| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Wu, Yong Liu, Lishuo Liu, Qiang Meng, Changwang Du, Kuo Li, Shan Dong, Yong Zhang, Huanfa Li, Hua Zhan. Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34261484. |
knockout of bmal1 in hippocampal dentate gyrus (dg) neurons of bmal1 |
2021-08-12 |
2023-08-13 |
human |
| Victor Rodrigues Santos, Igor Santana Melo, Amanda Larissa Dias Pacheco, Olagide Wagner de Castr. Life and death in the hippocampus: What's bad? Epilepsy & behavior : E&B. vol 121. issue Pt B. 2021-08-11. PMID:31759972. |
classically, neurodegeneration affects sensitive areas of the hippocampus, such as dentate gyrus (dg) hilus, as well as specific fields of the ammon's horn, ca3, and ca1. |
2021-08-11 |
2023-08-13 |
Not clear |
| Priya Gami-Patel, Irene van Dijken, Lieke H Meeter, Shamiram Melhem, Tjado H J Morrema, Wiep Scheper, John C van Swieten, Annemieke J M Rozemuller, Anke A Dijkstra, Jeroen J M Hoozeman. Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cells. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-08-11. PMID:32865835. |
in the hippocampus, overall levels of pperk and peif2α were higher in c9-ftd, including in granule cells of the dentate gyrus (dg). |
2021-08-11 |
2023-08-13 |
human |
| Priya Gami-Patel, Irene van Dijken, Lieke H Meeter, Shamiram Melhem, Tjado H J Morrema, Wiep Scheper, John C van Swieten, Annemieke J M Rozemuller, Anke A Dijkstra, Jeroen J M Hoozeman. Unfolded protein response activation in C9orf72 frontotemporal dementia is associated with dipeptide pathology and granulovacuolar degeneration in granule cells. Brain pathology (Zurich, Switzerland). vol 31. issue 1. 2021-08-11. PMID:32865835. |
in addition, increased levels of ck1δ were observed in granule cells in the dg of the hippocampus and granular layer of the cerebellum in c9-ftd. |
2021-08-11 |
2023-08-13 |
human |
| Elham Taha, Sudarshan Patil, Iliana Barrera, Julia Panov, Mohammad Khamaisy, Christopher G Proud, Clive R Bramham, Kobi Rosenblu. eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. Current biology : CB. vol 30. issue 18. 2021-08-09. PMID:32707059. |
levels of adult neurogenesis in the dentate gyrus (dg) of the hippocampus are correlated with unique cognitive functions. |
2021-08-09 |
2023-08-13 |
mouse |
| Ruxin Xie, Zhongke Wang, Tianyao Liu, Rui Xiao, Keyi Lv, Chuan Wu, Yi Luo, Yun Cai, Xiaotang Fa. AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function. Frontiers in cell and developmental biology. vol 9. 2021-07-31. PMID:34327201. |
gene silencing of trpc6 was performed by injecting adeno-associated virus (aav) expressing trpc6-specific shrna (shrna-trpc6) into the hippocampal dentate gyrus (dg). |
2021-07-31 |
2023-08-13 |
mouse |
| David Alcantara-Gonzalez, Elissavet Chartampila, Chiara Criscuolo, Helen E Scharfma. Early changes in synaptic and intrinsic properties of dentate gyrus granule cells in a mouse model of Alzheimer's disease neuropathology and atypical effects of the cholinergic antagonist atropine. Neurobiology of disease. vol 152. 2021-07-30. PMID:33484828. |
several studies have suggested that the hippocampal dentate gyrus (dg) may be an important area where hyperexcitability occurs. |
2021-07-30 |
2023-08-13 |
mouse |
| Pim R A Heckman, Femke Roig Kuhn, Frank Raven, Youri G Bolsius, Jos Prickaerts, Peter Meerlo, Robbert Haveke. Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation. Synapse (New York, N.Y.). vol 74. issue 6. 2021-07-29. PMID:32056276. |
in the present study, we assessed in mice whether sd also affects spatial pattern separation, a cognitive process that specifically requires the dentate gyrus (dg) subregion of the hippocampus. |
2021-07-29 |
2023-08-13 |
mouse |
| Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Y. Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat. Neuropharmacology. vol 194. 2021-07-28. PMID:34062164. |
in the present study, we screened mirna expression profiles and found that mir-211-5p was significantly down-regulated within the dentate gyrus (dg) hippocampus in the chronic unpredictable mild stress (cums) induced rat model of depression. |
2021-07-28 |
2023-08-13 |
rat |
| Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Y. Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat. Neuropharmacology. vol 194. 2021-07-28. PMID:34062164. |
taken together, the results of our study reveal that altered levels of mir-211-5p in the hippocampal dg area exert a significant impact on neurogenesis, apoptosis and thus depression-like behaviors in rats. |
2021-07-28 |
2023-08-13 |
rat |
| Poornima D E Weerasinghe-Mudiyanselage, Mary Jasmin Ang, Mai Wada, Sung-Ho Kim, Taekyun Shin, Miyoung Yang, Changjong Moo. Acute MPTP Treatment Impairs Dendritic Spine Density in the Mouse Hippocampus. Brain sciences. vol 11. issue 7. 2021-07-27. PMID:34201837. |
