| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gustavo Ortiz, Emiliano S Lopez, Juan P Salica, Constanza Potilinski, Mariano Fernández Acquier, Eduardo Chuluyan, Juan E Gall. Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina. Experimental eye research. vol 174. 2019-02-11. PMID:29778740. |
early events of dr are accompanied by neurodegeneration of the inner retina resulting in ganglion cell loss. |
2019-02-11 |
2023-08-13 |
mouse |
| Binapani Mahaling, Dadi A Srinivasarao, G Raghu, Rajesh K Kasam, G Bhanuprakash Reddy, Dhirendra S Katt. A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats. Nanoscale. vol 10. issue 35. 2019-02-05. PMID:29897081. |
after being administered as eye drops, the drug loaded nanoparticles significantly improved structural (retinal thickness and vascular health) and functional activity (rod and cone function) of retina as compared to dr controls that were treated with the drug alone or placebo nanoparticles. |
2019-02-05 |
2023-08-13 |
rat |
| Sudeshna Sil Kar, Santi P Mait. Automatic Detection of Retinal Lesions for Screening of Diabetic Retinopathy. IEEE transactions on bio-medical engineering. vol 65. issue 3. 2019-01-15. PMID:28541892. |
diabetic retinopathy (dr) is characterized by the progressive deterioration of retina with the appearance of different types of lesions that include microaneurysms, hemorrhages, exudates, etc. |
2019-01-15 |
2023-08-13 |
Not clear |
| Patricia Bogdanov, Joel Sampedro, Cristina Solà-Adell, Olga Simó-Servat, Carla Russo, Luisa Varela-Sende, Rafael Simó, Cristina Hernánde. Effects of Liposomal Formulation of Citicoline in Experimental Diabetes-Induced Retinal Neurodegeneration. International journal of molecular sciences. vol 19. issue 8. 2018-12-17. PMID:30127248. |
diabetic retinopathy (dr) has been classically considered a microcirculatory disease of the retina. |
2018-12-17 |
2023-08-13 |
mouse |
| Rute S Araújo, Daniela F Santos, Gabriela A Silv. The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies. Biochimie. vol 155. 2018-12-11. PMID:29960032. |
their role in the pathophysiology of the most common neovascular pathologies in the retina - age-related macular degeneration (amd), diabetic retinopathy (dr), and retinopathy of prematurity (rop) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Po-Lin Liao, Cheng-Hui Lin, Ching-Hao Li, Chi-Hao Tsai, Jau-Der Ho, George C Y Chiou, Jaw-Jou Kang, Yu-Wen Chen. Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy. Scientific reports. vol 7. 2018-11-14. PMID:28322323. |
diabetic retinopathy (dr), a major microvascular complication of diabetes, leads to retinal vascular leakage, neuronal dysfunction, and apoptosis within the retina. |
2018-11-14 |
2023-08-13 |
Not clear |
| Juan Wang, Jieping Zhang, Xin Chen, Yiting Yang, Fang Wang, Weiye Li, Maihemuti Awuti, Yaping Sun, Chunpin Lian, Zongyi Li, Min Wang, Jing-Ying Xu, Caixia Jin, Haibin Tian, Furong Gao, Jingfa Zhang, Debasish Sinha, Lixia Lu, Guo-Tong X. miR-365 promotes diabetic retinopathy through inhibiting Timp3 and increasing oxidative stress. Experimental eye research. vol 168. 2018-11-02. PMID:29196060. |
mir-365 was found to be highly expressed in the retina and the abnormality of mir-365/timp3 pathway is closely related to the pathology, like müller gliosis, and the visual injury in dr. |
2018-11-02 |
2023-08-13 |
rat |
| Rosario Amato, Massimo Dal Monte, Matteo Lulli, Vittoria Raffa, Giovanni Casin. Nanoparticle-Mediated Delivery of Neuroprotective Substances for the Treatment of Diabetic Retinopathy. Current neuropharmacology. vol 16. issue 7. 2018-10-22. PMID:28714394. |
the aim of this paper is to highlight recent data indicating that neurodegeneration is likely to play a primary role in the development of dr and that strategies based on nanomedicine may be exploited to deliver neuroprotection to the retina. |
2018-10-22 |
2023-08-13 |
Not clear |
| A O Shpakov, Yu R Ryzho. ENDOPLASMIC RETICULUM STRESS IN DIABETIC RETINOPATHY AND THE APPROACHES TO ITS CORRECTION. Tsitologiia. vol 58. issue 6. 2018-09-24. PMID:30192112. |
currently, there are three main upr-pathways that include inositol-requiring enzyme-1 (ire1), transcription factor-6 (atf6) and sensory kinase perk as the sensor components, all of which are involved in the pathological changes in the retina at dr, inducing the inflammation, apoptosis and vascular impairment therein. |
2018-09-24 |
2023-08-13 |
Not clear |
| A O Shpakov, Yu R Ryzho. ENDOPLASMIC RETICULUM STRESS IN DIABETIC RETINOPATHY AND THE APPROACHES TO ITS CORRECTION. Tsitologiia. vol 58. issue 6. 2018-09-24. PMID:30192112. |
