| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudio Palomo, Mikel Oiarbide, Jesús M. Aizpurua, Alberto González, Jesús M. García, Cristina Landa, Ibon Odriozola, Anthony Linde. Highly Diastereoselective Aldol Reactions with Camphor-Based Acetate Enolate Equivalents. The Journal of organic chemistry. vol 64. issue 22. 2019-11-20. PMID:11674736. |
in these instances, the achieved levels of asymmetric induction, typically 95:5 dr, are in the range of those attained in aldol reactions involving the lithium enolate of the methyl ketone 4, which is sterically more demanding. |
2019-11-20 |
2023-08-12 |
Not clear |
| Dinesh Kumar, Sandeep R Vemula, Narayanaganesh Balasubramanian, Gregory R Coo. Indium-Mediated Stereoselective Allylation. Accounts of chemical research. vol 49. issue 10. 2019-11-20. PMID:27700084. |
this laboratory has also investigated indium-mediated asymmetric intramolecular cyclization in the presence of amino acid additives to deliver biologically relevant chromanes with excellent diastereoselectivity (dr >99:1). |
2019-11-20 |
2023-08-13 |
Not clear |
| Can Li, Dan-Ni Xu, Chun Ma, Guang-Jian Mei, Feng Sh. Diastereo- and Enantioselective Construction of Dihydrobenzo[ e]indole Scaffolds via Catalytic Asymmetric [3 + 2] Cycloannulations. The Journal of organic chemistry. vol 83. issue 16. 2019-11-20. PMID:30022670. |
the first catalytic asymmetric construction of chiral dihydrobenzo[ e]indole scaffolds has been established in a highly diastereo- and enantioselective mode (30 examples, up to 99% yield, >95:5 dr, >99% ee), which makes use of chiral phosphoric acid-catalyzed [3 + 2] cycloannulations of azonaphthalene derivatives with 3-vinylindoles. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cong-Shuai Wang, Tian-Zhen Li, Yu-Chun Cheng, Ji Zhou, Guang-Jian Mei, Feng Sh. Catalytic Asymmetric [4 + 1] Cyclization of Benzofuran-Derived Azadienes with 3-Chlorooxindoles. The Journal of organic chemistry. vol 84. issue 6. 2019-11-20. PMID:30777434. |
a chiral guanidine-catalyzed asymmetric [4 + 1] cyclization of benzofuran-derived azadienes with 3-chlorooxindoles has been established, which constructed chiral spirooxindole frameworks with in situ generation of a five-membered ring with high diastereoselectivities (up to >95:5 dr) and good enantioselectivities (up to 94:6 er). |
2019-11-20 |
2023-08-13 |
Not clear |
| Yubiao Hong, Lucie Jarrige, Klaus Harms, Eric Megger. Chiral-at-Iron Catalyst: Expanding the Chemical Space for Asymmetric Earth-Abundant Metal Catalysis. Journal of the American Chemical Society. vol 141. issue 11. 2019-11-20. PMID:30839201. |
this is demonstrated with an enantioselective cannizzaro reaction (96% yield, 88% ee) and an asymmetric nazarov cyclization (89% yield, >20:1 dr, 83% ee). |
2019-11-20 |
2023-08-13 |
Not clear |
| Sidonie Aubert, Tania Katsina, Stellios Arseniyadi. A Sequential Pd-AAA/Cross-Metathesis/Cope Rearrangement Strategy for the Stereoselective Synthesis of Chiral Butenolides. Organic letters. vol 21. issue 7. 2019-11-20. PMID:30888193. |
a practical and highly enantio- (up to 94:6 er) and diastereoselective (up to >20:1 dr) synthesis of γ-butenolides bearing two adjacent stereogenic centers is reported featuring a sequential direct palladium-catalyzed asymmetric allylic alkylation/( e)-selective cross-metathesis/[3,3]-sigmatropic cope rearrangement from readily available α-substituted (5 h)-furan-2-ones. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ke-Xin Huang, Ming-Sheng Xie, Dong-Chao Wang, Ji-Wei Sang, Gui-Rong Qu, Hai-Ming Gu. Palladium-catalyzed asymmetric formal [3+2] cycloaddition of α-N-heterocyclic acrylates with vinyl epoxides for construction of isonucleoside analogs. Chemical communications (Cambridge, England). vol 55. issue 90. 2019-11-12. PMID:31650142. |
a highly efficient pd-catalyzed asymmetric formal [3+2] cycloaddition using α-n-heterocyclic acrylates to react with vinyl epoxides has been achieved for the first time to access chiral functionalized tetrahydrofuran skeletons (34 examples, up to 93% yield, >20 : 1 dr and 99% ee). |
2019-11-12 |
2023-08-13 |
Not clear |
