| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonas Hannestad, Jean-Dominique Gallezot, Beata Planeta-Wilson, Shu-Fei Lin, Wendol A Williams, Christopher H van Dyck, Robert T Malison, Richard E Carson, Yu-Shin Din. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biological psychiatry. vol 68. issue 9. 2011-02-15. PMID:20691429. |
in vitro, the affinity of methylphenidate for the norepinephrine transporter (net) is higher than that for the dopamine transporter (dat). |
2011-02-15 |
2023-08-12 |
Not clear |
| Ashutosh Kumar, Israr Ahmad, Smriti Shukla, Brajesh Kumar Singh, Devendra Kumar Patel, Haushila Prasad Pandey, Chetna Sing. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Free radical research. vol 44. issue 8. 2011-02-14. PMID:20553223. |
altered dopamine transporter (dat) and vesicular monoamine transporter-2 (vmat-2) are also documented in pd. |
2011-02-14 |
2023-08-12 |
rat |
| Jeff A Beeler, Nathaniel Daw, Cristianne R M Frazier, Xiaoxi Zhuan. Tonic dopamine modulates exploitation of reward learning. Frontiers in behavioral neuroscience. vol 4. 2011-02-07. PMID:21120145. |
we quantitatively evaluate the role of tonic dopamine in these functions by studying the behavior of hyperdopaminergic dat knockdown mice in an instrumental task in a semi-naturalistic homecage environment. |
2011-02-07 |
2023-08-12 |
mouse |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
the aim of this study was to examine rat thymus innervation using denervation techniques and to explore the related micro-anatomical localization of dopamine, d1, d2 receptors and dopamine membrane transporter (dat). |
2011-02-04 |
2023-08-12 |
rat |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
no variation in dopamine and dat immune reaction was observed following total or partial parasympathectomy or phrenic nerve cutting. |
2011-02-04 |
2023-08-12 |
rat |
| F Mignini, M Sabbatini, V D'Andrea, C Cavallott. Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. European journal of histochemistry : EJH. vol 54. issue 2. 2011-02-04. PMID:20558339. |
after chemical or surgical sympathectomy however, neither dopamine nor dat immune reaction was noted again. |
2011-02-04 |
2023-08-12 |
rat |
| David J Brook. Imaging dopamine transporters in Parkinson's disease. Biomarkers in medicine. vol 4. issue 5. 2011-02-04. PMID:20945978. |
the dopamine transporter (dat) is responsible for clearance of dopamine from the synaptic cleft after its release. |
2011-02-04 |
2023-08-12 |
human |
| David J Brook. Imaging dopamine transporters in Parkinson's disease. Biomarkers in medicine. vol 4. issue 5. 2011-02-04. PMID:20945978. |
imaging dat availability provides a measure of dopamine terminal function and a method for detecting striatal dopamine deficiency states present in idiopathic parkinson's disease and atypical neurodegenerative parkinsonian disorders such as multiple system atrophy and progressive supranuclear palsy. |
2011-02-04 |
2023-08-12 |
human |
| Kurt A Jellinge. Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20965169. |
recent neurochemical studies in postmortem brains of patients with parkinson's disease (pd), pd with dementia (pdd) and age-matched controls revealed significant decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in striatum, confirming previous studies indicating substantial loss of dopaminergic neurons and terminals. |
2011-02-04 |
2023-08-12 |
mouse |
| Theresa A Kopajtic, Yi Liu, Christopher K Surratt, David M Donovan, Amy H Newman, Jonathan L Kat. Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20855444. |
the benztropine analog n-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane (jhw 007) displays high affinity for the dopamine transporter (dat), but unlike typical dat ligands, has relatively low abuse liability and blocks the effects of cocaine, including its self-administration. |
2011-02-03 |
2023-08-12 |
mouse |
| Barbara J Caldarone, Neil E Paterson, Jia Zhou, Daniela Brunner, Alan P Kozikowski, Koen G C Westphal, Gerdien A H Korte-Bouws, Jolanda Prins, S Mechiel Korte, Berend Olivier, Afshin Ghavam. The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. The Journal of pharmacology and experimental therapeutics. vol 335. issue 3. 2011-02-03. PMID:20864506. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter, and serotonin transporter are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2011-02-03 |
