| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Turkanis, R Karle. Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats. Neuropharmacology. vol 21. issue 1. 1982-05-27. PMID:6278353. |
the effects of delta 9-tetrahydrocannabinol (delta 9-thc), two of its metabolites, 8 beta-hydroxy-delta 9-thc and 11-hydroxy-delta 9-thc, and cannabidiol were comparatively studied by means of an iron-induced cortical focal epilepsy in conscious rats with chronically implanted electrodes. |
1982-05-27 |
2023-08-12 |
rat |
| S A Turkanis, R Karle. Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats. Neuropharmacology. vol 21. issue 1. 1982-05-27. PMID:6278353. |
in contrast, cannabidiol, even in large doses (100 mg/kg) was devoid of all the effects of delta 9-thc. |
1982-05-27 |
2023-08-12 |
rat |
| S A Turkanis, R Karle. Central excitatory properties of delta 9-tetrahydrocannabinol and its metabolites in iron-induced epileptic rats. Neuropharmacology. vol 21. issue 1. 1982-05-27. PMID:6278353. |
furthermore, pretreatment with cannabidiol markedly altered the responses to delta 9-thc in the following ways: focal depression was partially blocked, polyspike activity was enhanced and convulsions abolished. |
1982-05-27 |
2023-08-12 |
rat |
| A Ohlsson, J E Lindgren, A Wahlén, S Agurell, L E Hollister, H K Gillespi. Single dose kinetics of deuterium labelled delta 1-tetrahydrocannabinol in heavy and light cannabis users. Biomedical mass spectrometry. vol 9. issue 1. 1982-05-21. PMID:6277407. |
single dose kinetics of deuterium labelled delta 1-tetrahydrocannabinol in heavy and light cannabis users. |
1982-05-21 |
2023-08-12 |
human |
| S A Turkanis, R Karle. Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat. Psychopharmacology. vol 75. issue 3. 1982-03-13. PMID:6275447. |
excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat. |
1982-03-13 |
2023-08-12 |
rat |
| S A Turkanis, R Karle. Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat. Psychopharmacology. vol 75. issue 3. 1982-03-13. PMID:6275447. |
the influences of delta 9-tetrahydrocannabinol (thc) and cannabidiol on electrically evoked cortical potentials of conscious rats with chronically implanted electrodes were investigated. |
1982-03-13 |
2023-08-12 |
rat |
| S Ferri, G Costa, G Murari, A M Panico, E Rapisarda, E Speroni, R Arrigo-Rein. Investigations on behavioral effects of an extract of Cannabis sativa L. in the rat. Psychopharmacology. vol 75. issue 2. 1982-03-13. PMID:6798604. |
the behavioral responses of the rat to an extract of cannabis sativa were examined after ip injection of 5, 15 and 30 mg/kg (expressed as delta 9 tetrahydrocannabinol). |
1982-03-13 |
2023-08-12 |
rat |
| S Agurell, S Carlsson, J E Lindgren, A Ohlsson, H Gillespie, L Holliste. Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography. Experientia. vol 37. issue 10. 1982-02-12. PMID:6273208. |
interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. |
1982-02-12 |
2023-08-12 |
Not clear |
| S A Turkanis, R Karle. Electrophysiologic properties of the cannabinoids. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6271840. |
the effects of the psychoactive cannabinoid delta 9-tetrahydrocannabinol (thc) and the nonpsychoactive cannabinoid cannabidiol (cbd) were investigated comparatively on electrically caused transcallosal cortical evoked responses, electrically induced limbic after discharges, photically evoked cortical afterdischarges, spontaneous cortical focal epileptic potentials, and spinal monosynaptic reflexes. |
1982-01-09 |
2023-08-12 |
Not clear |
| M A Elsohly, E Harland, J C Murphy, P Wirth, C W Walle. Cannabinoids in glaucoma: a primary screening procedure. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6271842. |
following this procedure we found that delta 8-thc, delta 9-thc, cannabinol, and nabilone were active while cannabidiol was inactive. |
1982-01-09 |
2023-08-12 |
Not clear |
| R Karler, S A Turkani. The cannabinoids as potential antiepileptics. Journal of clinical pharmacology. vol 21. issue S1. 1982-01-09. PMID:6975285. |
