| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Mou, Donghui Wang, Shuang Li, Xin Li, Jiahao Wang, Changpin Chen, Yanping Huo, Yingxiao Mu, Zhegang Huan. Surface Involvement in the Boosting of Chiral Organocatalysts for Efficient Asymmetric Catalysis. Macromolecular rapid communications. 2024-11-30. PMID:39614870. |
the cross-linking of 2d laminates from the assembly of hexameric macrocycles with one proline edge gave rise to rarely curled capsules with a diameter of 200-400 nm and excellent enantioselectivities as well as diastereoselectivities for asymmetric aldol reactions (94% ee and 1:13 dr). |
2024-11-30 |
2024-12-06 |
Not clear |
| Yan Zong, Xiaomei Zou, Hongqi Tao, Qiuchen Huang, Gen-Qiang Chen, Xumu Zhan. Highly Efficient and Enantioselective Iridium-Catalyzed Asymmetric Reductive Cycloetherification. Journal of the American Chemical Society. 2024-11-25. PMID:39586056. |
the dynamic kinetic resolution asymmetric hydrogenation (dkr-ah) process was also achieved, simultaneously constructing enantioenriched thp scaffolds with two contiguous stereogenic centers with high yields and stereoselectivities (up to 92% yield, up to 98.5:1.5 er and >20:1 dr). |
2024-11-25 |
2024-11-28 |
Not clear |
| Yuan Ma, Yang Gu, Shuai Guo, Xin Qin, Shijie Wen, Nianfeng Shi, Weiwei Dai, Yiqiang Che. Grade-Skewed Domain Adaptation via Asymmetric Bi-Classifier Discrepancy Minimization for Diabetic Retinopathy Grading. IEEE transactions on medical imaging. vol PP. 2024-10-23. PMID:39441682. |
under the grade-skewed domain adaptation problem, we propose a novel method for image-level supervised dr grading via asymmetric bi-classifier discrepancy minimization (abid). |
2024-10-23 |
2024-10-26 |
Not clear |
| Yuan-Zheng Wang, Ya-Nan Duan, Gen-Qiang Chen, Xumu Zhan. Design and Synthesis of Sulfur-Containing Tetradentate Ligands for Ir-Catalyzed Asymmetric Hydrogenation of Ketones. Organic letters. 2024-09-30. PMID:39347579. |
a series of novel tetradentate sulfur-containing ligands, termed as f-thiophamidol, were successfully designed and synthesized which exhibited excellent performance in the asymmetric hydrogenation of simple ketones (up to 99% yield, 99% ee) and α-substituted β-keto sulfonamides (up to 99% yield, 99% ee, 99:1 dr). |
2024-09-30 |
2024-10-02 |
Not clear |
| Pu-Fan Qian, Gang Zhou, Jia-Heng Hu, Bing-Jie Wang, Ao-Lian Jiang, Tao Zhou, Wen-Kui Yuan, Qi-Jun Yao, Jia-Hao Chen, Ke-Xin Kong, Bing-Feng Sh. Asymmetric Synthesis of Chiral Calix[4]arenes with Both Inherent and Axial Chirality via Cobalt-Catalyzed Enantioselective Intermolecular C-H Annulation. Angewandte Chemie (International ed. in English). 2024-09-11. PMID:39261278. |
herein, we report the asymmetric synthesis of calix[4]arenes featuring inherent or both inherent and axial chirality via a cobalt-catalyzed c-h activation/annulation strategy in high yield with excellent enantio- and diastereoselectivity (up to > 99% ee and > 20:1 dr). |
2024-09-11 |
2024-09-14 |
Not clear |
| Xihao Chang, Jiayin Zhang, Xiang Cheng, Xianhai Lv, Chang Gu. Ni/Cu Dual-Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-25. PMID:39049712. |
herein, a ni/cu dual-catalyzed asymmetric propargylic substitution reaction is presented to produce propargylated products with all-carbon quaternary stereocenters in high yields with significant diastereo- and enantioselectivities (up to >20:1 dr, >99% ee). |
2024-07-25 |
2024-07-28 |
Not clear |
| Kui Tian, Xin Chang, Lu Xiao, Xiu-Qin Dong, Chun-Jiang Wan. Stereodivergent synthesis of α-fluoro α-azaaryl γ-butyrolactones Fundamental research. vol 4. issue 1. 2024-06-27. PMID:38933830. |
herein, a novel asymmetric [3+2] annulation of α-fluoro α-azaaryl acetates with vinylethylene carbonate was successfully developed through cu/ir-catalyzed cascade allylic alkylation/lactonization, affording a variety of enantioenriched α-fluoro γ-butyrolactones bearing vicinal stereogenic centers with high reaction efficiency and excellent levels of both stereoselectivity and regioselectivity (up to 98% yield, generally >20:1 dr and >99% ee). |
