| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Jin, Juyeol Lee, Hu Shi, Jin Yong Lee, Eun Jeong Yoo, Choong Eui Song, Do Hyun Ry. Bioinspired Synthesis of Chiral 3,4-Dihydropyranones via S-to-O Acyl-Transfer Reactions. Organic letters. vol 20. issue 6. 2018-06-28. PMID:29484883. |
asymmetric michael addition-lactonization reactions of β,γ-unsaturated α-keto esters with thioesters are catalyzed by proline-derived urea, providing 3,4-dihydropyranones and spiro-3,4-dihydrocoumarin-fused 3',4'-dihydropyranones in high yield (up to 94%) with excellent stereoselectivities (up to >20:1 dr, 99% ee) under catalyst loadings as low as 1 mol %. |
2018-06-28 |
2023-08-13 |
Not clear |
| Yuyu Cheng, Yuzhe Han, Pengfei L. Organocatalytic Enantioselective [1 + 4] Annulation of Morita-Baylis-Hillman Carbonates with Electron-Deficient Olefins: Access to Chiral 2,3-Dihydrofuran Derivatives. Organic letters. vol 19. issue 18. 2018-06-19. PMID:28846432. |
morita-baylis-hillman carbonates reacted smoothly with β,γ-unsaturated α-keto ester and α,β-unsaturated ketone substrates under 1,2-bis[(2r,5r)-2,5-dimethylphospholano]benzene monoxide catalysis to furnish a wide range of optically active 2,3-dihydrofurans in high yields (up to 95%) with excellent asymmetric induction (up to >99% ee, >20:1 dr). |
2018-06-19 |
2023-08-13 |
Not clear |
| Weilong Wu, Cai You, Congcong Yin, Yuanhua Liu, Xiu-Qin Dong, Xumu Zhan. Enantioselective and Diastereoselective Construction of Chiral Amino Alcohols by Iridium-f-Amphox-Catalyzed Asymmetric Hydrogenation via Dynamic Kinetic Resolution. Organic letters. vol 19. issue 10. 2018-06-13. PMID:28448152. |
the iridium-f-amphox-catalyzed asymmetric hydrogenation of racemic α-amino β-unfunctionalized ketones proceeds via a dkr (dynamic kinetic resolution) process for the construction of various chiral n,n-disubstituted α-amino β-unfunctionalized alcohols in quantitative yields with excellent enantioselectivities and diastereoselectivities (all products >99% ee and >99:1 dr, ton up to 100 000). |
2018-06-13 |
2023-08-13 |
Not clear |
| K C Nicolaou, Guodu Liu, Kathryn Beabout, Megan D McCurry, Yousif Shamo. Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents. Journal of the American Chemical Society. vol 139. issue 10. 2018-06-04. PMID:28256128. |
utilizing mild basic conditions and as low as 0.5 mol % catalyst loading, and achieving up to >99:1 dr selectivity, this asymmetric reaction was successfully applied to produce enantioselectively (-)- and (+)-viridicatumtoxins b, and thus allowed assignment of the absolute configuration of this naturally occurring antibiotic. |
2018-06-04 |
2023-08-13 |
Not clear |
| Vadlamuri Veeraswamy, Gaurav Goswami, Satobhisha Mukherjee, Koena Ghosh, Manik Lal Saha, Arunava Sengupta, Manas K Ghora. Memory of Chirality Concept in Asymmetric Intermolecular Michael Addition of α-Amino Ester Enolates to Enones and Nitroalkenes. The Journal of organic chemistry. vol 83. issue 3. 2018-06-04. PMID:29272115. |
a highly stereoselective asymmetric intermolecular conjugate addition of α-amino ester derivatives to cyclic enones via the memory of chirality (moc) concept in high yields with excellent diastereo- and enantioselectivity (dr >99:1, up to 99% ee) is reported. |
2018-06-04 |
2023-08-13 |
Not clear |
