| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Hua Li, Ting-Fan Feng, Da-Ming D. Construction of Spirocyclopropane-Linked Heterocycles Containing Both Pyrazolones and Oxindoles through Michael/Alkylation Cascade Reactions. The Journal of organic chemistry. vol 80. issue 22. 2016-03-25. PMID:26491953. |
moreover, the squaramide-catalyzed asymmetric reactions of arylidenepyrazolones with 3-chlorooxindoles afforded the corresponding chiral spirocyclic heterocycles in excellent yields (up to 99%) with moderate diastereoselectivities (up to 87:13 dr) and moderate to high enantioselectivities (up to 74% ee). |
2016-03-25 |
2023-08-13 |
Not clear |
| Wei Dai, Xiao-Li Jiang, Qiong Wu, Feng Shi, Shu-Jiang T. Diastereo- and Enantioselective Construction of 3,3'-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions. The Journal of organic chemistry. vol 80. issue 11. 2016-02-24. PMID:25939045. |
the first catalytic enantioselective construction of a 3,3'-pyrrolidinyldispirooxindole scaffold has been established via organocatalytic asymmetric 1,3-dipolar cycloadditions of isatin-derived azomethine ylides with methyleneindolinones, which afforded structurally complex bis-spirooxindoles containing three contiguous and two quaternary stereogenic centers in generally high yields (up to 99%) and excellent diastereo- and enantioselectivities (up to >95:5 dr, 98% ee). |
2016-02-24 |
2023-08-13 |
Not clear |
| Yong You, Bao-Dong Cui, Ming-Qiang Zhou, Jian Zuo, Jian-Qiang Zhao, Xiao-Ying Xu, Xiao-Mei Zhang, Wei-Cheng Yua. Organocatalytic Asymmetric Michael/Friedel-Crafts Cascade Reaction of 3-Pyrrolyl-oxindoles and α,β-Unsaturated Aldehydes for the Construction of Chiral Spiro[5,6-dihydropyrido[1,2-a]pyrrole-3,3'-oxindoles]. The Journal of organic chemistry. vol 80. issue 11. 2016-02-24. PMID:25984596. |
the reactions were catalyzed by diphenylprolinol silyl ether and 2-fluorobenzoic acid via an asymmetric michael/friedel-crafts cascade process, followed by dehydration with p-toluenesulfonic acid to afford a wide variety of structurally diverse spiro[5,6-dihydropyrido[1,2-a]pyrrole-3,3'-oxindole] derivatives in high yields (up to 93%) and with high to excellent diastereo- and enantioselectivities (up to >99:1 dr and 97% ee). |
2016-02-24 |
2023-08-13 |
Not clear |
| Wu-Lin Yang, Yang-Zi Liu, Shuai Luo, Xingxin Yu, John S Fossey, Wei-Ping Den. The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides. Chemical communications (Cambridge, England). vol 51. issue 44. 2016-02-17. PMID:25952504. |
a highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides catalyzed by a novel chiral n,o-ligand/cu(oac)2 system is reported, affording dispiropyrrolidine derivatives with spiro quaternary stereogenic centers in good to excellent yields (up to 90%), excellent levels of diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to 97% ee). |
2016-02-17 |
2023-08-13 |
Not clear |
| Wu-Lin Yang, Fei-Fei Tang, Fu-Sheng He, Chun-Yan Li, Xingxin Yu, Wei-Ping Den. Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones. Organic letters. vol 17. issue 19. 2016-01-15. PMID:26402314. |
a highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to 5-alkylidene thia(oxa)zolidine-2,4-diones catalyzed by a chiral n,o-ligand/cu(ch3cn)4bf4 system is reported, affording structurally novel spirocyclic pyrrolidine-thia(oxa)zolidinediones with a spiro-heteroquaternary stereogenic center in good to excellent yields (up to 99%), with excellent levels of diastereo- and enantioselectivity (dr up to 99:1; ee up to 98%). |
2016-01-15 |
2023-08-13 |
Not clear |
| Yang Wang, Man-Su Tu, Lei Yin, Meng Sun, Feng Sh. Brønsted acid catalyzed asymmetric diels-alder reactions: stereoselective construction of spiro[tetrahydrocarbazole-3,3'-oxindole] framework. The Journal of organic chemistry. vol 80. issue 6. 2015-12-07. PMID:25692214. |
the chiral phosphoric acid catalyzed asymmetric diels-alder reactions of 2-vinylindoles with methyleneindolinones have been established, which efficiently construct the spiro[tetrahydrocarbazole-3,3'-oxindole] architecture with one quaternary and three contiguous stereogenic centers in high yields (up to 99%) and excellent stereoselectivities (up to >95:5 dr, 97% ee). |