| Yong-Xing Song, Da-Ming D. Asymmetric Construction of Bispiro[oxindole-pyrrolidine-rhodanine]s via Squaramide-Catalyzed Domino Michael/Mannich [3 + 2] Cycloaddition of Rhodanine Derivatives with N-(2,2,2-Trifluoroethyl)isatin Ketimines. The Journal of organic chemistry. vol 83. issue 16. 2019-09-10. PMID:29956933. |
squaramide-catalyzed asymmetric domino michael/mannich [3 + 2] cycloaddition reaction between rhodanine derivatives and n-(2,2,2-trifluoroethyl)isatin ketimines has been developed to synthesize various bispiro[oxindole-pyrrolidine-rhodanine]s with good to excellent yields (up to 99%) and excellent stereoselectivities (up to >99% ee and >99:1 dr). |
2019-09-10 |
2023-08-13 |
Not clear |
| Jing Liu, Caiying Li, Wen Chen, Kuanrong He, Huijuan Ma, Boqing Ma, Pei Zhao, Lu Tia. Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis. BioMed research international. vol 2019. 2019-07-18. PMID:30931324. |
the purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (adma) level and microvascular complications in diabetes mellitus (dm) including diabetic retinopathy (dr), diabetic neuropathy (dn), and diabetic nephropathy. |
2019-07-18 |
2023-08-13 |
Not clear |
| Zhengyu Han, Yu-Qing Guan, Gang Liu, Rui Wang, Xuguang Yin, Qingyang Zhao, Hengjiang Cong, Xiu-Qin Dong, Xumu Zhan. Iridium-Catalyzed Asymmetric Hydrogenation of Tetrasubstituted α-Fluoro-β-enamino Esters: Efficient Access to Chiral α-Fluoro-β-amino Esters with Two Adjacent Tertiary Stereocenters. Organic letters. vol 20. issue 20. 2019-03-07. PMID:30277402. |
an iridium-catalyzed highly efficient asymmetric hydrogenation of challenging tetrasubstituted α-fluoro-β-enamino esters was successfully developed using bisphosphine-thiourea (zhaophos) as the ligand, which prepared a series of chiral α-fluoro-β-amino esters containing two adjacent tertiary stereocenters with high yields and excellent diastereoselectivities/enantioselectivities (73%-99% yields, >25:1 dr, 91%->99% ee, and turnover number (ton) values up to 8600), and no defluorinate byproduct was detected. |
2019-03-07 |
2023-08-13 |
Not clear |
| Bo Zheng, Haohua Chen, Lei Zhu, Xiqiang Hou, Yan Wang, Yu Lan, Yungui Pen. Formal Asymmetric Cycloaddition of Activated α,β-Unsaturated Ketones with α-Diazomethylphosphonate Mediated by a Chiral Silver SPINOL Phosphate Catalyst. Organic letters. vol 21. issue 3. 2019-03-04. PMID:30633534. |
an efficient method for preparing highly functionalized chiral nonspiro-phosphonylpyrazolines via an asymmetric formal 1,3-dipolar cycloaddition reaction of α-diazomethylphosphonate with activated, acyclic α,β-unsaturated ketones, bearing an additional nitrile electron-withdrawing group, has been developed, utilizing an in situ generated chiral silver phosphate catalyst, affording excellent stereoselectivities (up to 98% ee, 99:1 dr) and yields (up to 95%). |
2019-03-04 |
2023-08-13 |
Not clear |
| Bastian Mechsner, Birgit Henßen, Jörg Pietruszk. First enantioselective total synthesis of altersolanol A. Organic & biomolecular chemistry. vol 16. issue 41. 2019-02-28. PMID:30283967. |
the key step towards the tetrahydroanthraquinone core was an asymmetric diels-alder (d-a) cycloaddition promoted by (r)-3,3'-diphenyl-binol/boron lewis acid with good to excellent yields and excellent diastereo- and enantioselectivity (>95 : 5 dr and 98 : 2 er). |
2019-02-28 |
2023-08-13 |
Not clear |
| Hiroyuki Suga, Masahiro Yoshiwara, Takaaki Yamaguchi, Takashi Bando, Mizuki Taguchi, Ayano Inaba, Yuichi Goto, Ayaka Kikuchi, Kennosuke Itoh, Yasunori Tod. Enantioselective synthesis of 8-azabicyclo[3.2.1]octanes via asymmetric 1,3-dipolar cycloadditions of cyclic azomethine ylides using a dual catalytic system. Chemical communications (Cambridge, England). vol 55. issue 11. 2019-02-04. PMID:30560972. |
the asymmetric cycloadditions afforded optically active 8-oxabicyclo[3.2.1]octanes with high diastereo- and enantioselectivities (up to >99 : 1 dr, 99% ee). |
2019-02-04 |
2023-08-13 |
Not clear |
| Kun-Ming Yu, Hui-Kai Zhu, Xiao-Li Zhao, Min Shi, Mei-Xin Zha. Organocatalyzed asymmetric tandem conjugate addition-protonation of isocyanoacetates to 2-chloroacrylonitrile. Organic & biomolecular chemistry. vol 17. issue 3. 2019-02-04. PMID:30575842. |
