| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Majid Motaghinejad, Manijeh Motevalia. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus. Neurotoxicity research. 2022-04-21. PMID:35446003. |
ihc data showed that minocycline also improved the localization and expression of creb and akt positive cells and decreased the gsk3 positive cells in the dg and ca1 regions of the hippocampus of mph-treated rats. |
2022-04-21 |
2023-08-13 |
rat |
| Majid Motaghinejad, Manijeh Motevalia. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus. Neurotoxicity research. 2022-04-21. PMID:35446003. |
minocycline also inhibited mph-induced changes of hippocampal cells' density and shape in both dg and ca1 areas of the hippocampus. |
2022-04-21 |
2023-08-13 |
rat |
| Sebastian B Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H Santibanez, Lorena Varela-Nalla. Wnt signaling in the adult hippocampal neurogenic niche. Stem cells (Dayton, Ohio). 2022-04-21. PMID:35446432. |
the subgranular zone (sgz) of the hippocampal dentate gyrus (dg) is a neurogenic niche of the adult brain that contains neural stem cells (nscs) able to generate excitatory glutamatergic granule neurons, which integrate into the dg circuit and contribute to hippocampal plasticity, learning, and memory. |
2022-04-21 |
2023-08-13 |
Not clear |
| Md Mamun Al-Amin, Robert K P Sullivan, Suzy Alexander, David A Carter, DanaKai Bradford, Thomas H J Burn. Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS neuroscience. vol 9. issue 1. 2022-04-18. PMID:35434279. |
we characterised hippocampal spine morphology in the ca1 and dentate gyrus (dg) and made electrophysiological recordings in the hippocampus of behaviourally naïve mice to measure ltp. |
2022-04-18 |
2023-08-13 |
mouse |
| Lanxiang Tian, Yukai Luo, Aisheng Zhan, Jie Ren, Huafeng Qin, Yongxin Pa. Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408982. |
however, it is unclear whether and how long-term hmf exposure affects ros levels in the entire hippocampus (i.e., the dentate gyrus (dg) and ammonia horn (ca) regions). |
2022-04-12 |
2023-08-13 |
mouse |
| Syed Salman Shahid, Qiuting Wen, Shannon L Risacher, Martin R Farlow, Frederick W Unverzagt, Liana G Apostolova, Tatiana M Foroud, Henrik Zetterberg, Kaj Blennow, Andrew J Saykina, Yu-Chien W. Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease. Brain : a journal of neurology. 2022-04-12. PMID:35411392. |
comparisons between cn and mci showed significant microstructural alterations in the hippocampal cornu ammonis (ca) 4 and dentate gyrus (dg) region, whereas ca1-3 was the most sensitive region for the later stages in the ad clinical continuum. |
2022-04-12 |
2023-08-13 |
human |
| Son T Ton, Julia R Laghi, Shih-Yen Tsai, Ashley A Blackwell, Natalie S Adamczyk, Jenna R Osterlund Oltmanns, Richard A Britten, Douglas G Wallace, Gwendolyn L Kartj. Exposure to 5 cGy 28Si Particles Induces Long-Term Microglial Activation in the Striatum and Subventricular Zone and Concomitant Neurogenic Suppression. Radiation research. 2022-04-04. PMID:35377458. |
an analysis of new neurons in the dg revealed an increase in doublecortin-positive (dcx+) hilar ectopic granule cells (hegc) which correlated with iba1+ cells, suggesting that microglial cells contributed to this aberrant distribution which may adversely affect hippocampal function. |
2022-04-04 |
2023-08-13 |
human |
| Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell. 2022-03-31. PMID:35355405. |
in the current study, we observed a prominent accumulation of the ad-like hyperphosphorylated and truncated tau (htau n368) proteins in hippocampal dentate gyrus (dg) mossy cells of 3xtg-ad mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Aurelio Franco-García, Francisco José Fernández-Gómez, Victoria Gómez-Murcia, Juana M Hidalgo, M Victoria Milanés, Cristina Núñe. Molecular Mechanisms Underlying the Retrieval and Extinction of Morphine Withdrawal-Associated Memories in the Basolateral Amygdala and Dentate Gyrus. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327388. |
hence, by using the conditioned place aversion (cpa) paradigm in rats, we investigated some of the molecular mechanisms that occurr during the retrieval and extinction of morphine withdrawal memories in the basolateral amygdala (bla) and the hippocampal dentate gyrus (dg), which control emotional and episodic memories, respectively. |
2022-03-25 |
2023-08-13 |
rat |
| Dominique F Leitner, Christopher William, Arline Faustin, Manor Askenazi, Evgeny Kanshin, Matija Snuderl, Declan McGuone, Thomas Wisniewski, Beatrix Ueberheide, Laura Gould, Orrin Devinsk. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta neuropathologica. 2022-03-25. PMID:35333953. |
to identify molecular signaling pathways, we performed label-free quantitative mass spectrometry on microdissected frontal cortex, hippocampal dentate gyrus (dg), and cornu ammonis (ca1-3) in sudc (n = 19) and pediatric control cases (n = 19) with an explained cause of death. |
2022-03-25 |
2023-08-13 |
Not clear |
