| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Wikle. Aspects of tolerance to and dependence on cannabis. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:828472. |
"dispositional tolerance" (increased rate of metabolism of delta 9-thc due to enzyme induction) may play a role in the development of tolerance or "reverse tolerance" to cannabis in man. |
1977-04-25 |
2023-08-11 |
monkey |
| A Wikle. Aspects of tolerance to and dependence on cannabis. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:828472. |
dependence on cannabis, in the sense of abstinence phenomena on abrupt withdrawal of delta 9-thc, has been demonstrated in monkeys made tolerant to delta 9-thc given four times daily for about 1 month. |
1977-04-25 |
2023-08-11 |
monkey |
| A Wikle. Aspects of tolerance to and dependence on cannabis. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:828472. |
in the west, where marijuana with relatively low delta 9-thc content is widely smoked, dependence in the sense of drug-seeking behavior appears to be less a function of any pharmacologic reinforcing properties the drug may have than of secondary (conditioned) reinforcement derived from the social milieu in which the marijuana is smoked. |
1977-04-25 |
2023-08-11 |
monkey |
| A Wikle. Aspects of tolerance to and dependence on cannabis. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:828472. |
in cultures where marijuana of higher delta 9-thc content, hashish, or ganja is used, pharmacologic reinforcement (through suppression of abstinence changes) may play a greater role in maintaining drug-seeking behavior. |
1977-04-25 |
2023-08-11 |
monkey |
| M Fin. Effects of acute and chronic inhalation of hashish, marijuana, and delta 9-tetrahydrocannabinol on brain electrical activity in man: evidence for tissue tolerance. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:1071390. |
effects of acute and chronic inhalation of hashish, marijuana, and delta 9-tetrahydrocannabinol on brain electrical activity in man: evidence for tissue tolerance. |
1977-04-25 |
2023-08-11 |
Not clear |
| M Fin. Effects of acute and chronic inhalation of hashish, marijuana, and delta 9-tetrahydrocannabinol on brain electrical activity in man: evidence for tissue tolerance. Annals of the New York Academy of Sciences. vol 282. 1977-04-25. PMID:1071390. |
an eeg profile for cannabis preparations equated for delta 9-thc activity has been defined in occasional cannabis users in new york and in long-term, high-dose hashish users in athens. |
1977-04-25 |
2023-08-11 |
Not clear |
| E E Knaus, R T Coutts, C W Kazakof. The separation, identification, and quantitation of cannabinoids and their tau=butyldimethylsilyl, trimethylsilylacetate, and diethylphosphate derivatives using high-pressure liquid chromatography, gas-liquid chromatography, and mass spectrometry. Journal of chromatographic science. vol 14. issue 11. 1976-12-30. PMID:977713. |
these methods include high-pressure liquid chromatographic and gas-liquid chromatographic separation of cannabinol, delta 9-tetrahydrocannabinol, delta 8-tetrahydrocannabinol, and cannabidiol as well as their tau-butyidimethylsilyl either and trimethylsilylacetate derivatives. |
1976-12-30 |
2023-08-11 |
Not clear |
| D Bach, A Raz, R Goldma. The effect of hashish compounds on pphospholipid phase transition. Biochimica et biophysica acta. vol 436. issue 4. 1976-10-20. PMID:952922. |
the interaction of hashish compounds, delta 1-tetrahydrocannabinol and cannabidiol, with dipalmitoyl phosphatidylcholine was investigated using differential scanning calorimetry. |
1976-10-20 |
2023-08-11 |
Not clear |
| A Raz, R Goldma. Effect of hashish compounds on mouse peritoneal macrophages. Laboratory investigation; a journal of technical methods and pathology. vol 34. issue 1. 1976-03-20. PMID:1246125. |
light microscopy reveals an induction of extensive vacuolation in the macrophage after exposure to either delta 1-tetrahydrocannabinol or cannabidiol. |
1976-03-20 |
2023-08-11 |
mouse |
| A Raz, R Goldma. Effect of hashish compounds on mouse peritoneal macrophages. Laboratory investigation; a journal of technical methods and pathology. vol 34. issue 1. 1976-03-20. PMID:1246125. |
