| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maura Castelli, Mauro Federici, Silvia Rossi, Valentina De Chiara, Francesco Napolitano, Valeria Studer, Caterina Motta, Lucia Sacchetti, Rosaria Romano, Alessandra Musella, Giorgio Bernardi, Alberto Siracusano, Howard H Gu, Nicola B Mercuri, Alessandro Usiello, Diego Centonz. Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. The European journal of neuroscience. vol 34. issue 9. 2012-02-17. PMID:22034972. |
as striatal da signalling modulates the endocannabinoid system (ecs), the present study was aimed at investigating cannabinoid cb1 receptor (cb1r) function in a model of adhd obtained by triple point-mutation in the dopamine transporter (dat) gene in mice, making them insensitive to cocaine [dat cocaine-insensitive (dat-ci) mice]. |
2012-02-17 |
2023-08-12 |
mouse |
| Gregory C Hadlock, Chad C Nelson, Anthony J Baucum, Glen R Hanson, Annette E Fleckenstei. Ex vivo identification of protein-protein interactions involving the dopamine transporter. Journal of neuroscience methods. vol 196. issue 2. 2012-02-16. PMID:21291912. |
the dopamine (da) transporter (dat) is a key regulator of dopaminergic signaling as it mediates the reuptake of extrasynaptic da and thereby terminates dopaminergic signaling. |
2012-02-16 |
2023-08-12 |
rat |
| Mark Hallet. Psychogenic parkinsonism. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21458829. |
there are clinical clues that can lead to the correct diagnosis, and laboratory testing with clinical neurophysiology or dat (dopamine transporter) scanning can be helpful as well. |
2012-02-16 |
2023-08-12 |
Not clear |
| Henk W Berendse, Dareia S Roos, Pieter Raijmakers, Richard L Dot. Motor and non-motor correlates of olfactory dysfunction in Parkinson's disease. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21705022. |
in 60 pd patients, [(123)i]fp-cit spect scans were available to assess the relationship between upsit scores and striatal dopamine transporter (dat) binding. |
2012-02-16 |
2023-08-12 |
Not clear |
| Yoshiyuki Kasahara, Yosefu Arime, Yumiko Kubo, Asami Fukui, Ichiro Sor. [Neuronal development of the hyperdopaminergic animal model]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 5-6. 2012-02-16. PMID:22256607. |
dopamine transporter knockout (dat ko) mice exhibited hyperdopaminergic tone in the nucleus accumbens and striatum, whereas they showed normal levels of extracellular dopamine in the prefrontal cortex. |
2012-02-16 |
2023-08-12 |
mouse |
| Haifeng Hou, Shugui Yin, Shaowei Jia, Shu Hu, Taotao Sun, Qing Chen, Rong Fa. Decreased striatal dopamine transporters in codeine-containing cough syrup abusers. Drug and alcohol dependence. vol 118. issue 2-3. 2012-02-09. PMID:21477952. |
the present study was designed to determine if the striatal dopamine transporter (dat) levels measured by (99m)tc-trodat-1 single photon emission computed tomography (spect) brain scans were altered in ccs-dependent subjects and to explore the ccs-caused brain impairment. |
2012-02-09 |
2023-08-12 |
human |
| Alicia M Pickrell, Milena Pinto, Aline Hida, Carlos T Morae. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 48. 2012-02-09. PMID:22131425. |
taking advantage of a dopamine transporter (dat) promoter-driven tetracycline transactivator protein (tta), we expressed mito-psti exclusively in dopaminergic neurons, creating a novel pd transgenic mouse model (pd-mito-psti mouse). |
2012-02-09 |
2023-08-12 |
mouse |
| Gonzalo Flores, María de Jesús Gómez-Villalobos, Leonardo Rodríguez-Sos. Prenatal amphetamine exposure effects on dopaminergic receptors and transporter in postnatal rats. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21611835. |
we investigated the influence of prenatal amphetamine exposure (pae) on dopamine (da) receptors, and dopamine transporter (dat) in various striatal and limbic subregions and locomotor activity induced by novel environmental conditions and amphetamine at two postnatal ages, 35 days old (prepubertal) and 60 days old (postpubertal). |
2012-02-08 |
2023-08-12 |
rat |
| Kevin H Chen, Edmund A Reese, Hyung-Wook Kim, Stanley I Rapoport, Jagadeesh S Ra. Disturbed neurotransmitter transporter expression in Alzheimer's disease brain. Journal of Alzheimer's disease : JAD. vol 26. issue 4. 2012-01-26. PMID:21743130. |
we hypothesized that altered reuptake of neurotransmitters by vesicular glutamate transporters (vgluts), excitatory amino acid transporters (eaats), the vesicular acetylcholine transporter (vacht), the serotonin reuptake transporter (sert), or the dopamine reuptake transporter (dat) are involved in the neurotransmission imbalance in ad. |
2012-01-26 |
2023-08-12 |
Not clear |
| Eric S Ramsson, Christopher D Howard, Dan P Covey, Paul A Garri. High doses of amphetamine augment, rather than disrupt, exocytotic dopamine release in the dorsal and ventral striatum of the anesthetized rat. Journal of neurochemistry. vol 119. issue 6. 2012-01-26. PMID:21806614. |
