| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd Wasim, Mohamed A Alfaleh, Shadab Md, Sanjula Baboota, Javed Ali, Syed Ehtaishamul Haqu. Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations. Drug delivery. vol 29. issue 1. 2022-05-11. PMID:35543534. |
based on the preclinical and clinical investigations, the profound role of increased oxidative stress, nuclear translocation of nf-kb, production of proinflammatory cytokines such as tnf-α, il-6, il-β, increased level of mmps, increased apoptosis, reduced angiogenesis, neurogenesis, and histological aberrations in ca1, ca2, ca3 and dg region of the hippocampus have been reported. |
2022-05-11 |
2023-08-13 |
Not clear |
| Shaokai Zhao, Bin Chen, Hui Wang, Zhiyuan Luo, Tao Zhan. A Feed-Forward Neural Network for Increasing the Hopfield-Network Storage Capacity. International journal of neural systems. 2022-05-10. PMID:35534937. |
in the hippocampal dentate gyrus (dg), pattern separation mainly depends on the concepts of 'expansion recoding', meaning random mixing of different dg input channels. |
2022-05-10 |
2023-08-13 |
mouse |
| K A Mitchnick, Z Ahmad, S D Mitchnick, J D Ryan, R S Rosenbaum, E Freu. Damage to the human dentate gyrus impairs the perceptual discrimination of complex, novel objects. Neuropsychologia. 2022-05-05. PMID:35513066. |
the hippocampus (hpc), and the dentate gyrus (dg) subregion in particular, is purported to be a pattern separator, orthogonally representing similar information so that distinct memories may be formed. |
2022-05-05 |
2023-08-13 |
human |
| Jaclyn Asouzu Johnson, Robert Ndou, Ejikeme Felix Mbajiorg. Combination Antiretroviral Therapy (cART) in Diabetes Exacerbates Diabetogenic Effects on Hippocampal Microstructure, Neurogenesis and Cytokine Perturbation in Male Sprague Dawley Rats. Diagnostics (Basel, Switzerland). vol 12. issue 4. 2022-04-23. PMID:35453953. |
the hippocampal neuronal number was reduced in av (dentate gyrus; dg region), in the db group (cornu ammonis subregion 1; ca1 and dg regions only) and in dav (all three hippocampal regions). |
2022-04-23 |
2023-08-13 |
rat |
| Viktor Aniol, Anna Manolova, Natalia Gulyaev. Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457079. |
the dentate gyrus (dg), an important part of the hippocampus, plays a significant role in learning, memory, and emotional behavior. |
2022-04-23 |
2023-08-13 |
Not clear |
| Julia Schneider, Johannes Weigel, Marie-Theres Wittmann, Pavel Svehla, Sebastian Ehrt, Fang Zheng, Tarek Elmzzahi, Julian Karpf, Lucía Paniagua-Herranz, Onur Basak, Arif Ekici, Andre Reis, Christian Alzheimer, Felipe Ortega de la O, Sabine Liebscher, Ruth Beckervordersandfort. Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. The EMBO journal. 2022-04-22. PMID:35451150. |
our study establishes astrocytes as enduring plastic elements in dg circuits, implicating a vital contribution of astrocyte dynamics to hippocampal plasticity. |
2022-04-22 |
2023-08-13 |
mouse |
| Majid Motaghinejad, Manijeh Motevalia. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus. Neurotoxicity research. 2022-04-21. PMID:35446003. |
furthermore, localization of total creb, akt, and gsk3 in the dg and ca1 areas of the hippocampus were measured using immunohistochemistry (ihc). |
2022-04-21 |
2023-08-13 |
rat |
| Majid Motaghinejad, Manijeh Motevalia. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus. Neurotoxicity research. 2022-04-21. PMID:35446003. |
ihc data showed that minocycline also improved the localization and expression of creb and akt positive cells and decreased the gsk3 positive cells in the dg and ca1 regions of the hippocampus of mph-treated rats. |
2022-04-21 |
2023-08-13 |
rat |
| Majid Motaghinejad, Manijeh Motevalia. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus. Neurotoxicity research. 2022-04-21. PMID:35446003. |
minocycline also inhibited mph-induced changes of hippocampal cells' density and shape in both dg and ca1 areas of the hippocampus. |
2022-04-21 |
2023-08-13 |
rat |
| Sebastian B Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H Santibanez, Lorena Varela-Nalla. Wnt signaling in the adult hippocampal neurogenic niche. Stem cells (Dayton, Ohio). 2022-04-21. PMID:35446432. |
the subgranular zone (sgz) of the hippocampal dentate gyrus (dg) is a neurogenic niche of the adult brain that contains neural stem cells (nscs) able to generate excitatory glutamatergic granule neurons, which integrate into the dg circuit and contribute to hippocampal plasticity, learning, and memory. |
2022-04-21 |
2023-08-13 |
Not clear |
| Md Mamun Al-Amin, Robert K P Sullivan, Suzy Alexander, David A Carter, DanaKai Bradford, Thomas H J Burn. Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus. AIMS neuroscience. vol 9. issue 1. 2022-04-18. PMID:35434279. |
we characterised hippocampal spine morphology in the ca1 and dentate gyrus (dg) and made electrophysiological recordings in the hippocampus of behaviourally naïve mice to measure ltp. |
