| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H K Borys, R Karle. Post-column derivatization procedure for the colorimetric analysis of tissue cannabinoids separated by high-performance liquid chromatography. Journal of chromatography. vol 205. issue 2. 1981-06-23. PMID:6260827. |
a new method for quantitating cannabidiol (cbd) and delta 9-tetrahydrocannabinol (thc) in mouse plasma and brain involves (1) the separation of cbd and thc from their major metabolites by the use of isocratic, reversed-phase high-performance liquid chromatography (hplc), and (2) the on-line reaction of the cannabinoids with fast blue salt b (fbb) as a the former elute from the column; the colored cannabinoid-fbb derivatives are then detected at 490 nm in a spectrophotometer with a sensitivity of less than 50 ng. |
1981-06-23 |
2023-08-12 |
mouse |
| K T Brady, R L Balste. The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys. Psychopharmacology. vol 72. issue 1. 1981-04-24. PMID:6258188. |
the effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys. |
1981-04-24 |
2023-08-12 |
rat |
| K T Brady, R L Balste. The effects of delta 9-tetrahydrocannabinol alone and in combination with cannabidiol on fixed-interval performance in rhesus monkeys. Psychopharmacology. vol 72. issue 1. 1981-04-24. PMID:6258188. |
it has been reported that cannabidiol (cbd) antagonizes the effects of delta 9-tetrahydrocannabinol (thc) on operant behavior in rats and pigeons. |
1981-04-24 |
2023-08-12 |
rat |
| K Watanabe, I Yamamoto, K Oguri, H Yoshimur. UDP-glucuronyltransferase activities of rabbit liver microsomes for cannabinoids. Journal of pharmacobio-dynamics. vol 3. issue 9. 1981-04-13. PMID:6780681. |
udp-glucuronyltransferase activities for delta 8-tetrahydrocannabinol, 11-hydroxy-delta 8-tetrahydrocannabinol, cannabidiol and cannabinol were examined using liver microsomes of rabbits. |
1981-04-13 |
2023-08-12 |
rabbit |
| K Watanabe, I Yamamoto, K Oguri, H Yoshimur. UDP-glucuronyltransferase activities of rabbit liver microsomes for cannabinoids. Journal of pharmacobio-dynamics. vol 3. issue 9. 1981-04-13. PMID:6780681. |
the activities for cannabidiol and cannabinol were 2.5 and 19 times higher, respectively, than those for delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol. |
1981-04-13 |
2023-08-12 |
rabbit |
| D Maor, T Treves, A D Korczy. Lack of effect of cannabinoids on carbonic anhydrase. Journal of neural transmission. vol 49. issue 3. 1981-03-17. PMID:6256470. |
in order to investigate whether these actions of cannabinoids are mediated through inhibition of carbonic anhydrase (ca), commercial solutions of the enzyme were exposed to delta 9-tetrahydrocannabinol and cannabidiol. |
1981-03-17 |
2023-08-12 |
Not clear |
| D P Tashkin, B M Calvarese, M S Simmons, B J Shapir. Respiratory status of seventy-four habitual marijuana smokers. Chest. vol 78. issue 5. 1981-01-29. PMID:7428453. |
paired and unpaired t analyses revealed lower values for specific airway conductance (-0.07 to -0.08 +/- 0.02; p < 0.001) in the marijuana smokers compared with either group of control subjects, but no differences in spirometric indices, closing volume or delta n2 750-1250. |
1981-01-29 |
2023-08-12 |
human |
| D P Tashkin, B M Calvarese, M S Simmons, B J Shapir. Respiratory status of seventy-four habitual marijuana smokers. Chest. vol 78. issue 5. 1981-01-29. PMID:7428453. |
when non-tobacco smoking marijuana users (n = 50) were matched with either non-tobacco smoking or tobacco smoking control subjects, significant differences were again noted in specific airway conductance (p < 0.001) but not in spirometric tests, closing volume or delta n2 750-1250. |
1981-01-29 |
2023-08-12 |
human |
| H R Frischknecht, B Sieber, P G Wase. Behavioral effects of hashish in mice. II. Nursing behavior and development of the sucklings. Psychopharmacology. vol 70. issue 2. 1981-01-26. PMID:6776575. |
adult mice were treated from parturition to weaning of their first litter with a hashish extract containing 40% delta 9-tetrahydrocannabinol (delta 9-thc), 45% cannabidiol, 9% cannabinol, and 6% other cannabinoids. |
1981-01-26 |
2023-08-12 |
mouse |
| A M Zimmerman, A Y Ra. Influence of cannabinoids on somatic cells in vivo. Pharmacology. vol 21. issue 4. 1980-12-16. PMID:6252564. |
in the subacute series, mice were treated for 5 consecutive days with delta 9-tetrahydrocannabinol (thc), cannabinol or cannabidiol at a dose of 10 mg/kg, the percentage of micronuclei in cannabinoid-treated mice was 3- to 5-fold greater than in the dimethyl sulfoxide controls. |
