| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Han, Xu-Feng Huang, Chao Den. Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19203411. |
aripiprazole also decreased dopamine transporter (dat) binding density in nac (for 1- and 12-wk treatment) and vta (1-wk treatment). |
2011-09-06 |
2023-08-12 |
Not clear |
| Courtney M Keller, Michael F Salvatore, Brandon S Pruett, Glenn F Guerin, Nicholas E Goeder. Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat. Psychopharmacology. vol 215. issue 3. 2011-09-01. PMID:21523347. |
methamphetamine (ma) increases extracellular dopamine (da) and at chronic high doses induces toxicity as indicated by decreased expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2011-09-01 |
2023-08-12 |
rat |
| Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlo. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21508084. |
in vitro selectivity profiling of met-1 demonstrated physiologically relevant transporter binding affinity at serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net) (323, 3020, and 3410 nm, respectively); whereas the parent compound amn082 had appreciable affinity at net (1385 nm). |
2011-08-30 |
2023-08-12 |
rat |
| Alejandro Higuera-Matas, Fanny Botreau, Nuria Del Olmo, Miguel Miguéns, Oscar Olías, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosi. Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 12. 2011-08-26. PMID:20655181. |
we evaluated the levels of the dopamine transporter (dat), and the d1- (d1r) and d2-type (d2r) dopaminergic receptors, as well as tyrosine hydroxylase (th) mrna in dopaminergic areas of the adult, cocaine self-administered, rat brain that had been chronically exposed to cp or vehicle (vh) during periadolescence. |
2011-08-26 |
2023-08-12 |
human |
| Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O'Shea, Eduardo D Martin, M Isabel Colado, Rosario Moratall. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21303698. |
methamphetamine (meth) and 3,4-methylenedioxymethamphetamine (mdma), amphetamine derivatives widely used as recreational drugs, induce similar neurotoxic effects in mice, including a marked loss of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum. |
2011-08-23 |
2023-08-12 |
mouse |
| Guy Mittleman, Stanford B Call, Jody L Cockroft, Dan Goldowitz, Douglas B Matthews, Charles D Blah. Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice. Alcohol (Fayetteville, N.Y.). vol 45. issue 4. 2011-08-23. PMID:21354763. |
preclinical and clinical evidence suggest an association between alcoholism and the primary regulator of extracellular dopamine concentrations, the dopamine transporter (dat). |
2011-08-23 |
2023-08-12 |
mouse |
| Guy Mittleman, Stanford B Call, Jody L Cockroft, Dan Goldowitz, Douglas B Matthews, Charles D Blah. Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: analyses in dopamine transporter knockout mice. Alcohol (Fayetteville, N.Y.). vol 45. issue 4. 2011-08-23. PMID:21354763. |
in vivo fixed potential amperometry in anesthetized mice was used to (1) identify functional characteristics of mesoaccumbens dopamine neurons related to genotype, including dopamine autoreceptor (dar) sensitivity, dat efficiency, and dat capacity, (2) determine if any of these characteristics correlated with alcohol drinking observed in dat+/+ and dat+/- animals, and (3) determine if sip-alcohol self-administration altered dar sensitivity, dat efficiency, and dat capacity by comparing these characteristics in wild-type (dat+/+) mice that were sip-alcohol naïve, with those that had undergone sip-alcohol testing. |
2011-08-23 |
2023-08-12 |
mouse |
| Jingying Liu, Lin Zhu, Karl Plössl, Brian P Lieberman, Hank F Kun. Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 21. issue 10. 2011-08-23. PMID:21458259. |
a series of novel n-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert) and norepinephrine (net) were determined via competitive radioligand binding assays. |
2011-08-23 |
2023-08-12 |
Not clear |
| Gholamreza Fazeli, Rajaraman Gnana Oli, Nicole Schupp, Helga Stoppe. The role of the dopamine transporter in dopamine-induced DNA damage. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:20875051. |
we studied the role of the dopamine transporter (dat) in mdck and mdck-dat cells, containing the human dat gene. |
2011-08-18 |
2023-08-12 |
human |
| Gholamreza Fazeli, Rajaraman Gnana Oli, Nicole Schupp, Helga Stoppe. The role of the dopamine transporter in dopamine-induced DNA damage. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:20875051. |
although stimulation of dopamine type 2 receptor (d(2)r) with quinpirole in the absence of dopamine did not induce genotoxicity in rat neuronal pc12 cells, interference with d(2)r signaling by inhibition of g-proteins, phosphoinositide 3 kinase and extracellular signal-regulated kinases reduced dopamine-induced genotoxicity and affected the ability of dat to take up dopamine. |
2011-08-18 |
2023-08-12 |
human |
| Gholamreza Fazeli, Rajaraman Gnana Oli, Nicole Schupp, Helga Stoppe. The role of the dopamine transporter in dopamine-induced DNA damage. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:20875051. |
