| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katherine S Peters, Emilio Rivera, Cassandra Warden, Paula A Harlow, Sabrina L Mitchell, M Wade Calcutt, David C Samuels, Milam A Brantle. Plasma Arginine and Citrulline are Elevated in Diabetic Retinopathy. American journal of ophthalmology. 2021-09-29. PMID:34587493. |
to determine if plasma levels of six arginine and citrulline-related metabolites (arginine, citrulline, asymmetric dimethylarginine [adma], ornithine, proline, and argininosuccinate) differ between patients with type 2 diabetes and diabetic retinopathy (dr) and type 2 diabetic controls or between patients with proliferative dr (pdr) and non-proliferative dr (npdr). |
2021-09-29 |
2023-08-13 |
Not clear |
| Min Zhang, Xue-Wen He, Ya Xiong, Xiong Zuo, Wei Zhou, Xiong-Li Li. Asymmetric construction of six vicinal stereogenic centers on hexahydroxanthones Chemical communications (Cambridge, England). vol 57. issue 55. 2021-07-12. PMID:34132270. |
asymmetric construction of six vicinal stereogenic centers on hexahydroxanthones inspired by the chemistry and biology of hexahydroxanthones, herein we report an organocatalytic michael-michael-aldol-decarboxylation reaction that provides efficient access to biologically interesting fully substituted hexahydroxanthones bearing six contiguous stereogenic centers from readily accessible materials in acceptable yields (up to 63%) and excellent stereoselectivities (up to 10 : 1 dr and >99% ee). |
2021-07-12 |
2023-08-13 |
Not clear |
| Le-Song Wu, Yi Ding, Ye-Qiang Han, Bing-Feng Sh. Asymmetric Synthesis of γ-Lactams Containing α,β-Contiguous Stereocenters via Pd(II)-Catalyzed Cascade Methylene C(sp Organic letters. vol 23. issue 6. 2021-06-21. PMID:33683896. |
herein, an asymmetric c-h activation strategy for accessing α,β-stereospecific γ-lactams in good yields (≤79%) with high enantio- and diastereoselectivities (≤96% ee and >20:1 dr) was described, which serves as an effective supplement to the existing strategies. |
2021-06-21 |
2023-08-13 |
Not clear |
| Ke-Xin Huang, Ming-Sheng Xie, Ji-Wei Sang, Gui-Rong Qu, Hai-Ming Gu. Asymmetric Synthesis of 3-Amine-tetrahydrothiophenes with a Quaternary Stereocenter via Nickel(II)/Trisoxazoline-Catalyzed Sulfa-Michael/Aldol Cascade Reaction: Divergent Access to Chiral Thionucleosides. Organic letters. vol 23. issue 1. 2021-06-10. PMID:33332122. |
a generally useful ni(ii)/trisoxazoline-catalyzed asymmetric sulfa-michael/aldol cascade reaction is introduced to access chiral 3-amine-tetrahydrothiophene derivatives containing a quaternary stereocenter (32 examples, up to 93% yield, > 20:1 dr and 92% ee). |
2021-06-10 |
2023-08-13 |
Not clear |
| Ronei Delfino da Fonseca, Paulo Roberto Santos, Melissa Silva Monteiro, Luciana Alves Fernandes, Andreia Henrique Campos, Díbio L Borges, Suélia De Siqueira Rodrigues Fleury Ros. Parametric evaluation of impedance curve in radiofrequency ablation: A quantitative description of the asymmetry and dynamic variation of impedance in bovine ex vivo model. PloS one. vol 16. issue 1. 2021-05-10. PMID:33449951. |
based on these parameters, three performance indices are defined: one to identify the magnitude of impedance curve asymmetry (δ), one drop ratio (dr) describing the percentage of impedance decrease until the minimum impedance point is reached, and ascent ratio (ar) describing the magnitude of increase in impedance from the minimum impedance point to its maximum point. |
2021-05-10 |
2023-08-13 |
cattle |
| Shu-Fang Wu, Man-Su Tu, Qing-Qing Hang, Shu Zhang, Haixia Ding, Yu-Chen Zhang, Feng Sh. Construction of chiral chroman scaffolds via catalytic asymmetric (4 + 2) cyclizations of para-quinone methide derivatives with 3-vinylindoles. Organic & biomolecular chemistry. vol 18. issue 28. 2021-04-22. PMID:32617552. |
a catalytic asymmetric (4 + 2) cyclization of ortho-hydroxyphenyl-substituted para-quinone methide derivatives with 3-vinylindoles has been established in the presence of chiral phosphoric acid, which provides a series of chiral chroman derivatives bearing an indole moiety in generally high yields (up to 97%), and with good enantioselectivities (up to 90% ee) and moderate to good diastereoselectivities (up to 95 : 5 dr). |