| Lin-Zhi Li, Cong-Shuai Wang, Wei-Feng Guo, Guang-Jian Mei, Feng Sh. Catalytic Asymmetric [4+2] Cycloaddition of in Situ Generated o-Quinone Methide Imines with o-Hydroxystyrenes: Diastereo- and Enantioselective Construction of Tetrahydroquinoline Frameworks. The Journal of organic chemistry. vol 83. issue 2. 2018-06-04. PMID:29276884. |
a catalytic asymmetric [4+2] cycloaddition of ortho-quinone methide imines in situ generated from o-aminobenzyl alcohols with o-hydroxystyrenes has been established under the catalysis of chiral phosphoramide, which afforded chiral tetrahydroquinolines in moderate to good yields, good enantioselectivities, and excellent diastereoselectivities (up to 82% yield, 93:7 er, all >95:5 dr). |
2018-06-04 |
2023-08-13 |
Not clear |
| Ji-Wei Ren, Jing Wang, Jun-An Xiao, Jun Li, Hao-Yue Xiang, Xiao-Qing Chen, Hua Yan. L-Pyroglutamic Sulphonamide as Hydrogen-Bonding Organocatalyst: Enantioselective Diels-Alder Cyclization to Construct Carbazolespirooxindoles. The Journal of organic chemistry. vol 82. issue 12. 2018-05-28. PMID:28558239. |
the newly designed catalyst was successfully applied in catalyzing asymmetric diels-alder cyclization of methyleneindolinones with 2-vinyl-1h-indoles to efficiently assemble carbazolespirooxindoles in excellent stereoselectivity (up to 99% ee, >20:1 dr) and yields (up to 99%). |
2018-05-28 |
2023-08-13 |
Not clear |
| Xing Yang, Shuai Pang, Feng Cheng, Yue Zhang, Ya-Wei Lin, Quan Yuan, Fang-Lin Zhang, Yi-Yong Huan. Enantioselective Synthesis of 1,3-Disubstituted 1,3-Dihydroisobenzofurans via a Cascade Allylboration/Oxo-Michael Reaction of o-Formyl Chalcones Catalyzed by a Chiral Phosphoric Acid. The Journal of organic chemistry. vol 82. issue 19. 2018-05-28. PMID:28886243. |
the first chiral brønsted acid-catalyzed asymmetric cascade allylboration/oxo-michael reaction between o-formyl chalcones and allylboronate has been successfully discovered, which afforded chiral 1,3-disubstituted 1,3-dihydroisobenzofurans with a yield, diastereoselective ratio (dr) and enantioselective excess (ee) up to 94%, 2.5:1, and 98%, respectively. |
2018-05-28 |
2023-08-13 |
Not clear |
| Xue Yang, Yu-Chen Zhang, Qiu-Ning Zhu, Man-Su Tu, Feng Sh. Diastereo- and Enantioselective Construction of the Hexahydrocoumarin Scaffold via an Organocatalytic Asymmetric [3 + 3] Cyclization. The Journal of organic chemistry. vol 81. issue 12. 2018-05-16. PMID:27164054. |
besides, this reaction also realized the first catalytic asymmetric [3 + 3] cyclization of 4-arylidene-2-aryloxazol-5(4h)-ones with cyclohexane-1,3-diones, which afforded structurally diverse 3-aminohexahydrocoumarin derivatives in excellent diastereoselectivities and high enantioselectivities (all >95:5 dr, up to 96:4 er). |
2018-05-16 |
2023-08-13 |
Not clear |
| Ming Yu Jin, Juncheng Li, Renke Huang, Yuxuan Zhou, Lung Wa Chung, Jun Joelle Wan. Catalytic asymmetric trifluoromethylthiolation of carbonyl compounds via a diastereo and enantioselective Cu-catalyzed tandem reaction. Chemical communications (Cambridge, England). vol 54. issue 36. 2018-05-08. PMID:29667658. |
the tandem reaction enables the asymmetric integration of the -scf3 group to carbonyl compounds, establishing chiral tertiary α-carbon centers and affording α-scf3-β-substituted carbonyl compounds in 50-92% yields with up to 20 : 1 dr and 96% ee. |
2018-05-08 |
2023-08-13 |
Not clear |
| Ke Li, Juxiang Wang, Kailin Wu, Daijun Zheng, Xiaojian Zhou, Wenyong Han, Nanwei Wan, Baodong Cui, Yongzheng Che. Enantioselective synthesis of 1,2,3,4-tetrahydroquinoline-4-ols and 2,3-dihydroquinolin-4(1H)-ones via a sequential asymmetric hydroxylation/diastereoselective oxidation process using Rhodococcus equi ZMU-LK19. Organic & biomolecular chemistry. vol 15. issue 17. 2018-04-26. PMID:28177033. |