high doses of amphetamine (amph) are thought to disrupt normal patterns of action potential-dependent dopaminergic neurotransmission by depleting vesicular stores of dopamine (da) and inducing robust non-exocytotic da release or efflux via dopamine transporter (dat) reversal. |
2012-01-26 |
2023-08-12 |
rat |
| Kai-Chun Yang, Hsiao-Lun Ku, Chia-Liang Wu, Shyh-Jen Wang, Chen-Chang Yang, Jou-Fang Deng, Ming-Been Lee, Yuan-Hwa Cho. Striatal dopamine transporter binding for predicting the development of delayed neuropsychological sequelae in suicide attempters by carbon monoxide poisoning: A SPECT study. Psychiatry research. vol 194. issue 3. 2012-01-26. PMID:22044533. |
this study examined the role of dopamine transporter (dat) binding for the prediction of dns. |
2012-01-26 |
2023-08-12 |
Not clear |
| Mingqing Xu, Zhicheng Li. Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 5. 2012-01-19. PMID:21078357. |
previous genetic association studies have reported a possible role of the dopamine transporter (dat, gene symbol: slc6a3) gene in the etiology of alcohol dependence, but the results were conflicting with each other. |
2012-01-19 |
2023-08-12 |
Not clear |
| A N Ortiz, D B Oien, J Moskovitz, M A Johnso. Quantification of reserve pool dopamine in methionine sulfoxide reductase A null mice. Neuroscience. vol 177. 2012-01-19. PMID:21219974. |
moreover, dopamine transporter (dat) labeling data indicate that the difference in measured da efflux was likely not caused by altered dat protein expression. |
2012-01-19 |
2023-08-12 |
mouse |
| B P Bergstrom, S G Sanberg, M Andersson, J Mithyantha, F I Carroll, P A Garri. Functional reorganization of the presynaptic dopaminergic terminal in parkinsonism. Neuroscience. vol 193. 2012-01-18. PMID:21787843. |
sustained release was replicated in intact animals after irreversible blockade of the dopamine transporter (dat) via rti-76, implicating neuronal uptake as a trigger. |
2012-01-18 |
2023-08-12 |
rat |
| Takato Hiranita, Paul L Soto, Stephen J Kohut, Theresa Kopajtic, Jianjing Cao, Amy H Newman, Gianluigi Tanda, Jonathan L Kat. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. The Journal of pharmacology and experimental therapeutics. vol 339. issue 2. 2012-01-16. PMID:21859929. |
rimcazole analogs differed from selective σr antagonists in their dual affinities for σrs and the dopamine transporter (dat) assessed with radioligand binding. |
2012-01-16 |
2023-08-12 |
Not clear |
| Tim Hahn, Sebastian Heinzel, Thomas Dresler, Michael M Plichta, Tobias J Renner, Falko Markulin, Peter M Jakob, Klaus-Peter Lesch, Andreas J Fallgatte. Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype. Human brain mapping. vol 32. issue 10. 2012-01-13. PMID:20845394. |
we addressed this issue by investigating the triadic interplay between vs reactivity during reward anticipation using functional magnetic resonance imaging, trait reward sensitivity, and dopamine (da) transporter genotype (40-bp 3'vntr of dat, slc6a3) affecting synaptic da neurotransmission. |
2012-01-13 |
2023-08-12 |
human |
| Clara Velazquez-Sanchez, Antonio Ferragud, Jaime Renau-Piqueras, Juan J Canale. Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction. The international journal of neuropsychopharmacology. vol 14. issue 5. 2012-01-06. PMID:20735880. |
n-substituted benztropine (bzt) analogs are molecules that display high affinity for the dopamine transporter (dat), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. |
2012-01-06 |
2023-08-12 |
mouse |
| Yosefu Arime, Yumiko Kubo, Ichiro Sor. Animal models of attention-deficit/hyperactivity disorder. Biological & pharmaceutical bulletin. vol 34. issue 9. 2011-12-30. PMID:21881220. |
there has been considerable research on this disorder using genetic, pharmacological, and neuroimaging approaches, and several animal models of ad/hd such as spontaneously hypertensive rat (shr), dopamine transporter (dat) knockout mice, coloboma mutant mouse, and grin1 mutant mouse have been reported. |
2011-12-30 |
2023-08-12 |
mouse |
| Deepangi Pandit, William Roosma, Milind Misra, Kathleen M Gilbert, William J Skawinski, Carol A Venanz. Conformational analysis of piperazine and piperidine analogs of GBR 12909: stochastic approach to evaluating the effects of force fields and solvent. Journal of molecular modeling. vol 17. issue 1. 2011-12-19. PMID:20414792. |
as a first step in the 3d-qsar modeling of the dopamine transporter (dat)/serotonin transporter (sert) selectivity of these compounds, we carried out conformational analyses of two analogs of 1: a piperazine (2) and a related piperidine (3). |
2011-12-19 |
2023-08-12 |
Not clear |
| Emily Karanges, Kong M Li, Craig Motbey, Paul D Callaghan, Andrew Katsifis, Iain S McGrego. Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents? The international journal of neuropsychopharmacology. vol 14. issue 4. 2011-12-16. PMID:21329552. |
subsequent ex-vivo analyses examined serum prx concentrations, striatal neurotransmitter content, and regional serotonin and dopamine transporter (sert, dat) binding density. |
2011-12-16 |
2023-08-12 |
human |