| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ran Zhang, Meixuan Chen, Zhongfang Deng, Lingchao Kong, Bing Shen, Lesha Zhan. Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury. Pharmaceutics. vol 15. issue 1. 2023-01-21. PMID:36678674. |
the co-localization results showed that bmecs, but not astrocytes, microglia, or neurons, presented mostly tunel-positive signals, especially in the dentate gyrus (dg) area of the hippocampus. |
2023-01-21 |
2023-08-14 |
rat |
| Shi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Zhi-Fang Chen, Bin-Bin Nie, Xiao-Feng Ren, Jing Wu, Wen-Chao Wang, Ying-Zhou Hu, Yi-Lin Gu, Long-Bao Lv, Yong Yin, Xin-Tian Hu, Zi-Long Qi. Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys. Science bulletin. vol 66. issue 9. 2023-01-19. PMID:36654241. |
here we induced genetic mutations in mecp2, a critical gene linked to rett syndrome (rtt) and autism spectrum disorders (asd), in the hippocampus (dg and ca1-4) of adolescent rhesus monkeys (macaca mulatta) in vivo via adeno-associated virus (aav)-delivered staphylococcus aureus cas9 with small guide rnas (sgrnas) targeting mecp2. |
2023-01-19 |
2023-08-14 |
human |
| Yunyun Li, Xiaodie Liu, Qianqian Fu, Wenxiang Fan, Xiaomei Shao, Jianqiao Fang, Jing-Gen Liu, Chi X. Electroacupuncture ameliorates depression-like behaviors comorbid to chronic neuropathic pain via Tet1-mediated restoration of adult neurogenesis. Stem cells (Dayton, Ohio). 2023-01-17. PMID:36648299. |
thus, we conclude that ea stimulation restores inhibited tet1 expression in hippocampal nscs of mice with chronic neuropathic pain, and increased tet1 expression ameliorates hypermethylation of prox1 and restores normal adult neurogenesis in the ventral dg, which contributes to the long-term antidepressant effect of ea. |
2023-01-17 |
2023-08-14 |
mouse |
| Yoon Ji Kwon, Sojeong Pak, Sunggu Yang, Sungchil Yan. Electrophysiological measurements of synaptic connectivity and plasticity in the longitudinal dentate gyrus network from mouse hippocampal slices. STAR protocols. vol 4. issue 1. 2023-01-12. PMID:36633949. |
longitudinal synaptic connections between dentate gyrus (dg) granule neurons in the hippocampus have been found to be correlated with increased anxiety. |
2023-01-12 |
2023-08-14 |
mouse |
| Masoumeh Nazari, Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Kourosh Arami, Alireza Komak. Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus. BMC neuroscience. vol 24. issue 1. 2023-01-12. PMID:36635629. |
in our previous work, we showed that cb1 antagonists increased the population spike (ps) amplitude, field excitatory post-synaptic potential (fepsp), and the ltp induction in the dentate gyrus (dg) of the rat hippocampus while the gaba |
2023-01-12 |
2023-08-14 |
mouse |
| Yuanduo Liu, Hongying Ma, Yangyang Wang, Boxu Ren, Lian Liu, Anbang Sun, Fengru Tan. Neonatal exposure to low-dose X-ray causes behavioral defects and abnormal hippocampal development in mice. IUBMB life. 2023-01-11. PMID:36629313. |
neuroinflammatory cells were observed in the dentate gyrus (dg) and ca3 areas of the hippocampus at pd3 + 1. |
2023-01-11 |
2023-08-14 |
mouse |
| Lívia Neves, Bruno Lobão-Soares, Ana Paula de Castro Araujo, Alan Michel Bezerra Furtunato, Izabela Paiva, Nicholy Souza, Anne Kelly Morais, George Nascimento, Elaine Gavioli, Adriano Bretanha Lopes Tort, Flávio Freitas Barbosa, Hindiael Belchio. Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task. Frontiers in behavioral neuroscience. vol 16. 2023-01-09. PMID:36620858. |