a cascade biocatalysis system involving asymmetric hydroxylation and diastereoselective oxidation was developed using rhodococcus equi zmu-lk19, which gave chiral 2-substituted-1,2,3,4-tetrahydroquinoline-4-ols (2) (up to 57% isolated yield, 99 : 1 dr, and >99% ee) and chiral 2-substituted-2,3-dihydroquinolin-4(1h)-ones (3) (up to 25% isolated yield, and >99% ee) from (±)-2-substituted-tetrahydroquinolines (1). |
2018-04-26 |
2023-08-13 |
Not clear |
| Ai-Bao Xia, Xiao-Long Zhang, Cheng-Ke Tang, Kai-Xiang Feng, Xiao-Hua Du, Dan-Qian X. One-pot asymmetric synthesis of a spiro[dihydrofurocoumarin/pyrazolone] scaffold by a Michael addition/I Organic & biomolecular chemistry. vol 15. issue 27. 2018-03-26. PMID:28650044. |
one-pot asymmetric synthesis of a spiro[dihydrofurocoumarin/pyrazolone] scaffold by a michael addition/i an asymmetric formal one-pot reaction of 4-hydroxycoumarins with unsaturated pyrazolones has been developed by merging a chiral bifunctional organocatalyst with molecular iodine, which furnished a series of optically active spiro[dihydrofurocoumarin/pyrazolone] heterocycles with spiro quaternary stereogenic centers in moderate to excellent yields (up to 99%) with excellent diastereoselectivities (up to >99 : 1 dr) and good to excellent enantioselectivities (up to 99% ee). |
2018-03-26 |
2023-08-13 |
Not clear |
| Can Li, Han Lu, Xiao-Xue Sun, Guang-Jian Mei, Feng Sh. Diastereo- and enantioselective construction of spirooxindole scaffolds through a catalytic asymmetric [3 + 3] cycloaddition. Organic & biomolecular chemistry. vol 15. issue 22. 2018-01-26. PMID:28537296. |
a chiral phosphoric acid-catalyzed asymmetric [3 + 3] cycloaddition of c3-substituted 2-indolylmethanols with isatin-derived azomethine ylides has been established, which afforded chiral spirooxindoles in considerable yields, moderate to good enantioselectivities and excellent diastereoselectivities (up to 85% yield, 96 : 4 er, all >95 : 5 dr). |
2018-01-26 |
2023-08-13 |
Not clear |
| Zhen-Yu Wang, Shu-Rong Ban, Meng-Chen Yang, Qing-Shan L. Highly enantioselective Michael addition of cyclohexanone to nitroolefins catalyzed by pyrrolidine-based bifunctional benzoylthiourea in water. Chirality. vol 28. issue 11. 2017-06-14. PMID:27791318. |
herein, we used pyrrolidine-based benzoylthiourea 1c to catalyze the asymmetric michael addition of cyclohexanone to various nitroolefins in water to afford the corresponding compounds in moderate to good yields, and with excellent diastereoselectivities (up to >99:1 dr) and enantioselectivities (up to 99% ee). |
2017-06-14 |
2023-08-13 |
Not clear |
| Dan-Jie Zhang, Ming-Sheng Xie, Gui-Rong Qu, Yao-Wei Gao, Hai-Ming Gu. Synthesis of Azacyclic Nucleoside Analogues via Asymmetric [3 + 2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines. Organic letters. vol 18. issue 4. 2016-07-19. PMID:26844591. |
with 9-(2-tosylvinyl)-9h-purines as the dipolarophiles, a series of chiral azacyclic nucleosides with four continuous stereocenters were obtained in 86-99% yields, >20:1 dr, and 94 → 99% ee via the cu(i)-catalyzed asymmetric [3 + 2] cycloaddition. |
2016-07-19 |
2023-08-13 |
Not clear |