d(2)r signaling was involved in the genotoxicity of dopamine by affecting activation and cell surface expression of dat and hence modulating dopamine uptake. |
2011-08-18 |
2023-08-12 |
human |
| Daniela Marazziti, Chiara Di Pietro, Silvia Mandillo, Elisabetta Golini, Rafaele Matteoni, Glauco P Tocchini-Valentin. Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, DeltaFosB expression, and conditioned place preference to amphetamine and cocaine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 6. 2011-08-18. PMID:21372109. |
the orphan g-protein-coupled receptor 37 (gpr37) colocalizes with the dopamine (da) transporter (dat) in mouse nigrostriatal presynaptic membranes, and its genetic ablation in homozygous null-mutant (gpr37-ko) mice provokes the marked increase of plasma membrane expression of dat, alteration of psychostimulant-induced locomotor activity, and reduction of catalepsy induced by da-receptor antagonists. |
2011-08-18 |
2023-08-12 |
mouse |
| Yuriko Iwakura, Yingjun Zheng, Maria Sibilia, Yuichi Abe, Ying-Shan Piao, Daisaku Yokomaku, Ran Wang, Yuta Ishizuka, Nobuyuki Takei, Hiroyuki Naw. Qualitative and quantitative re-evaluation of epidermal growth factor-ErbB1 action on developing midbrain dopaminergic neurons in vivo and in vitro: target-derived neurotrophic signaling (Part 1). Journal of neurochemistry. vol 118. issue 1. 2011-08-12. PMID:21517852. |
in vivo administration of erbb1 inhibitors to rat neonates diminished th and dopamine transporter (dat) levels in the striatum and globus pallidus but not in the frontal cortex. |
2011-08-12 |
2023-08-12 |
mouse |
| Simon Vermeire, Kurt Audenaert, Eva Vandermeulen, Tim Waelbers, Bart De Spiegeleer, Henri van Bree, Kathelijne Pereman. Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs. Veterinary journal (London, England : 1997). vol 188. issue 3. 2011-08-09. PMID:20558095. |
single photon emission computed tomography (spect) with the cocaine-analogue [(123)i]-fp-cit is widely used for in vivo assessment of the dopamine transporter (dat) availability. |
2011-08-09 |
2023-08-12 |
Not clear |
| A Millar, D Smith, J Choueiry, D Fisher, P Albert, V Knot. The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine. Neuroscience. vol 180. 2011-08-04. PMID:21315807. |
hypothesizing that individual differences in striatal dopamine levels may moderate auditory gating and its modulation by nicotine, this preliminary study used the mid-latency (p50) auditory event-related potential (erp) to examine the single dose (6 mg) effects of nicotine (vs. placebo) gum on sensory gating in 24 healthy nonsmokers varying in the genetic expression of the dopamine transporter (dat). |
2011-08-04 |
2023-08-12 |
Not clear |
| Ka Kit Wong, Martijn L T M Muller, Hiroto Kuwabara, Stephanie A Studenski, Nicolaas I Bohne. Olfactory loss and nigrostriatal dopaminergic denervation in the elderly. Neuroscience letters. vol 484. issue 3. 2011-08-02. PMID:20727944. |
community-dwelling subjects (n=73, 44 f/29 m, mean age 64.0±16.4, range 20-85) underwent brain dopamine transporter (dat) [(11)c]2-β-carbomethoxy-3β-(4-fluorophenyl) tropane (β-cft) positron emission tomography (pet) imaging and olfactory assessment using the 40-odor university of pennsylvania smell identification test (upsit). |
2011-08-02 |
2023-08-12 |
human |
| Jufang Shan, Jonathan A Javitch, Lei Shi, Harel Weinstei. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PloS one. vol 6. issue 1. 2011-08-02. PMID:21298009. |
the dopamine transporter (dat), a member of the neurotransmitter:na(+) symporter (nss) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the treatment of attention deficit disorder and depression. |
2011-08-02 |
2023-08-12 |
Not clear |
| Jasmin Bartl, Pille Link, Corinna Schlosser, Manfred Gerlach, Angelika Schmitt, Susanne Walitza, Peter Riederer, Edna Grünblat. Effects of methylphenidate: the cellular point of view. Attention deficit and hyperactivity disorders. vol 2. issue 4. 2011-08-01. PMID:21432609. |
the psychostimulant methylphenidate (mph) is the first choice of treatment in attention-deficit hyperactivity disorder and is based mainly on inhibition of dopamine transporter (dat). |
2011-08-01 |
2023-08-12 |
rat |
| Olof Eriksson, Bengt Långström, Ray Josephsso. Assessment of receptor occupancy-over-time of two dopamine transporter inhibitors by [(11)C]CIT and target controlled infusion. Upsala journal of medical sciences. vol 116. issue 2. 2011-07-28. PMID:21443419. |
occupancy-over-time was determined for two dopamine transporter (dat) inhibitors through modeling of their ability to displace the pet ligand [(11)c]cit. |
2011-07-28 |
2023-08-12 |
Not clear |
| Po See Chen, Tzung Lieh Yeh, I Hui Lee, Cheng Bill Lin, Hsin Chun Tsai, Kao Chin Chen, Nan-Tsing Chiu, Wei Jen Yao, Yen Kuang Yang, Yuan-Hwa Cho. Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study. NeuroImage. vol 56. issue 3. 2011-07-25. PMID:21371559. |
striatal dopaminergic activity is significantly correlated with various cognitive activities, mood regulation, and even metabolic homeostasis, and is modulated by the dopamine transporter (dat). |
2011-07-25 |
2023-08-12 |
human |