| Yu-Hsin Chen, Yen-Chou Chen, Yu-Tang Chin, Ching-Chiung Wang, Ling-Ling Hwang, Liang-Yo Yang, Dah-Yuu L. 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology. Aging. vol 14. issue undefined. 2022-03-22. PMID:35314517. |
furthermore, thsg increased the number of immature neurons in the subgranular zone (sgz) of the dentate gyrus (dg) of the hippocampus. |
2022-03-22 |
2023-08-13 |
mouse |
| Lianlian Wu, Ying Qin, Honghua Yuan, Yuhua Zhu, Ankang H. Anti-inflammatory and neuroprotective effects of insulin-like growth factor-1 overexpression in pentylenetetrazole (PTZ)-induced mouse model of chronic epilepsy. Brain research. 2022-03-14. PMID:35283097. |
moreover, we identified the evident increase in brdu-positive and dcx-positive cell populations in dentate gyrus (dg) in igf-1 transgenic mice, versus the w-t mice, indicative of the role of igf-1 overexpression in promoting long-term hippocampal neurogenesis in the chronic phase of epilepsy. |
2022-03-14 |
2023-08-13 |
mouse |
| Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ry. Effects of repetitive training on learning and memory performance of TLR2 KO mice. Behavioural brain research. 2022-03-12. PMID:35278481. |
in addition, highly repetitive training activated the neuronal cells in the prefrontal cortex, hippocampal ca3 and hippocampal dg regions of tlr2 ko mice, similar to wt mice. |
2022-03-12 |
2023-08-13 |
mouse |
| Jie Wang, Zihao Xia, Peng Sheng, Yanggang Rui, Jianwen Cao, Jie Zhang, Manman Gao, Li Wang, Duonan Yu, Bing Chun Ya. Targeting MicroRNA-144/451-AKT-GSK3β Axis Affects the Proliferation and Differentiation of Radial Glial Cells in the Mouse Hippocampal Dentate Gyrus. ACS chemical neuroscience. 2022-03-09. PMID:35261236. |
it is well known that aging induces a progressive decline in the proliferation and neural differentiation of radial glial cells (rgcs) in the hippocampal dentate gyrus (dg). |
2022-03-09 |
2023-08-13 |
mouse |
| Jie Wang, Zihao Xia, Peng Sheng, Yanggang Rui, Jianwen Cao, Jie Zhang, Manman Gao, Li Wang, Duonan Yu, Bing Chun Ya. Targeting MicroRNA-144/451-AKT-GSK3β Axis Affects the Proliferation and Differentiation of Radial Glial Cells in the Mouse Hippocampal Dentate Gyrus. ACS chemical neuroscience. 2022-03-09. PMID:35261236. |
furthermore, the proliferation and neural differentiation of rgcs in the mouse hippocampal dg was decreased by mir-144/451 knockout (mir-144/451 |
2022-03-09 |
2023-08-13 |
mouse |
| Hongxuan Kuang, Wenji Zhou, Yingwei Zeng, Da Xu, Wanqi Zhu, Shengjie Lin, Ruifang Fa. Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs. Chemosphere. 2022-03-08. PMID:35257710. |
compared with the control mice, only those exposed to 50 μg/kg/day pahs had significantly lower ltp in hippocampal ca1 region and dendritic spine density in hippocampal dg region (p < 0.05). |
2022-03-08 |
2023-08-13 |
mouse |
| Dasiel O Borroto-Escuela, Ramón Fores, Mariana Pita, Miguel A Barbancho, Pablo Zamorano-Gonzalez, Natalia García Casares, Kjell Fuxe, Manuel Narváe. Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats. Frontiers in pharmacology. vol 13. 2022-03-07. PMID:35250569. |
moreover, we observed the ability of the co-agonist treatment to enhance the cell proliferation in the dg of the dorsal hippocampus through 5- bromo-2'-deoxyuridine (brdu) expression analysis at 24 hours. |
2022-03-07 |
2023-08-13 |
rat |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
artificial intelligence-assisted morphological analysis revealed that male fkbp51 knock-out (ko) mice possess more elongated dentate gyrus (dg) but shorter hippocampal height in coronal sections when compared to wt. |
2022-03-04 |
2023-08-13 |
mouse |
| Bin Qiu, Zhaohui Zhong, Shawn Righter, Yuxue Xu, Jun Wang, Ran Deng, Chao Wang, Kent E Williams, Yao-Ying Ma, Gavriil Tsechpenakis, Tiebing Liang, Weidong Yon. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Cellular and molecular life sciences : CMLS. vol 79. issue 3. 2022-03-04. PMID:35244772. |
ko has more flattened hippocampus using ai-assisted measurement both pyramidal cell layer (pcl) of ca and granular cell layer (gcl) of dg distinguishable as two layers: deep cell layer and superficial layer. distinct map2 expression between deep and superficial layer between ko and wt, higher parkin expression in ko brain mechanism of fkbp51 inhibition resulting in parkin, map2, tau, and tubulin expression differences between ko and wt mice, and resulting neurite outgrowth differences. |
2022-03-04 |
2023-08-13 |
mouse |
| Yasunori Takahashi, Hiromu Okano, Kazumi Takashima, Ryota Ojiro, Qian Tang, Shunsuke Ozawa, Bunichiro Ogawa, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutan. Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neurogenesis. Toxicology letters. 2022-03-01. PMID:35227807. |
in rats, developmental exposure to ethanol (etoh) at high doses has shown to induce aberrant neurogenesis in neural progenitor cells (npcs) during weaning and suppress synaptic plasticity of newborn granule cells after maturation; neuroinflammation was even sustained until the adult stage in the hippocampal dentate gyrus (dg). |
2022-03-01 |
2023-08-13 |
rat |