studies on hippocampal lesions in rodents have shown that dentate gyrus (dg) and ca3 are necessary to detect object displacement in memory tasks. |
2023-01-09 |
2023-08-14 |
rat |
| Lívia Neves, Bruno Lobão-Soares, Ana Paula de Castro Araujo, Alan Michel Bezerra Furtunato, Izabela Paiva, Nicholy Souza, Anne Kelly Morais, George Nascimento, Elaine Gavioli, Adriano Bretanha Lopes Tort, Flávio Freitas Barbosa, Hindiael Belchio. Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task. Frontiers in behavioral neuroscience. vol 16. 2023-01-09. PMID:36620858. |
here, we chronically implanted microelectrode arrays in adult male wistar rats to record network oscillations from dg, ca3, and ca1 of the dorsal hippocampus while animals executed an object recognition task of high and low spatial displacement tests (hd: 108 cm, and ld: 54 cm, respectively). |
2023-01-09 |
2023-08-14 |
rat |
| Satoshi Deyama, Shun Aoki, Rinako Sugie, Hayato Fukuda, Satoshi Shuto, Masabumi Minami, Katsuyuki Kaned. Intranasal Administration of Resolvin E1 Produces Antidepressant-Like Effects via BDNF/VEGF-mTORC1 Signaling in the Medial Prefrontal Cortex. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-01-09. PMID:36622634. |
additionally, local infusion of rve1 into the medial prefrontal cortex (mpfc) or dorsal hippocampal dentate gyrus (dg) produces antidepressant-like effects. |
2023-01-09 |
2023-08-14 |
mouse |
| Fengmei Wei, Wenhao Li, Bo Ma, Ziqing Yan, Zhi Wang, Lu Zhang, Donghua Xian, Yongqing He, Xiao Deng, Yajie Chen, Zheng Tingjuan, Junfeng Zhang, Yuhong Jin. Local CRF and oxytocin receptors correlate with female experience-driven avoidance change and hippocampal neuronal plasticity. Neurochemistry international. 2023-01-09. PMID:36623734. |
the study explored how neonatal maternal deprivation (md) and post-weaning environmental enrichment (ee) impacted the ca1 and dg's neuronal plasticity in the dorsal hippocampus, and its relationships with passive avoidance, local corticotrophin-releasing factor (crf) levels, and oxytocin receptor (otr) levels in female balb/c mice. |
2023-01-09 |
2023-08-14 |
mouse |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
the dentate gyrus (dg), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the alzheimer's type due to alzheimer's disease (dat-ad), but less is known about the susceptibility of the dg to other tauopathies. |
2023-01-03 |
2023-08-14 |
human |
| Allegra Kawles, Grace Minogue, Antonia Zouridakis, Rachel Keszycki, Nathan Gill, Caren Nassif, Christina Coventry, Hui Zhang, Emily Rogalski, Margaret E Flanagan, Rudolph Castellani, Eileen H Bigio, M Marsel Mesulam, Changiz Geula, Tamar Gefe. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta neuropathologica communications. vol 11. issue 1. 2023-01-03. PMID:36597124. |
we conclude that the dg is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. |
2023-01-03 |
2023-08-14 |
human |
| Shirley Jaqueline Szriber, Leonardo Santana Novaes, Nilton Barreto Dos Santos, Carolina Demarchi Munhoz, Deise Carla Almeida Leite-Dellov. Imbalance in the ratio between mineralocorticoid and glucocorticoid receptors and neurodegeneration in the dentate gyrus of aged dogs. Veterinary world. vol 15. issue 11. 2023-01-02. PMID:36590120. |
given the aging changes in dogs' dentate gyrus (dg) and the possible involvement of cortisol receptors in this process, this study aimed to evaluate the expression of mr and gr and neuronal degeneration in this hippocampal region of aged dogs. |
2023-01-02 |
2023-08-14 |
Not clear |
| Qi Liu, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway. Ecotoxicology and environmental safety. vol 250. 2022-12-31. PMID:36586168. |
