| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Zhen Li, Ning-Xi Zeng, Kai-Ge Liu, Wu-Long Luo, Wen-Jun Lu, Li-Li W. [Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 23. 2021-12-24. PMID:34951250. |
immunofluorescence results demonstrated that ki-67/nesti-positive cells and brdu/dcx-positive cells in the hippocampal dg area were fewer(p<0.05) in lod group than in the aged group, and the positive cells in the exd group were more(p<0.05) than those in the lod group. |
2021-12-24 |
2023-08-13 |
rat |
| Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshim. Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4. Developmental neurobiology. 2021-12-21. PMID:34932871. |
sema3f and its receptor neuropilin-2 (nrp2) have been shown to be involved in the stereotyped pruning of the infrapyramidal bundle (ipb) of mossy fibers of the dentate gyrus (dg) in the developing hippocampus. |
2021-12-21 |
2023-08-13 |
mouse |
| Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshim. Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4. Developmental neurobiology. 2021-12-21. PMID:34932871. |
these results suggest that crmp family members have a distinct function in the axon pruning and targeting of mossy fibers of the hippocampal dg in the developing mouse brain. |
2021-12-21 |
2023-08-13 |
mouse |
| Hirofumi Hirakawa, Takeshi Terao, Koji Hatano, Masanao Shirahama, Tsuyoshi Kugimiya, Kentaro Kohno, Nobuyoshi Ishii, Hiroyuki Matsuta, Tsuyoshi Shimomura, Minoru Fujik. Increase in the left hippocampal dentate gyrus head volume after a 4-week bright light exposure in healthy participants: A randomized controlled study. Journal of psychiatric research. vol 145. 2021-12-11. PMID:34763283. |
bright light exposure (bl) induces neurogenesis in the adult rat hippocampal dentate gyrus (dg). |
2021-12-11 |
2023-08-13 |
human |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Li. Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation. Brain, behavior, and immunity. vol 100. 2021-12-11. PMID:34848340. |
hippocampal microglia in mice in the hfd group generally had a more activated phenotype evidenced by a smaller microglial territory area and increased cluster of differentiation 68 (cd68, a marker of phagocytic activity) immunoreactivity, while the microglial density in the dentate gyrus (dg) was decreased, indicating microglial decline. |
2021-12-11 |
2023-08-13 |
mouse |
| Yu W Sun, Yin P Luo, Xiao L Zheng, Xiao Y Wu, Hui Z Wen, Wen S Ho. Multiple Sessions of Entorhinal Cortex Deep Brain Stimulation in C57BL/6J Mice Increases Exploratory Behavior and Hippocampal Neurogenesis Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2021. 2021-12-11. PMID:34892574. |
we found that multiple sessions of ec dbs were tolerated in c57bl/6j mice, significantly increased exploratory behavior and the number of dcx-positive neurons in the dg area.clinical relevance- hippocampal neurogenesis may be part of the reason for dbs to improve memory, and the results of this study show that multiple sessions of ec dbs increases exploratory behavior and hippocampal neurogenesis, which is conducive to the application of dbs in nervous system diseases and mental diseases related to memory impairment. |
2021-12-11 |
2023-08-13 |
mouse |
| Marie-Gabrielle Goossens, Lars Emil Larsen, Marijke Vergaelen, Wytse Wadman, Chris Van den Haute, Wayra Brackx, Silke Proesmans, Jana Desloovere, Emma Christiaen, Erine Craey, Christian Vanhove, Kristl Vonck, Paul Boon, Robrecht Raed. Level of hM4D(Gi) DREADD Expression Determines Inhibitory and Neurotoxic Effects in the Hippocampus. eNeuro. vol 8. issue 6. 2021-12-10. PMID:34620623. |
our results indicate that prolonged, high levels of dreadd expression can have neurotoxic effects and that chemogenetic suppression of excitatory hippocampal neurons can paradoxically enhance dg evoked potentials. |
2021-12-10 |
2023-08-13 |
rat |
| Alexey A Kulikov, Alexandra A Naumova, Ekaterina P Aleksandrova, Margarita V Glazova, Elena V Chernigovskay. Audiogenic kindling stimulates aberrant neurogenesis, synaptopodin expression, and mossy fiber sprouting in the hippocampus of rats genetically prone to audiogenic seizures. Epilepsy & behavior : E&B. vol 125. 2021-12-10. PMID:34837844. |
however, after 21 ags increased proliferation was observed only in the dg, while the numbers of immature neurons expressed vglut1/2 were still enhanced in both hippocampal areas. |
2021-12-10 |
2023-08-13 |
rat |
| Ruike Wang, Zuntao Wu, Mengchen Liu, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huan. Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure. Brain research. vol 1767. 2021-12-09. PMID:34175265. |
the dg, ca1 and ca3 regions of the hippocampus showed a considerable increase in the expression of pre- and postsynaptic proteins (p < 0.001 vs 0.2% pb group). |
2021-12-09 |
