| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Tao He, Yi-Shuang Zhao, Ping Tian, Chuan-Chuan Wang, Han-Qing Dong, Guo-Qiang Li. Copper-catalyzed asymmetric hydroboration of α-dehydroamino acid derivatives: facile synthesis of chiral β-hydroxy-α-amino acids. Organic letters. vol 16. issue 5. 2014-06-09. PMID:24528372. |
the cu-catalyzed asymmetric conjugate hydroboration reaction of β-substituted α-dehydroamino acid derivatives has been established, affording enantioenriched syn- and anti-β-boronate-α-amino acid derivatives with excellent combined yields (83-99%, dr ≈ 1:1) and excellent enantioselectivities (92-98% ee). |
2014-06-09 |
2023-08-12 |
Not clear |
| Haibo Mei, Chen Xie, Lingmin Wu, Vadim A Soloshonok, Jianlin Han, Yi Pa. Asymmetric Mannich reactions of imidazo[2,1-b]thiazole-derived nucleophiles with (S(S))-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine. Organic & biomolecular chemistry. vol 11. issue 46. 2014-05-22. PMID:24163018. |
asymmetric mannich reactions of imidazo[2,1-b]thiazole-derived nucleophiles with (ss)-n-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine were found to proceed with reasonably good yields (55%-79%) and exceptionally high stereoselectivity (>99 : 1 dr). |
2014-05-22 |
2023-08-12 |
Not clear |
| Padmanabha V Kattamuri, Yiwen Xiong, Yi Pan, Guigen L. N,N-DIIsopropyl-N-phosphonyl imines lead to efficient asymmetric synthesis of aziridine-2-carboxylic esters. Organic & biomolecular chemistry. vol 11. issue 20. 2014-05-06. PMID:23563304. |
highly diastereoselective asymmetric synthesis of chiral aziridine-2-carboxylic esters is reported for 20 examples with good yields (51-87%) and excellent diastereoselectivities (>99:1 dr for most cases). |
2014-05-06 |
2023-08-12 |
Not clear |
| Jian-Bo Xie, Jian Luo, Timothy R Winn, David B Cordes, Guigen L. Group-assisted purification (GAP) chemistry for the synthesis of Velcade via asymmetric borylation of N-phosphinylimines. Beilstein journal of organic chemistry. vol 10. 2014-04-29. PMID:24778728. |
it was found that the optically pure isomer (dr > 99:1) can be readily obtained by washing the crude mixture of the asymmetric borylation reaction with hexane; the chiral n-phosphinyl auxiliary can be easily recovered after deprotection is finished. |
2014-04-29 |
2023-08-13 |
Not clear |
| Jinlong Zhang, Xihong Liu, Xiaojuan Ma, Rui Wan. Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam. Chemical communications (Cambridge, England). vol 49. issue 81. 2014-04-03. PMID:24000339. |
highly efficient asymmetric vinylogous 1,6-michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl-isoxazoles and michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25 : 1 dr and 96% ee). |
2014-04-03 |
2023-08-12 |
Not clear |
| Yunfei Cai, Xiaohua Liu, Pengfei Zhou, Yulong Kuang, Lili Lin, Xiaoming Fen. Iron-catalyzed asymmetric haloamination reactions. Chemical communications (Cambridge, England). vol 49. issue 73. 2014-03-10. PMID:23903004. |
the first iron(iii)/n,n'-dioxide-catalyzed asymmetric haloamination of 3-alkylidene- and 3-arylidene-indolin-2-ones was developed, affording the corresponding chiral oxindole derivatives bearing vicinal haloamine substituents with excellent results (up to 99% yield, 99% ee, >19 : 1 dr). |
2014-03-10 |
2023-08-12 |
Not clear |
| Alyn T Davies, James E Taylor, James Douglas, Christopher J Collett, Louis C Morrill, Charlene Fallan, Alexandra M Z Slawin, Gwydion Churchill, Andrew D Smit. Stereospecific asymmetric N-heterocyclic carbene (NHC)-catalyzed redox synthesis of trifluoromethyl dihydropyranones and mechanistic insights. The Journal of organic chemistry. vol 78. issue 18. 2014-02-28. PMID:23957790. |