2023-08-12 |
mouse |
| Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chi. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study. Psychiatry research. vol 184. issue 3. 2011-02-03. PMID:21030217. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. |
2011-02-03 |
2023-08-12 |
human |
| Andrea Varrone, Miklós Tóth, Carsten Steiger, Akihiro Takano, Denis Guilloteau, Masanori Ichise, Balázs Gulyás, Christer Halldi. Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 52. issue 1. 2011-02-02. PMID:21189414. |
18f-(e)-n-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β- (4'-methyl-phenyl)nortropane (18f-fe-pe2i) is a novel radioligand for dopamine transporter (dat) pet. |
2011-02-02 |
2023-08-12 |
rat |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Pedro Barroso-Chinea, Diego Álvarez de la Rosa, Javier Castro-Hernández, Josmar Salas-Hernández, Teresa Giráldez, Tomás González-Hernánde. The dopamine transporter is differentially regulated after dopaminergic lesion. Neurobiology of disease. vol 40. issue 3. 2011-01-25. PMID:20688165. |
the dopamine transporter (dat) is a transmembrane glycoprotein responsible for dopamine (da) uptake, which has been shown to be involved in da-cell degeneration in parkinson's disease (pd). |
2011-01-25 |
2023-08-12 |
rat |
| Milind Misra, Qing Shi, Xiaocong Ye, Ewa Gruszecka-Kowalik, Wei Bu, Zhanzhu Liu, Margaret M Schweri, Howard M Deutsch, Carol A Venanz. Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorganic & medicinal chemistry. vol 18. issue 20. 2011-01-24. PMID:20846865. |
complementary two-dimensional (2d) and three-dimensional (3d) quantitative structure-activity relationship (qsar) techniques were used to derive a preliminary model for the dopamine transporter (dat) binding affinity of 80 racemic threo-methylphenidate (mp) analogs. |
2011-01-24 |
2023-08-12 |
Not clear |
| Angela M Batman, Aloke K Dutta, Maarten E A Reith, Patrick M Beardsle. The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization. European journal of pharmacology. vol 648. issue 1-3. 2011-01-21. PMID:20840845. |
inhibitors with varying selectivity at the dopamine transporter (dat) have approximated these properties. |
2011-01-21 |
2023-08-12 |
Not clear |
| M A Cervinski, J D Foster, R A Vaugha. Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643191. |
we investigated the functional relationship between the soluble n-ethylmaleimide-sensitive factor attachment receptor (snare) protein syntaxin 1a (syn 1a) and the dopamine transporter (dat) by treating rat striatal tissue with botulinum neurotoxin c (bont/c) and co-transfecting syn 1a with dat in non-neuronal cells, followed by analysis of dat activity, phosphorylation, and regulation. |
2011-01-20 |
2023-08-12 |
rat |
| M A Cervinski, J D Foster, R A Vaugha. Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643191. |
treatment of striatal slices with bont/c resulted in elevated dopamine (da) transport vmax and reduced dat phosphorylation, while heterologous co-expression of syn 1a led to reduction in dat surface expression and transport vmax. |
2011-01-20 |
2023-08-12 |
rat |
| b' Anne Tammim\\xc3\\xa4ki, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Effect of genetic modifications in the synaptic dopamine clearance systems on addiction-like behaviour in mice. Basic & clinical pharmacology & toxicology. vol 108. issue 1. 2011-01-20. PMID:21118356.' |
in the dopamine transporter (dat), a vesicular monoamine transporter 2 (vmat2) or two dopamine-metabolizing enzymes (monoamine oxidase, mao, mainly mao-a isoenzyme, and catechol-o-methyltransferase, comt). |
2011-01-20 |
2023-08-12 |
mouse |
| Catrin Wernicke, Julian Hellmann, Ulrich Finckh, Hans Rommelspache. Chronic ethanol exposure changes dopamine D2 receptor splicing during retinoic acid-induced differentiation of human SH-SY5Y cells. Pharmacological reports : PR. vol 62. issue 4. 2011-01-12. PMID:20885005. |
the dopamine d2 receptor (drd2) and the dopamine transporter (dat) are decisively involved in dopaminergic signaling. |
2011-01-12 |
2023-08-12 |
human |