2015-12-07 |
2023-08-13 |
Not clear |
| Cole W Seifert, Suresh Pindi, Guigen L. Asymmetric Carbamoyl Anion Additions to Chiral N-Phosphonyl Imines via the GAP Chemistry Process and Stereoselectivity Enrichments. The Journal of organic chemistry. vol 80. issue 1. 2015-07-27. PMID:25458404. |
the asymmetric reaction resulted in chiral n-phosphonyl amino amides with good to excellent yields (71-99%) and good crude diastereoselectivities (dr 84:16-95:5). |
2015-07-27 |
2023-08-13 |
Not clear |
| Wei Tan, Xin Li, Yu-Xin Gong, Meng-Di Ge, Feng Sh. Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3'-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions. Chemical communications (Cambridge, England). vol 50. issue 100. 2015-07-06. PMID:25380514. |
an organocatalytic asymmetric formal [3+2] cycloaddition of isatin-derived 3-indolylmethanol with 3-methyl-2-vinylindole has been established, leading to highly stereoselective construction of a spiro[cyclopenta[b]indole-1,3'-oxindole] scaffold with the concomitant creation of three contiguous stereogenic centers (72-99% yield, all >95 : 5 dr, 90-98% ee), one of which is an all-carbon quaternary stereogenic center. |
2015-07-06 |
2023-08-13 |
Not clear |
| Hong-Hao Zhang, Xiao-Xue Sun, Jing Liang, Yue-Ming Wang, Chang-Chun Zhao, Feng Sh. Catalytic asymmetric Povarov reaction of isatin-derived 2-azadienes with 3-vinylindoles. Organic & biomolecular chemistry. vol 12. issue 47. 2015-07-01. PMID:25330069. |
the first catalytic asymmetric povarov reaction of isatin-derived 2-azadienes with 3-vinylindoles was established in the presence of chiral phosphoric acid, which tolerates a wide range of substrates with generally excellent diastereoselectivity and good enantioselectivity (up to >95 : 5 dr, 89 : 11 er). |
2015-07-01 |
2023-08-13 |
Not clear |
| Yong-Ming Sun, Nana Xin, Zhong-Yuan Xu, Li-Juan Liu, Fan-Jie Meng, He Zhang, Bao-Ci Fu, Qiu-Ju Liang, Hong-Xing Zheng, Li-Jun Sun, Chang-Qiu Zhao, Li-Biao Ha. Addition of optically pure H-phosphinate to ketones: selectivity, stereochemistry and mechanism. Organic & biomolecular chemistry. vol 12. issue 46. 2015-06-29. PMID:25327336. |
aromatic methyl ketones and cyclic asymmetric ketones underwent hydrophosphorylation with p-stereogenic h-p species in the presence of potassium carbonate to produce p,c-stereogenic tertiary α-hydroxyl phosphinates in excellent yields with up to 99 : 1 dr. |
2015-06-29 |
2023-08-13 |
Not clear |
| Stephen G Davies, Ai M Fletcher, Emma M Foster, Ian T T Houlsby, Paul M Roberts, Thomas M Schofield, James E Thomso. An efficient asymmetric synthesis of (-)-lupinine. Chemical communications (Cambridge, England). vol 50. issue 61. 2015-05-12. PMID:24938152. |
the asymmetric synthesis of (-)-lupinine was achieved in 8 steps, 15% overall yield and >99 : 1 dr from commercially available starting materials. |
2015-05-12 |
2023-08-13 |
Not clear |
| Zhongkai Tang, Yan Shi, Haibin Mao, Xuebin Zhu, Weipeng Li, Yixiang Cheng, Wen-Hua Zheng, Chengjian Zh. Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines. Organic & biomolecular chemistry. vol 12. issue 32. 2015-05-11. PMID:25004112. |
a highly efficient asymmetric organocatalytic addition of 3-substituted oxindole to isatin-derived ketimine is reported with excellent stereocontrol (>99 : 1 dr, >99% ee) under mild conditions. |
2015-05-11 |
2023-08-13 |
Not clear |
| Zhi-Qiang Liu, Zi-Wei Xiang, Zhou Shen, Qi Wu, Xian-Fu Li. Enzymatic enantioselective aldol reactions of isatin derivatives with cyclic ketones under solvent-free conditions. Biochimie. vol 101. 2014-12-09. PMID:24440638. |
nuclease p1 from penicillium citrinum was observed to directly catalyze the asymmetric aldol reactions between isatin derivatives and cyclic ketones with high isolated yields (up to 95%) and moderate to good stereoselectivity (dr up to >99/1, ee up to 82%). |