1980-12-16 |
2023-08-12 |
mouse |
| S M Belmore, L L Mille. Levels of processing and acute effects of marijuana on memory. Pharmacology, biochemistry, and behavior. vol 13. issue 2. 1980-11-24. PMID:7413691. |
subjects' memory for lists of words was tested following the smoking of a single marijuana cigarette containing 1.4% delta 9-thc or a placebo cigarette. |
1980-11-24 |
2023-08-12 |
human |
| H L White, R L Tansi. Effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism. Prostaglandins and medicine. vol 4. issue 6. 1980-11-20. PMID:6251493. |
effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism. |
1980-11-20 |
2023-08-12 |
human |
| H L White, R L Tansi. Effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism. Prostaglandins and medicine. vol 4. issue 6. 1980-11-20. PMID:6251493. |
delta 9-tetrahydrocannabinol (thc) and cannabidiol (cbd) caused a marked stimulation of phospholipase a2 when incubated with intact human platelets that were prelabeled with [14c] arachidonate. |
1980-11-20 |
2023-08-12 |
human |
| H Rosenkrantz, H J Esbe. Cannabinoid-induced hormone changes in monkeys and rats. Journal of toxicology and environmental health. vol 6. issue 2. 1980-09-28. PMID:6248648. |
other male rats were exposed to marihuana smoke at delta 9-thc doses of 2 or 4 mg/kg for 14 d. rhesus monkeys of either sex were given oral cannabidiol doses of 30, 100, and 300 mg/kg for 90 d. serum pituitary, steroid, and thyroid hormone levels were determined by radioimmunoassay. |
1980-09-28 |
2023-08-12 |
rat |
| M K Poddar, W L Dewe. Effects of cannabinoids on catecholamine uptake and release in hypothalamic and striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 214. issue 1. 1980-09-26. PMID:7391971. |
in vitro effects of delta 9-tetrahydrocannabinol (delta 9-thc), delta 8-tetrahydrocannabinol (delta 8-thc), cannabinol (cbn) and cannabidiol (cbd) have been studied on the uptake and release of 3h-labeled dopamine (da) and norepinephrine (ne) in the synaptosomal preparation of rat brain corpus striatum and hypothalamus. |
1980-09-26 |
2023-08-12 |
rat |
| A J Ganz, P G Wase. [Testing the pharmacological activity of some synthetic cannabinoids in mice (author's transl)]. Arzneimittel-Forschung. vol 30. issue 3. 1980-08-15. PMID:7387758. |
a series of synthetic cannabinoids were tested in mice for analgesic, anticonvulsant, sedative and reserpine antagonistic properties as well as for influence on body temperature and on motor coordination and compared with the natural delta 9-tetrahydrocannabinol (delta 9-thc), delta 8-tetrahydrocannabinol (delta 8-thc) and cannabidiol (cbd). |
1980-08-15 |
2023-08-12 |
mouse |
| D J Harvey, B R Martin, W D Pato. Identification of in vivo liver metabolites of delta 1-tetra-hydrocannabinol, cannabidiol, and cannabinol produced by the guninea-pig. The Journal of pharmacy and pharmacology. vol 32. issue 4. 1980-07-12. PMID:6103056. |
identification of in vivo liver metabolites of delta 1-tetra-hydrocannabinol, cannabidiol, and cannabinol produced by the guninea-pig. |
1980-07-12 |
2023-08-12 |
mouse |
| D J Harvey, B R Martin, W D Pato. Identification of in vivo liver metabolites of delta 1-tetra-hydrocannabinol, cannabidiol, and cannabinol produced by the guninea-pig. The Journal of pharmacy and pharmacology. vol 32. issue 4. 1980-07-12. PMID:6103056. |
the metabolites of delta 1-tetrahydroannabinol (delta 1-thc), cannabidiol (cbd), and cannabinol (cbn) produced in vivo by the guinea-pig have been studed by combined gas-liquid chromatography-mass spectrometry, 45 metabolites of delta 1-thc were identified of which 12 have not been reported before. |
1980-07-12 |
2023-08-12 |
mouse |
| C Lindamood, B K Colasant. Effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6245205. |
effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. |
1980-06-27 |
2023-08-12 |
rat |
| C Lindamood, B K Colasant. Effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6245205. |
doses of delta 9-tetrahydrocannabinol (delta 9-thc) and cannabidiol (cbd) affording the same degree of protection against seizures induced by maximal electroshock were compared for their effects on sodium-dependent high affinity choline uptake into six rat brain regions: cortex, striatum, medulla-pons, hypothalamus, midbrain and hippocampus. |
1980-06-27 |
2023-08-12 |
rat |