| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuefei Ma, Wenjian Lin, Zhenyu Lin, Ming Hao, Xinyuan Gao, Yue Zhang, Hongyu Kuan. Liraglutide alleviates H Peptides. vol 92. 2018-02-21. PMID:28450048. |
liraglutide alleviates h retinal ganglion cells (rgcs), which exist in the inner retina, are the retinal neurons which can be damaged in the early stage of diabetic retinopathy (dr). |
2018-02-21 |
2023-08-13 |
human |
| Sónia Simão, Daniela F Santos, Gabriela A Silv. Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells. Angiogenesis. vol 20. issue 1. 2018-02-12. PMID:27695972. |
rpe cells were chosen as target since one of the first events in dr is the dysfunction of the rpe retinal layer, which as a key function in maintaining the integrity of the retina. |
2018-02-12 |
2023-08-13 |
Not clear |
| Sandra S Hammer, Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A Lydic, Goldis Malek, Daniel R Saban, Xiaoxin X Wang, Sugata Hazra, Moshe Levi, Julia V Busik, Maria B Gran. The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. EBioMedicine. vol 22. 2018-01-31. PMID:28774737. |
in this manuscript, we show insight into dr pathogenesis by demonstrating an innovative signaling axis that unifies key metabolic regulators, sirtuin 1 and lxr, in modulating retinal cholesterol metabolism and inflammation in the diabetic retina. |
2018-01-31 |
2023-08-13 |
human |
| Ana I Arroba, Aurora Mazzeo, Daniele Cazzoni, Elena Beltramo, Cristina Hernández, Massimo Porta, Rafael Simó, Ángela M Valverd. Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. Molecular vision. vol 22. 2018-01-29. PMID:28050125. |
somatostatin (sst) is one of the most important neuroprotective factors synthesized by the retina: sst levels are decreased in parallel to retinal neurodegeneration in early stages of dr. |
2018-01-29 |
2023-08-13 |
Not clear |
| Ana I Arroba, Ángela M Valverd. Modulation of microglia in the retina: new insights into diabetic retinopathy. Acta diabetologica. vol 54. issue 6. 2017-12-26. PMID:28349217. |
during dr, the inflammatory process presents two opposite roles depending on the polarization of resident immune cells of the retina triggering proinflammatory (m1) or antiinflammatory (m2) actions. |
2017-12-26 |
2023-08-13 |
Not clear |
| R Filek, P Hooper, T Sheidow, J Gonder, D K Varma, L Heckler, W Hodge, S Chakrabarti, C M L Hutni. Structural and functional changes to the retina and optic nerve following panretinal photocoagulation over a 2-year time period. Eye (London, England). vol 31. issue 8. 2017-12-21. PMID:28452993. |
purposeto evaluate long-term structural and functional changes to the retina and optic nerve following panretinal photocoagulation (prp) in diabetic retinopathy (dr) patients.methodsparticipants were patients with dr requiring prp and control patients with dr not requiring prp. |
2017-12-21 |
2023-08-13 |
Not clear |
| F A Ganjifrockwala, J T Joseph, G Georg. Evaluation of kidney function and risk factors of retinopathy in Type 2 diabetes mellitus people in South Africa. Diabetes research and clinical practice. vol 127. 2017-12-05. PMID:28395215. |
diabetic retinopathy (dr) is a disease of the retina and an important microvascular complication of diabetes, frequently causing blindness in adults. |
2017-12-05 |
2023-08-13 |
Not clear |
| Mohammad Shamsul Ola, Abdullah S Alhomida, Carlos M Ferrario, Sarfaraz Ahma. Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Current medicinal chemistry. vol 24. issue 28. 2017-12-05. PMID:28403787. |
angiotensin ii (ang ii), an active component of the ras is increased in diabetic retina, and may play a significant role in neurovascular damage leading to the progression of dr. |
2017-12-05 |
2023-08-13 |
human |
| Sandra Morales, Kjersti Engan, Valery Naranjo, Adrian Colome. Retinal Disease Screening Through Local Binary Patterns. IEEE journal of biomedical and health informatics. vol 21. issue 1. 2017-11-16. PMID:26469792. |
the goal is to distinguish between diabetic retinopathy (dr), age-related macular degeneration (amd), and normal fundus images analyzing the texture of the retina background and avoiding a previous lesion segmentation stage. |
2017-11-16 |
2023-08-13 |
Not clear |
| Conghui Zhang, Jing Nie, Le Feng, Wentao Luo, Jun Yao, Fang Wang, Hao Wan. The emerging roles of clusterin on reduction of both blood retina barrier breakdown and neural retina damage in diabetic retinopathy. Discovery medicine. vol 21. issue 116. 2017-11-02. PMID:27232509. |
we explored the role of clusterin in reduction of both blood retina barrier (brb) breakdown and neural retina damage in early dr. immunofluorescent staining of proliferated diabetic retinopathy (pdr) membranes was performed to detect endogenous clusterin, and intravitreous injection of clusterin (clu group) or pbs (dr group) to streptozotocin-induced diabetic rats was conducted. |