2024-06-27 |
2024-06-29 |
Not clear |
| Shaofeng Xu, Wenqi Xu, Siqi Dong, Delong Liu, Wanbin Zhan. RuPHOX-Ru Catalyzed Asymmetric Cascade Hydrogenation of 3-Substituted Chromones for the Synthesis of Corresponding Chiral Chromanols. Chemistry (Weinheim an der Bergstrasse, Germany). 2024-05-02. PMID:38695858. |
an efficient ruphox-ru catalyzed asymmetric cascade hydrogenation of 3-substituted chromones has been achieved under mild reaction conditions, affording the corresponding chiral 3-substituted chromanols in high yields with excellent enantio- and diastereoselectivities (up to 99% yield, >99% ee and >20:1 dr). |
2024-05-02 |
2024-05-04 |
Not clear |
| Arindam Khatua, Debgopal Jana, Monosij Nandy, Pranay Shyamal, Alakesh Bisa. Total Synthesis of (+)- and (-)-Calycanthine by Means of Thio-Urea-Catalyzed Sequential Michael Reactions of Bis-oxindoles. The Journal of organic chemistry. 2024-03-28. PMID:38544463. |
a unified catalytic asymmetric approach to naturally occurring piperidinoindoline and pyrrololidinoindoline alkaloids has been realized via the development of a thio-urea-catalyzed sequential michael addition of bis-oxindole onto nitroethylene (up to 93% ee and >20:1 dr). |
2024-03-28 |
2024-03-30 |
Not clear |
| Kun Wang, Saisai Niu, Weijun Tang, Dong Xue, Jianliang Xiao, Hongfeng Li, Chao Wan. Ru-catalyzed asymmetric hydrogenation of α,β-unsaturated ketones Chemical communications (Cambridge, England). 2024-03-28. PMID:38545855. |
ru-catalyzed asymmetric hydrogenation of α,β-unsaturated ketones ru-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated ketones has been developed for the enantioselective synthesis of chiral α-substituted secondary alcohols with high diastereo- and enantioselectivities (up to >99 : 1 dr, 98% ee). |
2024-03-28 |
2024-03-30 |
Not clear |
| Jingli He, Zhaodi Li, Ruhui Li, Xuezhen Kou, Delong Liu, Wanbin Zhan. Bimetallic Ru/Ru-Catalyzed Asymmetric One-Pot Sequential Hydrogenations for the Stereodivergent Synthesis of Chiral Lactones. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-21. PMID:38509867. |
asymmetric sequential hydrogenations of α-methylene γ- or δ-keto carboxylic acids are established in one-pot using a bimetallic ru/ru catalyst system, achieving the stereodivergent synthesis of all four stereoisomers of both chiral γ- and δ-lactones with two non-vicinal carbon stereocenters in high yields (up to 99%) and with excellent stereoselectivities (up to >99% ee and >20:1 dr). |
2024-03-21 |
2024-03-23 |
Not clear |
| Yao-Bin Shen, Hui-Ling Qian, Lei Yang, Shun Zhou, Han-Wen Rao, Zhen-Hua Wang, Yong You, Yan-Ping Zhang, Jun-Qing Yin, Jian-Qiang Zhao, Wenjing Zhang, Wei-Cheng Yua. Cu-Catalyzed Direct Asymmetric Mannich Reaction of 2-Alkylazaarenes and Isatin-Derived Ketimines. Organic letters. 2024-02-22. PMID:38385527. |
the asymmetric addition of 2-alkylpyridines to isatin-derived ketimines proceeded smoothly to afford α,β-functionalized 2-substituted pyridines bearing 3-amino-3,3-disubstituted oxindole motifs with excellent results (≤99% yield, 99:1 dr, and 98% ee). |
2024-02-22 |
2024-02-24 |
Not clear |
| Liang Bai, Jian-Sheng Wei, Ling-Yi Zhong, Ao-Qiang Ma, Jian Wang, Zhi-Qiang Du, Ai-Bao Xia, Dan-Qian X. Enantioselective α-Amination of Amides by One-Pot Organo-/Iodine Sequential Catalysis. Organic letters. 2023-12-29. PMID:38157251. |
this methodology exhibited strong asymmetric induction, resulting in a typical enantiomeric excess value exceeding 99% and diastereoselectivity up to >99:1 dr. |
2023-12-29 |
2024-01-05 |
Not clear |
| Jixin Pian, Zhifei Zhao, Yujie Zhao, Lin He, Xiong-Li Liu, Yongsheng Li, Shi-Wu L. Asymmetric Synthesis of Tertiary α-Hydroxylation-Cyclopentanones via Synergetic Catalysis of Chiral-at-Metal Rhodium(III) Complexes/Pyrrolidine. The Journal of organic chemistry. 2023-12-28. PMID:38154059. |