the approaches to er stress correction in diabetic retina, which include the use of low-molecular chaperones, such as fenofibric acid, increased activity of chaperone-like p58ipk protein, and the restoration of activity of retinal hormonal signaling systems, whose functions are violated in dr, are discussed. |
2018-09-24 |
2023-08-13 |
Not clear |
| Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zhen. ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1. Experimental eye research. vol 166. 2018-09-11. PMID:29031854. |
diabetic retinopathy (dr), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. |
2018-09-11 |
2023-08-13 |
human |
| Yashodhara Sharma, Sandeep Saxena, Arvind Mishra, Anita Saxena, Shankar Madhav Nat. Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss. European journal of nutrition. vol 56. issue 6. 2018-08-01. PMID:28258307. |
the current treatment modalities of dr include laser photocoagulation therapy, intravitreal corticosteroids, intravitreal anti-vascular endothelial growth factor (vegf) agents and vitreo-retinal surgery which are costly, highly invasive, unproven for prolonged use and opted in advanced stages of dr. by then retina already encounters a vast damage. |
2018-08-01 |
2023-08-13 |
human |
| Dalia I Al-Dosari, Mohammed M Ahmed, Salim S Al-Rejaie, Abdullah S Alhomida, Mohammad S Ol. Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina. Nutrients. vol 9. issue 10. 2018-07-11. PMID:29064407. |
diabetes-induced oxidative stress is believed to be the key factor that initiates neuronal damage in the diabetic retina leading to dr. |
2018-07-11 |
2023-08-13 |
rat |
| Odunayo O Mugisho, Colin R Green, Jie Zhang, Nicolette Binz, Monica L Acosta, Elizabeth Rakoczy, Ilva D Rupentha. Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. International journal of molecular sciences. vol 18. issue 12. 2018-07-09. PMID:29186067. |
diabetic retinopathy (dr) develops due to hyperglycemia and inflammation-induced vascular disruptions in the retina with connexin43 expression patterns in the disease still debated. |
2018-07-09 |
2023-08-13 |
mouse |
| Tanya Moutray, Jennifer R Evans, Noemi Lois, David J Armstrong, Tunde Peto, Augusto Azuara-Blanc. Different lasers and techniques for proliferative diabetic retinopathy. The Cochrane database of systematic reviews. vol 3. 2018-04-30. PMID:29543992. |
proliferative dr (pdr) is a sight-threatening complication of dr and is characterised by the development of abnormal new vessels in the retina, optic nerve head or anterior segment of the eye. |
2018-04-30 |
2023-08-13 |
Not clear |
| Jianyan Hu, Tingting Li, Xinhua Du, Qiang Wu, Yun-Zheng L. G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. Vision research. vol 139. 2018-04-20. PMID:28539261. |
in the retina, gpr91 is predominately expressed in ganglion cells, a major cellular entity involved in the pathogenesis of diabetic retinopathy (dr) and other hypoxic retinal diseases. |
2018-04-20 |
2023-08-13 |
Not clear |
| Qian Chen, Jian-Xing M. Canonical Wnt signaling in diabetic retinopathy. Vision research. vol 139. 2018-04-20. PMID:28545982. |
this review highlights recent progress in studies of wnt signaling in dr. we discuss wnt signaling regulation in the retina and dysregulation of wnt signaling associated with ocular diseases with an emphasis on dr. we also discuss the therapeutic potential of modulating wnt signaling in dr. |
2018-04-20 |
2023-08-13 |
Not clear |
| Heping Xu, Mei Che. Diabetic retinopathy and dysregulated innate immunity. Vision research. vol 139. 2018-04-20. PMID:28571700. |
in the advanced stages of dr where immune privilege is comprised, circulating immune cells and serum proteins may infiltrate the retina and participate in retinal chronic inflammation and retinal vascular and neuronal damage. |
2018-04-20 |
2023-08-13 |
Not clear |
| Alistair J Barber, Basma Baccouch. Neurodegeneration in diabetic retinopathy: Potential for novel therapies. Vision research. vol 139. 2018-04-20. PMID:28988945. |
the concept of neurodegeneration as an early component of dr introduces the possibility to explore alternative therapies to prevent the onset of vision loss, including neuroprotective therapies and drugs targeting individual neurotransmitter systems, as well as more general neuroprotective approaches to preserve the integrity of the neural retina. |
2018-04-20 |
2023-08-13 |
Not clear |
| b' Tien Y Wong, Chui Ming Gemmy Cheung, Michael Larsen, Sanjay Sharma, Rafael Sim\\xc3\\xb. Diabetic retinopathy. Nature reviews. Disease primers. vol 2. 2018-03-20. PMID:27159554.' |
severe stages of dr include proliferative dr, caused by the abnormal growth of new retinal blood vessels, and diabetic macular oedema, in which there is exudation and oedema in the central part of the retina. |
2018-03-20 |
2023-08-13 |
Not clear |