2017-11-02 |
2023-08-13 |
rat |
| Conghui Zhang, Jing Nie, Le Feng, Wentao Luo, Jun Yao, Fang Wang, Hao Wan. The emerging roles of clusterin on reduction of both blood retina barrier breakdown and neural retina damage in diabetic retinopathy. Discovery medicine. vol 21. issue 116. 2017-11-02. PMID:27232509. |
the expressions of several tj protein genes were decreased in the retina of dr group (p<0.05), but elevated in that of clu group (p<0.05). |
2017-11-02 |
2023-08-13 |
rat |
| Jiang-Hui Wang, Damien Ling, Leilei Tu, Peter van Wijngaarden, Gregory J Dusting, Guei-Sheung Li. Gene therapy for diabetic retinopathy: Are we ready to make the leap from bench to bedside? Pharmacology & therapeutics. vol 173. 2017-10-30. PMID:28132907. |
diabetic retinopathy (dr), a chronic and progressive complication of diabetes mellitus, is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that further damages vision. |
2017-10-30 |
2023-08-13 |
Not clear |
| Yun-Ru Liao, Zi-Jing Li, Peng Zeng, Yu-Qing La. TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response. Biochemical and biophysical research communications. vol 493. issue 2. 2017-10-23. PMID:28843858. |
diabetic retinopathy (dr) is a major microvascular complication of diabetes, resulting in neuronal dysfunction, retinal vascular leakage, and apoptosis within the retina. |
2017-10-23 |
2023-08-13 |
mouse |
| Anne-Eva van der Wijk, John M Hughes, Ingeborg Klaassen, Cornelis J F Van Noorden, Reinier O Schlingeman. Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy? Journal of leukocyte biology. vol 102. issue 4. 2017-10-09. PMID:28724696. |
first, we review the pathologic processes that are known to be involved in the development of human dr. then, we summarize experimental evidence for the role of leukostasis in the development of dr and the mechanisms involved in leukostasis in the retina. |
2017-10-09 |
2023-08-13 |
human |
| Takahiro Mizukami, Yosuke Hotta, Naomichi Kata. Higher Numbers of Hyperreflective Foci Seen in the Vitreous on Spectral-Domain Optical Coherence Tomographic Images in Eyes with More Severe Diabetic Retinopathy. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. vol 238. issue 1-2. 2017-09-29. PMID:28486219. |
the aim of this study was to determine whether spectral-domain optical coherence tomography (sd-oct) can detect and quantify the number of hyperreflective foci attached to the retina and in the vitreous of patients at different stages of diabetic retinopathy (dr). |
2017-09-29 |
2023-08-13 |
Not clear |
| Ghazaleh Hajmousa, Alvaro A Elorza, Vera J M Nies, Erik L Jensen, Ruxandra A Nagy, Martin C Harmse. Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained. Stem cells and development. vol 25. issue 19. 2017-09-11. PMID:27473785. |
in dr, the loss of pericytes and subsequently endothelial cells leads to pathologic angiogenesis in retina. |
2017-09-11 |
2023-08-13 |
human |
| Qian Chen, Fangfang Qiu, Kelu Zhou, H Greg Matlock, Yusuke Takahashi, Raju V S Rajala, Yanhui Yang, Elizabeth Moran, Jian-Xing M. Pathogenic Role of Diabetes. vol 66. issue 6. 2017-08-22. PMID:28270521. |
our recent studies have shown that pparα is downregulated in the diabetic retina, which contributes to the pathogenesis of dr. |
2017-08-22 |
2023-08-13 |
Not clear |
| Saif Ahmad, Nehal M ElSherbiny, Mohammad Sarwar Jamal, Faisal A Alzahrani, Rizwanul Haque, Raziuddin Khan, Syed Kashif Zaidi, Mohammed H AlQahtani, Gregory I Liou, Kanchan Bhati. Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy. Journal of neuroimmunology. vol 295-296. 2017-08-17. PMID:27235348. |
in conclusion, the results suggest that ses treatment may be of therapeutic benefit in reducing the progression of dr by ameliorating hyperglycemia and inflammation in diabetic retina. |
2017-08-17 |
2023-08-13 |
mouse |
| Edoardo Midena, Elisabetta Pilott. Emerging Insights into Pathogenesis. Developments in ophthalmology. vol 60. 2017-08-16. PMID:28427061. |
dr has been considered a "chronic, low-grade inflammatory disease of the retina". |
2017-08-16 |
2023-08-13 |
human |
| Alessandro Rabiolo, Luigi Antonio De Vitis, Riccardo Sacconi, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querque. Emerging Issues for Ultra-Wide Field Angiography. Developments in ophthalmology. vol 60. 2017-08-16. PMID:28427064. |
the peripheral retina is involved in most dr lesions, and, thus, its proper visualization is crucial for the screening, diagnosis, monitoring, treatment, and prognosis of dr. to expand the field of view, wide-field and ultra-wide-field imaging have been developed, allowing images up to 200° of retinal surface in one single photo. |
2017-08-16 |
2023-08-13 |
Not clear |