catalytic and asymmetric domino michael/aldol reaction of 1,2-dicarbonyl compounds with α,β-unsaturated ketones under the synergetic catalysis of chiral-at-metal rhodium complexes and pyrrolidine to deliver tertiary α-hydroxylation-cyclopentanones (45-89% yields with 81-99% ee and up to >20:1 dr) bearing three contiguous stereogenic centers had been established. |
2023-12-28 |
2023-12-31 |
Not clear |
| Wenkun Chen, Jijun Jiang, Jun Wan. Asymmetric Ruthenium-Catalyzed C-H Activation by a Versatile Chiral-Amide-Directing Strategy. Angewandte Chemie (International ed. in English). 2023-12-16. PMID:38102747. |
asymmetric c-h activation of the related chiral benzamides with various olefins, aldehydes and propargylic alcohols has been accomplished with high stereoselectivities, affording a series of chiral products including 3,4-dihydroisocoumarins (up to 96% ee), isocoumarins (up to 92% ee), phthalides (up to 99% ee), chiral bicyclo[2.2.1]heptanes (>20:1 dr), 4-alkylidene-3,4-dihydroisocoumarins (up to 97% ee) and allenes (>20:1 dr). |
2023-12-16 |
2023-12-18 |
Not clear |
| Michał Błaszkiewicz, Agata Walulik, Kamila Florek, Ignacy Górecki, Olga Sławatyniec, Krzysztof Gomułk. Advances and Perspectives in Relation to the Molecular Basis of Diabetic Retinopathy-A Review. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001952. |
specifically, we focus on advanced glycation end products, vascular endothelial growth factor (vegf), asymmetric dimethylarginine, endothelin-1, and the epigenetic regulation mediated by micrornas (mirnas) in the context of dr. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yurim Kim, Yoseop Kim, Sung-Gon Ki. [4+2]-Cycloaddition of 2-Aminophenyl Enones with Cyclic N-Sulfimines to Access Enantioenriched Ring-Fused Aminals. Chemistry, an Asian journal. 2023-11-20. PMID:37984888. |
furthermore, an organocatalytic asymmetric [4+2]-cycloaddition was successfully achieved using a squaramide-based catalyst, enabling the enantioselective synthesis of chiral ring-fused tetrahydroquinazolines with high yields and enantio- as well as diastereoselectivities (up to 89% yield, 94% ee, and >30:1 dr). |
2023-11-20 |
2023-11-29 |
Not clear |
| Liangzhi Pang, Chun Wang, Congyue Ma, Jiaojiao Liu, Mengke Shi, Chuanzhi Yao, Jie Yu, Qiankun L. Palladium-Catalyzed Modular Assembly of P-Stereogenic and Axially Chiral Phosphinooxazoles (PHOX) Ligands by C-P Bond Cleavage/Intermolecular C(sp Organic letters. 2023-10-13. PMID:37831783. |
here, modular assembly of diverse p-stereogenic and axially chiral phosphinooxazoles ligands is achieved through palladium-catalyzed asymmetric cleavage of c-p bond/intermolecular c-h bond functionalization in high atroposelectivities and diastereoselectivities of up to >99% ee and >25:1 dr. |
2023-10-13 |
2023-10-15 |
Not clear |
| Subhankar Biswas, Siddhartha K Purkayastha, Ankur K Guha, Subhas Chandra Pa. Sequential organo and metal catalyzed reaction between 3-pyrrolyloxindoles and linear nitroenynes: access to cyclic aza-spirooxindoles. Chemical communications (Cambridge, England). 2023-09-23. PMID:37740344. |
an asymmetric michael addition/hydroarylation reaction sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a combination of silver and gold salts, provides a new series of cyclic aza-spirooxindole derivatives in excellent yields (up to 94%) and high diastero- and enantioselectivities (up to 7 : 1 dr, up to >99% ee). |
2023-09-23 |
2023-10-07 |
Not clear |
| Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang, Yongqiang Tu, Tong-Mei Ding, Yu-Yang Xi. Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems. Angewandte Chemie (International ed. in English). 2023-07-18. PMID:37462217. |
an asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine (spd-nh2) and pd(ii) complex, providing straightforward access to either bridged or fused bicyclic systems containing three stereogenic centers with excellent enantioselectivity (up to 99% ee) and diastereoselectivity (up to >20:1 dr). |
2023-07-18 |
2023-08-14 |
Not clear |