| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I G Karniol, I Shirakawa, N Kasinski, A Pfeferman, E A Carlin. Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man. European journal of pharmacology. vol 28. issue 1. 1975-02-18. PMID:4609777. |
cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man. |
1975-02-18 |
2023-08-11 |
Not clear |
| A Dittrich, B Woggo. [Subjective changes with delta 9 trans-tetrahydrocannabinol in cannabis naive subjects]. International pharmacopsychiatry. vol 9. issue 3. 1975-02-06. PMID:4609941. |
[subjective changes with delta 9 trans-tetrahydrocannabinol in cannabis naive subjects]. |
1975-02-06 |
2023-08-11 |
human |
| E A Carlini, I G Karniol, P F Renault, C R Schuste. Effects of marihuana in laboratory animals and in man. British journal of pharmacology. vol 50. issue 2. 1975-01-28. PMID:4609532. |
1 the pharmacological potencies of the resins from three different samples of brazilian marihuana (a, b and c) were determined through corneal areflexia in rabbits, decrease of spontaneous motor activity and induction of catatonia in mice, and decrease of rope climbing performance of rats.2 the delta(9)-tetrahydrocannabinol (delta(9) thc) content of the marihuanas, measured by gas chromatography, was 0.82, 2.02 and 0.52%, respectively, for samples a, b and c. approximately 2% cannabinol was present in samples a and b whereas the content of cannabidiol was approximately 0.1%.3 the petroleum ether extraction of the samples a, b and c yielded, respectively, 12.06, 14.56 and 4.26% of resin.4 in all animal tests resin b was nearly twice as active as resin a, whereas c was the weakest.5 the smoke of the marihuana samples was inhaled by 33 human subjects, under a double-blind standardized procedure. |
1975-01-28 |
2023-08-11 |
mouse |
| D K Lawrence, R G Pertwe. Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol. British journal of pharmacology. vol 49. issue 2. 1974-09-17. PMID:4793443. |
repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated delta(1)-tetrahydrocannabinol ([(3)h]-delta(1)-thc; 2 mg/kg i.v.) |
1974-09-17 |
2023-08-11 |
mouse |
| G B Chesher, C J Dahl, M Everingham, D M Jackson, H Marchant-Williams, G A Starme. The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice. British journal of pharmacology. vol 49. issue 4. 1974-06-17. PMID:4788032. |
after oral administration to mice, pethidine, delta(8)-tetrahydrocannabinol (thc), delta(9)-thc, a cannabis extract and cannabinol had a dose-dependent antinociceptive effect when measured by the hot-plate method. |
1974-06-17 |
2023-08-11 |
mouse |
| G B Chesher, C J Dahl, M Everingham, D M Jackson, H Marchant-Williams, G A Starme. The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice. British journal of pharmacology. vol 49. issue 4. 1974-06-17. PMID:4788032. |
after oral administration, three different cannabis extracts, delta(8)-thc, delta(9)-thc and morphine produced dose-dependent depressions of the passage of a charcoal meal in mice. |
1974-06-17 |
2023-08-11 |
mouse |
| G B Chesher, C J Dahl, M Everingham, D M Jackson, H Marchant-Williams, G A Starme. The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice. British journal of pharmacology. vol 49. issue 4. 1974-06-17. PMID:4788032. |
the effect of the three cannabis extracts on intestinal motility could be accounted for by their delta(9)-thc content.3. |
1974-06-17 |
2023-08-11 |
mouse |
| J D Graham, D M L. Cardiovascular and respiratory effects of cannabis in cat and rat. British journal of pharmacology. vol 49. issue 1. 1974-06-12. PMID:4787563. |
in anaesthetized rats, intravenous administration of cannabis extract (10 mg/kg), delta(1)-tetrahydrocannabinol (thc) (0.5 mg/kg) and delta(6)-thc (0.5 mg/kg) caused a reduction in systemic blood pressure, pulse rate and respiratory rate.2. |
1974-06-12 |
2023-08-11 |
rat |
| J D Graham, D M L. Cardiovascular and respiratory effects of cannabis in cat and rat. British journal of pharmacology. vol 49. issue 1. 1974-06-12. PMID:4787563. |
both cannabis extract and delta(1)-thc potentiated reflex vasodilation and direct vasoconstriction in the hindlimb induced by intravenous noradrenaline in the cat; they reduced reflex hindlimb vasoconstriction elicited by histamine, acetylcholine or bilateral carotid occlusion.6. |