comparative studies of the anticonvulsant properties of the cannabinoids and prototype antiepileptic drugs in numerous animal seizure models demonstrate that (1) as an anticonvulsant, cannabidiol (cbd), in contrast to delta 9-tetrahydrocannabinol (thc), is relatively selective in terms of both central nervous system (cns), depressant and excitatory properties; (2) the potency of cannabidiol, unlike that of phenytoin and phenobarbital, varies greatly with the species; (3) the large potency difference between the cannabinoids and the antiepileptics in the mouse appears to be due to dispositional differences, because brain concentrations of all the drugs are very similar; (4) tolerance to the anticonvulsant properties of cannabidiol is not a prominent feature; in three seizure models, tolerance developed in one, but "reverse tolerance" developed in the other two; and (5) the results of a study of the electrophysiologic mechanisms of action indicate that cannabidiol produces some unique effects and that its spectrum of antiepileptic activity may be different from that of the prototype drugs. |
1982-01-09 |
2023-08-12 |
mouse |
| C A Hunt, R T Jones, R I Herning, J Bachma. Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man. Journal of pharmacokinetics and biopharmaceutics. vol 9. issue 3. 1981-12-22. PMID:6270295. |
the pharmacokinetics of delta 9-tetrahydrocannabinol (thc) administered intravenously was evaluated in four subjects after oral administration of placebo and 1500 mg of cannabidiol (cbd) according to a crossover design. |
1981-12-22 |
2023-08-12 |
human |
| P Consroe, B S Fis. Rabbit behavioral model of marijuana psychoactivity in humans. Medical hypotheses. vol 7. issue 8. 1981-12-15. PMID:6270517. |
in a genetically unique colony of tetrahydrocannabinol-seizure susceptible (thc-ss) rabbits, nonfatal convulsions are elicited by delta 9thc, the major psychoactive ingredient of marijuana. |
1981-12-15 |
2023-08-12 |
rabbit |
| B S Fish, P Consroe, R R Fo. Inheritance of delta 9-tetrahydrocannabinol seizure susceptibility in rabbits. The Journal of heredity. vol 72. issue 3. 1981-11-24. PMID:6268703. |
delta 9-tetrahydrocannabinol (thc), the major psychoactive ingredient of marijuana, causes nonfatal convulsions in rabbits of a closed colony of new zealand white rabbits (uaz: nzw). |
1981-11-24 |
2023-08-12 |
Not clear |
| E Bertol, F Mar. Observations on cannabinoid content in Cannabis sativa L. grown in Tuscany, Italy. Bulletin on narcotics. vol 32. issue 4. 1981-11-22. PMID:6912080. |
the percentage of delta 9-tetrahydrocannabinol content in adult plants and the phenotype ratio of young plants were determined to differentiate fibre-type from drug-type cannabis plants. |
1981-11-22 |
2023-08-12 |
Not clear |
| P B Baker, B J Taylor, T A Goug. The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products. The Journal of pharmacy and pharmacology. vol 33. issue 6. 1981-10-29. PMID:6115009. |
methods are available for the determination of delta 9-tetrahydrocannabinol (thc) and its acids (thca) and published data on the levels of these compounds in cannabis are summarized. |
1981-10-29 |
2023-08-12 |
Not clear |
| J E Lindgren, A Ohlsson, S Agurell, L Hollister, H Gillespi. Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. Psychopharmacology. vol 74. issue 3. 1981-10-25. PMID:6267648. |
clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-thc) in heavy and light users of cannabis. |
1981-10-25 |
2023-08-12 |
Not clear |
| B K Ko. Levonantradol, a potent cannabinoid-related analgesic, antagonizes haloperidol-induced activation of striatal dopamine synthesis. European journal of pharmacology. vol 70. issue 2. 1981-10-14. PMID:6266845. |
delta 9-tetrahydrocannabinol at a dose 320 times higher than levonantradol also attenuated the haloperidol effect, but cannabidiol was inactive at a dose 750 times higher. |
1981-10-14 |
2023-08-12 |
Not clear |
| D S Poster, J S Penta, S Bruno, J S Macdonal. delta 9-tetrahydrocannabinol in clinical oncology. JAMA. vol 245. issue 20. 1981-07-20. PMID:6262541. |
after anecdotal reports of marijuana's providing antiemetic activity in cancer chemotherapy patients refractory to standard agents, orally administered delta 9-tetrahydrocannabinol (thc) was formally studied by a number of investigators. |
1981-07-20 |
2023-08-12 |
Not clear |
| A W Zuardi, E Finkelfarb, O F Bueno, R E Musty, I G Karnio. Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. Archives internationales de pharmacodynamie et de therapie. vol 249. issue 1. 1981-06-25. PMID:6261703. |
characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol. |
1981-06-25 |
2023-08-12 |
rat |