| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chie Seki, Hiroshi Ito, Tetsuya Ichimiya, Ryosuke Arakawa, Yoko Ikoma, Miho Shidahara, Jun Maeda, Akihiro Takano, Hidehiko Takahashi, Yuichi Kimura, Kazutoshi Suzuki, Iwao Kanno, Tetsuya Suhar. Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models. Annals of nuclear medicine. vol 24. issue 4. 2010-09-10. PMID:20364374. |
dopamine transporter (dat) is a reuptake carrier of dopamine at presynapse that regulates dopaminergic neural transmission. |
2010-09-10 |
2023-08-12 |
human |
| Andre C Felicio, Tais S Moriyama, Clecio Godeiro-Junior, Ming C Shih, Marcelo Q Hoexter, Vanderci Borges, Sonia M A Silva, Edson Amaro-Junior, Luiz A F Andrade, Henrique B Ferraz, Rodrigo A Bressa. Higher dopamine transporter density in Parkinson's disease patients with depression. Psychopharmacology. vol 211. issue 1. 2010-09-10. PMID:20495790. |
molecular imaging studies have shown a reduction of dopamine transporter (dat) density in depressed pd patients (dpd); however, dat role in the pathophysiology of pd depression is not clear since clinical matching was inappropriate and dat reduction could be attributed to pd severity. |
2010-09-10 |
2023-08-12 |
Not clear |
| Ji-Hoon Yoo, Alexis Bailey, Micheal Ansonoff, John E Pintar, Audrey Matifas, Brigitte L Kieffer, Ian Kitche. Lack of genotype effect on D1, D2 receptors and dopamine transporter binding in triple MOP-, DOP-, and KOP-opioid receptor knockout mice of three different genetic backgrounds. Synapse (New York, N.Y.). vol 64. issue 7. 2010-09-08. PMID:20196137. |
we investigated d1, d2 receptors and dopamine transporter (dat) binding levels in mice lacking all three opioid receptors and wild-type (wt) mice on three different genetic backgrounds. |
2010-09-08 |
2023-08-12 |
mouse |
| Jeffrey S Stehouwer, Lauryn M Daniel, Ping Chen, Ronald J Voll, Larry Williams, Susan J Plott, John R Votaw, Michael J Owens, Leonard Howell, Mark M Goodma. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography. Journal of medicinal chemistry. vol 53. issue 15. 2010-09-08. PMID:20597489. |
the n-(e)-fluorobutenyl-3beta-(para-halo-phenyl)nortropanes 9-12 were synthesized as ligands of the dopamine transporter (dat) for use as (18)f-labeled positron emission tomography (pet) imaging agents. |
2010-09-08 |
2023-08-12 |
monkey |
| Francesco Napolitano, Alessandra Bonito-Oliva, Mauro Federici, Manolo Carta, Francesco Errico, Salvatore Magara, Giuseppina Martella, Robert Nisticò, Diego Centonze, Antonio Pisani, Howard H Gu, Nicola B Mercuri, Alessandro Usiell. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720111. |
several lines of research support a crucial role for the dopamine transporter (dat) gene in this psychiatric disease. |
2010-09-03 |
2023-08-12 |
mouse |
| Francesco Napolitano, Alessandra Bonito-Oliva, Mauro Federici, Manolo Carta, Francesco Errico, Salvatore Magara, Giuseppina Martella, Robert Nisticò, Diego Centonze, Antonio Pisani, Howard H Gu, Nicola B Mercuri, Alessandro Usiell. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 33. 2010-09-03. PMID:20720111. |
recently, a knock-in mouse [dat-cocaine insensitive (dat-ci)] has been generated carrying a cocaine-insensitive dat that is functional but with reduced dopamine uptake function. |
2010-09-03 |
2023-08-12 |
mouse |
| Morten Ziebell, Lars H Pinborg, Gerda Thomsen, Robin de Nijs, Claus Svarer, Aase Wagner, Gitte M Knudse. MRI-guided region-of-interest delineation is comparable to manual delineation in dopamine transporter SPECT quantification in patients: a reproducibility study. Journal of nuclear medicine technology. vol 38. issue 2. 2010-09-01. PMID:20484180. |
a particularly sensitive step in the quantification of spect images of the dopamine transporter (dat) is a correct delineation of the region of interest (roi). |
2010-09-01 |
2023-08-12 |
Not clear |
| Noelia Granado, Sara Ares-Santos, Esther O'Shea, Carlos Vicario-Abejón, M Isabel Colado, Rosario Moratall. Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine. Neurotoxicity research. vol 18. issue 1. 2010-08-31. PMID:19760475. |
we examined the effect of meth on tyrosine hydroxylase (th) and dopamine transporter (dat) immunoreactivity in the different compartments of the striatum and in the nucleus accumbens. |
2010-08-31 |
2023-08-12 |
mouse |
| Felipe Opazo, Jörg B Schulz, Björn H Falkenburge. PKC links Gq-coupled receptors to DAT-mediated dopamine release. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20477913. |
the dopamine transporter (dat) mediates dopamine uptake in many brain areas and has been suggested to underlie dopamine release in the substantia nigra pars reticulata. |
2010-08-23 |
2023-08-12 |
rat |
| Manuel Garcia-Garcia, Immaculada Clemente, Judith Domínguez-Borràs, Carles Escer. Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context. Neuropsychologia. vol 48. issue 5. 2010-08-09. PMID:20117122. |