2023-08-13 |
rat |
| Jehoon Lee, Vishal Naik, Marcus Orzabal, Raine Lunde-Young, Jayanth Ramados. Morphological alteration in rat hippocampal neuronal dendrites following chronic binge prenatal alcohol exposure. Brain research. vol 1768. 2021-12-09. PMID:34297994. |
pae increased dendritic arborization and complexities of ca1, ca2/3, and dg neurons in the pnd 10 rat hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
| Dongmeng Liu, Dahui Xue, Wencan Lu, Zhuochun Yang, Li Li, Beibei Xia, Jinhua Wei, Xianxiong Chen, Yi Yang, Xiaomei Wang, Guimiao Li. BDE-47 induced PC-12 cell differentiation via TrkA downstream pathways and caused the loss of hippocampal neurons in BALB/c mice. Journal of hazardous materials. vol 422. 2021-12-06. PMID:34419847. |
h&e staining of brain showed neurons in dg and ca1 areas of hippocampus decreased after bde-47 exposure. |
2021-12-06 |
2023-08-13 |
mouse |
| Sandra De la Torre-Iturbe, Rubén Antonio Vázquez-Roque, Fidel de la Cruz-López, Gonzalo Flores, Linda Garcés-Ramíre. Dendritic and behavioral changes in rats neonatally treated with homocysteine; A proposal as an animal model to study the attention deficit hyperactivity disorder. Journal of chemical neuroanatomy. 2021-12-06. PMID:34871732. |
morphological changes were found mainly in the shape of dendritic spines in the prefrontal cortex (pfc-3), dorsal hippocampus (ca1), dentate gyrus (dg) and nucleus accumbens (nacc), in rats administered neonatally with homocysteine at both ages studied. |
2021-12-06 |
2023-08-13 |
rat |
| He Huang, Chao Zhao, Qian Hu, Qiang Liu, Yi-Man Sun, Chen Chen, Hui Huang, Cheng-Hua Zhou, Yu-Qing W. Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34480336. |
notch ligand jagged1 (0.5 mg/kg) and lentivirus overexpressing the notch1 intracellular domain (lv-nicd1) were microinjected into the hippocampal dentate gyrus (dg) 1 h or 4 days before ketamine administration, respectively. |
2021-12-03 |
2023-08-13 |
rat |
| He Huang, Chao Zhao, Qian Hu, Qiang Liu, Yi-Man Sun, Chen Chen, Hui Huang, Cheng-Hua Zhou, Yu-Qing W. Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34480336. |
the proliferation and differentiation of the neural stem cells (nscs) in the hippocampal dg were evaluated by double immunofluorescence staining 24 h after treatment. |
2021-12-03 |
2023-08-13 |
rat |
| He Huang, Chao Zhao, Qian Hu, Qiang Liu, Yi-Man Sun, Chen Chen, Hui Huang, Cheng-Hua Zhou, Yu-Qing W. Neonatal Anesthesia by Ketamine in Neonatal Rats Inhibits the Proliferation and Differentiation of Hippocampal Neural Stem Cells and Decreases Neurocognitive Function in Adulthood via Inhibition of the Notch1 Signaling Pathway. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34480336. |
microinjection of jagged1 or lv-nicd1 reversed the inhibitory effect of ketamine on the expression of notch1-related proteins in the hippocampal dg, attenuated the ketamine-mediated decrease in nsc proliferation and differentiation, and improved the cognitive function of 2-month-old rats after neonatal exposure to ketamine. |
2021-12-03 |
2023-08-13 |
rat |
| James Delorme, Lijing Wang, Femke Roig Kuhn, Varna Kodoth, Jingqun Ma, Jessy D Martinez, Frank Raven, Brandon A Toth, Vinodh Balendran, Alexis Vega Medina, Sha Jiang, Sara J Ato. Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity to inhibit memory consolidation. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 32. 2021-12-01. PMID:34344824. |
we find that ps6 is enhanced in dentate gyrus (dg) following single-trial contextual fear conditioning (cfc) but is reduced throughout the hippocampus after brief sleep deprivation (sd; which disrupts contextual fear memory [cfm] consolidation). |
2021-12-01 |
2023-08-13 |
mouse |
| Gaifen Li, Jia Liu, Yuying Guan, Xunming J. The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation. CNS neuroscience & therapeutics. vol 27. issue 12. 2021-12-01. PMID:34817133. |
the subventricular zone (svz) and hippocampal dentate gyrus (dg) are the main sites of adult neurogenesis in the brain. |
2021-12-01 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
with aging, oxidative damage to rna (8ohg) increased significantly in all hippocampal regions, while tau hyperphosphorylation (at100) was enhanced in dg, ca3, and sub in aged animals. |
2021-11-30 |
2023-08-13 |
Not clear |
| Olga Netsyk, Hayma Hammoud, Sergiy V Korol, Zhe Jin, Atieh S Tafreshiha, Bryndis Birni. Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis. Hippocampus. vol 30. issue 11. 2021-11-26. PMID:32533811. |
we have examined in two cell-types of the hippocampal projection neurons, the dentate gyrus (dg) granule cells and ca3 pyramidal neurons, if the gaba-activated tonic current density varied between the dorsal (septal) and the ventral (temporal) poles of the male mouse hippocampus. |
2021-11-26 |
2023-08-13 |
mouse |