n-heterocyclic carbene (nhc)-catalyzed redox asymmetric hetero-diels-alder reactions of α-aroyloxyaldehydes with β-trifluoromethyl enones generates synthetically useful dihydropyranones containing a stereogenic trifluoromethyl substituent in good yields (up to 81%) and excellent diastereoselectivity and enantioselectivity (up to >95:5 dr and >99% ee). |
2014-02-28 |
2023-08-12 |
Not clear |
| Peter J Rayner, Peter O'Brien, Richard A J Hora. Preparation and reactions of enantiomerically pure α-functionalized Grignard reagents. Journal of the American Chemical Society. vol 135. issue 21. 2013-12-06. PMID:23647498. |
the approach involves the synthesis of α-alkoxy and α-amino sulfoxides in ≥99:1 dr and ≥99:1 er via asymmetric deprotonation (s-buli/chiral diamine) and trapping with andersen's sulfinate (menthol derived). |
2013-12-06 |
2023-08-12 |
Not clear |
| Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei, Jinxing Y. Aminocatalyzed asymmetric Diels-Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives. Chemical communications (Cambridge, England). vol 49. issue 21. 2013-09-12. PMID:23389754. |
aminocatalyzed asymmetric diels-alder reaction between 2,4-dienals and rhodanine/hydantoin derivatives via trienamine mechanism has been developed to synthesize various spirocyclic compounds with good yields (up to 98%) and excellent stereoselectivities (up to 99% ee and >19 : 1 dr). |
2013-09-12 |
2023-08-12 |
Not clear |
| Jonathan T Reeves, Daniel R Fandrick, Zhulin Tan, Jinhua J Song, Sonia Rodriguez, Bo Qu, Soojin Kim, Oliver Niemeier, Zhibin Li, Denis Byrne, Scot Campbell, Ashish Chitroda, Phil DeCroos, Thomas Fachinger, Victor Fuchs, Nina C Gonnella, Nelu Grinberg, Nizar Haddad, Burkhard Jäger, Heewon Lee, Jon C Lorenz, Shengli Ma, Bikshandarkoil A Narayanan, Larry J Nummy, Ajith Premasiri, Frank Roschangar, Max Sarvestani, Sherry Shen, Earl Spinelli, Xiufeng Sun, Richard J Varsolona, Nathan Yee, Michael Brenner, Chris H Senanayak. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4. The Journal of organic chemistry. vol 78. issue 8. 2013-08-12. PMID:23544738. |
subsequently, an asymmetric propargylation was developed which provided the desired diastereomer in 4:1 diastereoselectivity and 75% yield with dr = 99:1 after crystallization. |
2013-08-12 |
2023-08-12 |
Not clear |
| Tian-You Qin, Wei-Wei Liao, Yan-Jing Zhang, Sean Xiao-An Zhan. Asymmetric organocatalytic allylic alkylation of Reissert compounds: a facile access to chiral 1,1-disubstituted 1,2-dihydroisoquinolines. Organic & biomolecular chemistry. vol 11. issue 6. 2013-06-28. PMID:23283114. |
the first asymmetric organocatalytic allylic alkylation of 1,2-dihydro-reissert compounds and morita-baylis-hillman (mbh) carbonates has been developed, which provided a novel protocol to construct enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers at c-1 position (up to 94% ee, dr > 20 : 1). |
2013-06-28 |
2023-08-12 |
Not clear |
| Luping Liu, Yuan Zhong, Panpan Zhang, Xianxing Jiang, Rui Wan. Core scaffold-inspired stereoselective synthesis of spiropyrazolones via an organocatalytic Michael/cyclization sequence. The Journal of organic chemistry. vol 77. issue 22. 2013-05-10. PMID:23072426. |
herein, the organocatalytic asymmetric michael/cyclization sequence of α-isothiocyanato imides and esters with a variety of unsaturated pyrazolones is presented, in general, affording functionalized spiropyrazolones containing three contiguous stereogenic centers in high levels of diastereo- and enantioselectivity (up to 20:1 dr and 99% ee). |
2013-05-10 |
2023-08-12 |
Not clear |
| Luca Deiana, Samson Afewerki, Carlos Palo-Nieto, Oscar Verho, Eric V Johnston, Armando Córdov. Highly enantioselective cascade transformations by merging heterogeneous transition metal catalysis with asymmetric aminocatalysis. Scientific reports. vol 2. 2013-04-16. PMID:23152942. |
