| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Shumay, John Chen, Joanna S Fowler, Nora D Volko. Genotype and ancestry modulate brain's DAT availability in healthy humans. PloS one. vol 6. issue 8. 2011-12-14. PMID:21826203. |
the dopamine transporter (dat) is a principal regulator of dopaminergic neurotransmission and its gene (the slc6a3) is a strong biological candidate gene for various behavioral- and neurological disorders. |
2011-12-14 |
2023-08-12 |
human |
| Roxann C Harvey, Sucharita Sen, Agripina Deaciuc, Linda P Dwoskin, Kathleen M Kanta. Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150910. |
after discontinuing adolescent treatments, adult rats were evaluated for cocaine self-administration and dopamine transporter (dat) function in the prefrontal cortex (pfc) and striatum. |
2011-12-12 |
2023-08-12 |
rat |
| Roxann C Harvey, Sucharita Sen, Agripina Deaciuc, Linda P Dwoskin, Kathleen M Kanta. Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150910. |
in the pfc, the maximal dopamine uptake (v(max)) at dat was decreased in shrs and increased in wky and wis rats by previous methylphenidate treatment. |
2011-12-12 |
2023-08-12 |
rat |
| Roxann C Harvey, Sucharita Sen, Agripina Deaciuc, Linda P Dwoskin, Kathleen M Kanta. Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150910. |
the affinity (k(m)) for dopamine at dat in the pfc was not different between strains, nor was v(max) or k(m) altered in the striatum by previous methylphenidate treatment in any strain. |
2011-12-12 |
2023-08-12 |
rat |
| Roxann C Harvey, Sucharita Sen, Agripina Deaciuc, Linda P Dwoskin, Kathleen M Kanta. Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21150910. |
methylphenidate-induced decreases in dopamine clearance by dat in the pfc may underlie increased cocaine self-administration in shrs. |
2011-12-12 |
2023-08-12 |
rat |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Sex differences in methamphetamine toxicity in mice: effect on brain dopamine signaling pathways. Psychoneuroendocrinology. vol 36. issue 7. 2011-12-09. PMID:21236583. |
dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) autoradiography in the lateral striatum showed a greater sensitivity in male mice treated with 20mg/kg methamphetamine compared to female mice. |
2011-12-09 |
2023-08-12 |
mouse |
| Mélanie Bourque, Bin Liu, Dean E Dluzen, Thérèse Di Paol. Sex differences in methamphetamine toxicity in mice: effect on brain dopamine signaling pathways. Psychoneuroendocrinology. vol 36. issue 7. 2011-12-09. PMID:21236583. |
striatal dopamine concentration and dat autoradiography showed a more extensive depletion in male mice given 40mg/kg methamphetamine compared to female mice. |
2011-12-09 |
2023-08-12 |
mouse |
| Amit Anand, Gavriel Barkay, Mario Dzemidzic, Daniel Albrecht, Harish Karne, Qi-Huang Zheng, Gary D Hutchins, Marc D Normandin, Karmen K Yode. Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar disorders. vol 13. issue 4. 2011-12-07. PMID:21843280. |
reuptake of synaptic dopamine by the dopamine transporter (dat) is the principal mechanism regulating dopamine neurotransmission, and is often used as a marker for presynaptic dopamine function. |
2011-12-07 |
2023-08-12 |
human |
| Anna Mané, Judith Gallego, Francisco Lomeña, Jose Javier Mateos, Emilio Fernandez-Egea, Guillermo Horga, Albert Cot, Javier Pavia, Miguel Bernardo, Eduard Parellad. A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients. Psychiatry research. vol 194. issue 1. 2011-12-06. PMID:21831607. |
a 4-year dopamine transporter (dat) imaging study in neuroleptic-naive first episode schizophrenia patients. |
2011-12-06 |
2023-08-12 |
Not clear |
| Anna Mané, Judith Gallego, Francisco Lomeña, Jose Javier Mateos, Emilio Fernandez-Egea, Guillermo Horga, Albert Cot, Javier Pavia, Miguel Bernardo, Eduard Parellad. A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients. Psychiatry research. vol 194. issue 1. 2011-12-06. PMID:21831607. |
a key component in dopaminergic neurotransmission is the striatal dopamine transporter (dat). |
2011-12-06 |
2023-08-12 |
Not clear |
| M Suárez-Piñera, M L Prat, A Mestre-Fusco, J Fuertes, S Mojal, E Balague. [Interobserver agreement in the visual and semi-quantitative analysis of the 123I-FP-CIT SPECT images in the diagnosis of Parkinsonian syndrome]. Revista espanola de medicina nuclear. vol 30. issue 4. 2011-11-28. PMID:21524823. |