golgi staining showed that acute mptp treatment significantly reduced the spine density of neuronal dendrites in the cornu ammonis 1 (ca1) apical/basal and dentate gyrus (dg) subregions of the mouse hippocampus at 8 and 16 days after treatment, although it did not affect dendritic complexity (e.g., number of crossing dendrites, total dendritic length, and branch points per neuron) in both ca1 and dg subregions at all time points after treatment. |
2021-07-27 |
2023-08-13 |
mouse |
| Dong-Oh Seo, Eric T Zhang, Sean C Piantadosi, David J Marcus, Laura E Motard, Bryce K Kan, Adrian M Gomez, Tammy K Nguyen, Li Xia, Michael R Brucha. A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing. Neuron. vol 109. issue 13. 2021-07-23. PMID:34081911. |
the dentate gyrus (dg), a subregion of the hippocampus, is thought to be an important brain region for disambiguating new experiences from prior experiences. |
2021-07-23 |
2023-08-13 |
Not clear |
| Mehrdad Jahanshahi, Masoumeh Khalili, Asra Margedar. Naringin Chelates Excessive Iron and Prevents the Formation of Amyloid-Beta Plaques in the Hippocampus of Iron-Overloaded Mice. Frontiers in pharmacology. vol 12. 2021-07-20. PMID:34276359. |
in addition, aβ plaque numbers in ca1, ca3, and dg areas of the hippocampus decreased significantly following treatment with 30 or 60 mg/kg/day naringin. |
2021-07-20 |
2023-08-13 |
mouse |
| - Nadeem, Rehan Ahmed Siddiqui, Shumaila Usman, Uzair Nisar, Ghulam Abba. Pre-weaning fluoxetine exposure perturbs social behavior at adulthood via altering hippocampal morphometry and PSD-95 expression in rats. Pakistan journal of pharmaceutical sciences. vol 34. issue 2(Supplementary). 2021-07-19. PMID:34275817. |
the morphometric analysis revealed significant increase in cell population and count of dentate gyrus (dg) region of hippocampus along with enhanced dendritic arborization. |
2021-07-19 |
2023-08-13 |
rat |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |
| Made Bagus Auriva Mataram, Puspa Hening, Fitria N Harjanti, Srikanth Karnati, Widya Wasityastuti, Dwi Aris Agung Nugrahaningsih, Dwi Liliek Kusindarta, Hevi Wihadmadyatam. The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer's disease. Journal of chemical neuroanatomy. vol 111. 2021-07-15. PMID:33188864. |
ethanolic extract (ose) on the neurons of the ca1, ca3, and dg hippocampal areas with the use of in vivo and in vitro models of alzheimer's diseases (ad). |
2021-07-15 |
2023-08-13 |
rat |
| Made Bagus Auriva Mataram, Puspa Hening, Fitria N Harjanti, Srikanth Karnati, Widya Wasityastuti, Dwi Aris Agung Nugrahaningsih, Dwi Liliek Kusindarta, Hevi Wihadmadyatam. The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer's disease. Journal of chemical neuroanatomy. vol 111. 2021-07-15. PMID:33188864. |
taken together, there findings suggest that ose has the potential as a neuroprotective agent (retaining the autobiographical memory),and the neuroproliferation of neurons in the ca1, ca3, and dg hippocampal areas in the rats¡ model of neurodegeneration was mediated by activation of npy expression. |
2021-07-15 |
2023-08-13 |
rat |
| Natalie N Nawarawong, Chelsea G Nickell, Deann M Hopkins, James R Pauly, Kimberly Nixo. Functional Activation of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis. Brain sciences. vol 11. issue 4. 2021-07-15. PMID:33921189. |
significant increases in neural stem cell (nsc) proliferation and subsequent "reactive neurogenesis" coincides with structural recovery in hippocampal dentate gyrus (dg). |
2021-07-15 |
2023-08-13 |
rat |
| Andrew Chih Wei Huang, Ying Hao Yu, Alan Bo Han He, Chen Yin O. Interactions between prelimbic cortex and basolateral amygdala contribute to morphine-induced conditioned taste aversion in conditioning and extinction. Neurobiology of learning and memory. vol 172. 2021-07-14. PMID:32407964. |
the consequences of exciting or destroying the prelimbic cortex (prl) or the basolateral amygdala (bla) remain unclear, including the effects on morphine-induced conditioned taste aversion (cta) in the conditioning and extinction phases, plasma corticosterone (cort) levels, and c-fos/p-erk expressions in the subareas of the medial prefrontal cortex (i.e., prl, infralimbic cortex [il], cingulate cortex 1 [cg1]), basolateral amygdala (bla), central amygdala (cea), hippocampus (i.e., ca1, ca2, ca3, and dentate gyrus [dg]), nucleus accumbens (nac), lateral hypothalamus (lh), and piriform cortex (pc). |
2021-07-14 |
2023-08-13 |
Not clear |
| Ayse Cigel, Oya Sayin, Seren Gulsen Gurgen, Atac Sonme. Long term neuroprotective effects of acute single dose MK-801treatment against traumatic brain injury in immature rats. Neuropeptides. vol 88. 2021-07-12. PMID:34098454. |
histopathological and immunohistochemical evaluations showed that treatment with mk-801 significantly ameliorated the trauma-induced hippocampal neuron loss and increased bdnf, ngf, nmda-r, gfap expressions in ca1, ca3, and dg hippocampal regions. |
2021-07-12 |
2023-08-13 |
rat |