2022-04-18 |
2023-08-13 |
mouse |
| Lanxiang Tian, Yukai Luo, Aisheng Zhan, Jie Ren, Huafeng Qin, Yongxin Pa. Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408982. |
however, it is unclear whether and how long-term hmf exposure affects ros levels in the entire hippocampus (i.e., the dentate gyrus (dg) and ammonia horn (ca) regions). |
2022-04-12 |
2023-08-13 |
mouse |
| Syed Salman Shahid, Qiuting Wen, Shannon L Risacher, Martin R Farlow, Frederick W Unverzagt, Liana G Apostolova, Tatiana M Foroud, Henrik Zetterberg, Kaj Blennow, Andrew J Saykina, Yu-Chien W. Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease. Brain : a journal of neurology. 2022-04-12. PMID:35411392. |
comparisons between cn and mci showed significant microstructural alterations in the hippocampal cornu ammonis (ca) 4 and dentate gyrus (dg) region, whereas ca1-3 was the most sensitive region for the later stages in the ad clinical continuum. |
2022-04-12 |
2023-08-13 |
human |
| Son T Ton, Julia R Laghi, Shih-Yen Tsai, Ashley A Blackwell, Natalie S Adamczyk, Jenna R Osterlund Oltmanns, Richard A Britten, Douglas G Wallace, Gwendolyn L Kartj. Exposure to 5 cGy 28Si Particles Induces Long-Term Microglial Activation in the Striatum and Subventricular Zone and Concomitant Neurogenic Suppression. Radiation research. 2022-04-04. PMID:35377458. |
an analysis of new neurons in the dg revealed an increase in doublecortin-positive (dcx+) hilar ectopic granule cells (hegc) which correlated with iba1+ cells, suggesting that microglial cells contributed to this aberrant distribution which may adversely affect hippocampal function. |
2022-04-04 |
2023-08-13 |
human |
| Shihong Li, Qiuzhi Zhou, Enjie Liu, Huiyun Du, Nana Yu, Haitao Yu, Weijin Wang, Mengzhu Li, Ying Weng, Yang Gao, Guilin Pi, Xin Wang, Dan Ke, Jian-Zhi Wan. Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit. Aging cell. 2022-03-31. PMID:35355405. |
in the current study, we observed a prominent accumulation of the ad-like hyperphosphorylated and truncated tau (htau n368) proteins in hippocampal dentate gyrus (dg) mossy cells of 3xtg-ad mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Aurelio Franco-García, Francisco José Fernández-Gómez, Victoria Gómez-Murcia, Juana M Hidalgo, M Victoria Milanés, Cristina Núñe. Molecular Mechanisms Underlying the Retrieval and Extinction of Morphine Withdrawal-Associated Memories in the Basolateral Amygdala and Dentate Gyrus. Biomedicines. vol 10. issue 3. 2022-03-25. PMID:35327388. |
hence, by using the conditioned place aversion (cpa) paradigm in rats, we investigated some of the molecular mechanisms that occurr during the retrieval and extinction of morphine withdrawal memories in the basolateral amygdala (bla) and the hippocampal dentate gyrus (dg), which control emotional and episodic memories, respectively. |
2022-03-25 |
2023-08-13 |
rat |
| Dominique F Leitner, Christopher William, Arline Faustin, Manor Askenazi, Evgeny Kanshin, Matija Snuderl, Declan McGuone, Thomas Wisniewski, Beatrix Ueberheide, Laura Gould, Orrin Devinsk. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta neuropathologica. 2022-03-25. PMID:35333953. |
to identify molecular signaling pathways, we performed label-free quantitative mass spectrometry on microdissected frontal cortex, hippocampal dentate gyrus (dg), and cornu ammonis (ca1-3) in sudc (n = 19) and pediatric control cases (n = 19) with an explained cause of death. |
2022-03-25 |
2023-08-13 |
Not clear |
| Yu-Hsin Chen, Yen-Chou Chen, Yu-Tang Chin, Ching-Chiung Wang, Ling-Ling Hwang, Liang-Yo Yang, Dah-Yuu L. 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology. Aging. vol 14. issue undefined. 2022-03-22. PMID:35314517. |
furthermore, thsg increased the number of immature neurons in the subgranular zone (sgz) of the dentate gyrus (dg) of the hippocampus. |
2022-03-22 |
2023-08-13 |
mouse |
| Lianlian Wu, Ying Qin, Honghua Yuan, Yuhua Zhu, Ankang H. Anti-inflammatory and neuroprotective effects of insulin-like growth factor-1 overexpression in pentylenetetrazole (PTZ)-induced mouse model of chronic epilepsy. Brain research. 2022-03-14. PMID:35283097. |
moreover, we identified the evident increase in brdu-positive and dcx-positive cell populations in dentate gyrus (dg) in igf-1 transgenic mice, versus the w-t mice, indicative of the role of igf-1 overexpression in promoting long-term hippocampal neurogenesis in the chronic phase of epilepsy. |
2022-03-14 |
2023-08-13 |
mouse |
| Ho Jung Bae, Jaehoon Kim, Hyo Jeoung Bae, Keontae Park, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Se Jin Park, Jong Hoon Ry. Effects of repetitive training on learning and memory performance of TLR2 KO mice. Behavioural brain research. 2022-03-12. PMID:35278481. |
in addition, highly repetitive training activated the neuronal cells in the prefrontal cortex, hippocampal ca3 and hippocampal dg regions of tlr2 ko mice, similar to wt mice. |
2022-03-12 |
2023-08-13 |
mouse |