| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emre Hari, Elif Kurt, Ali Bayram, Gozde Kizilates-Evin, Burak Acar, Tamer Demiralp, Hakan Gurvi. Volumetric changes within hippocampal subfields in Alzheimer's disease continuum. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2022-01-18. PMID:35041116. |
ancova results of the hippocampal subfields displayed statistically significant differences among the three groups in bilateral ca1, sub, and dg volumes (right ca1: f = 7.316, p = 0.002; left ca1: f = 6.768, p = 0.003; right sub: f = 9.390, p < 0.001; left sub: f = 5.925, p = 0.005; right dg: f = 9.469, p < 0.001; left dg: f = 9.354, p < 0.001), while ca3 volumes were not significantly different among the groups. |
2022-01-18 |
2023-08-13 |
Not clear |
| Marina F Souza, Katty A A L Medeiros, Lívia C R F Lins, José M M Bispo, Auderlan M Gois, Edson R Santos, Thiago H Almeida-Souza, João E C Melo, Heitor S Franco, Rodolfo S Silva, Eduardo A Pereira-Filho, Marco Aurelio M Freire, José R Santo. Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin. Brain research bulletin. 2022-01-18. PMID:35041849. |
the animals submitted to 9 inhalations of dm showed a reduction in immunoreactivity for th in the substantia nigra pars compacta (snpc), ventral tegmental area (vta), and dorsal striatum (ds) areas, and an increase in bdnf in the ds and ca1, ca3 and dentate gyrus (dg) hippocampal areas. |
2022-01-18 |
2023-08-13 |
rat |
| Marina F Souza, Katty A A L Medeiros, Lívia C R F Lins, José M M Bispo, Auderlan M Gois, Edson R Santos, Thiago H Almeida-Souza, João E C Melo, Heitor S Franco, Rodolfo S Silva, Eduardo A Pereira-Filho, Marco Aurelio M Freire, José R Santo. Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin. Brain research bulletin. 2022-01-18. PMID:35041849. |
conversely, the animals submitted to 15 inhalations of dm showed immunoreactivity reduced for th in the snpc and vta, and an increase in bdnf in the hippocampal areas (ca3 and dg). |
2022-01-18 |
2023-08-13 |
rat |
| Peng Ren, Bin Xiao, Lin-Ping Wang, Ying-Shun Li, Hua Jin, Qing-Hua Ji. Nitric oxide impairs spatial learning and memory in a rat model of Alzheimer's disease via disturbance of glutamate response in the hippocampal dentate gyrus during spatial learning. Behavioural brain research. 2022-01-16. PMID:35033612. |
however, whether no in the hippocampal dentate gyrus (dg) is involved in the spatial learning and memory impairments of ad by affecting the glutamate (glu) response during these processes is not well-understood. |
2022-01-16 |
2023-08-13 |
rat |
| Jinhu Kim, Dongseok Park, Na-Young Seo, Taek-Han Yoon, Gyu Hyun Kim, Sang-Hoon Lee, Jinsoo Seo, Ji Won Um, Kea Joo Lee, Jaewon K. LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 3. 2022-01-13. PMID:35022233. |
leucine-rich repeat transmembrane protein 3 (lrrtm3) is required for the excitatory synapse development of hippocampal dentate gyrus (dg) granule neurons. |
2022-01-13 |
2023-08-13 |
Not clear |
| Lena-Louise Schuele, Britta Schuermann, Andras Bilkei-Gorzo, Sara Gorgzadeh, Andreas Zimmer, Este Leidma. Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa). Scientific reports. vol 12. issue 1. 2022-01-13. PMID:35022487. |
here we sought to identify the cellular source of endocannabinoids in the subgranular zone of the dentate gyrus (dg) in hippocampus, an important neurogenic niche. |
2022-01-13 |
2023-08-13 |
mouse |
| Lena-Louise Schuele, Britta Schuermann, Andras Bilkei-Gorzo, Sara Gorgzadeh, Andreas Zimmer, Este Leidma. Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa). Scientific reports. vol 12. issue 1. 2022-01-13. PMID:35022487. |
these results identify dagla in nspcs in the dg or in astrocytes as a prominent regulator of adult hippocampal neurogenesis. |
2022-01-13 |
2023-08-13 |
mouse |
| Seong-Beom Park, Heung-Yeol Lim, Eun-Young Lee, Seung-Woo Yoo, Hyun-Suk Jung, Eunsoo Lee, Woong Sun, Inah Le. The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory. Progress in neurobiology. 2022-01-09. PMID:34999186. |
the fc receives inputs mostly from the lateral entorhinal cortex and perirhinal cortex while projecting exclusively to the crest of the dg within the hippocampus. |
2022-01-09 |
2023-08-13 |
rat |
| Seong-Beom Park, Heung-Yeol Lim, Eun-Young Lee, Seung-Woo Yoo, Hyun-Suk Jung, Eunsoo Lee, Woong Sun, Inah Le. The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory. Progress in neurobiology. 2022-01-09. PMID:34999186. |
our findings suggest that the episodic firing pattern of the place cells in the fc may play critical roles in learning a novel contextual environment by facilitating temoporally structured contextual pattern separation in the dg of the hippocampus. |
2022-01-09 |
2023-08-13 |
rat |
| Mohsen Jeyhoonabadi, Samad Alimoahmmadi, Shahin Hassanpour, Mohammad Hashemni. Betaine Ameliorates Depressive-Like Behaviors in Zinc Oxide Nanoparticles Exposed Mice. Biological trace element research. 2022-01-07. PMID:34993911. |