the preparative power of this process has been demonstrated in the context of asymmetric cascade michael/carbocyclization transformations that delivers cyclopentenes bearing an all carbon quaternary stereocenters in high yields with up to 30:1 dr and 99% ee. |
2013-04-16 |
2023-08-12 |
Not clear |
| Ganesh Pandey, Priyanka A Adate, Vedavati G Purani. Organocatalytic dynamic kinetic resolution via conjugate addition: synthesis of chiral trans-2,5-dialkylcyclohexanones. Organic & biomolecular chemistry. vol 10. issue 41. 2013-02-21. PMID:22972151. |
a novel strategy of initiating an organocatalysed dynamic kinetic resolution (dr up to 99 : 1 and er up to 94 : 6) for the synthesis of chiral trans-2,5-dialkylcyclohexanones by an asymmetric conjugate addition of dimethyl malonate on to 6-substituted cyclohexenones is reported. |
2013-02-21 |
2023-08-12 |
Not clear |
| Lu Liu, Ryan Sarkisian, Zhenghu Xu, Hong Wan. Asymmetric Michael addition of ketones to alkylidene malonates and allylidene malonates via enamine-metal Lewis acid bifunctional catalysis. The Journal of organic chemistry. vol 77. issue 17. 2013-01-10. PMID:22877155. |
novel enamine-metal lewis acid bifunctional catalysts were successfully applied to the asymmetric michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). |
2013-01-10 |
2023-08-12 |
Not clear |
| Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu, Jinxing Y. Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine. Chemical communications (Cambridge, England). vol 48. issue 73. 2013-01-02. PMID:22864403. |
a diamine-catalyzed asymmetric tandem reaction between α,β-unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20:1 dr). |
2013-01-02 |
2023-08-12 |
Not clear |
| Feng Shi, Gui-Juan Xing, Zhong-Lin Tao, Shi-Wei Luo, Shu-Jiang Tu, Liu-Zhu Gon. An asymmetric organocatalytic Povarov reaction with 2-hydroxystyrenes. The Journal of organic chemistry. vol 77. issue 16. 2012-12-19. PMID:22827481. |
an organocatalytic asymmetric three-component povarov reaction involving 2-hydroxystyrenes has been established to provide an efficient method to access structurally diverse cis-disubstituted tetrahydroquinolines in high stereoselectivities of up to >99:1 dr and 97% ee. |
2012-12-19 |
2023-08-12 |
Not clear |
| Anzhelika Kabro, Eduardo C Escudero-Adán, Vladimir V Grushin, Piet W N M van Leeuwe. Biomass conversion to high value chemicals: from furfural to chiral hydrofuroins in two steps. Organic letters. vol 14. issue 15. 2012-12-07. PMID:22831386. |
catalytic asymmetric transfer hydrogenation of rac-furoin and furil produces hydrofuroin with up to 99% ee and 9:1 dr. |
2012-12-07 |
2023-08-12 |
Not clear |
| Xin Huang, Jin Peng, Lin Dong, Ying-Chun Che. Asymmetric assembly of 2-oxindole and α-angelica lactone units to construct vicinal quaternary chiral centers. Chemical communications (Cambridge, England). vol 48. issue 18. 2012-05-16. PMID:22267122. |
the first organocatalytic asymmetric assembly of morita-baylis-hillman carbonates of isatins and α-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr >95:5). |
2012-05-16 |
2023-08-12 |
Not clear |
| Saumen Hajra, Debarshi Sinh. Catalytic enantioselective aziridoarylation of aryl cinnamyl ethers toward synthesis of trans-3-amino-4-arylchromans. The Journal of organic chemistry. vol 76. issue 18. 2012-02-17. PMID:21797274. |
combination of suitable copper catalyst and chiral bis-oxazoline ligand was found to be very efficient for asymmetric aziridination followed by intramolecular arylation (friedel-crafts) reaction to provide a general and direct method for the synthesis of trans-3-amino-4-arylchromans with high regio-, diastereo- (dr > 99:1), and enantioselectivity (up to 95% ee) with moderate yield. |
2012-02-17 |
2023-08-12 |
Not clear |