using (123)i-fp-cit spect images makes it possible to identify presynaptic deterioration of the dopaminergic pathway by studying the dopamine transporter (dat). |
2011-11-28 |
2023-08-12 |
Not clear |
| Ann D Cohen, Michael J Zigmond, Amanda D Smit. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain research. vol 1370. 2011-11-23. PMID:21062624. |
6-ohda caused a loss of cells in the substantia nigra that expressed both fg and tyrosine hydroxylase (th) and striatal terminals expressing th, the high affinity dopamine transporter (dat), and the vesicular monoamine transporter 2 (vmat2) as assessed 2-8 weeks later. |
2011-11-23 |
2023-08-12 |
Not clear |
| Joanna Solich, Agata Faron-Gorecka, Maciej Kusmider, Paulina Palach, Magdalena Gaska, Marta Dziedzicka-Wasylewsk. Norepinephrine transporter (NET) knock-out upregulates dopamine and serotonin transporters in the mouse brain. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21693154. |
in the present study we demonstrate that the life-long deletion of the noradrenaline transporter (net) induced up-regulation of two other monoamine transporters, dopamine and serotonin (dat and sert, respectively). |
2011-11-22 |
2023-08-12 |
mouse |
| Deanna M Navaroli, Zachary H Stevens, Zeljko Uzelac, Luke Gabriel, Michael J King, Lawrence M Lifshitz, Harald H Sitte, Haley E Melikia. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 39. 2011-11-21. PMID:21957239. |
the amphetamine- and cocaine-sensitive dopamine (da) transporter (dat) tightly controls extracellular da concentrations and half-life. |
2011-11-21 |
2023-08-12 |
Not clear |
| Jared W Young, Jordy van Enkhuizen, Catharine A Winstanley, Mark A Geye. Increased risk-taking behavior in dopamine transporter knockdown mice: further support for a mouse model of mania. Journal of psychopharmacology (Oxford, England). vol 25. issue 7. 2011-11-14. PMID:21421642. |
reduced functioning of the dopamine transporter (dat) has been linked to bipolar disorder (bd). |
2011-11-14 |
2023-08-12 |
mouse |
| D E Dluzen, J L McDermott, M Bourque, T Di Paolo, A S Darvesh, A B Buletko, N J Lapin. Markers associated with sex differences in methamphetamine-induced striatal dopamine neurotoxicity. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886559. |
in mice with a heterozygous mutation of their dopamine transporter (+/- dat), only female mice show significant differences in dopamine transporter binding and mrna and associated reductions in striatal dopamine content along with increases in ma-evoked striatal dopamine output. |
2011-11-10 |
2023-08-12 |
mouse |
| Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayam. Methylone and monoamine transporters: correlation with toxicity. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886563. |
we examined here the effects of methylone on the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using a heterologous expression system in cho cells, in association with its cytotoxicity. |
2011-11-10 |
2023-08-12 |
Not clear |
| Y Hagino, Y Takamatsu, H Yamamoto, T Iwamura, D L Murphy, G R Uhl, I Sora, K Iked. Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886569. |
the present study investigated the effects of mdma on extracellular dopamine (da(ex)) and serotonin (5-ht(ex)) levels in the striatum and prefrontal cortex (pfc) using in vivo microdialysis techniques in mice lacking da transporters (dat) and/or 5-ht transporters (sert). |
2011-11-10 |
2023-08-12 |
mouse |
| Ha Jin Jeong, Jeong-Hoon Kim, Songhee Jeo. Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 15. issue 4. 2011-11-10. PMID:21994482. |
amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (dat) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. |
2011-11-10 |
2023-08-12 |
Not clear |
| Karen Miguita, Quirino Cordeiro, Roseli Gedanke Shavitt, Eurípedes Constantino Miguel, Homero Vallad. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arquivos de neuro-psiquiatria. vol 69. issue 2B. 2011-11-08. PMID:21625751. |
in the present paper, we investigated the 5httlpr and stin2 polymorphisms in the promoter region of the serotonin transporter gene (slc6a4), the g861c polymorphism (rs6296) of the serotonin receptor 1d beta (htr1b), the t102c (rs6113) and c516t (rs6305) polymorphisms of the serotonin receptor gene subtype 2a (htr2a), the dat utr, dat intron 8 and dat intron 14 of the dopamine transporter gene (slc6a3), the val-158-met (rs4680) polymorphism of the comt and the silent mutation g1287a (rs5569) in the norepinephrine transporter gene (slc6a2). |
2011-11-08 |
2023-08-12 |
Not clear |