forty healthy volunteers were genotyped for the dopamine transporter (dat) gene slc6a3 or dat1 and performed an auditory-visual distraction paradigm in negative and neutral emotional context conditions. |
2010-08-09 |
2023-08-12 |
human |
| Gang Zhao, Jie Wang, Guo-Wei Qin, Li-He Gu. Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20084455. |
here, we assessed these potential actions using chinese hamster ovary cells expressing gamma-aminobutyric acid (gaba) transporter (gat-1), dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2010-08-02 |
2023-08-12 |
Not clear |
| Dean E Dluzen, Jing Ji, Janet L McDermot. Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice. Neuroscience letters. vol 476. issue 2. 2010-07-30. PMID:20382201. |
in this report we compared three different parameters of nigrostriatal dopaminergic (nsda) function - locomotor activity, striatal dopamine (da) levels and 3,4-dihydroxyphenylacetic acid (dopac)/da ratios between heterozygous mutant dopamine transporter mice (+/- dat) and their wild type controls (+/+ dat) at three different age range periods: 4-10, 11-17 and 18-24 months of age. |
2010-07-30 |
2023-08-12 |
mouse |
| Lucia Carvelli, Dawn S Matthies, Aurelio Gall. Molecular mechanisms of amphetamine actions in Caenorhabditis elegans. Molecular pharmacology. vol 78. issue 1. 2010-07-30. PMID:20410438. |
amph elicits its behavioral effects primarily by increasing extracellular dopamine (da) levels through the reversal of the da transporter (dat) cycle and, as a consequence, altering da signaling. |
2010-07-30 |
2023-08-12 |
caenorhabditis_elegans |
| Ioannis U Isaias, Giorgio Marotta, Shigeki Hirano, Margherita Canesi, Riccardo Benti, Andrea Righini, Chengke Tang, Roberto Cilia, Gianni Pezzoli, David Eidelberg, Angelo Antonin. Imaging essential tremor. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 6. 2010-07-28. PMID:20437537. |
to investigate over time changes in striatal dopamine transporter (dat), we performed two sequential n-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) tropane single photon computed tomography (spect) scans in 20 subjects with essential tremor (et), in 13 with parkinson disease (pd) and in 23 healthy controls (hc, one scan only). |
2010-07-28 |
2023-08-12 |
human |
| Fang-yin Dai, Liang Qiao, Xiao-ling Tong, Cun Cao, Peng Chen, Jun Chen, Cheng Lu, Zhong-huai Xian. Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant. The Journal of biological chemistry. vol 285. issue 25. 2010-07-21. PMID:20332088. |
by positional cloning, we identified the candidate gene of the mln locus, bm-iaanat, whose homologous gene (dat) converts dopamine into n-acetyldopamine, a precursor for n-acetyldopamine sclerotin in drosophila. |
2010-07-21 |
2023-08-12 |
drosophila_melanogaster |
| Fuat Balci, Elliot A Ludvig, Ron Abner, Xiaoxi Zhuang, Patrick Poon, Dani Brunne. Motivational effects on interval timing in dopamine transporter (DAT) knockdown mice. Brain research. vol 1325. 2010-07-19. PMID:20167208. |
motivational effects on interval timing in dopamine transporter (dat) knockdown mice. |
2010-07-19 |
2023-08-12 |
mouse |
| Fuat Balci, Elliot A Ludvig, Ron Abner, Xiaoxi Zhuang, Patrick Poon, Dani Brunne. Motivational effects on interval timing in dopamine transporter (DAT) knockdown mice. Brain research. vol 1325. 2010-07-19. PMID:20167208. |
we examined interval timing in mice that underexpress the dopamine transporter (dat) and have chronically higher levels of extracellular dopamine (zhuang et al., 2001). |
2010-07-19 |
2023-08-12 |
mouse |
| Fuat Balci, Elliot A Ludvig, Ron Abner, Xiaoxi Zhuang, Patrick Poon, Dani Brunne. Motivational effects on interval timing in dopamine transporter (DAT) knockdown mice. Brain research. vol 1325. 2010-07-19. PMID:20167208. |
our data are consistent with the view that tonic dopamine affects the sensitivity of an organism to external reward signals, and that this increased motivation for reward of dat kd mice lowers the threshold for initiating responding in a timing task. |
2010-07-19 |
2023-08-12 |
mouse |
| Antonio C Farias, Alexandre Cunha, Cássia R Benko, James T McCracken, Maria T Costa, Lucilene G Farias, Mara L Cordeir. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. Journal of child and adolescent psychopharmacology. vol 20. issue 2. 2010-07-15. PMID:20415606. |
recent studies have suggested that mn accumulates in dopaminergic neurons via the presynaptic dopamine transporter (dat). |
2010-07-15 |
2023-08-12 |
Not clear |
| Antonio C Farias, Alexandre Cunha, Cássia R Benko, James T McCracken, Maria T Costa, Lucilene G Farias, Mara L Cordeir. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. Journal of child and adolescent psychopharmacology. vol 20. issue 2. 2010-07-15. PMID:20415606. |
the pharmacotherapeutic effect of mph occurs primarily through its action of inhibiting dat, and thus increasing dopamine, as well as other catecholamines, at the synapse. |
2010-07-15 |
2023-08-12 |
Not clear |