| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 19. 2011-07-25. PMID:21562283. |
r-mdma (rectus-mdma) is relatively selective for 5-ht(2a) receptors, whereas s-mdma (sinister-mdma) inhibits both serotonin (sert) and dopamine transporters (dat; sert/dat ratio of 10 to 1). |
2011-07-25 |
2023-08-12 |
marmoset |
| Teresa R Franklin, Ze Wang, Yin Li, Jesse J Suh, Marina Goldman, Falk W Lohoff, Jeffrey Cruz, Rebecca Hazan, Will Jens, John A Detre, Wade Berrettini, Charles P O'Brien, Anna Rose Childres. Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. Addiction biology. vol 16. issue 2. 2011-07-20. PMID:21299752. |
previously we demonstrated profound effects of dopamine transporter (dat) slc6a3 genotype on limbic responses to smoking cues (scs). |
2011-07-20 |
2023-08-12 |
Not clear |
| Jun Zhu, Michael T Bardo, Thomas A Green, Peter J Wedlund, Linda P Dwoski. Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17953677. |
thus, enrichment differentially alters dynamic responses of the dopamine transporter (dat) to repeated da application in mpfc, but not in striatum. |
2011-07-19 |
2023-08-12 |
rat |
| Raul R Gainetdino. Strengths and limitations of genetic models of ADHD. Attention deficit and hyperactivity disorders. vol 2. issue 1. 2011-07-18. PMID:21432587. |
multiple studies have reported associations between polymorphisms in dopamine transporter (dat) gene and adhd. |
2011-07-18 |
2023-08-12 |
mouse |
| Sofia T Duarte, Carlos Ortez, Ana Pérez, Rafael Artuch, Angels García-Cazorl. Analysis of synaptic proteins in the cerebrospinal fluid as a new tool in the study of inborn errors of neurotransmission. Journal of inherited metabolic disease. vol 34. issue 2. 2011-07-15. PMID:21229320. |
dopamine receptor type 2 (d2r), dopamine transporter (dat) and vesicular monoamine transporter type 2 (vmat2) were analysed in csf samples from 30 healthy controls (11 days to 17 years) by western blot analysis. |
2011-07-15 |
2023-08-12 |
human |
| Christopher J Earley, Hiroto Kuwabara, Dean F Wong, Charlene Gamaldo, Rachel Salas, James Brasic, Hayden T Ravert, Robert F Dannals, Richard P Alle. The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome. Sleep. vol 34. issue 3. 2011-07-14. PMID:21358851. |
prior studies, all using spect techniques, failed to find any differences for dopamine transporter (dat) in restless legs syndrome (rls) subjects. |
2011-07-14 |
2023-08-12 |
human |
| Thomas E Wooters, Michael T Bardo, Linda P Dwoskin, Narasimha M Midde, Adrian M Gomez, Charles F Mactutus, Rosemarie M Booze, Jun Zh. Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics. Behavioural brain research. vol 219. issue 1. 2011-07-13. PMID:21219939. |
this study determined whether environmental enrichment differentially altered the effects of mpd on locomotor activity and dopamine (da) transporter (dat) function. |
2011-07-13 |
2023-08-12 |
rat |
| Anjali Rao, Diana Simmons, Alexander Sorki. Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20816972. |
dopamine (da) transporter (dat) functions at the surface of dopaminergic neurons to clear extracellular da. |
2011-07-05 |
2023-08-12 |
rat |
| Yu Luo, Yun Wang, Serena Y Kuang, Yung-Hsiao Chiang, Barry Hoffe. Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151937. |
compared to naïve mice that received meth binge treatment for the first time, mice pretreated with meth in adolescence showed a greater loss of tyrosine hydroxylase (th) immunoreactivity in striatum, loss of thir fibers in the substantia nigra reticulata (snr) as well as decreased dopamine transporter (dat) level and compromised da clearance in striatum. |
2011-07-05 |
2023-08-12 |
mouse |
| Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutt. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21446715. |
the novel compounds were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2011-07-04 |
2023-08-12 |
rat |
| Xiongzhao Zhu, Sufang Peng, Xiuling Ma, Ting L. [Effect of maternal deprivation on emotion and expression of dopamine transporter in adult rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 35. issue 1. 2011-06-30. PMID:20130362. |