consistent with these changes, we also observed that dlan-bl reduced the number of neurons in the ca1, ca3 and dg regions of the hippocampus, up-regulated the mrna expression levels of bax, down-regulated the mrna expression levels of bcl-2, bcl-xl and the protein expression level of pirs1, pakt, pgsk3β, β-catenin in the hippocampus. |
2022-12-31 |
2023-08-14 |
mouse |
| Azahara Oliva, Antonio Fernandez-Ruiz, Lindsay A Karab. CA2 orchestrates hippocampal network dynamics. Hippocampus. 2022-12-28. PMID:36575880. |
the hippocampus is composed of various subregions: ca1, ca2, ca3, and the dentate gyrus (dg). |
2022-12-28 |
2023-08-14 |
Not clear |
| Eu-Gene Kim, Wonseok Chang, SangYep Shin, Anjana Silwal Adhikari, Geun Hee Seol, Dae-Yong Song, Sun Seek Mi. Maternal separation in mice leads to anxiety-like/aggressive behavior and increases immunoreactivity for glutamic acid decarboxylase and parvalbumin in the adolescence ventral hippocampus. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 27. issue 1. 2022-12-28. PMID:36575939. |
gad67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (dg), ca3, ca1, subiculum, presubiculum, and parasubiculum. |
2022-12-28 |
2023-08-14 |
mouse |
| Youri G Bolsius, Pim R A Heckman, Camilla Paraciani, Sophia Wilhelm, Frank Raven, Elroy L Meijer, Martien J H Kas, Steve Ramirez, Peter Meerlo, Robbert Haveke. Recovering object-location memories after sleep deprivation-induced amnesia. Current biology : CB. 2022-12-28. PMID:36577400. |
here, we show that hippocampal object-location memories formed under sleep deprivation conditions can be successfully retrieved multiple days following training, using optogenetic dentate gyrus (dg) memory engram activation or treatment with the clinically approved phosphodiesterase 4 (pde4) inhibitor roflumilast. |
2022-12-28 |
2023-08-14 |
mouse |
| Alyssa M Ash, Elena Regele-Blasco, Désirée R Seib, Erin Chahley, Patrick D Skelton, Bryan W Luikart, Jason S Snyde. Adult-born Neurons Inhibit Developmentally-born Neurons during Spatial Learning. Neurobiology of learning and memory. 2022-12-26. PMID:36572174. |
ongoing neurogenesis in the dentate gyrus (dg) subregion of the hippocampus results in a heterogenous population of neurons. |
2022-12-26 |
2023-08-14 |
rat |
| Maria Kawalec, Piotr Wojtyniak, Ewelina Bielska, Anita Lewczuk, Anna Boratyńska-Jasińska, Małgorzata Beręsewicz-Haller, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Barbara Zabłock. Mitochondrial dynamics, elimination and biogenesis during post-ischemic recovery in ischemia-resistant and ischemia-vulnerable gerbil hippocampal regions. Biochimica et biophysica acta. Molecular basis of disease. 2022-12-25. PMID:36566873. |
our research revealed a significantly greater mtdna/ndna ratio in ca2-3, dg hippocampal regions (5.8 ± 1.4 vs 3.6 ± 0.8 in ca1) that corresponded to a neuronal resistance to i/r. |
2022-12-25 |
2023-08-14 |
Not clear |
| Yue Li, S Thameem Dheen, Fengru Tang, Yumin Luo, Ran Meng, Tay Sam Wah Samuel, Lan Zhan. Stage- and Subfield-Associated Hippocampal miRNA Expression Patterns after Pilocarpine-Induced Status Epilepticus. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551767. |
to investigate microrna (mirna) expression profiles before and after pilocarpine-induced status epilepticus (se) in the cornu ammonis (ca) and dentated gyrus (dg) areas of the mouse hippocampus, and to predict the downstream proteins and related pathways based on bioinformatic analysis. |
2022-12-23 |
2023-08-14 |
mouse |