina Yasvoina, Abraham Olvera-Barrios, Joel Mendes, Meidong Zhu, Cathy Egan, Adnan Tufail, Marcus Fruttige. Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy. Diabetes. 2024-07-05. PMID:38968415. |
to study the earliest stages of dr we performed histological phenotyping and quantitative analysis on postmortem retinas from 10 donors with diabetes and without signs of dr (such as microaneurysms and haemorrhages), plus 3 controls and 1 dr case, focusing on capillary loss in the deeper (dvp) and superficial vascular plexuses (svp) and neural retina effects. |
2024-07-05 |
2024-07-08 |
human |
| Qian Yang, Marina Yasvoina, Abraham Olvera-Barrios, Joel Mendes, Meidong Zhu, Cathy Egan, Adnan Tufail, Marcus Fruttige. Deciphering the connection between microvascular damage and neurodegeneration in early diabetic retinopathy. Diabetes. 2024-07-05. PMID:38968415. |
in conclusion, our findings demonstrate a novel histological biomarker for early-stage diabetes-related damage in human postmortem retina, common in people with diabetes before clinical dr diagnosis. |
2024-07-05 |
2024-07-08 |
human |
| Shivakumar K Reddy, Vasudha Devi, Amritha T M Seetharaman, S Shailaja, Kumar M R Bhat, Rajashekhar Gangaraju, Dinesh Upadhy. Cell and molecular targeted therapies for diabetic retinopathy. Frontiers in endocrinology. vol 15. 2024-07-01. PMID:38948520. |
this review explores distinctive pathophysiological phenomena of dr and identifiable cell types and molecules that could be targeted to mitigate the chronic changes occurring in the retina due to diabetes mellitus. |
2024-07-01 |
2024-07-03 |
human |
| Bo Li, Xu Zhao, Wanrun Xie, Zhenzhen Hong, Ye Cao, Yan Ding, Yi Zhan. Causal association of circulating metabolites with diabetic retinopathy: a bidirectional Mendelian randomization analysis. Frontiers in endocrinology. vol 15. 2024-05-27. PMID:38800471. |
the retina is a highly metabolically active tissue, and there is a lack of clarity about the relationship between metabolites and diabetic retinopathy (dr). |
2024-05-27 |
2024-05-31 |
Not clear |
| Gustavo Barreto Melo, Luis Filipe Nakayama, Viviane Santos Cardoso, Lucas Andrade Dos Santos, Fernando Korn Malerb. Synchronous Diagnosis of Diabetic Retinopathy by a Handheld Retinal Camera, Artificial Intelligence, and Simultaneous Specialist Confirmation. Ophthalmology. Retina. 2024-05-16. PMID:38750937. |
this study presents a proof of concept for utilizing a portable handheld retinal camera with an embedded artificial intelligence (ai) platform, complemented by a synchronous remote confirmation by retina specialists, for dr screening in an underserved rural area. |
2024-05-16 |
2024-05-27 |
Not clear |
| Beatriz Martins, Maria Pires, António Francisco Ambrósio, Henrique Girão, Rosa Fernande. Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction. Journal of biomedical science. vol 31. issue 1. 2024-05-11. PMID:38730462. |
retinal degenerative diseases, including diabetic retinopathy (dr) and age-related macular degeneration (amd), loom as threats to vision, causing detrimental effects on the structure and function of the retina. |
2024-05-11 |
2024-05-27 |
Not clear |
| Alexandra-Ioana Dănilă, Laura Andreea Ghenciu, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Roxana Iacob, Mihai-Alexandru Săndesc, Alexandra Corina Fau. Aldose Reductase as a Key Target in the Prevention and Treatment of Diabetic Retinopathy: A Comprehensive Review. Biomedicines. vol 12. issue 4. 2024-04-27. PMID:38672103. |
one of the key mechanisms related to dr pathogenesis is the polyol pathway, through which aldose reductase (ar) catalyzes the conversion of glucose to sorbitol within various tissues, including the retina, lens, ciliary body and iris. |
2024-04-27 |
2024-04-29 |
Not clear |
| Luwei Cai, Mengxue Xia, Fang Zhan. Redox Regulation of Immunometabolism in Microglia Underpinning Diabetic Retinopathy. Antioxidants (Basel, Switzerland). vol 13. issue 4. 2024-04-27. PMID:38671871. |
microglia, resident immune cells in the retina, are recognized as crucial drivers in the dr process. |
2024-04-27 |
2024-04-29 |
Not clear |
| Xueli Yang, Xiaoli W. The impact of sestrin2 on reactive oxygen species in diabetic retinopathy. Cell biochemistry and function. vol 42. issue 4. 2024-04-26. PMID:38666564. |
our results highlighted the inhibitory effect of sestrin2 in the damage of retina, thus presenting a novel therapeutic sight for dr. |
2024-04-26 |
2024-04-28 |
rat |
| Stela Vujosevic, Camilla Alovisi, Gabriele Piccoli, Marco Brambilla, Emanuele Torti, Elisa Marenzi, Francesco Leporati, Livio Luzi, Paolo Nucc. Severity of Disorganization of Retinal Layers and Visual Function Impairment in Diabetic Retinopathy. Ophthalmology. Retina. 2024-04-11. PMID:38604502. |
to evaluate best corrected visual acuity (bcva), retina sensitivity (rs) and fixation impairment by microperimetry (mp) due to the presence and severity of disorganization of inner and outer retinal layers (dril/drol) and ischemia in oct/oct-angiography(oct-a) in diabetic retinopathy (dr). |
2024-04-11 |
2024-04-14 |
Not clear |