an efficient organocatalytic asymmetric tandem conjugate addition-protonation of α-substituted isocyanoacetates to 2-chloroacrylonitrile catalyzed by dihydroquinine-derived thiourea has been investigated, affording the corresponding adducts with two non-adjacent tertiary-quaternary stereocenters in excellent yields (up to 99%) along with good to excellent diastereo- and enantioselectivities (up to 20 : 1 dr, up to 95% ee) under mild conditions. |
2019-02-04 |
2023-08-13 |
Not clear |
| Shermin S Goh, Sureshbabu Guduguntla, Takashi Kikuchi, Martin Lutz, Edwin Otten, Makoto Fujita, Ben L Fering. Desymmetrization of meso-Dibromocycloalkenes through Copper(I)-Catalyzed Asymmetric Allylic Substitution with Organolithium Reagents. Journal of the American Chemical Society. vol 140. issue 23. 2018-11-15. PMID:29790736. |
the highly regio- and enantioselective (up to >99:1 dr, up to 99:1 er) desymmetrization of meso-1,4-dibromocycloalk-2-enes using asymmetric allylic substitution with organolithium reagents to afford enantioenriched bromocycloalkenes (ring size of 5 to 7) has been achieved. |
2018-11-15 |
2023-08-13 |
Not clear |
| Mei-Rong Du, Li Yan, Nian-Sheng Li, Yu-Jie Wang, Ting Zhou, Jun-Lin Jian. Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway. Vascular pharmacology. vol 108. 2018-10-23. PMID:29777874. |
this study aims to investigate whether asymmetric dimethylarginine (adma) impacts the pathogenesis of dr via focusing on promoting retinal neovascularization and its underlying molecular mechanisms. |
2018-10-23 |
2023-08-13 |
rat |
| Wen Liu, Weidi Cao, Haipeng Hu, Lili Lin, Xiaoming Fen. Dynamic kinetic asymmetric transformations of β-halo-α-keto esters by N,N'-dioxide/Ni(ii)-catalyzed carbonyl-ene reaction. Chemical communications (Cambridge, England). vol 54. issue 64. 2018-08-08. PMID:30043009. |
dynamic kinetic asymmetric transformations of racemic β-halo-α-keto esters through carbonyl-ene reaction were realized using a chiral n,n'-dioxide-nickel(ii) complex, giving the corresponding β-halo-α-hydroxy esters containing two vicinal chiral tri- and tetrasubstituted carbon centers in good yields and dr with excellent ee values without the use of extra bases. |
2018-08-08 |
2023-08-13 |
Not clear |
| Amir Altaf, Jin-Woo Jung, Youngoo Yang, Kang-Yoon Lee, Sang-Hwa Yi, Keum Cheol Hwan. A 3-D Meandered Probe-Fed Dual-Band Circularly Polarized Dielectric Resonator Antenna. Sensors (Basel, Switzerland). vol 18. issue 8. 2018-07-30. PMID:30046016. |
in the upper cp band, pairs of higher broadside and even modes of the hexagonal dr are combined with a cp band that is induced by the asymmetric c-shaped metallic strip to yield a wide 3 db axial ratio bandwidth (arbw). |
2018-07-30 |
2023-08-13 |
Not clear |
| Shuo Qiao, Cody B Wilcox, Daniel K Unruh, Bo Jiang, Guigen L. Asymmetric [3 + 2] Cycloaddition of Chiral N-Phosphonyl Imines with Methyl Isocyanoacetate for Accessing 2-Imidazolines with Switchable Stereoselectivity. The Journal of organic chemistry. vol 82. issue 6. 2018-07-17. PMID:28249385. |
asymmetric [3 + 2] cycloaddition of chiral n-phosphonyl imines with methyl isocyanoacetate has been established, enabling controllable/switchable stereoselectivity access to 21 examples of cycloadducts with good to excellent chemical yields (up to 92%) and high diastereoselectivities (up to 99:1 dr). |
2018-07-17 |
2023-08-13 |
Not clear |
| Fei Tian, Fu-Sheng He, Hua Deng, Wu-Lin Yang, Wei-Ping Den. β-Silyl Acrylates in Asymmetric [3 + 2] Cycloadditions Affording Pyrrolidine Azasugar Derivatives. Organic letters. vol 20. issue 13. 2018-07-16. PMID:29901400. |
a highly efficient copper(i)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with 3-silyl unsaturated esters has been developed, providing elegant access to chiral 3-silylpyrrolidine derivatives bearing contiguous stereogenic centers in moderate-to-excellent yields (up to 99%) with high diastereo- and enantioselectivities (dr up to >99:1; ee up to 96%). |
2018-07-16 |
2023-08-13 |
Not clear |