| Xiao-Xue Sun, Hong-Hao Zhang, Guo-Hao Li, Li Meng, Feng Sh. Diastereo- and enantioselective construction of an indole-based 2,3-dihydrobenzofuran scaffold via catalytic asymmetric [3+2] cyclizations of quinone monoimides with 3-vinylindoles. Chemical communications (Cambridge, England). vol 52. issue 14. 2016-06-29. PMID:26783564. |
the first catalytic asymmetric [3+2] cyclization of quinone monoimides with olefins has been established, which employed 3-vinylindoles as a class of competent olefins and spiro-chiral phosphoric acid as a powerful chiral catalyst, leading to chemo-, diastereo- and enantioselective construction of a biologically important 2,3-dihydrobenzofuran framework with optical purity (up to 99% yield, >95 : 5 dr, 96 : 4 er). |
2016-06-29 |
2023-08-13 |
Not clear |
| Tohru Sekikawa, Takayuki Kitaguchi, Hayato Kitaura, Tatsuya Minami, Yasuo Hatanak. Anti-Selective Asymmetric Nitro-Michael Reaction of Furanones: Diastereocontrol by Catalyst. Organic letters. vol 18. issue 4. 2016-06-24. PMID:26835718. |
catalyst-controlled switching of diastereoselectivity from high syn-selectivity (>98/2 dr, syn) to anti-selectivity (up to 96/4 dr, anti) of the asymmetric nitro-michael reaction of furanones is described. |
2016-06-24 |
2023-08-13 |
Not clear |
| Ai-Bao Xia, Can Zhang, Yan-Peng Zhang, Yan-Jun Guo, Xiao-Long Zhang, Zhao-Bo Li, Dan-Qian X. Jørgensen-Hayashi catalysts supported on poly(ethylene glycol)s as highly efficient and reusable organocatalysts for the enamine-catalyzed asymmetric Michael reaction. Organic & biomolecular chemistry. vol 13. issue 37. 2016-06-21. PMID:26257265. |
a new kind of recyclable and reusable peg-supported jørgensen-hayashi catalyst is synthesized for the first time and proven to be efficient for the enamine-catalyzed asymmetric michael reaction with generally moderate to good diastereoselectivity and high to excellent enantioselectivity (up to 6 : 1 dr, 99% ee). |
2016-06-21 |
2023-08-13 |
Not clear |
| Yue-Ming Wang, Hong-Hao Zhang, Can Li, Tao Fan, Feng Sh. Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derived imines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3'-oxindole] framework. Chemical communications (Cambridge, England). vol 52. issue 9. 2016-06-20. PMID:26530257. |
a catalytic asymmetric chemoselective 1,3-dipolar cycloaddition (1,3-dc) of an azomethine ylide with imines has been established via a three-component reaction of isatin-derived imines, aldehydes and an amino-ester in the presence of chiral phosphoric acid, which efficiently constructed biologically important spiro[imidazolidine-2,3'-oxindole] frameworks in good yields, and with high diastereo- and enantioselectivities (up to 76% yield, 97 : 3 er, all >95 : 5 dr). |
2016-06-20 |
2023-08-13 |
Not clear |
| Wei Dai, Xiao-Li Jiang, Ji-Yu Tao, Feng Sh. Application of 3-Methyl-2-vinylindoles in Catalytic Asymmetric Povarov Reaction: Diastereo- and Enantioselective Synthesis of Indole-Derived Tetrahydroquinolines. The Journal of organic chemistry. vol 81. issue 1. 2016-04-27. PMID:26652222. |
the first application of 3-methyl-2-vinylindoles in catalytic asymmetric povarov reactions has been established via the three-component reactions of 3-methyl-2-vinylindoles, aldehydes, and anilines in the presence of chiral phosphoric acid, providing easy access to chiral indole-derived tetrahydroquinolines with three contiguous stereogenic centers at high yields (up to 99%) and with excellent diastereo- and enantioselectivities (all >95:5 dr, up to 96% ee). |
2016-04-27 |
2023-08-13 |
Not clear |