2014-12-09 |
2023-08-12 |
Not clear |
| Thomas H West, David S B Daniels, Alexandra M Z Slawin, Andrew D Smit. An isothiourea-catalyzed asymmetric [2,3]-rearrangement of allylic ammonium ylides. Journal of the American Chemical Society. vol 136. issue 12. 2014-11-25. PMID:24588738. |
benzotetramisole promotes the catalytic asymmetric [2,3]-rearrangement of allylic quaternary ammonium salts (either isolated or prepared in situ from p-nitrophenyl bromoacetate and the corresponding allylic amine), generating syn-α-amino acid derivatives with excellent diastereo- and enantioselectivity (up to >95:5 dr; up to >99% ee). |
2014-11-25 |
2023-08-12 |
Not clear |
| Siobhan R Smith, James Douglas, Hugues Prevet, Peter Shapland, Alexandra M Z Slawin, Andrew D Smit. Isothiourea-catalyzed asymmetric synthesis of β-lactams and β-amino esters from arylacetic acid derivatives and N-sulfonylaldimines. The Journal of organic chemistry. vol 79. issue 4. 2014-10-17. PMID:24432704. |
the isothiourea hbtm-2.1 (5 mol %) catalyzes the asymmetric formal [2 + 2] cycloaddition of both arylacetic acids (following activation with tosyl chloride) and preformed 2-arylacetic anhydrides with n-sulfonylaldimines, generating stereodefined 2,3-diaryl-β-amino esters (after ring-opening) and 3,4-diaryl-anti-β-lactams, respectively, with high diastereocontrol (up to >95:5 dr) and good to excellent enantiocontrol. |
2014-10-17 |
2023-08-12 |
Not clear |
| Louis C Morrill, Lyndsay A Ledingham, Jean-Philippe Couturier, Jasmine Bickel, Andrew D Harper, Charlene Fallan, Andrew D Smit. 2-Arylacetic anhydrides as ammonium enolate precursors. Organic & biomolecular chemistry. vol 12. issue 4. 2014-10-13. PMID:24292454. |
readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (hbtm-2.1)-mediated catalytic asymmetric intermolecular michael addition-lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and >99% ee). |
2014-10-13 |
2023-08-12 |
Not clear |
| Jingyun Ren, Yuan Liu, Liyan Song, Rongbiao Ton. Scalable asymmetric total syntheses of (+)-Psoracorylifol B and (+)-ent-Psoracorylifol C. Organic letters. vol 16. issue 11. 2014-10-06. PMID:24819702. |
scalable asymmetric total syntheses of (+)-psoracorylifol b and (+)-ent-psoracorylifol c. the first, asymmetric total syntheses of potent antimicrobial psoracorylifol b (>1.3 g obtained, dr 10.5:1) with a 9.4% overall yield on a gram scale in 14 steps and ent-psoracorylifol c with a 4.3% yield in 16 steps were achieved. |
2014-10-06 |
2023-08-13 |
Not clear |
| Jianfeng Zheng, Lili Lin, Yulong Kuang, Jiannan Zhao, Xiaohua Liu, Xiaoming Fen. Magnesium(II)-catalyzed asymmetric hetero-Diels-Alder reaction of Brassard's dienes with isatins. Chemical communications (Cambridge, England). vol 50. issue 8. 2014-08-13. PMID:24305614. |
the first catalytic asymmetric hetero-diels-alder reaction of brassard's dienes with isatins was realized using mg(ii)/n,n'-dioxide complexes as catalysts, affording the corresponding chiral spirolactones bearing tetrasubstituted centers in up to 99% yield with up to 99% ee and >99 : 1 dr within 3 hours. |
2014-08-13 |
2023-08-12 |
Not clear |
| Casper L Hansen, Janie W Clausen, Ragnhild G Ohm, Erhad Ascic, Sebastian T Le Quement, David Tanner, Thomas E Nielse. Ruthenium hydride/Brønsted acid-catalyzed tandem isomerization/N-acyliminium cyclization sequence for the synthesis of tetrahydro-β-carbolines. The Journal of organic chemistry. vol 78. issue 24. 2014-07-08. PMID:24180610. |
finally, diastereo- and enantioselective versions of the title reaction have been examined using substrate control (with dr >15: 1) and asymmetric catalysis (ee up to 57%), respectively. |
2014-07-08 |
2023-08-12 |
Not clear |
| Sijia Liu, Jianrong Steve Zho. Desymmetrization of cyclic olefins via asymmetric Heck reaction and hydroarylation. Chemical communications (Cambridge, England). vol 49. issue 100. 2014-06-23. PMID:24196697. |
an asymmetric heck reaction allows desymmetrization of substituted cyclic olefins in high dr and ee. |
2014-06-23 |
2023-08-12 |
Not clear |