the effect of hashish compounds on macrophages is essentially irreversible; exposure for 15 minutes to 10(-5) m of delta 1-thc or cannabidiol and a thorough wash in 20 per cent serum-medium, suffices to trigger the sequence of vacuolation and total cell death in the culture. |
1976-03-20 |
2023-08-11 |
mouse |
| B Hine, M Torrelio, S Gersho. Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats. Research communications in chemical pathology and pharmacology. vol 12. issue 1. 1976-01-26. PMID:1237925. |
the same dose of cannabinol (cbn) or cannabidiol (cbd) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-thc. |
1976-01-26 |
2023-08-11 |
rat |
| B Hine, M Torrelio, S Gersho. Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats. Research communications in chemical pathology and pharmacology. vol 12. issue 1. 1976-01-26. PMID:1237925. |
these data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-thc that might be relevant to possible clinical use of cannabis in narcotic detoxification. |
1976-01-26 |
2023-08-11 |
rat |
| W D Purnell, J M Greg. Delta(9)-tetrahydrocannabinol,, euphoria and intraocular pressure in man. Annals of ophthalmology. vol 7. issue 7. 1975-10-11. PMID:1147519. |
delta(9)-tetrahydrocannabinol (thc), an active narcotic principle of marijuana, was solubilized and administered intravenously to two male volunteers. |
1975-10-11 |
2023-08-11 |
human |
| R G Pertwe. Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4451752. |
1 three injections of cannabis extract (500 mg/kg s.c. given over 3 or 5 days) diminished thymus gland weight but not the weights of spleen or liver in weanling female and adult male mice kept at room temperature.2 both cannabis extract (500 mg/kg s.c.) and delta(1)-tetrahydrocannabinol (delta(1)-thc; 10 and 20 mg/kg i.p.) |
1975-06-12 |
2023-08-11 |
mouse |
| R G Pertwe. Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4451752. |
elevated corticosterone levels in mouse plasma.3 a pretreatment that consisted of three daily subcutaneous injections of 500 mg/kg of cannabis extract and that was shown to produce tolerance to the ;cataleptic' effect of delta(1)-thc (2 mg/kg i.v.) |
1975-06-12 |
2023-08-11 |
mouse |
| R G Pertwe. Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4451752. |
three daily injections of delta(1)-thc (10 or 30 mg/kg s.c.) also produced tolerance.5 in a thermoneutral environment (30-32 degrees c) in which cannabis extract does not produce hypothermia, the drug no longer reduced thymus gland weight. |
1975-06-12 |
2023-08-11 |
mouse |
| R G Pertwe. Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4451752. |
however the effect of cannabis extract and of delta(1)-thc on corticosterone plasma levels was the same at room temperature as at 30-32 degrees c. tolerance to the latter effect of delta(1)-thc was also produced equally readily under the two conditions.6 it is concluded that pretreatment with cannabis extract or delta(1)-thc can produce tolerance to the effect of delta(1)-thc on corticosterone levels in mouse plasma and does so without impairing the effect of immobilization stress on corticosterone release. |
1975-06-12 |
2023-08-11 |
mouse |
| R G Pertwe. Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol. British journal of pharmacology. vol 51. issue 3. 1975-06-12. PMID:4451752. |
in addition, both the rise in corticosterone plasma levels produced by cannabis or delta(1)-thc and the development of tolerance to this effect can still take place in the absence of hypothermia. |
1975-06-12 |
2023-08-11 |
mouse |
| G B Chesher, D M Jackson, G A Starme. Interaction of cannabis and general anaesthetic agents in mice. British journal of pharmacology. vol 50. issue 4. 1975-05-21. PMID:4280927. |
1 a cannabis extract (i) (in a concentration equivalent to 10 mg delta(9)-tetrahydro-cannabinol(thc)/kg) prolonged pentobarbitone anaesthesia in mice maximally 20 min to 2 h after medication. |
1975-05-21 |
2023-08-11 |
mouse |
| G B Chesher, D M Jackson, G A Starme. Interaction of cannabis and general anaesthetic agents in mice. British journal of pharmacology. vol 50. issue 4. 1975-05-21. PMID:4280927. |
the effect was still significant after 8 h, but less than at 2 hours.2 the cannabis extract (i) (equivalent to 10 mg delta(9)-thc/kg) prolonged both pentobarbitone and ether anaesthesia in mice when administered 20 min before the anaesthetic. |
1975-05-21 |
2023-08-11 |
mouse |