to investigate the change of emotion and striatum dopamine transporter(dat) expression in adult male rats experiencing maternal deprivation, and to explore whether dna methylation is involved in the regulatory mechanism of dat expression. |
2011-06-30 |
2023-08-12 |
rat |
| Lee E Eiden, Eberhard Weih. VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse. Annals of the New York Academy of Sciences. vol 1216. 2011-06-21. PMID:21272013. |
the effects of amphetamine (amph) and cocaine (coc), for example, depend on the ability to increase dopamine in the synapse, by effects on either the plasma membrane transporter dat or the vesicular transporter for monoamine storage, vmat2. |
2011-06-21 |
2023-08-12 |
Not clear |
| John A Gruner, Joanne R Mathiasen, Dorothy G Flood, Maciej Gasio. Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats. The Journal of pharmacology and experimental therapeutics. vol 337. issue 2. 2011-06-21. PMID:21300706. |
the nature of sydnocarb-induced facilitation of dopamine (da) neurotransmission [da release versus da transporter (dat) inhibition] is not clear. |
2011-06-21 |
2023-08-12 |
human |
| H A Boger, P Mannangatti, D J Samuvel, A J Saylor, T S Bender, J F McGinty, A M Fortress, V Zaman, P Huang, L D Middaugh, P K Randall, L D Jayanthi, B Rohrer, K L Helke, A-C Granholm, S Ramamoorth. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, brain, and behavior. vol 10. issue 2. 2011-06-15. PMID:20860702. |
dopamine neurotransmitter markers indicated no genotypic difference in striatal tyrosine hydroxylase, da transporter (dat) or vesicular monoamine transporter 2 (vmat2) immunoreactivity at any age. |
2011-06-15 |
2023-08-12 |
mouse |
| Akiko Muroyama, Shota Kobayashi, Yasuhide Mitsumot. Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice. Neuroscience research. vol 69. issue 4. 2011-06-15. PMID:21185886. |
to investigate the selective daergic neurotoxicity, we have developed an immunological technique to isolate daergic synaptosomes from mouse striatal tissues using an antibody against 20 amino acid residues in the extracellular second loop of dopamine transporter (dat). |
2011-06-15 |
2023-08-12 |
mouse |
| Akiko Muroyama, Shota Kobayashi, Yasuhide Mitsumot. Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice. Neuroscience research. vol 69. issue 4. 2011-06-15. PMID:21185886. |
gbr-12909, a dopamine uptake inhibitor, completely reversed the mptp-induced decrease of dat protein in the daergic synaptosomes. |
2011-06-15 |
2023-08-12 |
mouse |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
in this report, we employed cbv-weighted phmri to compare cocaine-modulated neuronal activity in dopamine transporter (dat) knockout (ko) and wild-type mice. |
2011-06-10 |
2023-08-12 |
mouse |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (dat, net, and sert) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. |
2011-06-10 |
2023-08-12 |
mouse |
| Esther Cubo, Mateo Diez López, Jon Infante Ceberio, Isabel Lanchas Alfonso, Begoña Miguel Martinez, José Berciano, Fernando Iglesias, José A Obes. Striatal dopamine function in a family with multiple SCA-3 phenotypes. Journal of neurology. vol 258. issue 2. 2011-06-08. PMID:20809346. |
sca-3 can present with a levodopa responsive parkinsonism phenotype, and an abnormal dat scan showing predominant impairment of presynaptic dopamine function. |
2011-06-08 |
2023-08-12 |
Not clear |
| Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossell. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. vol 46. issue 3. 2011-06-02. PMID:21272963. |
with the aim of obtaining compounds possessing high sert selectivity, in the present work we synthesized and studied the inhibition of serotonin (sert), dopamine (dat) and norepinephrine (net) transporters by docking studies and experimental binding measurements of a series of 4-(aryl)piperidin-3-one o-4-benzyl oxime hydrochlorides (1-10) of both e and z configuration. |
2011-06-02 |
2023-08-12 |
Not clear |