1974-06-12 |
2023-08-11 |
rat |
| I G Karniol, E A Carlin. Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol. Psychopharmacologia. vol 33. issue 1. 1974-03-05. PMID:4358666. |
pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol. |
1974-03-05 |
2023-08-11 |
Not clear |
| D P Tashkin, B J Shapiro, I M Fran. Acute pulmonary physiologic effects of smoked marijuana and oral (Delta)9 -tetrahydrocannabinol in healthy young men. The New England journal of medicine. vol 289. issue 7. 1973-09-13. PMID:4718513. |
acute pulmonary physiologic effects of smoked marijuana and oral (delta)9 -tetrahydrocannabinol in healthy young men. |
1973-09-13 |
2023-08-11 |
Not clear |
| R G Pertwe. The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice. British journal of pharmacology. vol 46. issue 4. 1973-05-02. PMID:4655271. |
it is concluded that delta(1)-tetrahydrocannabinol (delta(1)-thc) is largely responsible for the effect of cannabis extract on mobility; the potency ratio of delta(1)-thc to cannabis extract is between 10 and 20. |
1973-05-02 |
2023-08-11 |
mouse |
| O J Rafaelsen, P Bech, J Christiansen, H Christrup, J Nyboe, L Rafaelse. Cannabis and alcohol: effects on stimulated car driving. Science (New York, N.Y.). vol 179. issue 4076. 1973-04-16. PMID:4569248. |
cannabis resin containing 4 percent delta(1)-tetrahydrocannabinol was administered orally in three doses equivalent to 8, 12, and 16 milligrams of that component. |
1973-04-16 |
2023-08-11 |
Not clear |
| M D Low, H Klonoff, A Marcu. The neurophysiological basis of the marijuana experience. Canadian Medical Association journal. vol 108. issue 2. 1973-03-23. PMID:4684623. |
all variables were recorded over 45 minutes before and 45 minutes after smoking a marijuana cigarette containing either 4.8, 9.1 or less than 0.01 mg. delta(9)-thc.high doses of marijuana induced a significant decrease in the peak power of the alpha rhythm and an increase in auditory evoked-response latency. |
1973-03-23 |
2023-08-11 |
Not clear |
| S Casswell, D F Mark. Cannabis and temporal disintegration in experienced and naive subjects. Science (New York, N.Y.). vol 179. issue 4075. 1973-03-19. PMID:4567504. |
the effects of 3.3 and 6.6 milligrams of delta(9)-tetrahydrocannabinol and of placebo on performance of three cognitive tasks were compared for naive subjects and experienced cannabis smokers. |
1973-03-19 |
2023-08-11 |
human |
| F Mikes, P G Wase. Marihuana components: effects of smoking on delta-9-tetrahydrocannabinol and cannabidiol. Science (New York, N.Y.). vol 172. issue 3988. 1971-06-30. PMID:5574523. |
cigarettes impregnated with various preparations of delta(9)-tetrahydro-cannabinol (delta(9)-thc) and cannabidiol were artificially smoked, and the smoke was analyzed by means of gas chromatography and a combination of gas chromatography and mass spectrometry. |
1971-06-30 |
2023-08-11 |
Not clear |
| F Mikes, P G Wase. Marihuana components: effects of smoking on delta-9-tetrahydrocannabinol and cannabidiol. Science (New York, N.Y.). vol 172. issue 3988. 1971-06-30. PMID:5574523. |
the ratio of delta(9)-thc to cannabidiol in smoke is different from that in starting material. |
1971-06-30 |
2023-08-11 |
Not clear |
| F Mikes, P G Wase. Marihuana components: effects of smoking on delta-9-tetrahydrocannabinol and cannabidiol. Science (New York, N.Y.). vol 172. issue 3988. 1971-06-30. PMID:5574523. |
it is suggested that these differences are the result of partial cyclization of the cannabidiol to delta(9)-thc. |
1971-06-30 |
2023-08-11 |
Not clear |
| F Mikes, P G Wase. Marihuana components: effects of smoking on delta-9-tetrahydrocannabinol and cannabidiol. Science (New York, N.Y.). vol 172. issue 3988. 1971-06-30. PMID:5574523. |
an increase in the percentage of cannabinol in smoke is the result of a partial dehydrogenation drogenation of delta(9)-thc or cannabidiol. |
1971-06-30 |
2023-08-11 |
Not clear |
| R Mechoulam, A Shani, H Edery, Y Grunfel. Chemical basis of hashish activity. Science (New York, N.Y.). vol 169. issue 3945. 1970-08-25. PMID:4987683. |
cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with delta(1)-tetrahydrocannabinol do not cause a change in the activity of the latter, under the experimental conditions used. |
1970-08-25 |
2023-08-11 |
monkey |