administration of zno nps decreased the thickness of hippocampus and pyramidal neurons in the hippocampal dentate gyrus (dg) and ca1 regions were sparsely arranged. |
2022-01-07 |
2023-08-13 |
mouse |
| Shweta Tripathi, Sushil K Jh. REM Sleep Deprivation Alters Learning-Induced Cell Proliferation and Generation of Newborn Young Neurons in the Dentate Gyrus of the Dorsal Hippocampus. ACS chemical neuroscience. 2022-01-06. PMID:34990120. |
on the other hand, rem sleep deprivation (rem-sd) induces detrimental effects on training-induced cell proliferation in the hippocampus's dentate gyrus (dg). |
2022-01-06 |
2023-08-13 |
Not clear |
| H S Nandini, K L Krishna, Chinnappa Apattir. Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease. Journal of chemical neuroanatomy. 2022-01-01. PMID:34973350. |
treatment with ose and ose+lev also restored the hippocampal architecture by ameliorating the neuronal count in ca1, ca3 and dg regions. |
2022-01-01 |
2023-08-13 |
human |
| Hui-Zhen Li, Ning-Xi Zeng, Kai-Ge Liu, Wu-Long Luo, Wen-Jun Lu, Li-Li W. [Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 23. 2021-12-24. PMID:34951250. |
immunofluorescence method was used to detect the number of ki-67/nesti-positive cells and brdu/dcx-positive cells in the hippocampal dg area of each group. |
2021-12-24 |
2023-08-13 |
rat |
| Hui-Zhen Li, Ning-Xi Zeng, Kai-Ge Liu, Wu-Long Luo, Wen-Jun Lu, Li-Li W. [Preliminary study on cerebrospinal fluid proteomics of Erxian Decoction against neurogenesis impairment in late-onset depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 23. 2021-12-24. PMID:34951250. |
immunofluorescence results demonstrated that ki-67/nesti-positive cells and brdu/dcx-positive cells in the hippocampal dg area were fewer(p<0.05) in lod group than in the aged group, and the positive cells in the exd group were more(p<0.05) than those in the lod group. |
2021-12-24 |
2023-08-13 |
rat |
| Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshim. Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4. Developmental neurobiology. 2021-12-21. PMID:34932871. |
sema3f and its receptor neuropilin-2 (nrp2) have been shown to be involved in the stereotyped pruning of the infrapyramidal bundle (ipb) of mossy fibers of the dentate gyrus (dg) in the developing hippocampus. |
2021-12-21 |
2023-08-13 |
mouse |
| Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshim. Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4. Developmental neurobiology. 2021-12-21. PMID:34932871. |
these results suggest that crmp family members have a distinct function in the axon pruning and targeting of mossy fibers of the hippocampal dg in the developing mouse brain. |
2021-12-21 |
2023-08-13 |
mouse |
| Hirofumi Hirakawa, Takeshi Terao, Koji Hatano, Masanao Shirahama, Tsuyoshi Kugimiya, Kentaro Kohno, Nobuyoshi Ishii, Hiroyuki Matsuta, Tsuyoshi Shimomura, Minoru Fujik. Increase in the left hippocampal dentate gyrus head volume after a 4-week bright light exposure in healthy participants: A randomized controlled study. Journal of psychiatric research. vol 145. 2021-12-11. PMID:34763283. |
bright light exposure (bl) induces neurogenesis in the adult rat hippocampal dentate gyrus (dg). |
2021-12-11 |
2023-08-13 |
human |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Hong Zhuang, Xiuting Yao, Hong Li, Qian Li, Chenxi Yang, Conghui Wang, Dan Xu, Yu Xiao, Yuan Gao, Jiayi Gao, Mingze Bi, Rui Liu, Gaojun Teng, Lijie Li. Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation. Brain, behavior, and immunity. vol 100. 2021-12-11. PMID:34848340. |
hippocampal microglia in mice in the hfd group generally had a more activated phenotype evidenced by a smaller microglial territory area and increased cluster of differentiation 68 (cd68, a marker of phagocytic activity) immunoreactivity, while the microglial density in the dentate gyrus (dg) was decreased, indicating microglial decline. |
2021-12-11 |
2023-08-13 |
mouse |
| Yu W Sun, Yin P Luo, Xiao L Zheng, Xiao Y Wu, Hui Z Wen, Wen S Ho. Multiple Sessions of Entorhinal Cortex Deep Brain Stimulation in C57BL/6J Mice Increases Exploratory Behavior and Hippocampal Neurogenesis Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2021. 2021-12-11. PMID:34892574. |
we found that multiple sessions of ec dbs were tolerated in c57bl/6j mice, significantly increased exploratory behavior and the number of dcx-positive neurons in the dg area.clinical relevance- hippocampal neurogenesis may be part of the reason for dbs to improve memory, and the results of this study show that multiple sessions of ec dbs increases exploratory behavior and hippocampal neurogenesis, which is conducive to the application of dbs in nervous system diseases and mental diseases related to memory impairment. |
2021-12-11 |
2023-08-13 |
mouse |