2021-04-22 |
2023-08-13 |
Not clear |
| Yang-Zi Liu, Zhongao Wang, Zesheng Huang, Wu-Lin Yang, Wei-Ping Den. Sulfone as a Transient Activating Group in the Palladium-Catalyzed Asymmetric [4 + 3] Cycloaddition of Trimethylenemethane Enabling the Enantioselective Synthesis of Fused Azepines. Organic letters. vol 23. issue 3. 2021-02-05. PMID:33481618. |
the palladium-catalyzed asymmetric [4 + 3] cycloaddition of a sulfonyl-trimethylenemethane (tmm) donor with azadienes furnished various sulfonyl-fused azepines with exclusive regioselectivities and excellent stereoselectivities (up to >20:1 dr, >99% ee) in high yields (up to 93%). |
2021-02-05 |
2023-08-13 |
Not clear |
| Gavin Yong-Quan Ng, David Yang-Wei Fann, Dong-Gyu Jo, Christopher G Sobey, Thiruma V Arumuga. Epigenetic Regulation by Dietary Restriction: Part II. Conditioning medicine. vol 2. issue 6. 2021-01-10. PMID:32039346. |
it is highly plausible that epigenetic regulation by dr may help explain the asymmetric manifestation of dr effects in different individuals. |
2021-01-10 |
2023-08-13 |
Not clear |
| Li Zhou, Wen-Guang Yan, Xiu-Li Sun, Lijia Wang, Yong Tan. A Versatile Enantioselective Catalytic Cyclopropanation-Rearrangement Approach to the Divergent Construction of Chiral Spiroaminals and Fused Bicyclic Acetals. Angewandte Chemie (International ed. in English). vol 59. issue 43. 2020-12-17. PMID:32677727. |
remarkably, the asymmetric cp-ra for exocyclic vinyl substrates without a pro-stereogenic carbon at the β-position has been realized for the first time and a broad substrate scope with excellent results (33 examples; 34-99 % yields; >95/5 dr and 91-99 % ee) has been achieved. |
2020-12-17 |
2023-08-13 |
Not clear |
| Junwei Wang, Lei Zhao, Quanjin Rong, Cheng Lv, Yu Lu, Xiang Pan, Lin Zhao, Lihong H. Asymmetric Synthesis of 3,3'-Tetrahydrofuryl Spirooxindoles via Palladium-Catalyzed [3+2] Cycloadditions of Methyleneindolinones with Vinylethylene Carbonates. Organic letters. vol 22. issue 15. 2020-12-04. PMID:32790422. |
a palladium-catalyzed asymmetric [3+2] cycloaddition reaction of methyleneindolinones with vinylethylene carbonates has been successfully developed, which provides a highly efficient method for the synthesis of structurally diverse 3,3'-tetrahydrofuryl spirooxindoles in high yields (≤99%) with excellent stereoselectivities (>20:1 dr, ≤99% ee). |
2020-12-04 |
2023-08-13 |
Not clear |
| Zongpeng Zhang, Fan Xiao, Hui-Min Wu, Xiu-Qin Dong, Chun-Jiang Wan. Pd-Catalyzed Asymmetric Hydroalkylation of 1,3-Dienes: Access to Unnatural α-Amino Acid Derivatives Containing Vicinal Quaternary and Tertiary Stereogenic Centers. Organic letters. vol 22. issue 2. 2020-10-28. PMID:31895576. |
pd-phosphinooxazoline (pd-phox)-catalyzed asymmetric hydroalkylation of 1,3-dienes with azlactones was successfully developed for the first time, affording various enantioenriched α-quaternary α-amino acid derivatives bearing contiguous quaternary and tertiary stereogenic centers in good yields with exclusive regioselectivity and excellent stereoselective control (up to 92% yield, >20:1 dr, and >99% ee). |
2020-10-28 |
2023-08-13 |
Not clear |
| Yu-Qing Guan, Zhengyu Han, Xiuxiu Li, Cai You, Xuefeng Tan, Hui Lv, Xumu Zhan. A cheap metal for a challenging task: nickel-catalyzed highly diastereo- and enantioselective hydrogenation of tetrasubstituted fluorinated enamides. Chemical science. vol 10. issue 1. 2020-09-30. PMID:30746080. |
nickel-catalyzed asymmetric hydrogenation of challenging tetrasubstituted fluorinated enamides has been achieved, affording chiral α-fluoro-β-amino esters in high yields with excellent diastereo- and enantioselectivities (up to 98% yield, >99 : 1 dr, up to >99% ee). |
2020-09-30 |
2023-08-13 |
Not clear |
| Wei-Sian Li, Ting-Shen Kuo, Meng-Chi Hsieh, Ming-Kang Tsai, Ping-Yu Wu, Hsyueh-Liang W. Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines. Organic letters. vol 22. issue 14. 2020-09-28. PMID:32628021. |
reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the rh-catalyzed asymmetric allylation of aliphatic aldimines. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chu-Yi Huang, Ting Zhou, Ge Li, Ming-Yuan Li, Xiao-Ming Xiong, Mei-Ting Wu, Jun-Lin Jian. Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes. Amino acids. vol 51. issue 10-12. 2020-05-04. PMID:31576457. |
asymmetric dimethylarginine (adma) was reported to be elevated in dr patients. |
2020-05-04 |
2023-08-13 |
rat |
| Bin Lu, Xiaoyu Wu, Chengyang Li, Guangni Ding, Wanfang Li, Xiaomin Xie, Zhaoguo Zhan. Highly Diastereo- and Enantioselective Access to syn-α-Amido β-Hydroxy Esters via Ruthenium-Catalyzed Dynamic Kinetic Resolution-Asymmetric Hydrogenation. The Journal of organic chemistry. vol 84. issue 6. 2020-03-31. PMID:30776889. |
dynamic kinetic resolution (dkr) of racemic aryl α-amino β-ketoesters via ru-diphosphine-catalyzed asymmetric hydrogenation was realized at 70 °c under 50 atm of hydrogen, affording syn α-amido β-hydroxy esters in high yields (up to 96%) with high reactivity (ton up to 940) and diastereo- and enantioselectivities (up to 99:1 dr, 98% ee). |
2020-03-31 |
2023-08-13 |
Not clear |
| Xiaoping Li, Juzhang Yan, Jialiang Qin, Shilin Lin, Weiwen Chen, Ruoting Zhan, Huicai Huan. Enantioselective Synthesis of Benzofuran-Fused N-Heterocycles via Chiral Squaramide Catalyzed [4 + 2] Cyclization of Azadienes with Azlactones. The Journal of organic chemistry. vol 84. issue 12. 2020-03-31. PMID:31188599. |
an asymmetric cyclization reaction of azadienes and azlactones was investigated by employing a cinchona squaramide catalyst, which could afford a series of benzofuran-fused six-membered heterocycles containing a α,α-disubstituted amino acid unit in a highly diastereoselective (>20:1 dr) and enantioselective (up to 99% ee) manner with good to excellent yields (up to 92%). |
2020-03-31 |
2023-08-13 |
Not clear |
| Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A Mejias-Aponte, Jorge A Gomez, Gabriel E Mateo-Semidey, Gerard M J Beaudoin, Carlos A Paladini, Joseph F Cheer, Marisela Morale. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell reports. vol 26. issue 5. 2020-03-13. PMID:30699344. |
here, we show that dr serotonin transporter (sert) neurons establish both asymmetric and symmetric synapses on vta dopamine neurons, but most of these synapses are asymmetric. |
2020-03-13 |
2023-08-13 |
Not clear |
| Yusuke Miyazaki, Biao Zhou, Hiroaki Tsuji, Motoi Kawatsur. Nickel-Catalyzed Asymmetric Friedel-Crafts Propargylation of 3-Substituted Indoles with Propargylic Carbonates Bearing an Internal Alkyne Group. Organic letters. vol 22. issue 5. 2020-03-06. PMID:32073861. |
a wide array of the propargylic carbonates as well as 3-substituted indoles can be applicable to the asymmetric nickel catalysis, providing the corresponding chiral c-3 propargylated indolenine derivatives bearing two vicinal chiral centers in up to 89% yield with up to >99% ee and 94:6 dr (24 examples). |
2020-03-06 |
2023-08-13 |
Not clear |
| Saumen Hajra, Suhas Shivajirao Bhosale, Atanu Hazra, Nikhil Kanauji. The one pot asymmetric synthesis of 3,3'-pyrrolidonyl spiroxindoles via a regio- and stereoselective domino reaction. Organic & biomolecular chemistry. vol 17. issue 35. 2019-12-10. PMID:31432867. |
a highly efficient regio- and stereoselective domino aziridine ring opening and lactamization reaction between aziridines and 3-carboxy oxindole esters has been developed for the one pot asymmetric synthesis of 4-aryl-3,3'-spiropyrrolidonyl oxindoles with excellent selectivity (dr >99 : 1 and ee up to >99%). |
2019-12-10 |
2023-08-13 |
Not clear |
| Youran Liu, Fei Chen, Yan-Mei He, Chenghao Li, Qing-Hua Fa. Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation. Organic & biomolecular chemistry. vol 17. issue 20. 2019-12-02. PMID:31070209. |
excellent enantio- and diastereoselectivity (up to 99% ee and >20 : 1 dr), and/or unprecedented chemoselectivity were obtained in the asymmetric hydrogenation of 2,4-diaryl-3h-benzo[b]azepines and 2,4-diaryl-3h-benzo[b][1,4]diazepines. |
2019-12-02 |
2023-08-13 |
Not clear |